Details for: HSD11B1

Gene ID: 3290

Symbol: HSD11B1

Ensembl ID: ENSG00000117594

Description: hydroxysteroid 11-beta dehydrogenase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 7.9378
    Cell Significance Index: 10.2700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 6.6108
    Cell Significance Index: 90.6600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 6.3603
    Cell Significance Index: 82.3000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.5705
    Cell Significance Index: 60.1500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.3623
    Cell Significance Index: -5.1700
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.5308
    Cell Significance Index: 7.2900
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.8890
    Cell Significance Index: 9.8200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.8153
    Cell Significance Index: 13.0800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7143
    Cell Significance Index: 494.0500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3715
    Cell Significance Index: 7.2500
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.3674
    Cell Significance Index: 4.0100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.3157
    Cell Significance Index: 4.6600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3109
    Cell Significance Index: 4.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1750
    Cell Significance Index: 12.3800
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.1736
    Cell Significance Index: 1.0000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1652
    Cell Significance Index: 4.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1211
    Cell Significance Index: 21.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1192
    Cell Significance Index: 23.9100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1031
    Cell Significance Index: 1.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0776
    Cell Significance Index: 9.5500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0358
    Cell Significance Index: 1.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0283
    Cell Significance Index: 2.1800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0155
    Cell Significance Index: 0.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0152
    Cell Significance Index: 6.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0036
    Cell Significance Index: 4.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0017
    Cell Significance Index: -0.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0023
    Cell Significance Index: -4.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0043
    Cell Significance Index: -7.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0069
    Cell Significance Index: -4.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0078
    Cell Significance Index: -5.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0086
    Cell Significance Index: -13.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0112
    Cell Significance Index: -6.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0191
    Cell Significance Index: -12.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0221
    Cell Significance Index: -16.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0251
    Cell Significance Index: -11.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0260
    Cell Significance Index: -14.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0308
    Cell Significance Index: -3.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0361
    Cell Significance Index: -6.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0399
    Cell Significance Index: -8.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0410
    Cell Significance Index: -11.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0448
    Cell Significance Index: -8.9000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0678
    Cell Significance Index: -7.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0687
    Cell Significance Index: -9.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0772
    Cell Significance Index: -11.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0985
    Cell Significance Index: -12.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1074
    Cell Significance Index: -10.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1127
    Cell Significance Index: -5.3000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1140
    Cell Significance Index: -4.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1188
    Cell Significance Index: -13.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1247
    Cell Significance Index: -14.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1268
    Cell Significance Index: -3.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1357
    Cell Significance Index: -14.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1421
    Cell Significance Index: -16.2800
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1442
    Cell Significance Index: -1.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1643
    Cell Significance Index: -10.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1682
    Cell Significance Index: -11.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1813
    Cell Significance Index: -8.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1836
    Cell Significance Index: -5.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1887
    Cell Significance Index: -14.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2187
    Cell Significance Index: -8.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2188
    Cell Significance Index: -3.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2312
    Cell Significance Index: -4.8400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2506
    Cell Significance Index: -6.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2596
    Cell Significance Index: -16.3600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2624
    Cell Significance Index: -3.8100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2643
    Cell Significance Index: -3.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2645
    Cell Significance Index: -13.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2646
    Cell Significance Index: -9.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2674
    Cell Significance Index: -14.0400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2732
    Cell Significance Index: -4.6700
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.2736
    Cell Significance Index: -4.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2778
    Cell Significance Index: -15.5900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2917
    Cell Significance Index: -6.2400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2921
    Cell Significance Index: -2.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3238
    Cell Significance Index: -15.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3327
    Cell Significance Index: -10.6000
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.3332
    Cell Significance Index: -4.7400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3336
    Cell Significance Index: -2.2600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.3415
    Cell Significance Index: -4.3000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3461
    Cell Significance Index: -5.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3552
    Cell Significance Index: -11.6300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3889
    Cell Significance Index: -9.4200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3996
    Cell Significance Index: -14.6700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4019
    Cell Significance Index: -11.4700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.4083
    Cell Significance Index: -1.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4144
    Cell Significance Index: -14.5600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4230
    Cell Significance Index: -6.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4306
    Cell Significance Index: -12.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4335
    Cell Significance Index: -11.8000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.4353
    Cell Significance Index: -5.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4460
    Cell Significance Index: -11.9100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4461
    Cell Significance Index: -4.8500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4471
    Cell Significance Index: -9.4900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.4498
    Cell Significance Index: -4.4500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4598
    Cell Significance Index: -11.4700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4631
    Cell Significance Index: -13.6400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4715
    Cell Significance Index: -5.8800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.4764
    Cell Significance Index: -6.7700
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.4777
    Cell Significance Index: -4.8500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4852
    Cell Significance Index: -13.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HSD11B1 is a membrane-bound enzyme that exhibits both NADP+ and NADPH-dependent activities. It is a homodimeric enzyme composed of two identical subunits, each containing a flavin adenine dinucleotide (FAD) cofactor. The enzyme is highly specific for the conversion of cortisone to cortisol, with a Km value of 6.5 μM. HSD11B1 is predominantly expressed in tissues that require the modulation of glucocorticoid levels, such as the brain, adrenal glands, and peripheral tissues. **Pathways and Functions** HSD11B1 plays a critical role in regulating glucocorticoid levels in the body through the conversion of cortisone to cortisol. This process is essential for maintaining the homeostasis of glucocorticoids in various tissues. The enzyme is involved in the following pathways: 1. **Glucocorticoid biosynthesis**: HSD11B1 catalyzes the conversion of cortisone to cortisol, a critical step in the biosynthesis of glucocorticoids. 2. **Steroid catabolism**: The enzyme is also involved in the catabolism of steroids, including the conversion of cortisol to cortisone. 3. **Metabolism of lipids and steroids**: HSD11B1 is involved in the metabolism of lipids and steroids, including the conversion of cholesterol to cholesteryl esters. **Clinical Significance** Dysregulation of HSD11B1 has been implicated in various diseases, including: 1. **Glucocorticoid resistance**: HSD11B1 deficiency or overexpression can lead to glucocorticoid resistance, a condition characterized by impaired glucocorticoid action. 2. **Adrenal insufficiency**: HSD11B1 deficiency can lead to adrenal insufficiency, a condition characterized by impaired cortisol production. 3. **Cancer**: HSD11B1 overexpression has been observed in various types of cancer, including prostate cancer, suggesting a potential role in tumor progression. 4. **Neurological disorders**: HSD11B1 has been implicated in the pathogenesis of various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, HSD11B1 is a critical enzyme involved in the regulation of glucocorticoid levels in the body. Its dysregulation has been implicated in various diseases, highlighting the importance of this enzyme in maintaining homeostasis and preventing disease.

Genular Protein ID: 2468074247

Symbol: DHI1_HUMAN

Name: 7-oxosteroid reductase

UniProtKB Accession Codes:

P28845 B2R9Z1 D3DT89

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 80 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 29 DrugCentral 1 EC 2 EMBL 13 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 40 PDBsum 40 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 33 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1885595

Title: The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization.

PubMed ID: 1885595

DOI: 10.1016/s0021-9258(18)55351-5

PubMed ID: 12414862

Title: Association studies between microsatellite markers within the gene encoding human 11beta-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism.

PubMed ID: 12414862

DOI: 10.1210/jc.2001-011375

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8319583

Title: Structure and function of the hepatic form of 11 beta-hydroxysteroid dehydrogenase in the squirrel monkey, an animal model of glucocorticoid resistance.

PubMed ID: 8319583

DOI: 10.1210/endo.133.1.8319583

PubMed ID: 10497248

Title: The N-terminal anchor sequences of 11beta-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane.

PubMed ID: 10497248

DOI: 10.1074/jbc.274.40.28762

PubMed ID: 11481269

Title: Expression and putative role of 11 beta-hydroxysteroid dehydrogenase isozymes within the human eye.

PubMed ID: 11481269

PubMed ID: 12460758

Title: Purification of full-length recombinant human and rat type 1 11beta-hydroxysteroid dehydrogenases with retained oxidoreductase activities.

PubMed ID: 12460758

DOI: 10.1016/s1046-5928(02)00547-8

PubMed ID: 12858176

Title: Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency.

PubMed ID: 12858176

DOI: 10.1038/ng1214

PubMed ID: 14973125

Title: Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme.

PubMed ID: 14973125

DOI: 10.1074/jbc.m313615200

PubMed ID: 15095019

Title: Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism.

PubMed ID: 15095019

DOI: 10.1007/s00018-003-3476-y

PubMed ID: 15152005

Title: Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase.

PubMed ID: 15152005

DOI: 10.1074/jbc.m313666200

PubMed ID: 15280030

Title: Hexose-6-phosphate dehydrogenase determines the reaction direction of 11beta-hydroxysteroid dehydrogenase type 1 as an oxoreductase.

PubMed ID: 15280030

DOI: 10.1016/j.febslet.2004.06.065

PubMed ID: 17593962

Title: Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids.

PubMed ID: 17593962

DOI: 10.1371/journal.pone.0000561

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21453287

Title: Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11beta-hydroxysteroid dehydrogenase 1.

PubMed ID: 21453287

DOI: 10.1042/bj20110022

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27927697

Title: Absence of 11-keto reduction of cortisone and 11-ketotestosterone in the model organism zebrafish.

PubMed ID: 27927697

DOI: 10.1530/joe-16-0495

PubMed ID: 30902677

Title: Enzymatic interconversion of the oxysterols 7beta,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11beta-hydroxysteroid dehydrogenase type 1 and 2.

PubMed ID: 30902677

DOI: 10.1016/j.jsbmb.2019.03.011

PubMed ID: 15513927

Title: Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation.

PubMed ID: 15513927

DOI: 10.1074/jbc.m411104200

PubMed ID: 17070044

Title: Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors.

PubMed ID: 17070044

DOI: 10.1016/j.bmcl.2006.10.008

PubMed ID: 17919905

Title: The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors.

PubMed ID: 17919905

DOI: 10.1016/j.bmcl.2007.09.070

PubMed ID: 18485702

Title: Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.

PubMed ID: 18485702

DOI: 10.1016/j.bmcl.2008.04.069

PubMed ID: 18069989

Title: Structural characterization and pharmacodynamic effects of an orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor.

PubMed ID: 18069989

DOI: 10.1111/j.1747-0285.2007.00603.x

PubMed ID: 18553955

Title: Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model.

PubMed ID: 18553955

DOI: 10.1021/jm800310g

PubMed ID: 19217779

Title: Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors.

PubMed ID: 19217779

DOI: 10.1016/j.bmcl.2009.01.058

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 292
  • Mass: 32401
  • Checksum: 4632D0F3BBEFC474
  • Sequence:
    • MAFMKKYLLP ILGLFMAYYY YSANEEFRPE MLQGKKVIVT GASKGIGREM AYHLAKMGAH 
VVVTARSKET LQKVVSHCLE LGAASAHYIA GTMEDMTFAE QFVAQAGKLM GGLDMLILNH 
ITNTSLNLFH DDIHHVRKSM EVNFLSYVVL TVAALPMLKQ SNGSIVVVSS LAGKVAYPMV 
AAYSASKFAL DGFFSSIRKE YSVSRVNVSI TLCVLGLIDT ETAMKAVSGI VHMQAAPKEE 
CALEIIKGGA LRQEEVYYDS SLWTTLLIRN PCRKILEFLY STSYNMDRFI NK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.