Gene HSPA1B - ENSG00000204388 | NCBI Gene ID: 3304

Details for: HSPA1B

Gene ID: 3304

Symbol: HSPA1B

Ensembl ID: ENSG00000204388

Description: heat shock protein family A (Hsp70) member 1B

Associated with

Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Attenuation phase
(R-HSA-3371568)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to heat stress
(R-HSA-3371556)
Cytokine signaling in immune system
(R-HSA-1280215)
Hsf1 activation
(R-HSA-3371511)
Hsf1-dependent transactivation
(R-HSA-3371571)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-HSA-3371497)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interferon signaling
(R-HSA-913531)
Neutrophil degranulation
(R-HSA-6798695)
Pkr-mediated signaling
(R-HSA-9833482)
Regulation of hsf1-mediated heat shock response
(R-HSA-3371453)
Aggresome
(GO:0016235)
Atp-dependent protein disaggregase activity
(GO:0140545)
Atp-dependent protein folding chaperone
(GO:0140662)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Atp metabolic process
(GO:0046034)
Blood microparticle
(GO:0072562)
C3hc4-type ring finger domain binding
(GO:0055131)
Cellular heat acclimation
(GO:0070370)
Cellular response to heat
(GO:0034605)
Cellular response to oxidative stress
(GO:0034599)
Cellular response to steroid hormone stimulus
(GO:0071383)
Centriole
(GO:0005814)
Centrosome
(GO:0005813)
Chaperone cofactor-dependent protein refolding
(GO:0051085)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endoplasmic reticulum
(GO:0005783)
Enzyme binding
(GO:0019899)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Ficolin-1-rich granule lumen
(GO:1904813)
Focal adhesion
(GO:0005925)
G protein-coupled receptor binding
(GO:0001664)
Heat shock protein binding
(GO:0031072)
Histone deacetylase binding
(GO:0042826)
Inclusion body
(GO:0016234)
Mitochondrion
(GO:0005739)
Mrna catabolic process
(GO:0006402)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001240)
Negative regulation of inclusion body assembly
(GO:0090084)
Negative regulation of protein ubiquitination
(GO:0031397)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of erythrocyte differentiation
(GO:0045648)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of microtubule nucleation
(GO:0090063)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
(GO:0070434)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of tumor necrosis factor-mediated signaling pathway
(GO:1903265)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein folding chaperone
(GO:0044183)
Protein refolding
(GO:0042026)
Protein stabilization
(GO:0050821)
Regulation of mitotic spindle assembly
(GO:1901673)
Regulation of protein ubiquitination
(GO:0031396)
Ribonucleoprotein complex
(GO:1990904)
Rna binding
(GO:0003723)
Signaling receptor binding
(GO:0005102)
Symbiont entry into host cell
(GO:0046718)
Ubiquitin protein ligase binding
(GO:0031625)
Unfolded protein binding
(GO:0051082)
Vesicle
(GO:0031982)
Virus receptor activity
(GO:0001618)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 4.74
Marker Score: 3790
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 4.18
Marker Score: 5445
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.82
Marker Score: 3259
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.74
Marker Score: 127378
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 3.73
Marker Score: 2923
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.25
Marker Score: 3474
Cell Name: theca cell (CL0000503)
Fold Change: 3.1
Marker Score: 2224
Cell Name: supporting cell (CL0000630)
Fold Change: 2.96
Marker Score: 5563
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.95
Marker Score: 5885
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.94
Marker Score: 3554
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.83
Marker Score: 8880
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 2.81
Marker Score: 1762
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.72
Marker Score: 1029
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 2.68
Marker Score: 2525.5
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.64
Marker Score: 6436
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.61
Marker Score: 4284.5
Cell Name: germ cell (CL0000586)
Fold Change: 2.61
Marker Score: 4551.5
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 2.58
Marker Score: 2301
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 2.57
Marker Score: 1711
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 2.56
Marker Score: 1940
Cell Name: thymocyte (CL0000893)
Fold Change: 2.46
Marker Score: 2573
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 2.45
Marker Score: 1639
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.42
Marker Score: 2549.5
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 2.4
Marker Score: 8903
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.39
Marker Score: 15550
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.35
Marker Score: 4914
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 2.35
Marker Score: 1573
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.35
Marker Score: 1849
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 2.32
Marker Score: 1297
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.32
Marker Score: 14824
Cell Name: inflammatory cell (CL0009002)
Fold Change: 2.29
Marker Score: 984
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 2.25
Marker Score: 2709
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.25
Marker Score: 938
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 2.23
Marker Score: 1522
Cell Name: late pro-B cell (CL0002048)
Fold Change: 2.23
Marker Score: 2631
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.2
Marker Score: 4469
Cell Name: reticular cell (CL0000432)
Fold Change: 2.2
Marker Score: 802
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 2.19
Marker Score: 509
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.18
Marker Score: 28819
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 2.18
Marker Score: 1857
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 2.18
Marker Score: 2717
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.17
Marker Score: 4921
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.12
Marker Score: 4835
Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
Fold Change: 2.12
Marker Score: 480
Cell Name: mature T cell (CL0002419)
Fold Change: 2.12
Marker Score: 20995
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 2.11
Marker Score: 5329
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 2.09
Marker Score: 2962
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.07
Marker Score: 23355
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 2.07
Marker Score: 455
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.04
Marker Score: 15206
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 2.04
Marker Score: 1089
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 2.03
Marker Score: 3451.5
Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.01
Marker Score: 3510
Cell Name: Unknown (CL0002371)
Fold Change: 2.01
Marker Score: 2139
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.99
Marker Score: 2405
Cell Name: kidney cell (CL1000497)
Fold Change: 1.97
Marker Score: 1313
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.97
Marker Score: 5351
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.94
Marker Score: 3220
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.92
Marker Score: 477
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 1.92
Marker Score: 1261
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.9
Marker Score: 19111
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.9
Marker Score: 976
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.9
Marker Score: 942
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.87
Marker Score: 592
Cell Name: neural cell (CL0002319)
Fold Change: 1.86
Marker Score: 898
Cell Name: keratocyte (CL0002363)
Fold Change: 1.86
Marker Score: 428
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.86
Marker Score: 16004
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.86
Marker Score: 2859
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 1.86
Marker Score: 724
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.84
Marker Score: 2107
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.84
Marker Score: 2705
Cell Name: stromal cell (CL0000499)
Fold Change: 1.84
Marker Score: 2150
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1.83
Marker Score: 651
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.8
Marker Score: 4718
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.79
Marker Score: 2849
Cell Name: enterocyte (CL0000584)
Fold Change: 1.77
Marker Score: 8505
Cell Name: keratinocyte (CL0000312)
Fold Change: 1.77
Marker Score: 1477
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.76
Marker Score: 4927
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 1.76
Marker Score: 608
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.75
Marker Score: 1097
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 1.71
Marker Score: 639
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 1.71
Marker Score: 513
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 1.71
Marker Score: 1450.5
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 1.7
Marker Score: 1629
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.69
Marker Score: 8871
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 1.69
Marker Score: 1223
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.66
Marker Score: 2814.5
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 1.66
Marker Score: 1429
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.66
Marker Score: 774
Cell Name: peptic cell (CL0000155)
Fold Change: 1.65
Marker Score: 690
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.64
Marker Score: 12820
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 1.63
Marker Score: 839
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.63
Marker Score: 1534
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.63
Marker Score: 1625.5
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.62
Marker Score: 1635
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.62
Marker Score: 2295
Cell Name: stem cell (CL0000034)
Fold Change: 1.62
Marker Score: 3840
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 1.59
Marker Score: 466
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.58
Marker Score: 371
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.57
Marker Score: 13675

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Other Information

Description

**Key characteristics:** * HSPA1B is a chaperone protein that helps to prevent the aggregation of misfolded or damaged proteins. * It is a key regulator of the HSR, which is a protective mechanism that helps cells survive and maintain homeostasis under stress conditions. * HSPA1B is induced by various stimuli, including infection, heat, and stress. * It is a key regulator of inflammation and cell death. * It is also involved in the regulation of apoptosis. **Pathways and functions:** * HSPA1B is involved in the regulation of the HSR. * It helps to prevent the aggregation of misfolded or damaged proteins. * It also helps to regulate the expression of other HSPs. * It is involved in the regulation of inflammation and cell death. * It is also involved in the regulation of apoptosis. **Clinical significance:** * Mutations in HSPA1B have been linked to several human diseases, including amyotrophic lateral sclerosis, heat-induced acute respiratory distress syndrome (HIAIDS), and sepsis. * HSPA1B inhibitors are being investigated as potential treatments for these diseases. * HSPA1B is a promising target for the development of new therapies for human diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.