Details for: HSPE1

Gene ID: 3336

Symbol: HSPE1

Ensembl ID: ENSG00000115541

Description: heat shock protein family E (Hsp10) member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 728.7591
    Cell Significance Index: -113.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 424.5725
    Cell Significance Index: -107.6900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 325.5754
    Cell Significance Index: -134.1200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 282.8502
    Cell Significance Index: -133.5400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 254.0703
    Cell Significance Index: -130.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 104.2211
    Cell Significance Index: -128.5000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 39.9610
    Cell Significance Index: -107.0500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 34.1303
    Cell Significance Index: -134.6800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 29.7107
    Cell Significance Index: -91.2600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 6.2119
    Cell Significance Index: 94.3500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 6.1534
    Cell Significance Index: 49.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 6.1321
    Cell Significance Index: 164.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.2227
    Cell Significance Index: 137.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.8274
    Cell Significance Index: 138.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.5561
    Cell Significance Index: 214.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.4303
    Cell Significance Index: 306.3800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.2433
    Cell Significance Index: 46.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.5231
    Cell Significance Index: 249.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.3764
    Cell Significance Index: 398.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.3036
    Cell Significance Index: 406.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.2830
    Cell Significance Index: 591.8300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.0428
    Cell Significance Index: 70.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.9862
    Cell Significance Index: 62.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.9508
    Cell Significance Index: 1611.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.8376
    Cell Significance Index: 363.7600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.8304
    Cell Significance Index: 98.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.6382
    Cell Significance Index: 362.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.6187
    Cell Significance Index: 1157.7900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.6145
    Cell Significance Index: 15.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.2341
    Cell Significance Index: 25.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.9672
    Cell Significance Index: 146.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.9627
    Cell Significance Index: 253.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9600
    Cell Significance Index: 53.3500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.9004
    Cell Significance Index: 17.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.7338
    Cell Significance Index: 91.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.4507
    Cell Significance Index: 417.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2111
    Cell Significance Index: 1093.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9032
    Cell Significance Index: 46.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7723
    Cell Significance Index: 125.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7561
    Cell Significance Index: 35.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.5118
    Cell Significance Index: 387.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4426
    Cell Significance Index: 28.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4300
    Cell Significance Index: 73.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4024
    Cell Significance Index: 5.4900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.3516
    Cell Significance Index: 2.5300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2823
    Cell Significance Index: 3.6200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.2118
    Cell Significance Index: 1.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2051
    Cell Significance Index: 150.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1932
    Cell Significance Index: 38.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1915
    Cell Significance Index: 6.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1869
    Cell Significance Index: 4.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1659
    Cell Significance Index: 32.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1363
    Cell Significance Index: 25.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1337
    Cell Significance Index: 13.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0424
    Cell Significance Index: 15.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0477
    Cell Significance Index: -4.8800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0480
    Cell Significance Index: -35.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0509
    Cell Significance Index: -95.8400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0511
    Cell Significance Index: -0.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0761
    Cell Significance Index: -47.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0868
    Cell Significance Index: -160.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1035
    Cell Significance Index: -159.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1202
    Cell Significance Index: -163.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1682
    Cell Significance Index: -94.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1760
    Cell Significance Index: -111.8000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2596
    Cell Significance Index: -7.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2719
    Cell Significance Index: -57.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2747
    Cell Significance Index: -12.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2815
    Cell Significance Index: -127.7700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3377
    Cell Significance Index: -17.0700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4100
    Cell Significance Index: -16.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4699
    Cell Significance Index: -37.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6023
    Cell Significance Index: -69.0000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6177
    Cell Significance Index: -15.7800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6423
    Cell Significance Index: -11.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6850
    Cell Significance Index: -21.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7439
    Cell Significance Index: -86.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7662
    Cell Significance Index: -16.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7848
    Cell Significance Index: -48.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.8497
    Cell Significance Index: -123.5100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.8808
    Cell Significance Index: -52.8800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.9878
    Cell Significance Index: -112.7600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.0613
    Cell Significance Index: -8.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.2107
    Cell Significance Index: -76.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.3034
    Cell Significance Index: -135.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.3177
    Cell Significance Index: -101.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.3630
    Cell Significance Index: -36.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.4934
    Cell Significance Index: -83.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.7270
    Cell Significance Index: -36.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.9932
    Cell Significance Index: -122.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.0498
    Cell Significance Index: -137.8300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.3420
    Cell Significance Index: -14.1500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.4199
    Cell Significance Index: -36.2600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.4608
    Cell Significance Index: -72.4800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -2.4812
    Cell Significance Index: -15.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.5957
    Cell Significance Index: -64.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.8463
    Cell Significance Index: -125.9000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.8713
    Cell Significance Index: -105.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -3.0617
    Cell Significance Index: -78.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -3.2352
    Cell Significance Index: -59.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HSPE1 is a small heat shock protein (HSP) with a molecular weight of approximately 10 kDa. Its primary function is to act as a chaperone, assisting in the refolding of proteins that have been denatured by stress or oxidative damage. HSPE1 is also involved in regulating apoptosis, a process of programmed cell death, by modulating the activity of cysteine-type endopeptidases. Additionally, HSPE1 interacts with various signaling molecules, including Rho GTPases, to regulate cellular responses to stress and damage. **Pathways and Functions:** HSPE1 is involved in several key cellular pathways, including: 1. **Protein Folding and Refolding:** HSPE1 assists in the refolding of denatured proteins, ensuring the proper functioning of cellular machinery. 2. **Apoptosis Regulation:** HSPE1 modulates the activity of cysteine-type endopeptidases, influencing the process of programmed cell death. 3. **Rho GTPase Signaling:** HSPE1 interacts with Rho GTPases to regulate cellular responses to stress and damage. 4. **Mitochondrial Function:** As a mitochondrial chaperone, HSPE1 is involved in maintaining mitochondrial homeostasis and function. 5. **Cellular Stress Response:** HSPE1 is activated in response to cellular stress, including heat shock, oxidative stress, and hypoxia. **Clinical Significance:** Dysregulation of HSPE1 has been implicated in various diseases, including: 1. **Cancer:** HSPE1 expression is altered in various types of cancer, including breast, prostate, and lung cancer. 2. **Neurodegenerative Disorders:** HSPE1 expression is reduced in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Metabolic Disorders:** HSPE1 is involved in regulating glucose metabolism and insulin sensitivity, making it a potential target for the treatment of metabolic disorders. In conclusion, HSPE1 is a multifaceted protein that plays a critical role in maintaining cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of HSPE1 and its potential therapeutic applications.

Genular Protein ID: 4239186144

Symbol: CH10_HUMAN

Name: 10 kDa heat shock protein, mitochondrial

UniProtKB Accession Codes:

P61604 O95421 Q04984 Q53X54 Q9UDH0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 EMDB 4 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7914093

Title: Identification and cloning of human chaperonin 10 homologue.

PubMed ID: 7914093

DOI: 10.1016/0167-4781(94)90211-9

PubMed ID: 7916212

Title: Isolation, sequence analysis and characterization of a cDNA encoding human chaperonin 10.

PubMed ID: 7916212

DOI: 10.1016/0167-4781(94)90268-2

PubMed ID: 12483302

Title: Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter.

PubMed ID: 12483302

DOI: 10.1007/s00439-002-0837-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10763410

Title: Mapping and characterization of the eukaryotic early pregnancy factor/chaperonin 10 gene family.

PubMed ID: 10763410

DOI: 10.1023/a:1024488422990

PubMed ID: 7912672

Title: The purification of early-pregnancy factor to homogeneity from human platelets and identification as chaperonin 10.

PubMed ID: 7912672

DOI: 10.1111/j.1432-1033.1994.tb18897.x

PubMed ID: 1346131

Title: Mammalian mitochondrial chaperonin 60 functions as a single toroidal ring.

PubMed ID: 1346131

DOI: 10.1016/s0021-9258(18)48338-x

PubMed ID: 11422376

Title: The effect of nucleotides and mitochondrial chaperonin 10 on the structure and chaperone activity of mitochondrial chaperonin 60.

PubMed ID: 11422376

DOI: 10.1046/j.1432-1327.2001.02243.x

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25918392

Title: Crystal structure of the human mitochondrial chaperonin symmetrical football complex.

PubMed ID: 25918392

DOI: 10.1073/pnas.1411718112

Sequence Information:

  • Length: 102
  • Mass: 10932
  • Checksum: 1F3192C81F6EDB78
  • Sequence:
    • MAGQAFRKFL PLFDRVLVER SAAETVTKGG IMLPEKSQGK VLQATVVAVG SGSKGKGGEI 
QPVSVKVGDK VLLPEYGGTK VVLDDKDYFL FRDGDILGKY VD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.