HSP90AA1 | ENSG00000080824 | NCBI 3320

Details for: HSP90AA1

Gene ID: 3320

Symbol: HSP90AA1

Ensembl ID: ENSG00000080824

Description: heat shock protein 90 alpha family class A member 1

Associated with

Aggrephagy
(R-HSA-9646399)
Anchoring of the basal body to the plasma membrane
(R-HSA-5620912)
Attenuation phase
(R-HSA-3371568)
Aurka activation by tpx2
(R-HSA-8854518)
Autophagy
(R-HSA-9612973)
Axon guidance
(R-HSA-422475)
Bacterial infection pathways
(R-HSA-9824439)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to heat stress
(R-HSA-3371556)
Centrosome maturation
(R-HSA-380287)
Chaperone mediated autophagy
(R-HSA-9613829)
Cilium assembly
(R-HSA-5617833)
Constitutive signaling by egfrviii
(R-HSA-5637810)
Constitutive signaling by ligand-responsive egfr cancer variants
(R-HSA-1236382)
Constitutive signaling by overexpressed erbb2
(R-HSA-9634285)
Cytokine signaling in immune system
(R-HSA-1280215)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downregulation of erbb2 signaling
(R-HSA-8863795)
Drug-mediated inhibition of erbb2 signaling
(R-HSA-9652282)
Drug resistance in erbb2 kd mutants
(R-HSA-9665230)
Drug resistance in erbb2 tmd/jmd mutants
(R-HSA-9665737)
Enos activation
(R-HSA-203615)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
G2/m transition
(R-HSA-69275)
Gene expression (transcription)
(R-HSA-74160)
Gene silencing by rna
(R-HSA-211000)
Hsf1 activation
(R-HSA-3371511)
Hsf1-dependent transactivation
(R-HSA-3371571)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-HSA-3371497)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
Innate immune system
(R-HSA-168249)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Macroautophagy
(R-HSA-1632852)
Metabolism
(R-HSA-1430728)
Metabolism of cofactors
(R-HSA-8978934)
Metabolism of nitric oxide: nos3 activation and regulation
(R-HSA-202131)
Metabolism of vitamins and cofactors
(R-HSA-196854)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic prometaphase
(R-HSA-68877)
M phase
(R-HSA-68886)
Nervous system development
(R-HSA-9675108)
Neutrophil degranulation
(R-HSA-6798695)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Piwi-interacting rna (pirna) biogenesis
(R-HSA-5601884)
Programmed cell death
(R-HSA-5357801)
Recruitment of numa to mitotic centrosomes
(R-HSA-380320)
Regulated necrosis
(R-HSA-5218859)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of necroptotic cell death
(R-HSA-5675482)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Resistance of erbb2 kd mutants to afatinib
(R-HSA-9665249)
Resistance of erbb2 kd mutants to neratinib
(R-HSA-9665246)
Resistance of erbb2 kd mutants to osimertinib
(R-HSA-9665247)
Resistance of erbb2 kd mutants to sapitinib
(R-HSA-9665244)
Resistance of erbb2 kd mutants to tesevatinib
(R-HSA-9665245)
Resistance of erbb2 kd mutants to trastuzumab
(R-HSA-9665233)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rho gtpase cycle
(R-HSA-9012999)
Ripk1-mediated regulated necrosis
(R-HSA-5213460)
Sars-cov infections
(R-HSA-9679506)
Scavenging by class f receptors
(R-HSA-3000484)
Selective autophagy
(R-HSA-9663891)
Sema3a pak dependent axon repulsion
(R-HSA-399954)
Semaphorin interactions
(R-HSA-373755)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by egfrviii in cancer
(R-HSA-5637812)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb2 ecd mutants
(R-HSA-9665348)
Signaling by erbb2 in cancer
(R-HSA-1227990)
Signaling by erbb2 kd mutants
(R-HSA-9664565)
Signaling by erbb2 tmd/jmd mutants
(R-HSA-9665686)
Signaling by interleukins
(R-HSA-449147)
Signaling by ligand-responsive egfr variants in cancer
(R-HSA-5637815)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Tetrahydrobiopterin (bh4) synthesis, recycling, salvage and regulation
(R-HSA-1474151)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-HSA-8852276)
Uptake and actions of bacterial toxins
(R-HSA-5339562)
Uptake and function of diphtheria toxin
(R-HSA-5336415)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vegfr2 mediated vascular permeability
(R-HSA-5218920)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cell in vitro (CL0001034)
Fold Change: 3.74
Cell Significance Index: 6
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.18
Cell Significance Index: 3
Cell Name: odontoblast (CL0000060)
Fold Change: 1.88
Cell Significance Index: 2
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.75
Cell Significance Index: 2
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.65
Cell Significance Index: 2
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.46
Cell Significance Index: 2
Cell Name: lactocyte (CL0002325)
Fold Change: 1.25
Cell Significance Index: 1
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.24
Cell Significance Index: 1
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.22
Cell Significance Index: 1
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.21
Cell Significance Index: 1
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.21
Cell Significance Index: 2
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.2
Cell Significance Index: 1
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.2
Cell Significance Index: 1
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.19
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Cell Significance Index: 1
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.14
Cell Significance Index: 1
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.12
Cell Significance Index: 1
Cell Name: kidney cell (CL1000497)
Fold Change: 1.11
Cell Significance Index: 1
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.1
Cell Significance Index: 1
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1
Cell Significance Index: 1
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1
Cell Significance Index: 1
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1
Cell Significance Index: 1
Cell Name: peg cell (CL4033014)
Fold Change: 1
Cell Significance Index: 1
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1
Cell Significance Index: 1
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1
Cell Significance Index: 1
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: cell (CL0000000)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: epidermal cell (CL0000362)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: perivascular cell (CL4033054)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: glioblast (CL0000030)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: theca cell (CL0000503)
Fold Change: 0.96
Cell Significance Index: 1
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.95
Cell Significance Index: 1
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.94
Cell Significance Index: 1
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.94
Cell Significance Index: 1
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.94
Cell Significance Index: 1
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.94
Cell Significance Index: 1
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.94
Cell Significance Index: 1
Cell Name: Merkel cell (CL0000242)
Fold Change: 0.94
Cell Significance Index: 1
Cell Name: germ cell (CL0000586)
Fold Change: 0.94
Cell Significance Index: 1
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.93
Cell Significance Index: 1
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.93
Cell Significance Index: 1
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.93
Cell Significance Index: 1
Cell Name: supporting cell (CL0000630)
Fold Change: 0.93
Cell Significance Index: 1
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.93
Cell Significance Index: 1
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.93
Cell Significance Index: 1
Cell Name: activated type II NK T cell (CL0000931)
Fold Change: 0.93
Cell Significance Index: 1
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.93
Cell Significance Index: 1
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.93
Cell Significance Index: 1
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 0.93
Cell Significance Index: 1
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 0.93
Cell Significance Index: 1
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.92
Cell Significance Index: 1
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.92
Cell Significance Index: 1
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.92
Cell Significance Index: 1
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.92
Cell Significance Index: 1
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.92
Cell Significance Index: 1
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.92
Cell Significance Index: 1
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: 0.92
Cell Significance Index: 1
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.92
Cell Significance Index: 1
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.92
Cell Significance Index: 1
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.92
Cell Significance Index: 1
Cell Name: chondroblast (CL0000058)
Fold Change: 0.92
Cell Significance Index: 1
Cell Name: malignant cell (CL0001064)
Fold Change: 0.92
Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** HSP90AA1 is a 90-kDa protein that is constitutively expressed in most cell types. It is a member of the HSP90 family, which is characterized by its ability to bind to and stabilize the folding of client proteins. HSP90AA1 has been shown to interact with a wide range of client proteins, including kinases, phosphatases, and other chaperones. It is also known to be involved in various signaling pathways, including the EGFR and ER signaling pathways. **Pathways and Functions** HSP90AA1 is involved in a wide range of cellular processes, including: * Cell cycle regulation: HSP90AA1 is involved in the regulation of the cell cycle, particularly at the G2/M phase. * Apoptosis: HSP90AA1 has been shown to inhibit apoptosis by stabilizing the folding of pro-apoptotic proteins. * Immune response: HSP90AA1 is involved in the regulation of immune responses, particularly in the activation of natural killer cells. * Signaling pathways: HSP90AA1 is involved in the signaling pathways of various growth factor receptors, including the EGFR and ER. * Protein folding: HSP90AA1 is involved in the folding of client proteins, particularly those that are prone to misfolding or aggregation. **Clinical Significance** HSP90AA1 has been implicated in various diseases, including: * Cancer: HSP90AA1 is overexpressed in many types of cancer, including breast, lung, and colon cancer. Its dysregulation has been shown to contribute to cancer progression and resistance to therapy. * Neurodegenerative diseases: HSP90AA1 has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. * Inflammatory diseases: HSP90AA1 has been shown to contribute to the development of inflammatory diseases, including rheumatoid arthritis and multiple sclerosis. * Infectious diseases: HSP90AA1 has been implicated in the pathogenesis of infectious diseases, including HIV and tuberculosis. In conclusion, HSP90AA1 is a multifunctional protein that plays a crucial role in various cellular processes, including cell cycle regulation, apoptosis, and immune response. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, inflammatory diseases, and infectious diseases. Further research is needed to fully understand the mechanisms by which HSP90AA1 contributes to disease and to develop therapeutic strategies to target its dysregulation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.