Details for: HSPB1
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 5.62
Marker Score: 7,316 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 4.89
Marker Score: 3,825 - Cell Name: secretory cell (CL0000151)
Fold Change: 4.52
Marker Score: 8,259 - Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 4.11
Marker Score: 21,613 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 4
Marker Score: 29,742 - Cell Name: supporting cell (CL0000630)
Fold Change: 3.98
Marker Score: 7,483 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.96
Marker Score: 3,375 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.96
Marker Score: 3,734 - Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 3.91
Marker Score: 2,972 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.79
Marker Score: 9,267 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 3.75
Marker Score: 49,435 - Cell Name: theca cell (CL0000503)
Fold Change: 3.74
Marker Score: 2,682 - Cell Name: myofibroblast cell (CL0000186)
Fold Change: 3.73
Marker Score: 4,602 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.69
Marker Score: 3,941 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.53
Marker Score: 22,528 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 3.53
Marker Score: 5,429 - Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.51
Marker Score: 1,155 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.49
Marker Score: 27,287 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 3.43
Marker Score: 5,630 - Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 3.38
Marker Score: 2,552 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 3.35
Marker Score: 6,687 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.33
Marker Score: 11,820 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 3.3
Marker Score: 2,348 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.28
Marker Score: 111,746 - Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 3.24
Marker Score: 4,459 - Cell Name: type I pneumocyte (CL0002062)
Fold Change: 3.23
Marker Score: 3,893 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 3.22
Marker Score: 8,443 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 3.22
Marker Score: 2,540 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 3.21
Marker Score: 27,637 - Cell Name: smooth muscle cell (CL0000192)
Fold Change: 3.17
Marker Score: 2,084 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 3.16
Marker Score: 7,979 - Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 3.13
Marker Score: 1,765 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 3.11
Marker Score: 5,266 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.09
Marker Score: 3,734 - Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 3.05
Marker Score: 1,032 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 3.04
Marker Score: 3,197 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 3
Marker Score: 764 - Cell Name: inflammatory cell (CL0009002)
Fold Change: 2.99
Marker Score: 1,288 - Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 2.97
Marker Score: 690 - Cell Name: reticular cell (CL0000432)
Fold Change: 2.96
Marker Score: 1,082 - Cell Name: club cell (CL0000158)
Fold Change: 2.96
Marker Score: 3,453 - Cell Name: epithelial cell (CL0000066)
Fold Change: 2.95
Marker Score: 4,695 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.95
Marker Score: 19,216 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.94
Marker Score: 7,867 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.91
Marker Score: 32,768 - Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 2.91
Marker Score: 4,116 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.9
Marker Score: 18,894 - Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 2.9
Marker Score: 700 - Cell Name: decidual cell (CL2000002)
Fold Change: 2.89
Marker Score: 12,476 - Cell Name: basal cell (CL0000646)
Fold Change: 2.89
Marker Score: 3,732 - Cell Name: endocardial cell (CL0002350)
Fold Change: 2.88
Marker Score: 1,630 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 2.88
Marker Score: 2,745 - Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.86
Marker Score: 1,081 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 2.85
Marker Score: 16,908 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 2.84
Marker Score: 913 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.78
Marker Score: 8,728 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: 2.77
Marker Score: 1,426 - Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.76
Marker Score: 1,148 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.76
Marker Score: 1,605 - Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 2.74
Marker Score: 1,139 - Cell Name: pericyte (CL0000669)
Fold Change: 2.74
Marker Score: 1,602 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.74
Marker Score: 5,720 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.74
Marker Score: 10,550 - Cell Name: granulocyte (CL0000094)
Fold Change: 2.73
Marker Score: 1,225 - Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 2.73
Marker Score: 942 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 2.71
Marker Score: 7,365 - Cell Name: endothelial cell (CL0000115)
Fold Change: 2.7
Marker Score: 2,423 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.7
Marker Score: 4,480 - Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 2.69
Marker Score: 1,679 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.66
Marker Score: 5,404 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 2.66
Marker Score: 35,340 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 2.64
Marker Score: 1,661 - Cell Name: muscle cell (CL0000187)
Fold Change: 2.64
Marker Score: 748 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 2.63
Marker Score: 3,719 - Cell Name: granulosa cell (CL0000501)
Fold Change: 2.62
Marker Score: 26,335 - Cell Name: fibroblast (CL0000057)
Fold Change: 2.6
Marker Score: 2,513 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.6
Marker Score: 6,120 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.59
Marker Score: 66,367 - Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 2.58
Marker Score: 818 - Cell Name: pneumocyte (CL0000322)
Fold Change: 2.57
Marker Score: 4,136 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.57
Marker Score: 3,780 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 2.56
Marker Score: 2,415 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.56
Marker Score: 2,601 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 2.55
Marker Score: 1,740 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 2.55
Marker Score: 2,658 - Cell Name: cell in vitro (CL0001034)
Fold Change: 2.54
Marker Score: 87,866 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 2.53
Marker Score: 4,299 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 2.52
Marker Score: 1,686 - Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.51
Marker Score: 4,383 - Cell Name: lung ciliated cell (CL1000271)
Fold Change: 2.51
Marker Score: 1,191 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 2.5
Marker Score: 2,505 - Cell Name: mature T cell (CL0002419)
Fold Change: 2.5
Marker Score: 24,789 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.5
Marker Score: 2,648 - Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 2.46
Marker Score: 2,121 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 2.46
Marker Score: 10,255 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.45
Marker Score: 3,558 - Cell Name: keratinocyte (CL0000312)
Fold Change: 2.44
Marker Score: 2,035 - Cell Name: neural crest cell (CL0011012)
Fold Change: 2.44
Marker Score: 2,603 - Cell Name: kidney cell (CL1000497)
Fold Change: 2.43
Marker Score: 1,623 - Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.42
Marker Score: 5,485
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1174219597
Symbol: HSPB1_HUMAN
Name: Heat shock protein beta-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3714473
Title: Sequence and organization of genes encoding the human 27 kDa heat shock protein.
PubMed ID: 3714473
PubMed ID: 2243808
Title: cDNA sequence of a human heat shock protein HSP27.
PubMed ID: 2243808
PubMed ID: 10777697
Title: Small heat shock protein 27 (HSP27) associates with tubulin/microtubules in HeLa cells.
PubMed ID: 10777697
PubMed ID: 9110174
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12853948
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2295696
Title: Identification of two related markers for common acute lymphoblastic leukemia as heat shock proteins.
PubMed ID: 2295696
DOI: 10.1172/jci114413
PubMed ID: 8325890
Title: The 28-kDa protein whose phosphorylation is induced by protein kinase C activators in MCF-7 cells belongs to the family of low molecular mass heat shock proteins and is the estrogen-regulated 24-kDa protein.
PubMed ID: 8325890
PubMed ID: 1560006
Title: Copurification of small heat shock protein with alpha B crystallin from human skeletal muscle.
PubMed ID: 1560006
PubMed ID: 1730670
Title: Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II.
PubMed ID: 1730670
PubMed ID: 2743305
Title: Induction of the estrogen-regulated '24K' protein by heat shock.
PubMed ID: 2743305
PubMed ID: 1763035
Title: The 29-kDa proteins phosphorylated in thrombin-activated human platelets are forms of the estrogen receptor-related 27-kDa heat shock protein.
PubMed ID: 1763035
PubMed ID: 1332886
Title: Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins.
PubMed ID: 1332886
PubMed ID: 8093612
Title: Small heat shock proteins are molecular chaperones.
PubMed ID: 8093612
PubMed ID: 8774846
Title: A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress.
PubMed ID: 8774846
PubMed ID: 10383393
Title: Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation.
PubMed ID: 10383393
PubMed ID: 10751411
Title: Identification and characterization of a novel protein from Sertoli cells, PASS1, that associates with mammalian small stress protein hsp27.
PubMed ID: 10751411
PubMed ID: 11342557
Title: HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 (3DHSP27).
PubMed ID: 11342557
PubMed ID: 15976317
Title: Heat shock protein 27 is associated with freedom from graft vasculopathy after human cardiac transplantation.
PubMed ID: 15976317
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16548883
Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.
PubMed ID: 16548883
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17924679
Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
PubMed ID: 17924679
DOI: 10.1021/pr070152u
PubMed ID: 18088087
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19464326
Title: HSPB7 is a SC35 speckle resident small heat shock protein.
PubMed ID: 19464326
PubMed ID: 19166925
Title: PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5.
PubMed ID: 19166925
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 15122254
Title: Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.
PubMed ID: 15122254
DOI: 10.1038/ng1354
PubMed ID: 18832141
Title: Mutations in the HSP27 (HSPB1) gene cause dominant, recessive, and sporadic distal HMN/CMT type 2.
PubMed ID: 18832141
PubMed ID: 18952241
Title: A clinical phenotype of distal hereditary motor neuronopathy type II with a novel HSPB1 mutation.
PubMed ID: 18952241
PubMed ID: 20178975
Title: Increased monomerization of mutant HSPB1 leads to protein hyperactivity in Charcot-Marie-Tooth neuropathy.
PubMed ID: 20178975
PubMed ID: 20870250
Title: A novel HSPB1 mutation in an Italian patient with CMT2/dHMN phenotype.
PubMed ID: 20870250
PubMed ID: 22176143
Title: HSPB1 and HSPB8 in inherited neuropathies: study of an Italian cohort of dHMN and CMT2 patients.
PubMed ID: 22176143
PubMed ID: 22206013
Title: The mutational spectrum in a cohort of Charcot-Marie-Tooth disease type 2 among the Han Chinese in Taiwan.
PubMed ID: 22206013
PubMed ID: 23728742
Title: Charcot-Marie-Tooth causing HSPB1 mutations increase Cdk5-mediated phosphorylation of neurofilaments.
PubMed ID: 23728742
PubMed ID: 23948568
Title: Structure and properties of G84R and L99M mutants of human small heat shock protein HspB1 correlating with motor neuropathy.
PubMed ID: 23948568
PubMed ID: 23643870
Title: Physico-chemical properties of R140G and K141Q mutants of human small heat shock protein HspB1 associated with hereditary peripheral neuropathies.
PubMed ID: 23643870
PubMed ID: 25965061
Title: Characterization of mutants of human small heat shock protein HspB1 carrying replacements in the n-terminal domain and associated with hereditary motor neuron diseases.
PubMed ID: 25965061
PubMed ID: 27492805
Title: Molecular chaperones in the pathogenesis of amyotrophic lateral sclerosis: the role of HSPB1.
PubMed ID: 27492805
DOI: 10.1002/humu.23062
PubMed ID: 28144995
Title: Axonal Neuropathies due to Mutations in Small Heat Shock Proteins: Clinical, Genetic, and Functional Insights into Novel Mutations.
PubMed ID: 28144995
DOI: 10.1002/humu.23189
Sequence Information:
- Length: 205
- Mass: 22783
- Checksum: 1B4DC44A6F6606D5
- Sequence:
MTERRVPFSL LRGPSWDPFR DWYPHSRLFD QAFGLPRLPE EWSQWLGGSS WPGYVRPLPP AAIESPAVAA PAYSRALSRQ LSSGVSEIRH TADRWRVSLD VNHFAPDELT VKTKDGVVEI TGKHEERQDE HGYISRCFTR KYTLPPGVDP TQVSSSLSPE GTLTVEAPMP KLATQSNEIT IPVTFESRAQ LGGPEAAKSD ETAAK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.