HSPA1B | ENSG00000204388 | NCBI 3304

Details for: HSPA1B

Gene ID: 3304

Symbol: HSPA1B

Ensembl ID: ENSG00000204388

Description: heat shock protein family A (Hsp70) member 1B

Associated with

Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Attenuation phase
(R-HSA-3371568)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to heat stress
(R-HSA-3371556)
Cytokine signaling in immune system
(R-HSA-1280215)
Hsf1 activation
(R-HSA-3371511)
Hsf1-dependent transactivation
(R-HSA-3371571)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-HSA-3371497)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interferon signaling
(R-HSA-913531)
Mitochondrial unfolded protein response (uprmt)
(R-HSA-9841251)
Neutrophil degranulation
(R-HSA-6798695)
Pkr-mediated signaling
(R-HSA-9833482)
Regulation of hsf1-mediated heat shock response
(R-HSA-3371453)
Aggresome
(GO:0016235)
Atp-dependent protein disaggregase activity
(GO:0140545)
Atp-dependent protein folding chaperone
(GO:0140662)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Atp metabolic process
(GO:0046034)
Blood microparticle
(GO:0072562)
C3hc4-type ring finger domain binding
(GO:0055131)
Cellular heat acclimation
(GO:0070370)
Cellular response to heat
(GO:0034605)
Cellular response to oxidative stress
(GO:0034599)
Cellular response to steroid hormone stimulus
(GO:0071383)
Centriole
(GO:0005814)
Centrosome
(GO:0005813)
Chaperone cofactor-dependent protein refolding
(GO:0051085)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endoplasmic reticulum
(GO:0005783)
Enzyme binding
(GO:0019899)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Ficolin-1-rich granule lumen
(GO:1904813)
Focal adhesion
(GO:0005925)
G protein-coupled receptor binding
(GO:0001664)
Heat shock protein binding
(GO:0031072)
Histone deacetylase binding
(GO:0042826)
Inclusion body
(GO:0016234)
Mitochondrion
(GO:0005739)
Mrna catabolic process
(GO:0006402)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001240)
Negative regulation of inclusion body assembly
(GO:0090084)
Negative regulation of protein ubiquitination
(GO:0031397)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of erythrocyte differentiation
(GO:0045648)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of microtubule nucleation
(GO:0090063)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
(GO:0070434)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of tumor necrosis factor-mediated signaling pathway
(GO:1903265)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein folding chaperone
(GO:0044183)
Protein refolding
(GO:0042026)
Protein stabilization
(GO:0050821)
Regulation of mitotic spindle assembly
(GO:1901673)
Regulation of protein ubiquitination
(GO:0031396)
Ribonucleoprotein complex
(GO:1990904)
Rna binding
(GO:0003723)
Signaling receptor binding
(GO:0005102)
Symbiont entry into host cell
(GO:0046718)
Ubiquitin protein ligase binding
(GO:0031625)
Unfolded protein binding
(GO:0051082)
Vesicle
(GO:0031982)
Virus receptor activity
(GO:0001618)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 593.3965
Cell Significance Index: -92.3000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 356.9579
Cell Significance Index: -90.5400
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 229.7137
Cell Significance Index: -94.6300
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 223.6022
Cell Significance Index: -90.8400
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 211.8729
Cell Significance Index: -100.0300
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 149.2201
Cell Significance Index: -100.1300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 96.0573
Cell Significance Index: -91.7100
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 76.2963
Cell Significance Index: -94.0700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 36.0863
Cell Significance Index: -96.6700
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 23.8403
Cell Significance Index: -94.0800
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 23.0705
Cell Significance Index: -70.8600
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 18.0153
Cell Significance Index: 191.4100
Cell Name: theca cell (CL0000503)
Fold Change: 14.6382
Cell Significance Index: 86.0000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 12.1333
Cell Significance Index: 347.8100
Cell Name: kidney cell (CL1000497)
Fold Change: 7.3576
Cell Significance Index: 58.7500
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 7.0408
Cell Significance Index: 54.2700
Cell Name: odontoblast (CL0000060)
Fold Change: 5.8732
Cell Significance Index: 752.9100
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 4.0826
Cell Significance Index: 52.2900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.2439
Cell Significance Index: 170.3200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 3.1448
Cell Significance Index: 222.4100
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 2.8417
Cell Significance Index: 70.8700
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.8409
Cell Significance Index: 74.7000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.7797
Cell Significance Index: 381.7300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.5129
Cell Significance Index: 1111.0200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.6888
Cell Significance Index: 79.3700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.5781
Cell Significance Index: 73.5800
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.4600
Cell Significance Index: 25.8000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.4406
Cell Significance Index: 50.0600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.3675
Cell Significance Index: 246.5200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.3260
Cell Significance Index: 156.3800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.2747
Cell Significance Index: 156.7400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.2014
Cell Significance Index: 32.7000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.1771
Cell Significance Index: 33.9200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9870
Cell Significance Index: 160.5200
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.9579
Cell Significance Index: 10.0000
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.9368
Cell Significance Index: 511.6000
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.7393
Cell Significance Index: 38.5100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2493
Cell Significance Index: 225.1200
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2444
Cell Significance Index: 48.5100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1597
Cell Significance Index: 15.8000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1503
Cell Significance Index: 28.6100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1241
Cell Significance Index: 4.3600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0466
Cell Significance Index: 2.4200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0424
Cell Significance Index: 32.0900
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0304
Cell Significance Index: 3.1100
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0053
Cell Significance Index: -0.1100
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0419
Cell Significance Index: -2.1200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0504
Cell Significance Index: -94.8100
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0537
Cell Significance Index: -2.2000
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0650
Cell Significance Index: -119.8000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0700
Cell Significance Index: -14.0500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0708
Cell Significance Index: -51.9400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0767
Cell Significance Index: -27.5100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0778
Cell Significance Index: -13.2900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0778
Cell Significance Index: -119.8000
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0881
Cell Significance Index: -119.7300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0893
Cell Significance Index: -66.1300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1060
Cell Significance Index: -2.8300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1143
Cell Significance Index: -71.3800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1173
Cell Significance Index: -66.1300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1489
Cell Significance Index: -94.5600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1540
Cell Significance Index: -6.9800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2191
Cell Significance Index: -99.4600
Cell Name: lactocyte (CL0002325)
Fold Change: -0.2524
Cell Significance Index: -32.6100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.2562
Cell Significance Index: -5.5500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3121
Cell Significance Index: -65.7400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.4695
Cell Significance Index: -12.5600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.5116
Cell Significance Index: -58.6100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.5314
Cell Significance Index: -14.8500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.5637
Cell Significance Index: -42.0100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.6024
Cell Significance Index: -70.2000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.6371
Cell Significance Index: -72.7300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.6498
Cell Significance Index: -94.4600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.7200
Cell Significance Index: -8.1800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.7906
Cell Significance Index: -49.8300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.9116
Cell Significance Index: -94.9200
Cell Name: peg cell (CL4033014)
Fold Change: -0.9116
Cell Significance Index: -21.0600
Cell Name: retinal rod cell (CL0000604)
Fold Change: -1.0025
Cell Significance Index: -11.9500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.1401
Cell Significance Index: -87.4900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.1596
Cell Significance Index: -91.8400
Cell Name: early pro-B cell (CL0002046)
Fold Change: -1.2428
Cell Significance Index: -80.1800
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.2867
Cell Significance Index: -19.2800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.4939
Cell Significance Index: -91.5900
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.5110
Cell Significance Index: -84.7900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.5963
Cell Significance Index: -21.7800
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -1.6666
Cell Significance Index: -13.5900
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.7876
Cell Significance Index: -65.6200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.8451
Cell Significance Index: -59.1000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.8974
Cell Significance Index: -31.7600
Cell Name: glioblast (CL0000030)
Fold Change: -1.9094
Cell Significance Index: -11.9900
Cell Name: type I muscle cell (CL0002211)
Fold Change: -1.9304
Cell Significance Index: -47.1000
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -1.9363
Cell Significance Index: -39.4000
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -1.9780
Cell Significance Index: -34.2000
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -2.0371
Cell Significance Index: -50.9200
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -2.0826
Cell Significance Index: -92.1200
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -2.4224
Cell Significance Index: -35.1700
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -2.4467
Cell Significance Index: -92.6500
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -2.4919
Cell Significance Index: -27.0900
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -2.4933
Cell Significance Index: -64.0900
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -2.5289
Cell Significance Index: -52.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** HSPA1B is a 70-kDa protein that belongs to the Hsp70 family of heat shock proteins. It is a molecular chaperone that recognizes and binds to unfolded or misfolded proteins, preventing their aggregation and facilitating their refolding into their native conformation. HSPA1B has been shown to have a wide range of functions, including: * Protein folding and refolding * Protein stabilization * Negative regulation of apoptosis and cell growth * Positive regulation of erythrocyte differentiation and gene expression * Regulation of mitotic spindle assembly and protein ubiquitination **Pathways and Functions** HSPA1B is involved in various signaling pathways, including: * Interferon signaling: HSPA1B is induced by interferon-γ (IFN-γ) and regulates the expression of interferon-stimulated genes (ISGs). * NF-κB signaling: HSPA1B regulates the activity of NF-κB, a transcription factor that plays a key role in immune responses and inflammation. * ATP-dependent protein disaggregase activity: HSPA1B is involved in the disaggregation of protein aggregates, which is essential for maintaining protein homeostasis. * Atp-dependent protein folding chaperone: HSPA1B is a molecular chaperone that recognizes and binds to unfolded or misfolded proteins, preventing their aggregation and facilitating their refolding into their native conformation. **Clinical Significance** HSPA1B has been implicated in various diseases, including: * Cancer: HSPA1B is overexpressed in several types of cancer, including breast, lung, and prostate cancer, and is associated with poor prognosis. * Neurodegenerative diseases: HSPA1B has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it may play a role in protein aggregation and neurodegeneration. * Inflammatory diseases: HSPA1B is involved in the regulation of inflammatory responses and may play a role in the pathogenesis of inflammatory diseases, such as rheumatoid arthritis and atherosclerosis. In addition, HSPA1B has been used as a biomarker for various diseases, including cancer and neurodegenerative diseases. Its expression levels can be used to monitor disease progression and response to treatment. In conclusion, HSPA1B is a molecular chaperone that plays a crucial role in maintaining protein homeostasis and protecting cells against various stresses. Its expression is regulated by various signaling pathways, and it has been implicated in various diseases, including cancer, neurodegenerative diseases, and inflammatory diseases. Further research is needed to fully understand the role of HSPA1B in human disease and to explore its potential as a therapeutic target.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.