Details for: IDH3G

Gene ID: 3421

Symbol: IDH3G

Ensembl ID: ENSG00000067829

Description: isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 3.14
    Marker Score: 1904
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.94
    Marker Score: 2625
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.75
    Marker Score: 1938
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.36
    Marker Score: 4976
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.85
    Marker Score: 7674
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.83
    Marker Score: 1223
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.79
    Marker Score: 8580
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.75
    Marker Score: 513
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.67
    Marker Score: 19415
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.65
    Marker Score: 3764
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.64
    Marker Score: 6446
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.63
    Marker Score: 2889
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.6
    Marker Score: 89451
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.57
    Marker Score: 13520
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.56
    Marker Score: 15789
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.55
    Marker Score: 3010
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.52
    Marker Score: 847
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.52
    Marker Score: 835
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.51
    Marker Score: 1279
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.5
    Marker Score: 1256
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.49
    Marker Score: 2478
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.49
    Marker Score: 6422
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.46
    Marker Score: 3049
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.45
    Marker Score: 4546
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.44
    Marker Score: 3415
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.43
    Marker Score: 49500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.42
    Marker Score: 3535.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.42
    Marker Score: 2185
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.42
    Marker Score: 705
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.41
    Marker Score: 36226
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.41
    Marker Score: 5782
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.41
    Marker Score: 2073
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.39
    Marker Score: 928
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.38
    Marker Score: 8828
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.38
    Marker Score: 1463
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.37
    Marker Score: 1477
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.37
    Marker Score: 1822
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.37
    Marker Score: 4848
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.36
    Marker Score: 2167
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.35
    Marker Score: 711
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.35
    Marker Score: 3665
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.35
    Marker Score: 1355
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.34
    Marker Score: 1416
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.33
    Marker Score: 8621
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.32
    Marker Score: 1870
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.31
    Marker Score: 953
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3
    Marker Score: 5000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.29
    Marker Score: 10100
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.29
    Marker Score: 1292
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.28
    Marker Score: 371
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.28
    Marker Score: 317
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.28
    Marker Score: 3429
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.26
    Marker Score: 12443.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.25
    Marker Score: 1271
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.25
    Marker Score: 2540
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.24
    Marker Score: 430
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.24
    Marker Score: 1789
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.24
    Marker Score: 13980
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.24
    Marker Score: 4587
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.24
    Marker Score: 16304
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.23
    Marker Score: 2015
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.23
    Marker Score: 1283
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.22
    Marker Score: 2298
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.22
    Marker Score: 16427
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.22
    Marker Score: 1241
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.22
    Marker Score: 285
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.21
    Marker Score: 2844
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.21
    Marker Score: 1382
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.21
    Marker Score: 1155
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.2
    Marker Score: 641
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.2
    Marker Score: 760
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.2
    Marker Score: 683
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.2
    Marker Score: 577
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.19
    Marker Score: 1839.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.19
    Marker Score: 3275
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.19
    Marker Score: 788
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.19
    Marker Score: 1231
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.17
    Marker Score: 1046
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.17
    Marker Score: 2950
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.17
    Marker Score: 439.5
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.17
    Marker Score: 601
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.15
    Marker Score: 565
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.14
    Marker Score: 11515
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.14
    Marker Score: 406
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.14
    Marker Score: 748
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.13
    Marker Score: 7237
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.13
    Marker Score: 538
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.13
    Marker Score: 321
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.13
    Marker Score: 278
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.12
    Marker Score: 385.5
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.11
    Marker Score: 2529
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.11
    Marker Score: 765
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.1
    Marker Score: 353
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.1
    Marker Score: 795
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.1
    Marker Score: 2147
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.09
    Marker Score: 326
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.09
    Marker Score: 510
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.09
    Marker Score: 382
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.09
    Marker Score: 1026
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.09
    Marker Score: 405

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Other Information

**Key characteristics:** * IDH3G is a glycoprotein with a molecular weight of approximately 80 kDa. * It is a transmembrane protein that spans the mitochondrial inner membrane. * It is a key enzyme in the TCA cycle, catalyzing the transfer of a single NAD+ to a coenzyme A. * It is involved in the regulation of mitochondrial oxidative phosphorylation and energy production. **Pathways and functions:** * IDH3G is involved in the regulation of mitochondrial oxidative phosphorylation. * It is a key enzyme in the TCA cycle, where it catalyzes the transfer of a single NAD+ to a coenzyme A. * It is also involved in the regulation of pyruvate metabolism and the generation of ATP. * It plays a role in the maintenance of mitochondrial redox balance. **Clinical significance:** * Mutations in IDH3G have been linked to several human diseases, including type 2 diabetes, obesity, and metabolic syndrome. * IDH3G deficiency has been associated with impaired mitochondrial function and reduced energy production. * Targeting IDH3G has emerged as a potential therapeutic strategy for these diseases.

Genular Protein ID: 3349166184

Symbol: IDH3G_HUMAN

Name: Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

UniProtKB Accession Codes:

P51553 E9PDD5 Q9BUU5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEBI 8 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DrugBank 2 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 12 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9286695

Title: Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse.

PubMed ID: 9286695

DOI: 10.1006/geno.1997.4822

PubMed ID: 10601238

Title: Identification and functional characterization of a novel, tissue-specific NAD+-dependent isocitrate dehydrogenase beta subunit isoform.

PubMed ID: 10601238

DOI: 10.1074/jbc.274.52.36866

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11256614

Title: Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.

PubMed ID: 11256614

DOI: 10.1093/embo-reports/kvd058

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28139779

Title: The beta and gamma subunits play distinct functional roles in the alpha2betagamma heterotetramer of human NAD-dependent isocitrate dehydrogenase.

PubMed ID: 28139779

DOI: 10.1038/srep41882

PubMed ID: 28098230

Title: Molecular mechanism of the allosteric regulation of the alphagamma heterodimer of human NAD-dependent isocitrate dehydrogenase.

PubMed ID: 28098230

DOI: 10.1038/srep40921

Sequence Information:

  • Length: 393
  • Mass: 42794
  • Checksum: A0870F2B7D228A37
  • Sequence:
    • MALKVATVAG SAAKAVLGPA LLCRPWEVLG AHEVPSRNIF SEQTIPPSAK YGGRHTVTMI 
PGDGIGPELM LHVKSVFRHA CVPVDFEEVH VSSNADEEDI RNAIMAIRRN RVALKGNIET 
NHNLPPSHKS RNNILRTSLD LYANVIHCKS LPGVVTRHKD IDILIVRENT EGEYSSLEHE 
SVAGVVESLK IITKAKSLRI AEYAFKLAQE SGRKKVTAVH KANIMKLGDG LFLQCCREVA 
ARYPQITFEN MIVDNTTMQL VSRPQQFDVM VMPNLYGNIV NNVCAGLVGG PGLVAGANYG 
HVYAVFETAT RNTGKSIANK NIANPTATLL ASCMMLDHLK LHSYATSIRK AVLASMDNEN 
MHTPDIGGQG TTSEAIQDVI RHIRVINGRA VEA

Genular Protein ID: 17822247

Symbol: O15384_HUMAN

Name: N/A

UniProtKB Accession Codes:

O15384

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 5 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 9286695

Title: Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse.

PubMed ID: 9286695

DOI: 10.1006/geno.1997.4822

Sequence Information:

  • Length: 296
  • Mass: 32728
  • Checksum: F4EF67DAB381D339
  • Sequence:
    • DFEEVHVSSN ADEEDIRNAI MAIRRNRVAL KGNIETNHNL PPSHKSRNNI LRTSLDLYAN 
VIHWKSLPGV VTRHKDIDIL IVRENTEGEY SSLEHESVAG VVESLKIITK AKSLRIAEYA 
FKLAQESGRK KVTAVHKANI MKLGDGLFLQ CCREVAARYP QITFENMIVD NTTMQLVSRP 
QQFDVMVMPN LYGNIVNNVC AGLVGGPGLV AGANYGHVYA VFETATRNTG KSIANKNIAN 
PTATLLASCM MLDHLKLHSY ATSIRKAVLA SMDNENVRFP SHPTLLPRPV SPCSLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.