Details for: HSPB1

Gene ID: 3315

Symbol: HSPB1

Ensembl ID: ENSG00000106211

Description: heat shock protein family B (small) member 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.62
    Marker Score: 7,316
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.89
    Marker Score: 3,825
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 4.52
    Marker Score: 8,259
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.11
    Marker Score: 21,613
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 4
    Marker Score: 29,742
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.98
    Marker Score: 7,483
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.96
    Marker Score: 3,375
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.96
    Marker Score: 3,734
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 3.91
    Marker Score: 2,972
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.79
    Marker Score: 9,267
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.75
    Marker Score: 49,435
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.74
    Marker Score: 2,682
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 3.73
    Marker Score: 4,602
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.69
    Marker Score: 3,941
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.53
    Marker Score: 22,528
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.53
    Marker Score: 5,429
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.51
    Marker Score: 1,155
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.49
    Marker Score: 27,287
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.43
    Marker Score: 5,630
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.38
    Marker Score: 2,552
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.35
    Marker Score: 6,687
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.33
    Marker Score: 11,820
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.3
    Marker Score: 2,348
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.28
    Marker Score: 111,746
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.24
    Marker Score: 4,459
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.23
    Marker Score: 3,893
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.22
    Marker Score: 8,443
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.22
    Marker Score: 2,540
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 3.21
    Marker Score: 27,637
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.17
    Marker Score: 2,084
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.16
    Marker Score: 7,979
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 3.13
    Marker Score: 1,765
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.11
    Marker Score: 5,266
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.09
    Marker Score: 3,734
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 3.05
    Marker Score: 1,032
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.04
    Marker Score: 3,197
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 3
    Marker Score: 764
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.99
    Marker Score: 1,288
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.97
    Marker Score: 690
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.96
    Marker Score: 1,082
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.96
    Marker Score: 3,453
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.95
    Marker Score: 4,695
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.95
    Marker Score: 19,216
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.94
    Marker Score: 7,867
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.91
    Marker Score: 32,768
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.91
    Marker Score: 4,116
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.9
    Marker Score: 18,894
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.9
    Marker Score: 700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.89
    Marker Score: 12,476
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.89
    Marker Score: 3,732
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.88
    Marker Score: 1,630
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.88
    Marker Score: 2,745
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.86
    Marker Score: 1,081
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.85
    Marker Score: 16,908
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.84
    Marker Score: 913
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.78
    Marker Score: 8,728
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.77
    Marker Score: 1,426
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.76
    Marker Score: 1,148
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.76
    Marker Score: 1,605
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 2.74
    Marker Score: 1,139
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.74
    Marker Score: 1,602
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.74
    Marker Score: 5,720
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.74
    Marker Score: 10,550
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.73
    Marker Score: 1,225
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.73
    Marker Score: 942
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.71
    Marker Score: 7,365
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.7
    Marker Score: 2,423
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.7
    Marker Score: 4,480
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 2.69
    Marker Score: 1,679
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.66
    Marker Score: 5,404
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.66
    Marker Score: 35,340
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.64
    Marker Score: 1,661
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.64
    Marker Score: 748
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.63
    Marker Score: 3,719
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.62
    Marker Score: 26,335
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.6
    Marker Score: 2,513
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.6
    Marker Score: 6,120
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.59
    Marker Score: 66,367
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.58
    Marker Score: 818
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.57
    Marker Score: 4,136
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.57
    Marker Score: 3,780
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.56
    Marker Score: 2,415
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.56
    Marker Score: 2,601
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.55
    Marker Score: 1,740
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.55
    Marker Score: 2,658
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.54
    Marker Score: 87,866
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.53
    Marker Score: 4,299
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.52
    Marker Score: 1,686
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.51
    Marker Score: 4,383
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.51
    Marker Score: 1,191
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.5
    Marker Score: 2,505
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.5
    Marker Score: 24,789
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.5
    Marker Score: 2,648
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.46
    Marker Score: 2,121
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.46
    Marker Score: 10,255
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.45
    Marker Score: 3,558
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.44
    Marker Score: 2,035
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.44
    Marker Score: 2,603
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.43
    Marker Score: 1,623
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.42
    Marker Score: 5,485

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HSPB1 is a 16-kDa protein that belongs to the small heat shock protein family. It is characterized by its ability to bind to and chaperone unfolded or misfolded proteins, promoting their correct folding and degradation. HSPB1 also interacts with various signaling molecules, including kinases, phosphatases, and transcription factors, to regulate cellular responses to stress and stimuli. Its expression is induced by heat shock, oxidative stress, and other forms of cellular stress, and it plays a critical role in maintaining cellular homeostasis and preventing apoptosis. **Pathways and Functions** HSPB1 is involved in various cellular pathways, including: 1. **Chaperone-mediated protein folding**: HSPB1 binds to and chaperones unfolded or misfolded proteins, promoting their correct folding and degradation. 2. **Protein degradation**: HSPB1 interacts with ubiquitin ligases and proteasomes to regulate protein degradation and maintain protein homeostasis. 3. **Signaling pathways**: HSPB1 interacts with various signaling molecules, including kinases, phosphatases, and transcription factors, to regulate cellular responses to stress and stimuli. 4. **Cell growth and differentiation**: HSPB1 regulates cell growth and differentiation by modulating signaling pathways related to cell cycle progression and apoptosis. 5. **Autophagy**: HSPB1 regulates autophagy by interacting with autophagy-related proteins and modulating the autophagic process. **Clinical Significance** HSPB1 has been implicated in various diseases, including: 1. **Neurodegenerative diseases**: HSPB1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it plays a role in protein aggregation and clearance. 2. **Cancer**: HSPB1 has been found to be overexpressed in various types of cancer, including breast, lung, and prostate cancer, where it promotes tumor growth and metastasis. 3. **Cardiovascular disease**: HSPB1 has been implicated in cardiovascular disease, where it regulates cellular responses to stress and inflammation. 4. **Muscular dystrophy**: HSPB1 has been found to be mutated in certain types of muscular dystrophy, where it plays a critical role in maintaining muscle homeostasis and preventing muscle degeneration. In conclusion, HSPB1 is a multifunctional protein that plays a critical role in maintaining cellular homeostasis and responding to various forms of stress. Its dysregulation has been implicated in various diseases, highlighting the importance of HSPB1 in maintaining cellular health and preventing disease.

Genular Protein ID: 1174219597

Symbol: HSPB1_HUMAN

Name: Heat shock protein beta-1

UniProtKB Accession Codes:

P04792 B2R4N8 Q6FI47 Q96C20 Q96EI7 Q9UC31 Q9UC34 Q9UC35 Q9UC36

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 10 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 3 EMBL 19 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 44 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OGP 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 6 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3714473

Title: Sequence and organization of genes encoding the human 27 kDa heat shock protein.

PubMed ID: 3714473

DOI: 10.1093/nar/14.10.4127

PubMed ID: 2243808

Title: cDNA sequence of a human heat shock protein HSP27.

PubMed ID: 2243808

DOI: 10.1093/nar/18.21.6457

PubMed ID: 10777697

Title: Small heat shock protein 27 (HSP27) associates with tubulin/microtubules in HeLa cells.

PubMed ID: 10777697

DOI: 10.1006/bbrc.2000.2553

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2295696

Title: Identification of two related markers for common acute lymphoblastic leukemia as heat shock proteins.

PubMed ID: 2295696

DOI: 10.1172/jci114413

PubMed ID: 8325890

Title: The 28-kDa protein whose phosphorylation is induced by protein kinase C activators in MCF-7 cells belongs to the family of low molecular mass heat shock proteins and is the estrogen-regulated 24-kDa protein.

PubMed ID: 8325890

DOI: 10.1016/s0021-9258(18)82451-6

PubMed ID: 1560006

Title: Copurification of small heat shock protein with alpha B crystallin from human skeletal muscle.

PubMed ID: 1560006

DOI: 10.1016/s0021-9258(18)42574-4

PubMed ID: 1730670

Title: Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II.

PubMed ID: 1730670

DOI: 10.1016/s0021-9258(18)48354-8

PubMed ID: 2743305

Title: Induction of the estrogen-regulated '24K' protein by heat shock.

PubMed ID: 2743305

PubMed ID: 1763035

Title: The 29-kDa proteins phosphorylated in thrombin-activated human platelets are forms of the estrogen receptor-related 27-kDa heat shock protein.

PubMed ID: 1763035

DOI: 10.1073/pnas.88.24.11212

PubMed ID: 1332886

Title: Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins.

PubMed ID: 1332886

DOI: 10.1016/0014-5793(92)81216-9

PubMed ID: 8093612

Title: Small heat shock proteins are molecular chaperones.

PubMed ID: 8093612

DOI: 10.1016/s0021-9258(18)53882-5

PubMed ID: 8774846

Title: A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress.

PubMed ID: 8774846

DOI: 10.1016/0014-5793(96)00816-2

PubMed ID: 10383393

Title: Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation.

PubMed ID: 10383393

DOI: 10.1074/jbc.274.27.18947

PubMed ID: 10751411

Title: Identification and characterization of a novel protein from Sertoli cells, PASS1, that associates with mammalian small stress protein hsp27.

PubMed ID: 10751411

DOI: 10.1074/jbc.m001981200

PubMed ID: 11342557

Title: HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 (3DHSP27).

PubMed ID: 11342557

DOI: 10.1074/jbc.m103001200

PubMed ID: 15976317

Title: Heat shock protein 27 is associated with freedom from graft vasculopathy after human cardiac transplantation.

PubMed ID: 15976317

DOI: 10.1161/01.res.0000174815.10996.08

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16548883

Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.

PubMed ID: 16548883

DOI: 10.1111/j.1462-5822.2005.00644.x

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19464326

Title: HSPB7 is a SC35 speckle resident small heat shock protein.

PubMed ID: 19464326

DOI: 10.1016/j.bbamcr.2009.05.005

PubMed ID: 19166925

Title: PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5.

PubMed ID: 19166925

DOI: 10.1016/j.cellsig.2009.01.009

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15122254

Title: Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.

PubMed ID: 15122254

DOI: 10.1038/ng1354

PubMed ID: 18832141

Title: Mutations in the HSP27 (HSPB1) gene cause dominant, recessive, and sporadic distal HMN/CMT type 2.

PubMed ID: 18832141

DOI: 10.1212/01.wnl.0000319696.14225.67

PubMed ID: 18952241

Title: A clinical phenotype of distal hereditary motor neuronopathy type II with a novel HSPB1 mutation.

PubMed ID: 18952241

DOI: 10.1016/j.jns.2008.09.031

PubMed ID: 20178975

Title: Increased monomerization of mutant HSPB1 leads to protein hyperactivity in Charcot-Marie-Tooth neuropathy.

PubMed ID: 20178975

DOI: 10.1074/jbc.m109.082644

PubMed ID: 20870250

Title: A novel HSPB1 mutation in an Italian patient with CMT2/dHMN phenotype.

PubMed ID: 20870250

DOI: 10.1016/j.jns.2010.09.008

PubMed ID: 22176143

Title: HSPB1 and HSPB8 in inherited neuropathies: study of an Italian cohort of dHMN and CMT2 patients.

PubMed ID: 22176143

DOI: 10.1111/j.1529-8027.2011.00361.x

PubMed ID: 22206013

Title: The mutational spectrum in a cohort of Charcot-Marie-Tooth disease type 2 among the Han Chinese in Taiwan.

PubMed ID: 22206013

DOI: 10.1371/journal.pone.0029393

PubMed ID: 23728742

Title: Charcot-Marie-Tooth causing HSPB1 mutations increase Cdk5-mediated phosphorylation of neurofilaments.

PubMed ID: 23728742

DOI: 10.1007/s00401-013-1133-6

PubMed ID: 23948568

Title: Structure and properties of G84R and L99M mutants of human small heat shock protein HspB1 correlating with motor neuropathy.

PubMed ID: 23948568

DOI: 10.1016/j.abb.2013.07.028

PubMed ID: 23643870

Title: Physico-chemical properties of R140G and K141Q mutants of human small heat shock protein HspB1 associated with hereditary peripheral neuropathies.

PubMed ID: 23643870

DOI: 10.1016/j.biochi.2013.04.014

PubMed ID: 25965061

Title: Characterization of mutants of human small heat shock protein HspB1 carrying replacements in the n-terminal domain and associated with hereditary motor neuron diseases.

PubMed ID: 25965061

DOI: 10.1371/journal.pone.0126248

PubMed ID: 27492805

Title: Molecular chaperones in the pathogenesis of amyotrophic lateral sclerosis: the role of HSPB1.

PubMed ID: 27492805

DOI: 10.1002/humu.23062

PubMed ID: 28144995

Title: Axonal Neuropathies due to Mutations in Small Heat Shock Proteins: Clinical, Genetic, and Functional Insights into Novel Mutations.

PubMed ID: 28144995

DOI: 10.1002/humu.23189

Sequence Information:

  • Length: 205
  • Mass: 22783
  • Checksum: 1B4DC44A6F6606D5
  • Sequence:
    • MTERRVPFSL LRGPSWDPFR DWYPHSRLFD QAFGLPRLPE EWSQWLGGSS WPGYVRPLPP 
AAIESPAVAA PAYSRALSRQ LSSGVSEIRH TADRWRVSLD VNHFAPDELT VKTKDGVVEI 
TGKHEERQDE HGYISRCFTR KYTLPPGVDP TQVSSSLSPE GTLTVEAPMP KLATQSNEIT 
IPVTFESRAQ LGGPEAAKSD ETAAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.