Details for: HSD11B1

Gene ID: 3290

Symbol: HSD11B1

Ensembl ID: ENSG00000117594

Description: hydroxysteroid 11-beta dehydrogenase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 6.35
    Marker Score: 8763
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 4.83
    Marker Score: 2545
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.53
    Marker Score: 1056
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.49
    Marker Score: 7154
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.25
    Marker Score: 938
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 2.03
    Marker Score: 1340
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2
    Marker Score: 1704
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.98
    Marker Score: 7677
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.86
    Marker Score: 462
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.84
    Marker Score: 462
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.72
    Marker Score: 544
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168718
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.34
    Marker Score: 8631
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.31
    Marker Score: 826
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.28
    Marker Score: 5541
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.16
    Marker Score: 3036
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.11
    Marker Score: 5959
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.09
    Marker Score: 7264
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16469
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251804
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71821
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48046
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.99
    Marker Score: 227
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.95
    Marker Score: 1091
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5318
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.87
    Marker Score: 11631
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.85
    Marker Score: 1602
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.76
    Marker Score: 1541
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.73
    Marker Score: 495.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.69
    Marker Score: 4173
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.65
    Marker Score: 1241.5
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.61
    Marker Score: 138
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.61
    Marker Score: 592
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 477
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.59
    Marker Score: 914
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.59
    Marker Score: 153
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.59
    Marker Score: 1379
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.57
    Marker Score: 666
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.53
    Marker Score: 321
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.53
    Marker Score: 566
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.51
    Marker Score: 125
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.51
    Marker Score: 1563
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.5
    Marker Score: 210
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.48
    Marker Score: 16255
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.47
    Marker Score: 646
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.45
    Marker Score: 698
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 440
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.42
    Marker Score: 236
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.41
    Marker Score: 314
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.4
    Marker Score: 965
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.4
    Marker Score: 495
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.38
    Marker Score: 144
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.38
    Marker Score: 1528
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.35
    Marker Score: 97
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.35
    Marker Score: 152
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.35
    Marker Score: 110
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.33
    Marker Score: 125
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.33
    Marker Score: 1188
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.33
    Marker Score: 183
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.31
    Marker Score: 309
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.3
    Marker Score: 97
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.3
    Marker Score: 141
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.29
    Marker Score: 93
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.28
    Marker Score: 129
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.28
    Marker Score: 395
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.26
    Marker Score: 125
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.26
    Marker Score: 5732
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.25
    Marker Score: 2619
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.25
    Marker Score: 127
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.25
    Marker Score: 112
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.24
    Marker Score: 145
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.24
    Marker Score: 142
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.24
    Marker Score: 387
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.24
    Marker Score: 133
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 70
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.24
    Marker Score: 81
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.23
    Marker Score: 224
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.22
    Marker Score: 148
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.22
    Marker Score: 69
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.22
    Marker Score: 143
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.22
    Marker Score: 1856
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.21
    Marker Score: 85.5
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.21
    Marker Score: 63
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.21
    Marker Score: 73
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.2
    Marker Score: 252
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.2
    Marker Score: 87
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.2
    Marker Score: 71
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.19
    Marker Score: 66
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.19
    Marker Score: 67
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.19
    Marker Score: 545
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.19
    Marker Score: 11863
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.19
    Marker Score: 1781
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.19
    Marker Score: 48

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Other Information

**Key characteristics:** - HSD11B1 is a protein that is involved in the metabolism of steroids. - It is a member of the NADP+-dependent 11-beta-hydroxysteroid dehydrogenase (NADP+) superfamily of enzymes. - It is expressed in a variety of cells, including immune cells, and is involved in the synthesis and degradation of steroids. - It is a key regulator of steroid metabolism. **Pathways and functions:** - HSD11B1 is involved in the synthesis of cortisol, a hormone that is produced in the adrenal glands. - It is also involved in the catabolism of steroids, including the production of cholesterol and bile acids. - It is involved in the regulation of inflammation and immune responses. **Clinical significance:** - Mutations in HSD11B1 have been linked to a number of human diseases, including adrenal insufficiency, primary aldosteronism, and autoimmune disorders. - These diseases are caused by defects in the production or function of HSD11B1 protein. - HSD11B1 inhibitors are being investigated as a treatment for these diseases.

Genular Protein ID: 2468074247

Symbol: DHI1_HUMAN

Name: 7-oxosteroid reductase

UniProtKB Accession Codes:

P28845 B2R9Z1 D3DT89

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 80 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 29 DrugCentral 1 EC 2 EMBL 13 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 47 PDBsum 40 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 33 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1885595

Title: The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization.

PubMed ID: 1885595

DOI: 10.1016/s0021-9258(18)55351-5

PubMed ID: 12414862

Title: Association studies between microsatellite markers within the gene encoding human 11beta-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism.

PubMed ID: 12414862

DOI: 10.1210/jc.2001-011375

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8319583

Title: Structure and function of the hepatic form of 11 beta-hydroxysteroid dehydrogenase in the squirrel monkey, an animal model of glucocorticoid resistance.

PubMed ID: 8319583

DOI: 10.1210/endo.133.1.8319583

PubMed ID: 10497248

Title: The N-terminal anchor sequences of 11beta-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane.

PubMed ID: 10497248

DOI: 10.1074/jbc.274.40.28762

PubMed ID: 11481269

Title: Expression and putative role of 11 beta-hydroxysteroid dehydrogenase isozymes within the human eye.

PubMed ID: 11481269

PubMed ID: 12460758

Title: Purification of full-length recombinant human and rat type 1 11beta-hydroxysteroid dehydrogenases with retained oxidoreductase activities.

PubMed ID: 12460758

DOI: 10.1016/s1046-5928(02)00547-8

PubMed ID: 12858176

Title: Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency.

PubMed ID: 12858176

DOI: 10.1038/ng1214

PubMed ID: 14973125

Title: Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme.

PubMed ID: 14973125

DOI: 10.1074/jbc.m313615200

PubMed ID: 15095019

Title: Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism.

PubMed ID: 15095019

DOI: 10.1007/s00018-003-3476-y

PubMed ID: 15152005

Title: Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase.

PubMed ID: 15152005

DOI: 10.1074/jbc.m313666200

PubMed ID: 15280030

Title: Hexose-6-phosphate dehydrogenase determines the reaction direction of 11beta-hydroxysteroid dehydrogenase type 1 as an oxoreductase.

PubMed ID: 15280030

DOI: 10.1016/j.febslet.2004.06.065

PubMed ID: 17593962

Title: Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids.

PubMed ID: 17593962

DOI: 10.1371/journal.pone.0000561

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21453287

Title: Hepatic reduction of the secondary bile acid 7-oxolithocholic acid is mediated by 11beta-hydroxysteroid dehydrogenase 1.

PubMed ID: 21453287

DOI: 10.1042/bj20110022

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27927697

Title: Absence of 11-keto reduction of cortisone and 11-ketotestosterone in the model organism zebrafish.

PubMed ID: 27927697

DOI: 10.1530/joe-16-0495

PubMed ID: 30902677

Title: Enzymatic interconversion of the oxysterols 7beta,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11beta-hydroxysteroid dehydrogenase type 1 and 2.

PubMed ID: 30902677

DOI: 10.1016/j.jsbmb.2019.03.011

PubMed ID: 15513927

Title: Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation.

PubMed ID: 15513927

DOI: 10.1074/jbc.m411104200

PubMed ID: 17070044

Title: Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors.

PubMed ID: 17070044

DOI: 10.1016/j.bmcl.2006.10.008

PubMed ID: 17919905

Title: The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors.

PubMed ID: 17919905

DOI: 10.1016/j.bmcl.2007.09.070

PubMed ID: 18485702

Title: Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.

PubMed ID: 18485702

DOI: 10.1016/j.bmcl.2008.04.069

PubMed ID: 18069989

Title: Structural characterization and pharmacodynamic effects of an orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor.

PubMed ID: 18069989

DOI: 10.1111/j.1747-0285.2007.00603.x

PubMed ID: 18553955

Title: Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model.

PubMed ID: 18553955

DOI: 10.1021/jm800310g

PubMed ID: 19217779

Title: Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors.

PubMed ID: 19217779

DOI: 10.1016/j.bmcl.2009.01.058

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 292
  • Mass: 32401
  • Checksum: 4632D0F3BBEFC474
  • Sequence:
    • MAFMKKYLLP ILGLFMAYYY YSANEEFRPE MLQGKKVIVT GASKGIGREM AYHLAKMGAH 
VVVTARSKET LQKVVSHCLE LGAASAHYIA GTMEDMTFAE QFVAQAGKLM GGLDMLILNH 
ITNTSLNLFH DDIHHVRKSM EVNFLSYVVL TVAALPMLKQ SNGSIVVVSS LAGKVAYPMV 
AAYSASKFAL DGFFSSIRKE YSVSRVNVSI TLCVLGLIDT ETAMKAVSGI VHMQAAPKEE 
CALEIIKGGA LRQEEVYYDS SLWTTLLIRN PCRKILEFLY STSYNMDRFI NK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.