Details for: HSP90AA1

Gene ID: 3320

Symbol: HSP90AA1

Ensembl ID: ENSG00000080824

Description: heat shock protein 90 alpha family class A member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1520.0081
    Cell Significance Index: -236.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 977.8296
    Cell Significance Index: -248.0200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 705.4295
    Cell Significance Index: -290.6000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 616.4288
    Cell Significance Index: -291.0300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 538.6819
    Cell Significance Index: -277.0900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 435.0527
    Cell Significance Index: -291.9300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 228.6213
    Cell Significance Index: -281.8800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 82.4362
    Cell Significance Index: -220.8400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 78.8779
    Cell Significance Index: -242.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 74.6798
    Cell Significance Index: -294.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 41.0402
    Cell Significance Index: -89.8200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 17.1927
    Cell Significance Index: 182.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 10.0132
    Cell Significance Index: 525.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 9.8299
    Cell Significance Index: 281.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 8.9261
    Cell Significance Index: 1144.2800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 8.6094
    Cell Significance Index: 66.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 8.5378
    Cell Significance Index: 401.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 7.3054
    Cell Significance Index: 253.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 6.2367
    Cell Significance Index: 1124.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 6.0719
    Cell Significance Index: 746.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 5.7229
    Cell Significance Index: 785.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 5.4136
    Cell Significance Index: 2956.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.9238
    Cell Significance Index: 129.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 4.3923
    Cell Significance Index: 1941.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.3593
    Cell Significance Index: 281.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.3228
    Cell Significance Index: 201.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.2424
    Cell Significance Index: 500.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.7323
    Cell Significance Index: 101.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.6887
    Cell Significance Index: 476.5600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.5934
    Cell Significance Index: 95.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.5530
    Cell Significance Index: 705.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.5384
    Cell Significance Index: 81.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.8259
    Cell Significance Index: 199.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.6323
    Cell Significance Index: 24.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.3960
    Cell Significance Index: 178.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1404
    Cell Significance Index: 429.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.9809
    Cell Significance Index: 710.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.7913
    Cell Significance Index: 51.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.7525
    Cell Significance Index: 98.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.5332
    Cell Significance Index: 261.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7566
    Cell Significance Index: 74.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.7565
    Cell Significance Index: 554.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.5060
    Cell Significance Index: 383.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2169
    Cell Significance Index: 7.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1781
    Cell Significance Index: 28.9600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0960
    Cell Significance Index: 180.6800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0747
    Cell Significance Index: -101.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1126
    Cell Significance Index: -11.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1315
    Cell Significance Index: -242.5400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1319
    Cell Significance Index: -2.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1446
    Cell Significance Index: -222.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1503
    Cell Significance Index: -111.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1895
    Cell Significance Index: -120.3500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2713
    Cell Significance Index: -169.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3019
    Cell Significance Index: -19.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3338
    Cell Significance Index: -17.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.3902
    Cell Significance Index: -220.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3908
    Cell Significance Index: -24.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.4021
    Cell Significance Index: -278.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.4256
    Cell Significance Index: -193.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.4619
    Cell Significance Index: -87.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4905
    Cell Significance Index: -56.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6882
    Cell Significance Index: -144.9600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6919
    Cell Significance Index: -20.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7338
    Cell Significance Index: -12.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.8933
    Cell Significance Index: -257.0300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.9747
    Cell Significance Index: -17.2300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -1.0339
    Cell Significance Index: -112.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.4373
    Cell Significance Index: -208.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.4626
    Cell Significance Index: -167.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.6335
    Cell Significance Index: -190.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.6431
    Cell Significance Index: -130.1300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.7040
    Cell Significance Index: -13.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.7736
    Cell Significance Index: -119.2600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -2.0112
    Cell Significance Index: -23.9800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -2.1214
    Cell Significance Index: -39.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -2.3323
    Cell Significance Index: -65.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -2.4856
    Cell Significance Index: -63.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -2.7223
    Cell Significance Index: -208.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.7550
    Cell Significance Index: -286.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -3.0679
    Cell Significance Index: -139.0600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -3.1300
    Cell Significance Index: -53.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -3.3344
    Cell Significance Index: -72.2400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -3.4744
    Cell Significance Index: -240.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -3.5718
    Cell Significance Index: -214.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -3.6081
    Cell Significance Index: -159.6000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -3.6758
    Cell Significance Index: -47.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.8714
    Cell Significance Index: -52.8200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -3.9160
    Cell Significance Index: -33.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -4.6201
    Cell Significance Index: -174.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.7154
    Cell Significance Index: -289.1000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -4.8237
    Cell Significance Index: -52.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -4.8949
    Cell Significance Index: -130.9400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -4.9101
    Cell Significance Index: -140.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -5.2497
    Cell Significance Index: -168.1400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -5.4531
    Cell Significance Index: -61.9500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -5.5540
    Cell Significance Index: -163.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -5.6754
    Cell Significance Index: -141.8700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -6.4845
    Cell Significance Index: -238.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -6.8630
    Cell Significance Index: -224.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HSP90AA1 is a 90-kDa protein that is constitutively expressed in most cell types. It is a member of the HSP90 family, which is characterized by its ability to bind to and stabilize the folding of client proteins. HSP90AA1 has been shown to interact with a wide range of client proteins, including kinases, phosphatases, and other chaperones. It is also known to be involved in various signaling pathways, including the EGFR and ER signaling pathways. **Pathways and Functions** HSP90AA1 is involved in a wide range of cellular processes, including: * Cell cycle regulation: HSP90AA1 is involved in the regulation of the cell cycle, particularly at the G2/M phase. * Apoptosis: HSP90AA1 has been shown to inhibit apoptosis by stabilizing the folding of pro-apoptotic proteins. * Immune response: HSP90AA1 is involved in the regulation of immune responses, particularly in the activation of natural killer cells. * Signaling pathways: HSP90AA1 is involved in the signaling pathways of various growth factor receptors, including the EGFR and ER. * Protein folding: HSP90AA1 is involved in the folding of client proteins, particularly those that are prone to misfolding or aggregation. **Clinical Significance** HSP90AA1 has been implicated in various diseases, including: * Cancer: HSP90AA1 is overexpressed in many types of cancer, including breast, lung, and colon cancer. Its dysregulation has been shown to contribute to cancer progression and resistance to therapy. * Neurodegenerative diseases: HSP90AA1 has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. * Inflammatory diseases: HSP90AA1 has been shown to contribute to the development of inflammatory diseases, including rheumatoid arthritis and multiple sclerosis. * Infectious diseases: HSP90AA1 has been implicated in the pathogenesis of infectious diseases, including HIV and tuberculosis. In conclusion, HSP90AA1 is a multifunctional protein that plays a crucial role in various cellular processes, including cell cycle regulation, apoptosis, and immune response. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, inflammatory diseases, and infectious diseases. Further research is needed to fully understand the mechanisms by which HSP90AA1 contributes to disease and to develop therapeutic strategies to target its dysregulation.

Genular Protein ID: 2723957671

Symbol: HS90A_HUMAN

Name: Heat shock 86 kDa

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2780322

Title: Nucleotide sequence of a full-length cDNA for 90 kDa heat-shock protein from human peripheral blood lymphocytes.

PubMed ID: 2780322

DOI: 10.1093/nar/17.17.7108

PubMed ID: 1368637

Title: Molecular cloning of cDNA encoding a human heat-shock protein whose expression is induced by adenovirus type 12 E1A in HeLa cells.

PubMed ID: 1368637

DOI: 10.1271/bbb1961.54.3163

PubMed ID: 2527334

Title: Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein.

PubMed ID: 2527334

DOI: 10.1128/mcb.9.6.2615-2626.1989

PubMed ID: 16269234

Title: The HSP90 family of genes in the human genome: insights into their divergence and evolution.

PubMed ID: 16269234

DOI: 10.1016/j.ygeno.2005.08.012

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 2469626

Title: Heat-shock proteins, Hsp84 and Hsp86, of mice and men: two related genes encode formerly identified tumour-specific transplantation antigens.

PubMed ID: 2469626

DOI: 10.1016/0378-1119(88)90182-5

PubMed ID: 2591742

Title: Cloning and analysis of a human 86-kDa heat-shock-protein-encoding gene.

PubMed ID: 2591742

DOI: 10.1016/0378-1119(89)90408-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2492519

Title: Two human 90-kDa heat shock proteins are phosphorylated in vivo at conserved serines that are phosphorylated in vitro by casein kinase II.

PubMed ID: 2492519

DOI: 10.1016/s0021-9258(19)81631-9

PubMed ID: 10409742

Title: Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.

PubMed ID: 10409742

DOI: 10.1128/mcb.19.8.5523

PubMed ID: 15937123

Title: S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities.

PubMed ID: 15937123

DOI: 10.1073/pnas.0407294102

PubMed ID: 2507541

Title: The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminal threonine residues.

PubMed ID: 2507541

DOI: 10.1016/s0021-9258(18)71488-9

PubMed ID: 8289821

Title: The carboxy-terminal region of mammalian HSP90 is required for its dimerization and function in vivo.

PubMed ID: 8289821

DOI: 10.1128/mcb.14.2.1459-1464.1994

PubMed ID: 7588731

Title: Mechanism of dimer formation of the 90-kDa heat-shock protein.

PubMed ID: 7588731

DOI: 10.1111/j.1432-1033.1995.001_1.x

PubMed ID: 9195923

Title: Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin.

PubMed ID: 9195923

DOI: 10.1074/jbc.272.26.16224

PubMed ID: 9660753

Title: Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90.

PubMed ID: 9660753

DOI: 10.1074/jbc.273.29.18007

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 11274138

Title: Stable association of hsp90 and p23, but Not hsp70, with active human telomerase.

PubMed ID: 11274138

DOI: 10.1074/jbc.c100055200

PubMed ID: 11583998

Title: Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex.

PubMed ID: 11583998

DOI: 10.1074/jbc.m105931200

PubMed ID: 11276205

Title: A CD14-independent LPS receptor cluster.

PubMed ID: 11276205

DOI: 10.1038/86342

PubMed ID: 12526792

Title: Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70.

PubMed ID: 12526792

DOI: 10.1016/s0092-8674(02)01250-3

PubMed ID: 12853476

Title: Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system.

PubMed ID: 12853476

DOI: 10.1093/emboj/cdg362

PubMed ID: 12604615

Title: Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone.

PubMed ID: 12604615

DOI: 10.1074/jbc.m212761200

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15235609

Title: SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells.

PubMed ID: 15235609

DOI: 10.1038/ncb1151

PubMed ID: 15708368

Title: Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions.

PubMed ID: 15708368

DOI: 10.1016/j.abb.2004.12.020

PubMed ID: 15383005

Title: Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole.

PubMed ID: 15383005

DOI: 10.1042/bj20040690

PubMed ID: 15577939

Title: Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.

PubMed ID: 15577939

DOI: 10.1038/sj.emboj.7600496

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16807684

Title: Phosphoproteomic analysis of the human pituitary.

PubMed ID: 16807684

DOI: 10.1007/s11102-006-8916-x

PubMed ID: 16531226

Title: Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90.

PubMed ID: 16531226

DOI: 10.1016/j.str.2005.12.009

PubMed ID: 17947705

Title: Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase.

PubMed ID: 17947705

DOI: 10.4049/jimmunol.179.9.6291

PubMed ID: 18400751

Title: Conserved conformational changes in the ATPase cycle of human Hsp90.

PubMed ID: 18400751

DOI: 10.1074/jbc.m800540200

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 19875381

Title: A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein.

PubMed ID: 19875381

DOI: 10.1074/mcp.m900261-mcp200

PubMed ID: 16139798

Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

PubMed ID: 16139798

DOI: 10.1016/j.bbrc.2005.08.132

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 17028174

Title: Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling.

PubMed ID: 17028174

DOI: 10.1073/pnas.0603781103

PubMed ID: 18256191

Title: The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis.

PubMed ID: 18256191

DOI: 10.1242/dev.018150

PubMed ID: 19696785

Title: Hsp90 is regulated by a switch point in the C-terminal domain.

PubMed ID: 19696785

DOI: 10.1038/embor.2009.153

PubMed ID: 20628368

Title: Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.

PubMed ID: 20628368

DOI: 10.1038/cr.2010.103

PubMed ID: 20353823

Title: Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response.

PubMed ID: 20353823

DOI: 10.1016/j.cellsig.2010.03.012

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22066472

Title: Human heat shock protein (Hsp) 90 interferes with Neisseria meningitidis adhesin A (NadA)-mediated adhesion and invasion.

PubMed ID: 22066472

DOI: 10.1111/j.1462-5822.2011.01722.x

PubMed ID: 23569206

Title: Cdc37 (cell division cycle 37) restricts Hsp90 (heat shock protein 90) motility by interaction with N-terminal and middle domain binding sites.

PubMed ID: 23569206

DOI: 10.1074/jbc.m112.439257

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24613385

Title: Hsp70 and Hsp90 oppositely regulate TGF-beta signaling through CHIP/Stub1.

PubMed ID: 24613385

DOI: 10.1016/j.bbrc.2014.02.124

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24681825

Title: The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling.

PubMed ID: 24681825

DOI: 10.18632/oncotarget.1850

PubMed ID: 25973397

Title: Hsp90, the concertmaster: tuning transcription.

PubMed ID: 25973397

DOI: 10.3389/fonc.2015.00100

PubMed ID: 25609812

Title: Tom70 mediates Sendai virus-induced apoptosis on mitochondria.

PubMed ID: 25609812

DOI: 10.1128/jvi.02959-14

PubMed ID: 25738358

Title: C-terminal domain of SMYD3 serves as a unique HSP90-regulated motif in oncogenesis.

PubMed ID: 25738358

DOI: 10.18632/oncotarget.2970

PubMed ID: 26517842

Title: Client proteins and small molecule inhibitors display distinct binding preferences for constitutive and stress-induced HSP90 isoforms and their conformationally restricted mutants.

PubMed ID: 26517842

DOI: 10.1371/journal.pone.0141786

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27295069

Title: Hsp90: Friends, clients and natural foes.

PubMed ID: 27295069

DOI: 10.1016/j.biochi.2016.05.018

PubMed ID: 26991466

Title: Review: The HSP90 molecular chaperone-an enigmatic ATPase.

PubMed ID: 26991466

DOI: 10.1002/bip.22835

PubMed ID: 27353360

Title: The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.

PubMed ID: 27353360

DOI: 10.1038/ncomms12037

PubMed ID: 26754925

Title: IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.

PubMed ID: 26754925

DOI: 10.1038/srep19174

PubMed ID: 29127155

Title: Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.

PubMed ID: 29127155

DOI: 10.15252/embj.201796700

PubMed ID: 30559449

Title: Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens.

PubMed ID: 30559449

DOI: 10.1038/s41467-018-07750-5

PubMed ID: 29743370

Title: Herpes Simplex Virus 1 Inhibits TANK-Binding Kinase 1 through Formation of the Us11-Hsp90 Complex.

PubMed ID: 29743370

DOI: 10.1128/jvi.00402-18

PubMed ID: 9108479

Title: Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent.

PubMed ID: 9108479

DOI: 10.1016/s0092-8674(00)80203-2

PubMed ID: 9817749

Title: In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis.

PubMed ID: 9817749

DOI: 10.1083/jcb.143.4.901

PubMed ID: 16307917

Title: Chaperoned ubiquitylation -- crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex.

PubMed ID: 16307917

DOI: 10.1016/j.molcel.2005.09.023

Sequence Information:

  • Length: 732
  • Mass: 84660
  • Checksum: 969F65FCC0BC86FD
  • Sequence:
  • MPEETQTQDQ PMEEEEVETF AFQAEIAQLM SLIINTFYSN KEIFLRELIS NSSDALDKIR 
    YESLTDPSKL DSGKELHINL IPNKQDRTLT IVDTGIGMTK ADLINNLGTI AKSGTKAFME 
    ALQAGADISM IGQFGVGFYS AYLVAEKVTV ITKHNDDEQY AWESSAGGSF TVRTDTGEPM 
    GRGTKVILHL KEDQTEYLEE RRIKEIVKKH SQFIGYPITL FVEKERDKEV SDDEAEEKED 
    KEEEKEKEEK ESEDKPEIED VGSDEEEEKK DGDKKKKKKI KEKYIDQEEL NKTKPIWTRN 
    PDDITNEEYG EFYKSLTNDW EDHLAVKHFS VEGQLEFRAL LFVPRRAPFD LFENRKKKNN 
    IKLYVRRVFI MDNCEELIPE YLNFIRGVVD SEDLPLNISR EMLQQSKILK VIRKNLVKKC 
    LELFTELAED KENYKKFYEQ FSKNIKLGIH EDSQNRKKLS ELLRYYTSAS GDEMVSLKDY 
    CTRMKENQKH IYYITGETKD QVANSAFVER LRKHGLEVIY MIEPIDEYCV QQLKEFEGKT 
    LVSVTKEGLE LPEDEEEKKK QEEKKTKFEN LCKIMKDILE KKVEKVVVSN RLVTSPCCIV 
    TSTYGWTANM ERIMKAQALR DNSTMGYMAA KKHLEINPDH SIIETLRQKA EADKNDKSVK 
    DLVILLYETA LLSSGFSLED PQTHANRIYR MIKLGLGIDE DDPTADDTSA AVTEEMPPLE 
    GDDDTSRMEE VD

Genular Protein ID: 2236158157

Symbol: Q86SX1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 262
  • Mass: 29031
  • Checksum: 886BBF5DEE3BFF29
  • Sequence:
  • MPPCSGGDGS TPPGPSLRDR DCPAQSAEYP RDRLDPRPGS PSEASSPPFL RSRAPVNWYQ 
    EKAQVFLWHL MVSGSTTLLC LWKQPFHVSA FPVTASLAFR QSQGAGQHLY KDLQPFILLR 
    LLMPEETQTQ DQPMEEEEVE TFAFQAEIAQ LMSLIINTFY SNKEIFLREL ISNSSDALDK 
    IRYESLTDPS KLDSGKELHI NLIPNKQDRT LTIVDTGIGM TKADLINNLG TIAKSGTKAF 
    MEALQAGADI SMIGQFGVGF YS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.