Details for: HSPE1

Gene ID: 3336

Symbol: HSPE1

Ensembl ID: ENSG00000115541

Description: heat shock protein family E (Hsp10) member 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 5
    Marker Score: 88,774
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.39
    Marker Score: 3,434
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 4.12
    Marker Score: 2,199
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 4.04
    Marker Score: 19,865
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.01
    Marker Score: 3,417
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.74
    Marker Score: 127,391
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.74
    Marker Score: 9,126
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.69
    Marker Score: 3,945
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.6
    Marker Score: 5,539
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.53
    Marker Score: 1,301
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 3.53
    Marker Score: 1,128
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.35
    Marker Score: 3,491
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 3.29
    Marker Score: 2,489
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.29
    Marker Score: 32,543
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.15
    Marker Score: 41,584
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.11
    Marker Score: 11,045
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 3.09
    Marker Score: 18,763
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.06
    Marker Score: 2,574
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.04
    Marker Score: 5,047
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.03
    Marker Score: 1,261
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3
    Marker Score: 15,746
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.99
    Marker Score: 4,228
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.99
    Marker Score: 2,353
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.96
    Marker Score: 2,325
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.94
    Marker Score: 2,218
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.89
    Marker Score: 7,744
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.86
    Marker Score: 7,035
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.86
    Marker Score: 99,025
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.85
    Marker Score: 7,982
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.82
    Marker Score: 18,374
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.82
    Marker Score: 1,887
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.82
    Marker Score: 2,018
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.78
    Marker Score: 4,471
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.78
    Marker Score: 1,427
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.77
    Marker Score: 21,664
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.77
    Marker Score: 5,540
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.77
    Marker Score: 4,823
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.76
    Marker Score: 1,381
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.76
    Marker Score: 3,336
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.75
    Marker Score: 2,788
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.75
    Marker Score: 4,371
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.74
    Marker Score: 23,806
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.71
    Marker Score: 2,559
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.7
    Marker Score: 1,957
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.69
    Marker Score: 1,204
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.68
    Marker Score: 7,390
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.66
    Marker Score: 5,563
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.65
    Marker Score: 4,972
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.64
    Marker Score: 2,643
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.64
    Marker Score: 12,677
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.63
    Marker Score: 19,582
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.61
    Marker Score: 5,917
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.6
    Marker Score: 4,267
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.6
    Marker Score: 3,119
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.6
    Marker Score: 1,630
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.58
    Marker Score: 7,649
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.55
    Marker Score: 8,021
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.55
    Marker Score: 9,823
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.55
    Marker Score: 16,599
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.54
    Marker Score: 28,661
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.54
    Marker Score: 3,314
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.54
    Marker Score: 2,265
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.54
    Marker Score: 875
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.52
    Marker Score: 1,196
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.52
    Marker Score: 3,562
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.52
    Marker Score: 4,495
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.51
    Marker Score: 4,274
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.51
    Marker Score: 3,607
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.5
    Marker Score: 5,086
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.5
    Marker Score: 1,610
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.5
    Marker Score: 1,285
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 2.48
    Marker Score: 1,136
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.47
    Marker Score: 591
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.47
    Marker Score: 2,643
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.47
    Marker Score: 813
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.47
    Marker Score: 14,643
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.47
    Marker Score: 24,839
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.47
    Marker Score: 2,320
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.46
    Marker Score: 7,170
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.45
    Marker Score: 1,112
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.45
    Marker Score: 758
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.44
    Marker Score: 826
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.43
    Marker Score: 9,966
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.43
    Marker Score: 4,444
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 2.43
    Marker Score: 1,010
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.43
    Marker Score: 1,396
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.43
    Marker Score: 1,836
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.42
    Marker Score: 1,618
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.41
    Marker Score: 2,155
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.41
    Marker Score: 935
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.4
    Marker Score: 1,399
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.4
    Marker Score: 15,288
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 2.39
    Marker Score: 3,002
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 2.39
    Marker Score: 778
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.39
    Marker Score: 955
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.39
    Marker Score: 8,843
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.39
    Marker Score: 3,080
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.38
    Marker Score: 1,175
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.37
    Marker Score: 898
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.37
    Marker Score: 60,668

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HSPE1 is a small heat shock protein (HSP) with a molecular weight of approximately 10 kDa. Its primary function is to act as a chaperone, assisting in the refolding of proteins that have been denatured by stress or oxidative damage. HSPE1 is also involved in regulating apoptosis, a process of programmed cell death, by modulating the activity of cysteine-type endopeptidases. Additionally, HSPE1 interacts with various signaling molecules, including Rho GTPases, to regulate cellular responses to stress and damage. **Pathways and Functions:** HSPE1 is involved in several key cellular pathways, including: 1. **Protein Folding and Refolding:** HSPE1 assists in the refolding of denatured proteins, ensuring the proper functioning of cellular machinery. 2. **Apoptosis Regulation:** HSPE1 modulates the activity of cysteine-type endopeptidases, influencing the process of programmed cell death. 3. **Rho GTPase Signaling:** HSPE1 interacts with Rho GTPases to regulate cellular responses to stress and damage. 4. **Mitochondrial Function:** As a mitochondrial chaperone, HSPE1 is involved in maintaining mitochondrial homeostasis and function. 5. **Cellular Stress Response:** HSPE1 is activated in response to cellular stress, including heat shock, oxidative stress, and hypoxia. **Clinical Significance:** Dysregulation of HSPE1 has been implicated in various diseases, including: 1. **Cancer:** HSPE1 expression is altered in various types of cancer, including breast, prostate, and lung cancer. 2. **Neurodegenerative Disorders:** HSPE1 expression is reduced in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Metabolic Disorders:** HSPE1 is involved in regulating glucose metabolism and insulin sensitivity, making it a potential target for the treatment of metabolic disorders. In conclusion, HSPE1 is a multifaceted protein that plays a critical role in maintaining cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of HSPE1 and its potential therapeutic applications.

Genular Protein ID: 4239186144

Symbol: CH10_HUMAN

Name: 10 kDa heat shock protein, mitochondrial

UniProtKB Accession Codes:

P61604 O95421 Q04984 Q53X54 Q9UDH0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 EMDB 4 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 6 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7914093

Title: Identification and cloning of human chaperonin 10 homologue.

PubMed ID: 7914093

DOI: 10.1016/0167-4781(94)90211-9

PubMed ID: 7916212

Title: Isolation, sequence analysis and characterization of a cDNA encoding human chaperonin 10.

PubMed ID: 7916212

DOI: 10.1016/0167-4781(94)90268-2

PubMed ID: 12483302

Title: Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter.

PubMed ID: 12483302

DOI: 10.1007/s00439-002-0837-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10763410

Title: Mapping and characterization of the eukaryotic early pregnancy factor/chaperonin 10 gene family.

PubMed ID: 10763410

DOI: 10.1023/a:1024488422990

PubMed ID: 7912672

Title: The purification of early-pregnancy factor to homogeneity from human platelets and identification as chaperonin 10.

PubMed ID: 7912672

DOI: 10.1111/j.1432-1033.1994.tb18897.x

PubMed ID: 1346131

Title: Mammalian mitochondrial chaperonin 60 functions as a single toroidal ring.

PubMed ID: 1346131

DOI: 10.1016/s0021-9258(18)48338-x

PubMed ID: 11422376

Title: The effect of nucleotides and mitochondrial chaperonin 10 on the structure and chaperone activity of mitochondrial chaperonin 60.

PubMed ID: 11422376

DOI: 10.1046/j.1432-1327.2001.02243.x

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25918392

Title: Crystal structure of the human mitochondrial chaperonin symmetrical football complex.

PubMed ID: 25918392

DOI: 10.1073/pnas.1411718112

Sequence Information:

  • Length: 102
  • Mass: 10932
  • Checksum: 1F3192C81F6EDB78
  • Sequence:
    • MAGQAFRKFL PLFDRVLVER SAAETVTKGG IMLPEKSQGK VLQATVVAVG SGSKGKGGEI 
QPVSVKVGDK VLLPEYGGTK VVLDDKDYFL FRDGDILGKY VD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.