Details for: HSPE1

Gene ID: 3336

Symbol: HSPE1

Ensembl ID: ENSG00000115541

Description: heat shock protein family E (Hsp10) member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 5
    Marker Score: 88774
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.39
    Marker Score: 3434
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 4.12
    Marker Score: 2199
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 4.04
    Marker Score: 19865
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.01
    Marker Score: 3417
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.74
    Marker Score: 127391
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.74
    Marker Score: 9126
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.69
    Marker Score: 3945
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.6
    Marker Score: 5539
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.53
    Marker Score: 1300.5
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 3.53
    Marker Score: 1128
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.35
    Marker Score: 3490.5
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 3.29
    Marker Score: 2489
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.29
    Marker Score: 32543
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.15
    Marker Score: 41584
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.11
    Marker Score: 11045
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 3.09
    Marker Score: 18762.5
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.06
    Marker Score: 2574
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.04
    Marker Score: 5047
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.03
    Marker Score: 1261
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3
    Marker Score: 15746
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.99
    Marker Score: 4228
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.99
    Marker Score: 2353
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.96
    Marker Score: 2325
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.94
    Marker Score: 2218
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.89
    Marker Score: 7744
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.86
    Marker Score: 7034.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.86
    Marker Score: 99024.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.85
    Marker Score: 7982
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.82
    Marker Score: 18374
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.82
    Marker Score: 1887
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.82
    Marker Score: 2018
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.78
    Marker Score: 4471
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.78
    Marker Score: 1427
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.77
    Marker Score: 21663.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.77
    Marker Score: 5540
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.77
    Marker Score: 4823
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.76
    Marker Score: 1381
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.76
    Marker Score: 3336
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.75
    Marker Score: 2788
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.75
    Marker Score: 4371
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.74
    Marker Score: 23806
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.71
    Marker Score: 2559
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.7
    Marker Score: 1957
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.69
    Marker Score: 1204
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.68
    Marker Score: 7390
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.66
    Marker Score: 5563
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.65
    Marker Score: 4972
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.64
    Marker Score: 2643
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.64
    Marker Score: 12677
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.63
    Marker Score: 19582
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.61
    Marker Score: 5917
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.6
    Marker Score: 4266.5
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.6
    Marker Score: 3119
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.6
    Marker Score: 1630
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.58
    Marker Score: 7649
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.55
    Marker Score: 8021
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.55
    Marker Score: 9823
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.55
    Marker Score: 16599
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.54
    Marker Score: 28661
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.54
    Marker Score: 3314
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.54
    Marker Score: 2265
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.54
    Marker Score: 875
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.52
    Marker Score: 1196
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.52
    Marker Score: 3562
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.52
    Marker Score: 4495
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.51
    Marker Score: 4274
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.51
    Marker Score: 3607
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.5
    Marker Score: 5086
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.5
    Marker Score: 1610
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.5
    Marker Score: 1285
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 2.48
    Marker Score: 1136
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.47
    Marker Score: 591
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.47
    Marker Score: 2642.5
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.47
    Marker Score: 813
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.47
    Marker Score: 14643
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.47
    Marker Score: 24839
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.47
    Marker Score: 2320
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.46
    Marker Score: 7170
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.45
    Marker Score: 1112
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.45
    Marker Score: 758
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.44
    Marker Score: 826
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.43
    Marker Score: 9966
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.43
    Marker Score: 4444
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 2.43
    Marker Score: 1010
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.43
    Marker Score: 1396
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.43
    Marker Score: 1836
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.42
    Marker Score: 1618
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.41
    Marker Score: 2155
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.41
    Marker Score: 935
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.4
    Marker Score: 1398.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.4
    Marker Score: 15288
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 2.39
    Marker Score: 3001.5
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 2.39
    Marker Score: 778
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.39
    Marker Score: 955
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.39
    Marker Score: 8843
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.39
    Marker Score: 3080
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.38
    Marker Score: 1175
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.37
    Marker Score: 898
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.37
    Marker Score: 60668

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Other Information

**Key characteristics:** - HSPE1 is a chaperone protein that helps to protect other proteins from degradation. - It is a member of the HSP family of heat shock proteins, which are induced in response to stress conditions. - HSPE1 is a cysteine-type endopeptidase that is involved in the activation of other HSPs. - It is also involved in the refolding of misfolded proteins. **Pathways and functions:** - HSPE1 is involved in the activation of the p38 MAPK pathway, which is a major stress response pathway. - It also regulates the expression of other HSPs, including HSP70 and HSP90. - HSPE1 is involved in the regulation of inflammation and apoptosis. - It is also involved in the folding and trafficking of proteins in the endoplasmic reticulum. **Clinical significance:** - Mutations in the HSPE1 gene have been linked to a number of human diseases, including amyotrophic lateral sclerosis, polycystic kidney disease, and Alzheimer's disease. - HSPE1 is a potential therapeutic target for these diseases, as it is a key regulator of inflammation and apoptosis. **Additional information:** - HSPE1 is a highly conserved protein that is found in organisms from yeast to humans. - It is a transmembrane protein that is expressed on the surface of cells. - It is a chaperone that binds to misfolded or damaged proteins and helps to fold them into their proper conformations. - It is a key regulator of the immune response, as it is involved in the activation of the p38 MAPK pathway, which is a major stress response pathway.

Genular Protein ID: 4239186144

Symbol: CH10_HUMAN

Name: 10 kDa heat shock protein, mitochondrial

UniProtKB Accession Codes:

P61604 O95421 Q04984 Q53X54 Q9UDH0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 EMDB 4 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 6 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7914093

Title: Identification and cloning of human chaperonin 10 homologue.

PubMed ID: 7914093

DOI: 10.1016/0167-4781(94)90211-9

PubMed ID: 7916212

Title: Isolation, sequence analysis and characterization of a cDNA encoding human chaperonin 10.

PubMed ID: 7916212

DOI: 10.1016/0167-4781(94)90268-2

PubMed ID: 12483302

Title: Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter.

PubMed ID: 12483302

DOI: 10.1007/s00439-002-0837-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10763410

Title: Mapping and characterization of the eukaryotic early pregnancy factor/chaperonin 10 gene family.

PubMed ID: 10763410

DOI: 10.1023/a:1024488422990

PubMed ID: 7912672

Title: The purification of early-pregnancy factor to homogeneity from human platelets and identification as chaperonin 10.

PubMed ID: 7912672

DOI: 10.1111/j.1432-1033.1994.tb18897.x

PubMed ID: 1346131

Title: Mammalian mitochondrial chaperonin 60 functions as a single toroidal ring.

PubMed ID: 1346131

DOI: 10.1016/s0021-9258(18)48338-x

PubMed ID: 11422376

Title: The effect of nucleotides and mitochondrial chaperonin 10 on the structure and chaperone activity of mitochondrial chaperonin 60.

PubMed ID: 11422376

DOI: 10.1046/j.1432-1327.2001.02243.x

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25918392

Title: Crystal structure of the human mitochondrial chaperonin symmetrical football complex.

PubMed ID: 25918392

DOI: 10.1073/pnas.1411718112

Sequence Information:

  • Length: 102
  • Mass: 10932
  • Checksum: 1F3192C81F6EDB78
  • Sequence:
    • MAGQAFRKFL PLFDRVLVER SAAETVTKGG IMLPEKSQGK VLQATVVAVG SGSKGKGGEI 
QPVSVKVGDK VLLPEYGGTK VVLDDKDYFL FRDGDILGKY VD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.