Details for: HSPB1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 821.9796
Cell Significance Index: -127.8600 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 459.1486
Cell Significance Index: -116.4600 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 349.5833
Cell Significance Index: -144.0100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 284.3117
Cell Significance Index: -134.2300 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 251.6402
Cell Significance Index: -129.4400 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 203.0484
Cell Significance Index: -136.2500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 112.7534
Cell Significance Index: -139.0200 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 43.3580
Cell Significance Index: -116.1500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 36.2679
Cell Significance Index: -143.1200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 36.0595
Cell Significance Index: -110.7600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 22.2289
Cell Significance Index: -48.6500 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 19.6530
Cell Significance Index: 208.8100 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 14.2442
Cell Significance Index: 122.4000 - Cell Name: theca cell (CL0000503)
Fold Change: 11.9029
Cell Significance Index: 69.9300 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 9.9837
Cell Significance Index: 176.4300 - Cell Name: kidney cell (CL1000497)
Fold Change: 8.9100
Cell Significance Index: 71.1400 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 8.0495
Cell Significance Index: 74.1300 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 6.6013
Cell Significance Index: 47.4100 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 6.4149
Cell Significance Index: 156.5200 - Cell Name: epidermal cell (CL0000362)
Fold Change: 5.7707
Cell Significance Index: 13.0100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 5.5947
Cell Significance Index: 1008.5400 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 5.0236
Cell Significance Index: 57.0700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 5.0057
Cell Significance Index: 615.5000 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 4.9422
Cell Significance Index: 30.4200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 4.7879
Cell Significance Index: 356.8400 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 4.7377
Cell Significance Index: 24.9300 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 4.7234
Cell Significance Index: 51.3500 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.5190
Cell Significance Index: 129.5400 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 4.4722
Cell Significance Index: 72.1600 - Cell Name: odontoblast (CL0000060)
Fold Change: 4.3622
Cell Significance Index: 559.2100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.3392
Cell Significance Index: 118.1100 - Cell Name: peg cell (CL4033014)
Fold Change: 4.0262
Cell Significance Index: 93.0200 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 3.6294
Cell Significance Index: 75.9700 - Cell Name: granulosa cell (CL0000501)
Fold Change: 3.5657
Cell Significance Index: 93.7600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 3.3585
Cell Significance Index: 1484.8600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 3.0180
Cell Significance Index: 414.4600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.9885
Cell Significance Index: 156.9100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.5985
Cell Significance Index: 72.6200 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 2.5740
Cell Significance Index: 19.8400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 2.1568
Cell Significance Index: 1177.8800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.9302
Cell Significance Index: 100.2700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.7280
Cell Significance Index: 295.0700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.2598
Cell Significance Index: 250.0200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.0958
Cell Significance Index: 51.5000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9845
Cell Significance Index: 888.8900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.8176
Cell Significance Index: 21.8300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.6748
Cell Significance Index: 43.5400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.5797
Cell Significance Index: 438.8100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.5418
Cell Significance Index: 38.3200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5219
Cell Significance Index: 51.6300 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.4853
Cell Significance Index: 7.3700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.4789
Cell Significance Index: 16.6400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.4494
Cell Significance Index: 34.4900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4363
Cell Significance Index: 83.0300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4143
Cell Significance Index: 48.8600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.2938
Cell Significance Index: 33.5400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1440
Cell Significance Index: 2.4100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1161
Cell Significance Index: 218.5400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.1072
Cell Significance Index: 78.6000 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.1001
Cell Significance Index: 1.5000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0376
Cell Significance Index: 17.0900 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0257
Cell Significance Index: 2.6300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0103
Cell Significance Index: 14.0000 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.0027
Cell Significance Index: 0.0300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0606
Cell Significance Index: -44.8600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0666
Cell Significance Index: -122.8300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0789
Cell Significance Index: -121.4700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0808
Cell Significance Index: -28.9700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1290
Cell Significance Index: -80.5400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1451
Cell Significance Index: -81.8400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1530
Cell Significance Index: -97.1600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1605
Cell Significance Index: -7.4900 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: -0.2664
Cell Significance Index: -1.0200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.2815
Cell Significance Index: -56.4700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3404
Cell Significance Index: -71.7000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3609
Cell Significance Index: -103.8400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.3835
Cell Significance Index: -11.0500 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.4202
Cell Significance Index: -54.2900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4478
Cell Significance Index: -6.1100 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.5335
Cell Significance Index: -4.3500 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: -0.5720
Cell Significance Index: -3.5400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.6354
Cell Significance Index: -72.8000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.7460
Cell Significance Index: -86.9400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.7749
Cell Significance Index: -112.6400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.8555
Cell Significance Index: -30.0600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.9370
Cell Significance Index: -74.2100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -1.1521
Cell Significance Index: -52.2200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.2621
Cell Significance Index: -131.4100 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -1.4948
Cell Significance Index: -61.2500 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -1.5581
Cell Significance Index: -45.7600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.5781
Cell Significance Index: -106.1100 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -1.6036
Cell Significance Index: -13.4700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.6061
Cell Significance Index: -51.4400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.8186
Cell Significance Index: -111.5000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.9626
Cell Significance Index: -120.6300 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.9970
Cell Significance Index: -58.8200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -2.0476
Cell Significance Index: -103.4800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -2.0557
Cell Significance Index: -54.9900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -2.2379
Cell Significance Index: -141.0500 - Cell Name: pro-T cell (CL0000827)
Fold Change: -2.3071
Cell Significance Index: -58.9400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1174219597
Symbol: HSPB1_HUMAN
Name: Heat shock protein beta-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3714473
Title: Sequence and organization of genes encoding the human 27 kDa heat shock protein.
PubMed ID: 3714473
PubMed ID: 2243808
Title: cDNA sequence of a human heat shock protein HSP27.
PubMed ID: 2243808
PubMed ID: 10777697
Title: Small heat shock protein 27 (HSP27) associates with tubulin/microtubules in HeLa cells.
PubMed ID: 10777697
PubMed ID: 9110174
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12853948
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2295696
Title: Identification of two related markers for common acute lymphoblastic leukemia as heat shock proteins.
PubMed ID: 2295696
DOI: 10.1172/jci114413
PubMed ID: 8325890
Title: The 28-kDa protein whose phosphorylation is induced by protein kinase C activators in MCF-7 cells belongs to the family of low molecular mass heat shock proteins and is the estrogen-regulated 24-kDa protein.
PubMed ID: 8325890
PubMed ID: 1560006
Title: Copurification of small heat shock protein with alpha B crystallin from human skeletal muscle.
PubMed ID: 1560006
PubMed ID: 1730670
Title: Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II.
PubMed ID: 1730670
PubMed ID: 2743305
Title: Induction of the estrogen-regulated '24K' protein by heat shock.
PubMed ID: 2743305
PubMed ID: 1763035
Title: The 29-kDa proteins phosphorylated in thrombin-activated human platelets are forms of the estrogen receptor-related 27-kDa heat shock protein.
PubMed ID: 1763035
PubMed ID: 1332886
Title: Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins.
PubMed ID: 1332886
PubMed ID: 8093612
Title: Small heat shock proteins are molecular chaperones.
PubMed ID: 8093612
PubMed ID: 8774846
Title: A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress.
PubMed ID: 8774846
PubMed ID: 10383393
Title: Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation.
PubMed ID: 10383393
PubMed ID: 10751411
Title: Identification and characterization of a novel protein from Sertoli cells, PASS1, that associates with mammalian small stress protein hsp27.
PubMed ID: 10751411
PubMed ID: 11342557
Title: HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 (3DHSP27).
PubMed ID: 11342557
PubMed ID: 15976317
Title: Heat shock protein 27 is associated with freedom from graft vasculopathy after human cardiac transplantation.
PubMed ID: 15976317
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16548883
Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.
PubMed ID: 16548883
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17924679
Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
PubMed ID: 17924679
DOI: 10.1021/pr070152u
PubMed ID: 18088087
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19464326
Title: HSPB7 is a SC35 speckle resident small heat shock protein.
PubMed ID: 19464326
PubMed ID: 19166925
Title: PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5.
PubMed ID: 19166925
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 15122254
Title: Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.
PubMed ID: 15122254
DOI: 10.1038/ng1354
PubMed ID: 18832141
Title: Mutations in the HSP27 (HSPB1) gene cause dominant, recessive, and sporadic distal HMN/CMT type 2.
PubMed ID: 18832141
PubMed ID: 18952241
Title: A clinical phenotype of distal hereditary motor neuronopathy type II with a novel HSPB1 mutation.
PubMed ID: 18952241
PubMed ID: 20178975
Title: Increased monomerization of mutant HSPB1 leads to protein hyperactivity in Charcot-Marie-Tooth neuropathy.
PubMed ID: 20178975
PubMed ID: 20870250
Title: A novel HSPB1 mutation in an Italian patient with CMT2/dHMN phenotype.
PubMed ID: 20870250
PubMed ID: 22176143
Title: HSPB1 and HSPB8 in inherited neuropathies: study of an Italian cohort of dHMN and CMT2 patients.
PubMed ID: 22176143
PubMed ID: 22206013
Title: The mutational spectrum in a cohort of Charcot-Marie-Tooth disease type 2 among the Han Chinese in Taiwan.
PubMed ID: 22206013
PubMed ID: 23728742
Title: Charcot-Marie-Tooth causing HSPB1 mutations increase Cdk5-mediated phosphorylation of neurofilaments.
PubMed ID: 23728742
PubMed ID: 23948568
Title: Structure and properties of G84R and L99M mutants of human small heat shock protein HspB1 correlating with motor neuropathy.
PubMed ID: 23948568
PubMed ID: 23643870
Title: Physico-chemical properties of R140G and K141Q mutants of human small heat shock protein HspB1 associated with hereditary peripheral neuropathies.
PubMed ID: 23643870
PubMed ID: 25965061
Title: Characterization of mutants of human small heat shock protein HspB1 carrying replacements in the n-terminal domain and associated with hereditary motor neuron diseases.
PubMed ID: 25965061
PubMed ID: 27492805
Title: Molecular chaperones in the pathogenesis of amyotrophic lateral sclerosis: the role of HSPB1.
PubMed ID: 27492805
DOI: 10.1002/humu.23062
PubMed ID: 28144995
Title: Axonal Neuropathies due to Mutations in Small Heat Shock Proteins: Clinical, Genetic, and Functional Insights into Novel Mutations.
PubMed ID: 28144995
DOI: 10.1002/humu.23189
Sequence Information:
- Length: 205
- Mass: 22783
- Checksum: 1B4DC44A6F6606D5
- Sequence:
MTERRVPFSL LRGPSWDPFR DWYPHSRLFD QAFGLPRLPE EWSQWLGGSS WPGYVRPLPP AAIESPAVAA PAYSRALSRQ LSSGVSEIRH TADRWRVSLD VNHFAPDELT VKTKDGVVEI TGKHEERQDE HGYISRCFTR KYTLPPGVDP TQVSSSLSPE GTLTVEAPMP KLATQSNEIT IPVTFESRAQ LGGPEAAKSD ETAAK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.