Details for: IGFBP5
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: embryonic stem cell (CL0002322)
Fold Change: 150.3589
Cell Significance Index: -61.9400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 121.8194
Cell Significance Index: -49.4900 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 121.8116
Cell Significance Index: -57.5100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 52.1711
Cell Significance Index: -49.8100 - Cell Name: glomerular capillary endothelial cell (CL1001005)
Fold Change: 34.1927
Cell Significance Index: 127.4400 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 12.4664
Cell Significance Index: -38.2900 - Cell Name: theca cell (CL0000503)
Fold Change: 11.0519
Cell Significance Index: 64.9300 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 9.4548
Cell Significance Index: 121.0900 - Cell Name: perivascular cell (CL4033054)
Fold Change: 8.7303
Cell Significance Index: 40.3100 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 6.5085
Cell Significance Index: 139.1200 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 6.1023
Cell Significance Index: 66.3400 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 4.9791
Cell Significance Index: 104.2200 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 4.7491
Cell Significance Index: 49.5800 - Cell Name: preadipocyte (CL0002334)
Fold Change: 4.1850
Cell Significance Index: 81.6800 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 3.8861
Cell Significance Index: 14.8800 - Cell Name: supporting cell (CL0000630)
Fold Change: 2.9586
Cell Significance Index: 13.6700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.8918
Cell Significance Index: 397.1300 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 2.2856
Cell Significance Index: 19.7700 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.9394
Cell Significance Index: 248.6200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.3382
Cell Significance Index: 38.3600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.3381
Cell Significance Index: 69.7000 - Cell Name: keratocyte (CL0002363)
Fold Change: 1.0678
Cell Significance Index: 16.9400 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.9436
Cell Significance Index: 16.6800 - Cell Name: chondroblast (CL0000058)
Fold Change: 0.9336
Cell Significance Index: 5.4800 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.6174
Cell Significance Index: 3.7300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.5968
Cell Significance Index: 263.8400 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.5372
Cell Significance Index: 3.6400 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.5336
Cell Significance Index: 13.0200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.3394
Cell Significance Index: 625.9600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3188
Cell Significance Index: 39.2000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2362
Cell Significance Index: 129.0000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1755
Cell Significance Index: 35.2100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1335
Cell Significance Index: 2.2400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1270
Cell Significance Index: 80.6700 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.0345
Cell Significance Index: 0.2900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0072
Cell Significance Index: 1.3100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0037
Cell Significance Index: 6.9300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0015
Cell Significance Index: 2.3000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0150
Cell Significance Index: -6.8300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0178
Cell Significance Index: -13.1800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0263
Cell Significance Index: -9.4200 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0334
Cell Significance Index: -23.0800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0422
Cell Significance Index: -57.3400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0424
Cell Significance Index: -3.0000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0516
Cell Significance Index: -32.2100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0709
Cell Significance Index: -40.0100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0753
Cell Significance Index: -55.2300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0800
Cell Significance Index: -60.5300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0962
Cell Significance Index: -19.0900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1412
Cell Significance Index: -20.5300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1613
Cell Significance Index: -33.9700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1734
Cell Significance Index: -17.7100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1908
Cell Significance Index: -54.8900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.2023
Cell Significance Index: -34.5500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2474
Cell Significance Index: -12.8500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2720
Cell Significance Index: -31.7000 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.2834
Cell Significance Index: -36.6200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3142
Cell Significance Index: -23.4200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.3196
Cell Significance Index: -16.1500 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3548
Cell Significance Index: -9.3300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.4134
Cell Significance Index: -19.4300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.4607
Cell Significance Index: -35.3600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4818
Cell Significance Index: -55.2000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.5120
Cell Significance Index: -31.4700 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.5216
Cell Significance Index: -59.5400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5535
Cell Significance Index: -57.6300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.5634
Cell Significance Index: -37.8800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6610
Cell Significance Index: -52.3500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.7476
Cell Significance Index: -33.0700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.7586
Cell Significance Index: -19.5000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.7676
Cell Significance Index: -40.3000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.8098
Cell Significance Index: -28.1400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.8972
Cell Significance Index: -57.8800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.9264
Cell Significance Index: -58.3900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.9267
Cell Significance Index: -43.2100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.9406
Cell Significance Index: -35.6200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.9494
Cell Significance Index: -25.3500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.9883
Cell Significance Index: -55.4600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.0175
Cell Significance Index: -62.3800 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -1.0230
Cell Significance Index: -14.6900 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -1.0765
Cell Significance Index: -26.8500 - Cell Name: peg cell (CL4033014)
Fold Change: -1.1024
Cell Significance Index: -25.4700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -1.1798
Cell Significance Index: -32.9700 - Cell Name: type II muscle cell (CL0002212)
Fold Change: -1.2848
Cell Significance Index: -20.7300 - Cell Name: Mueller cell (CL0000636)
Fold Change: -1.3570
Cell Significance Index: -10.4400 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -1.3599
Cell Significance Index: -21.0400 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.3599
Cell Significance Index: -49.9200 - Cell Name: muscle fibroblast (CL1001609)
Fold Change: -1.4170
Cell Significance Index: -8.6800 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.4389
Cell Significance Index: -47.1100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.4812
Cell Significance Index: -39.6900 - Cell Name: pro-T cell (CL0000827)
Fold Change: -1.5000
Cell Significance Index: -38.3200 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -1.5248
Cell Significance Index: -36.9400 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -1.6153
Cell Significance Index: -32.4300 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -1.6264
Cell Significance Index: -26.8000 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -1.6485
Cell Significance Index: -57.7500 - Cell Name: connective tissue cell (CL0002320)
Fold Change: -1.6534
Cell Significance Index: -15.9400 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.6718
Cell Significance Index: -53.2500 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -1.7171
Cell Significance Index: -49.0000 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -1.7172
Cell Significance Index: -26.0800 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -1.7751
Cell Significance Index: -30.4200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3314915111
Symbol: IBP5_HUMAN
Name: Insulin-like growth factor-binding protein 5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1850258
Title: Molecular cloning of a new human insulin-like growth factor binding protein.
PubMed ID: 1850258
PubMed ID: 1709938
Title: Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human.
PubMed ID: 1709938
PubMed ID: 7511611
Title: Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5.
PubMed ID: 7511611
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1850257
Title: A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells.
PubMed ID: 1850257
PubMed ID: 7683690
Title: Extracellular matrix contains insulin-like growth factor binding protein-5: potentiation of the effects of IGF-I.
PubMed ID: 7683690
PubMed ID: 9883900
Title: Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5.
PubMed ID: 9883900
PubMed ID: 18930415
Title: Complement 1s is the serine protease that cleaves IGFBP-5 in human osteoarthritic joint fluid.
PubMed ID: 18930415
PubMed ID: 20345844
Title: Decreased caveolin-1 levels contribute to fibrosis and deposition of extracellular IGFBP-5.
PubMed ID: 20345844
PubMed ID: 22117064
Title: Defining the disulfide bonds of insulin-like growth factor-binding protein-5 by tandem mass spectrometry with electron transfer dissociation and collision-induced dissociation.
PubMed ID: 22117064
PubMed ID: 26091039
Title: A single kinase generates the majority of the secreted phosphoproteome.
PubMed ID: 26091039
PubMed ID: 26103640
Title: IGFBP-5 Promotes Fibrosis Independently of Its Translocation to the Nucleus and Its Interaction with Nucleolin and IGF.
PubMed ID: 26103640
PubMed ID: 36949068
Title: IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis.
PubMed ID: 36949068
PubMed ID: 9822601
Title: Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions.
PubMed ID: 9822601
Sequence Information:
- Length: 272
- Mass: 30570
- Checksum: 0A7AD37C6EEA3A81
- Sequence:
MVLLTAVLLL LAAYAGPAQS LGSFVHCEPC DEKALSMCPP SPLGCELVKE PGCGCCMTCA LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC LNEKSYREQV KIERDSREHE EPTTSEMAEE TYSPKIFRPK HTRISELKAE AVKKDRRKKL TQSKFVGGAE NTAHPRIISA PEMRQESEQG PCRRHMEASL QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI CWCVDKYGMK LPGMEYVDGD FQCHTFDSSN VE
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.