Details for: IDH3G

Gene ID: 3421

Symbol: IDH3G

Ensembl ID: ENSG00000067829

Description: isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 219.1646
    Cell Significance Index: -34.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 124.5449
    Cell Significance Index: -31.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 89.0870
    Cell Significance Index: -42.0600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 88.6631
    Cell Significance Index: -36.0200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 79.7408
    Cell Significance Index: -41.0200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 62.7997
    Cell Significance Index: -42.1400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.9369
    Cell Significance Index: -36.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.7124
    Cell Significance Index: -39.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.2837
    Cell Significance Index: -40.5800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.6013
    Cell Significance Index: -29.4900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.1681
    Cell Significance Index: -24.5600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6697
    Cell Significance Index: -10.2200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 4.3584
    Cell Significance Index: 36.6100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.7542
    Cell Significance Index: 165.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.4686
    Cell Significance Index: 287.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.6329
    Cell Significance Index: 41.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4840
    Cell Significance Index: 69.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3240
    Cell Significance Index: 85.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0541
    Cell Significance Index: 144.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9343
    Cell Significance Index: 25.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9022
    Cell Significance Index: 492.7400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8495
    Cell Significance Index: 24.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8022
    Cell Significance Index: 144.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7785
    Cell Significance Index: 36.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7649
    Cell Significance Index: 98.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7304
    Cell Significance Index: 51.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7169
    Cell Significance Index: 88.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7090
    Cell Significance Index: 52.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6956
    Cell Significance Index: 307.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6815
    Cell Significance Index: 35.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6032
    Cell Significance Index: 27.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5791
    Cell Significance Index: 36.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5776
    Cell Significance Index: 12.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5544
    Cell Significance Index: 28.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5128
    Cell Significance Index: 60.4700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4534
    Cell Significance Index: 10.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4435
    Cell Significance Index: 15.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4374
    Cell Significance Index: 43.2700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4170
    Cell Significance Index: 10.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4105
    Cell Significance Index: 52.6300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3981
    Cell Significance Index: 5.9700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3847
    Cell Significance Index: 7.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2698
    Cell Significance Index: 54.1200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1951
    Cell Significance Index: 2.0200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1885
    Cell Significance Index: 1.5100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1821
    Cell Significance Index: 4.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1787
    Cell Significance Index: 34.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1593
    Cell Significance Index: 143.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1451
    Cell Significance Index: 4.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1198
    Cell Significance Index: 42.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1147
    Cell Significance Index: 4.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0681
    Cell Significance Index: 2.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0457
    Cell Significance Index: 0.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0272
    Cell Significance Index: 19.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0078
    Cell Significance Index: 1.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0019
    Cell Significance Index: 0.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0006
    Cell Significance Index: -0.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0108
    Cell Significance Index: -0.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0112
    Cell Significance Index: -21.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0193
    Cell Significance Index: -13.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0218
    Cell Significance Index: -2.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0232
    Cell Significance Index: -42.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0269
    Cell Significance Index: -41.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0326
    Cell Significance Index: -5.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0344
    Cell Significance Index: -46.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0430
    Cell Significance Index: -27.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0458
    Cell Significance Index: -33.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0568
    Cell Significance Index: -9.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0605
    Cell Significance Index: -34.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0702
    Cell Significance Index: -31.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0746
    Cell Significance Index: -46.5800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0766
    Cell Significance Index: -0.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0786
    Cell Significance Index: -9.0100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0855
    Cell Significance Index: -1.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1304
    Cell Significance Index: -1.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1465
    Cell Significance Index: -42.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2185
    Cell Significance Index: -31.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2190
    Cell Significance Index: -46.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2593
    Cell Significance Index: -15.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2603
    Cell Significance Index: -2.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2615
    Cell Significance Index: -5.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2672
    Cell Significance Index: -21.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3492
    Cell Significance Index: -26.8000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3812
    Cell Significance Index: -6.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3891
    Cell Significance Index: -40.5100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4095
    Cell Significance Index: -11.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4313
    Cell Significance Index: -29.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4709
    Cell Significance Index: -8.0700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4957
    Cell Significance Index: -8.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5940
    Cell Significance Index: -8.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5944
    Cell Significance Index: -36.4400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.6211
    Cell Significance Index: -5.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6284
    Cell Significance Index: -35.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6727
    Cell Significance Index: -16.8200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6943
    Cell Significance Index: -20.4500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7590
    Cell Significance Index: -21.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7666
    Cell Significance Index: -33.9100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.7667
    Cell Significance Index: -7.0600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8812
    Cell Significance Index: -32.3500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.9038
    Cell Significance Index: -13.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** IDH3G is expressed in a wide range of cell types, including myeloid dendritic cells, extravillous trophoblasts, and monocytes, suggesting its involvement in various physiological and pathological processes. 2. **Mitochondrial Localization:** IDH3G is localized to the mitochondrial matrix, indicating its role in mitochondrial metabolism and energy production. 3. **Non-Catalytic Subunit:** IDH3G lacks catalytic activity, but its presence in the isocitrate dehydrogenase complex suggests that it may regulate the activity or stability of the catalytic subunit. 4. **Conservation Across Species:** IDH3G is conserved across species, from humans to mice, suggesting its evolutionary importance and functional significance. **Pathways and Functions:** 1. **Citric Acid Cycle (TCA Cycle):** IDH3G is integral to the TCA cycle, a key metabolic pathway that generates energy for the cell through the oxidation of acetyl-CoA. 2. **Mitochondrial Metabolism:** IDH3G is localized to the mitochondrial matrix, suggesting its role in regulating mitochondrial metabolism and energy production. 3. **Isocitrate Metabolic Process:** IDH3G is involved in the isocitrate metabolic process, which is a crucial step in the TCA cycle. 4. **Energy Homeostasis:** IDH3G may contribute to energy homeostasis by regulating mitochondrial metabolism and energy production. **Clinical Significance:** 1. **Immune Response:** IDH3G expression in myeloid dendritic cells and monocytes suggests its involvement in immune responses, particularly in the context of cancer and infectious diseases. 2. **Cancer Metabolism:** Alterations in IDH3G expression or function may contribute to cancer metabolism and energy homeostasis. 3. **Mitochondrial Diseases:** IDH3G may play a role in mitochondrial diseases, such as mitochondrial myopathies, which are characterized by defects in mitochondrial energy production. 4. **Metabolic Disorders:** IDH3G may be involved in metabolic disorders, such as diabetes and obesity, which are characterized by dysregulation of energy homeostasis. In conclusion, IDH3G is a non-catalytic subunit of the isocitrate dehydrogenase complex that plays a crucial role in mitochondrial metabolism and energy production. Its expression patterns and functional significance suggest its involvement in various physiological and pathological processes, including immune responses, cancer metabolism, and mitochondrial diseases. Further studies are needed to fully elucidate the role of IDH3G in human health and disease.

Genular Protein ID: 3349166184

Symbol: IDH3G_HUMAN

Name: Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

UniProtKB Accession Codes:

P51553 E9PDD5 Q9BUU5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEBI 8 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9286695

Title: Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse.

PubMed ID: 9286695

DOI: 10.1006/geno.1997.4822

PubMed ID: 10601238

Title: Identification and functional characterization of a novel, tissue-specific NAD+-dependent isocitrate dehydrogenase beta subunit isoform.

PubMed ID: 10601238

DOI: 10.1074/jbc.274.52.36866

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11256614

Title: Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.

PubMed ID: 11256614

DOI: 10.1093/embo-reports/kvd058

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28139779

Title: The beta and gamma subunits play distinct functional roles in the alpha2betagamma heterotetramer of human NAD-dependent isocitrate dehydrogenase.

PubMed ID: 28139779

DOI: 10.1038/srep41882

PubMed ID: 28098230

Title: Molecular mechanism of the allosteric regulation of the alphagamma heterodimer of human NAD-dependent isocitrate dehydrogenase.

PubMed ID: 28098230

DOI: 10.1038/srep40921

Sequence Information:

  • Length: 393
  • Mass: 42794
  • Checksum: A0870F2B7D228A37
  • Sequence:
    • MALKVATVAG SAAKAVLGPA LLCRPWEVLG AHEVPSRNIF SEQTIPPSAK YGGRHTVTMI 
PGDGIGPELM LHVKSVFRHA CVPVDFEEVH VSSNADEEDI RNAIMAIRRN RVALKGNIET 
NHNLPPSHKS RNNILRTSLD LYANVIHCKS LPGVVTRHKD IDILIVRENT EGEYSSLEHE 
SVAGVVESLK IITKAKSLRI AEYAFKLAQE SGRKKVTAVH KANIMKLGDG LFLQCCREVA 
ARYPQITFEN MIVDNTTMQL VSRPQQFDVM VMPNLYGNIV NNVCAGLVGG PGLVAGANYG 
HVYAVFETAT RNTGKSIANK NIANPTATLL ASCMMLDHLK LHSYATSIRK AVLASMDNEN 
MHTPDIGGQG TTSEAIQDVI RHIRVINGRA VEA

Genular Protein ID: 17822247

Symbol: O15384_HUMAN

Name: N/A

UniProtKB Accession Codes:

O15384

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 3 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 9286695

Title: Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse.

PubMed ID: 9286695

DOI: 10.1006/geno.1997.4822

Sequence Information:

  • Length: 296
  • Mass: 32728
  • Checksum: F4EF67DAB381D339
  • Sequence:
    • DFEEVHVSSN ADEEDIRNAI MAIRRNRVAL KGNIETNHNL PPSHKSRNNI LRTSLDLYAN 
VIHWKSLPGV VTRHKDIDIL IVRENTEGEY SSLEHESVAG VVESLKIITK AKSLRIAEYA 
FKLAQESGRK KVTAVHKANI MKLGDGLFLQ CCREVAARYP QITFENMIVD NTTMQLVSRP 
QQFDVMVMPN LYGNIVNNVC AGLVGGPGLV AGANYGHVYA VFETATRNTG KSIANKNIAN 
PTATLLASCM MLDHLKLHSY ATSIRKAVLA SMDNENVRFP SHPTLLPRPV SPCSLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.