Details for: HSPB1

Gene ID: 3315

Symbol: HSPB1

Ensembl ID: ENSG00000106211

Description: heat shock protein family B (small) member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.62
    Marker Score: 7316
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.89
    Marker Score: 3825
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 4.52
    Marker Score: 8259
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.11
    Marker Score: 21613
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 4
    Marker Score: 29742
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.98
    Marker Score: 7483
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.96
    Marker Score: 3375
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.96
    Marker Score: 3734
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 3.91
    Marker Score: 2972
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.79
    Marker Score: 9267
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.75
    Marker Score: 49435
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.74
    Marker Score: 2682
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 3.73
    Marker Score: 4602
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.69
    Marker Score: 3941
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.53
    Marker Score: 22528
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.53
    Marker Score: 5428.5
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.51
    Marker Score: 1155
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.49
    Marker Score: 27286.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.43
    Marker Score: 5629.5
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.38
    Marker Score: 2551.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.35
    Marker Score: 6687
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.33
    Marker Score: 11819.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.3
    Marker Score: 2348
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.28
    Marker Score: 111746
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.24
    Marker Score: 4459
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.23
    Marker Score: 3893
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.22
    Marker Score: 8443
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.22
    Marker Score: 2540
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 3.21
    Marker Score: 27637
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.17
    Marker Score: 2084
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.16
    Marker Score: 7979
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 3.13
    Marker Score: 1765
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.11
    Marker Score: 5266
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.09
    Marker Score: 3734
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 3.05
    Marker Score: 1032
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.04
    Marker Score: 3197
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 3
    Marker Score: 764
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.99
    Marker Score: 1288
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.97
    Marker Score: 690
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.96
    Marker Score: 1082
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.96
    Marker Score: 3453
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.95
    Marker Score: 4695
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.95
    Marker Score: 19216
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.94
    Marker Score: 7867
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.91
    Marker Score: 32767.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.91
    Marker Score: 4116
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.9
    Marker Score: 18894
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.9
    Marker Score: 700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.89
    Marker Score: 12476
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.89
    Marker Score: 3732
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.88
    Marker Score: 1630
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.88
    Marker Score: 2745
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.86
    Marker Score: 1081
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.85
    Marker Score: 16907.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.84
    Marker Score: 913
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.78
    Marker Score: 8728
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.77
    Marker Score: 1426
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.76
    Marker Score: 1148
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.76
    Marker Score: 1605
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 2.74
    Marker Score: 1139
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.74
    Marker Score: 1602
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.74
    Marker Score: 5720
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.74
    Marker Score: 10550
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.73
    Marker Score: 1225
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.73
    Marker Score: 942
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.71
    Marker Score: 7365
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.7
    Marker Score: 2423
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.7
    Marker Score: 4480
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 2.69
    Marker Score: 1679
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.66
    Marker Score: 5404
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.66
    Marker Score: 35339.5
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.64
    Marker Score: 1661
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.64
    Marker Score: 748
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.63
    Marker Score: 3719
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.62
    Marker Score: 26335
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.6
    Marker Score: 2513
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.6
    Marker Score: 6119.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.59
    Marker Score: 66367
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.58
    Marker Score: 818
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.57
    Marker Score: 4136
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.57
    Marker Score: 3780
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.56
    Marker Score: 2415
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.56
    Marker Score: 2601
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.55
    Marker Score: 1740
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.55
    Marker Score: 2658
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.54
    Marker Score: 87866
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.53
    Marker Score: 4299
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.52
    Marker Score: 1686
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.51
    Marker Score: 4382.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.51
    Marker Score: 1191
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.5
    Marker Score: 2504.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.5
    Marker Score: 24789
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.5
    Marker Score: 2648
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.46
    Marker Score: 2121
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.46
    Marker Score: 10254.5
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.45
    Marker Score: 3558
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.44
    Marker Score: 2035
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.44
    Marker Score: 2603
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.43
    Marker Score: 1623
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.42
    Marker Score: 5485

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Other Information

**Key characteristics:** - HSPB1 is a chaperone protein that is highly abundant in mammalian cells. - It is a member of the HSPB family of chaperones, which are a group of proteins that are involved in the folding and assembly of proteins. - HSPB1 is a chaperone for a variety of proteins, including those that are involved in the folding of other HSPB proteins, as well as for proteins that are involved in the assembly of proteins. - HSPB1 is also a regulator of the unfolded protein response (UPR). **Pathways and functions:** - HSPB1 is involved in the attenuation phase of the UPR. - It binds to misfolded or denatured proteins, which triggers the UPR. - HSPB1 then helps to fold these proteins and to restore their function. - HSPB1 also plays a role in the regulation of the cellular response to stress, including heat stress. - It is involved in the activation of the Esr-mediated signaling pathway, which is a major stress response pathway in mammalian cells. - HSPB1 is also involved in the regulation of the Mapk family signaling cascade, which is another major stress response pathway in mammalian cells. **Clinical significance:** - Mutations in HSPB1 have been linked to a number of human diseases, including heat stroke, myocardial infarction, and cancer. - HSPB1 is a potential therapeutic target for these diseases. - Small molecule drugs that target HSPB1 have been shown to be effective in protecting cells from damage caused by heat stress.

Genular Protein ID: 1174219597

Symbol: HSPB1_HUMAN

Name: Heat shock protein beta-1

UniProtKB Accession Codes:

P04792 B2R4N8 Q6FI47 Q96C20 Q96EI7 Q9UC31 Q9UC34 Q9UC35 Q9UC36

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 10 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 3 EMBL 19 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 44 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OGP 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 6 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3714473

Title: Sequence and organization of genes encoding the human 27 kDa heat shock protein.

PubMed ID: 3714473

DOI: 10.1093/nar/14.10.4127

PubMed ID: 2243808

Title: cDNA sequence of a human heat shock protein HSP27.

PubMed ID: 2243808

DOI: 10.1093/nar/18.21.6457

PubMed ID: 10777697

Title: Small heat shock protein 27 (HSP27) associates with tubulin/microtubules in HeLa cells.

PubMed ID: 10777697

DOI: 10.1006/bbrc.2000.2553

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2295696

Title: Identification of two related markers for common acute lymphoblastic leukemia as heat shock proteins.

PubMed ID: 2295696

DOI: 10.1172/jci114413

PubMed ID: 8325890

Title: The 28-kDa protein whose phosphorylation is induced by protein kinase C activators in MCF-7 cells belongs to the family of low molecular mass heat shock proteins and is the estrogen-regulated 24-kDa protein.

PubMed ID: 8325890

DOI: 10.1016/s0021-9258(18)82451-6

PubMed ID: 1560006

Title: Copurification of small heat shock protein with alpha B crystallin from human skeletal muscle.

PubMed ID: 1560006

DOI: 10.1016/s0021-9258(18)42574-4

PubMed ID: 1730670

Title: Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II.

PubMed ID: 1730670

DOI: 10.1016/s0021-9258(18)48354-8

PubMed ID: 2743305

Title: Induction of the estrogen-regulated '24K' protein by heat shock.

PubMed ID: 2743305

PubMed ID: 1763035

Title: The 29-kDa proteins phosphorylated in thrombin-activated human platelets are forms of the estrogen receptor-related 27-kDa heat shock protein.

PubMed ID: 1763035

DOI: 10.1073/pnas.88.24.11212

PubMed ID: 1332886

Title: Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins.

PubMed ID: 1332886

DOI: 10.1016/0014-5793(92)81216-9

PubMed ID: 8093612

Title: Small heat shock proteins are molecular chaperones.

PubMed ID: 8093612

DOI: 10.1016/s0021-9258(18)53882-5

PubMed ID: 8774846

Title: A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress.

PubMed ID: 8774846

DOI: 10.1016/0014-5793(96)00816-2

PubMed ID: 10383393

Title: Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation.

PubMed ID: 10383393

DOI: 10.1074/jbc.274.27.18947

PubMed ID: 10751411

Title: Identification and characterization of a novel protein from Sertoli cells, PASS1, that associates with mammalian small stress protein hsp27.

PubMed ID: 10751411

DOI: 10.1074/jbc.m001981200

PubMed ID: 11342557

Title: HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 (3DHSP27).

PubMed ID: 11342557

DOI: 10.1074/jbc.m103001200

PubMed ID: 15976317

Title: Heat shock protein 27 is associated with freedom from graft vasculopathy after human cardiac transplantation.

PubMed ID: 15976317

DOI: 10.1161/01.res.0000174815.10996.08

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16548883

Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.

PubMed ID: 16548883

DOI: 10.1111/j.1462-5822.2005.00644.x

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19464326

Title: HSPB7 is a SC35 speckle resident small heat shock protein.

PubMed ID: 19464326

DOI: 10.1016/j.bbamcr.2009.05.005

PubMed ID: 19166925

Title: PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5.

PubMed ID: 19166925

DOI: 10.1016/j.cellsig.2009.01.009

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15122254

Title: Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.

PubMed ID: 15122254

DOI: 10.1038/ng1354

PubMed ID: 18832141

Title: Mutations in the HSP27 (HSPB1) gene cause dominant, recessive, and sporadic distal HMN/CMT type 2.

PubMed ID: 18832141

DOI: 10.1212/01.wnl.0000319696.14225.67

PubMed ID: 18952241

Title: A clinical phenotype of distal hereditary motor neuronopathy type II with a novel HSPB1 mutation.

PubMed ID: 18952241

DOI: 10.1016/j.jns.2008.09.031

PubMed ID: 20178975

Title: Increased monomerization of mutant HSPB1 leads to protein hyperactivity in Charcot-Marie-Tooth neuropathy.

PubMed ID: 20178975

DOI: 10.1074/jbc.m109.082644

PubMed ID: 20870250

Title: A novel HSPB1 mutation in an Italian patient with CMT2/dHMN phenotype.

PubMed ID: 20870250

DOI: 10.1016/j.jns.2010.09.008

PubMed ID: 22176143

Title: HSPB1 and HSPB8 in inherited neuropathies: study of an Italian cohort of dHMN and CMT2 patients.

PubMed ID: 22176143

DOI: 10.1111/j.1529-8027.2011.00361.x

PubMed ID: 22206013

Title: The mutational spectrum in a cohort of Charcot-Marie-Tooth disease type 2 among the Han Chinese in Taiwan.

PubMed ID: 22206013

DOI: 10.1371/journal.pone.0029393

PubMed ID: 23728742

Title: Charcot-Marie-Tooth causing HSPB1 mutations increase Cdk5-mediated phosphorylation of neurofilaments.

PubMed ID: 23728742

DOI: 10.1007/s00401-013-1133-6

PubMed ID: 23948568

Title: Structure and properties of G84R and L99M mutants of human small heat shock protein HspB1 correlating with motor neuropathy.

PubMed ID: 23948568

DOI: 10.1016/j.abb.2013.07.028

PubMed ID: 23643870

Title: Physico-chemical properties of R140G and K141Q mutants of human small heat shock protein HspB1 associated with hereditary peripheral neuropathies.

PubMed ID: 23643870

DOI: 10.1016/j.biochi.2013.04.014

PubMed ID: 25965061

Title: Characterization of mutants of human small heat shock protein HspB1 carrying replacements in the n-terminal domain and associated with hereditary motor neuron diseases.

PubMed ID: 25965061

DOI: 10.1371/journal.pone.0126248

PubMed ID: 27492805

Title: Molecular chaperones in the pathogenesis of amyotrophic lateral sclerosis: the role of HSPB1.

PubMed ID: 27492805

DOI: 10.1002/humu.23062

PubMed ID: 28144995

Title: Axonal Neuropathies due to Mutations in Small Heat Shock Proteins: Clinical, Genetic, and Functional Insights into Novel Mutations.

PubMed ID: 28144995

DOI: 10.1002/humu.23189

Sequence Information:

  • Length: 205
  • Mass: 22783
  • Checksum: 1B4DC44A6F6606D5
  • Sequence:
    • MTERRVPFSL LRGPSWDPFR DWYPHSRLFD QAFGLPRLPE EWSQWLGGSS WPGYVRPLPP 
AAIESPAVAA PAYSRALSRQ LSSGVSEIRH TADRWRVSLD VNHFAPDELT VKTKDGVVEI 
TGKHEERQDE HGYISRCFTR KYTLPPGVDP TQVSSSLSPE GTLTVEAPMP KLATQSNEIT 
IPVTFESRAQ LGGPEAAKSD ETAAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.