Details for: IGFBP5

Gene ID: 3488

Symbol: IGFBP5

Ensembl ID: ENSG00000115461

Description: insulin like growth factor binding protein 5

Associated with

  • Metabolism of proteins
    (R-HSA-392499)
  • Post-translational protein modification
    (R-HSA-597592)
  • Post-translational protein phosphorylation
    (R-HSA-8957275)
  • Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
    (R-HSA-381426)
  • Cellular response to camp
    (GO:0071320)
  • Cellular response to organic cyclic compound
    (GO:0071407)
  • Endoplasmic reticulum lumen
    (GO:0005788)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Female pregnancy
    (GO:0007565)
  • Fibronectin binding
    (GO:0001968)
  • Glucose homeostasis
    (GO:0042593)
  • Hair follicle morphogenesis
    (GO:0031069)
  • Insulin-like growth factor binding protein complex
    (GO:0016942)
  • Insulin-like growth factor i binding
    (GO:0031994)
  • Insulin-like growth factor ii binding
    (GO:0031995)
  • Insulin-like growth factor receptor signaling pathway
    (GO:0048009)
  • Insulin-like growth factor ternary complex
    (GO:0042567)
  • Intracellular signal transduction
    (GO:0035556)
  • Lung alveolus development
    (GO:0048286)
  • Mammary gland involution
    (GO:0060056)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of growth
    (GO:0045926)
  • Negative regulation of insulin-like growth factor receptor signaling pathway
    (GO:0043569)
  • Negative regulation of muscle tissue development
    (GO:1901862)
  • Negative regulation of osteoblast differentiation
    (GO:0045668)
  • Negative regulation of skeletal muscle hypertrophy
    (GO:1904205)
  • Negative regulation of smooth muscle cell migration
    (GO:0014912)
  • Negative regulation of smooth muscle cell proliferation
    (GO:0048662)
  • Negative regulation of translation
    (GO:0017148)
  • Osteoblast differentiation
    (GO:0001649)
  • Positive regulation of insulin-like growth factor receptor signaling pathway
    (GO:0043568)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of vascular associated smooth muscle cell migration
    (GO:1904754)
  • Positive regulation of vascular associated smooth muscle cell proliferation
    (GO:1904707)
  • Protein binding
    (GO:0005515)
  • Regulation of cell growth
    (GO:0001558)
  • Regulation of insulin-like growth factor receptor signaling pathway
    (GO:0043567)
  • Response to growth hormone
    (GO:0060416)
  • Signal transduction
    (GO:0007165)
  • Striated muscle cell differentiation
    (GO:0051146)
  • Type b pancreatic cell proliferation
    (GO:0044342)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.12
    Marker Score: 4,403
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.08
    Marker Score: 5,314
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.8
    Marker Score: 3,619
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.47
    Marker Score: 6,518
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.38
    Marker Score: 2,406
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.26
    Marker Score: 43,031
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 3.22
    Marker Score: 835
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.18
    Marker Score: 1,323
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.11
    Marker Score: 999
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.07
    Marker Score: 2,616
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 3.05
    Marker Score: 710
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 3.04
    Marker Score: 1,575
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.99
    Marker Score: 4,950
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.91
    Marker Score: 18,954
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.77
    Marker Score: 1,499
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.74
    Marker Score: 11,834
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.53
    Marker Score: 4,865
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.44
    Marker Score: 21,168
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.4
    Marker Score: 598
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.39
    Marker Score: 1,571
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.38
    Marker Score: 598
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.38
    Marker Score: 1,706
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.31
    Marker Score: 520
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.3
    Marker Score: 2,841
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 2.3
    Marker Score: 584
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.29
    Marker Score: 528
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.28
    Marker Score: 1,106
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.21
    Marker Score: 1,727
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.2
    Marker Score: 3,048
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.19
    Marker Score: 2,947
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.18
    Marker Score: 2,107
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.14
    Marker Score: 2,938
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.08
    Marker Score: 3,409
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.03
    Marker Score: 3,130
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.03
    Marker Score: 574
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.01
    Marker Score: 2,152
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.97
    Marker Score: 847
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.96
    Marker Score: 742
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.95
    Marker Score: 890
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.89
    Marker Score: 534
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.84
    Marker Score: 4,825
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.8
    Marker Score: 1,202
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.79
    Marker Score: 526
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.75
    Marker Score: 1,645
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.74
    Marker Score: 1,142
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.73
    Marker Score: 426
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.71
    Marker Score: 5,884
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.69
    Marker Score: 19,078
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.69
    Marker Score: 1,287
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.67
    Marker Score: 918
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.65
    Marker Score: 1,041
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.64
    Marker Score: 1,741
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.63
    Marker Score: 563
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.59
    Marker Score: 785
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.58
    Marker Score: 843
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.52
    Marker Score: 388
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.49
    Marker Score: 937
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,244
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.45
    Marker Score: 49,196
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.42
    Marker Score: 801
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.41
    Marker Score: 1,554
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.4
    Marker Score: 3,286
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.37
    Marker Score: 1,477
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.36
    Marker Score: 51,823
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.32
    Marker Score: 349
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.3
    Marker Score: 798
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.27
    Marker Score: 401
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.26
    Marker Score: 709
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.26
    Marker Score: 19,703
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.25
    Marker Score: 3,141
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.23
    Marker Score: 2,333
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.22
    Marker Score: 642
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.21
    Marker Score: 6,350
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.21
    Marker Score: 12,136
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.2
    Marker Score: 2,637
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.19
    Marker Score: 10,465
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.18
    Marker Score: 2,159
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.18
    Marker Score: 561
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.18
    Marker Score: 1,739
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.17
    Marker Score: 1,376
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.15
    Marker Score: 336
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.12
    Marker Score: 652
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.09
    Marker Score: 436
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.09
    Marker Score: 4,525
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.08
    Marker Score: 8,011
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.07
    Marker Score: 1,156
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.07
    Marker Score: 264
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.07
    Marker Score: 3,959
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.05
    Marker Score: 330
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.04
    Marker Score: 386
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.03
    Marker Score: 270
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.01
    Marker Score: 342
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,727
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,951
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.99
    Marker Score: 1,108
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.98
    Marker Score: 1,224
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,398
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.97
    Marker Score: 1,121
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.97
    Marker Score: 265
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.95
    Marker Score: 454

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IGFBP5 is a 21-kDa protein that belongs to the IGFBP family, which consists of five members: IGFBP1-5. IGFBP5 is characterized by its ability to bind to IGFs, including IGF-I and IGF-II, with high affinity. This binding capacity allows IGFBP5 to regulate the availability of IGFs for binding to their receptors, thereby modulating their biological activity. IGFBP5 is also known to interact with other proteins, such as growth factor receptors, and to regulate various signaling pathways, including the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway. **Pathways and Functions** IGFBP5 is involved in various cellular processes, including: 1. **Regulation of IGF signaling**: IGFBP5 can both positively and negatively regulate IGF signaling pathways, depending on the context and cell type. In some cases, IGFBP5 can enhance IGF signaling by increasing the availability of IGFs for binding to their receptors, while in other cases, it can inhibit IGF signaling by binding to IGFs and preventing their interaction with receptors. 2. **Cell growth and differentiation**: IGFBP5 can regulate cell growth and differentiation by modulating the availability of IGFs for binding to their receptors. IGFBP5 has been shown to inhibit the growth of certain cell types, such as cancer cells, by reducing the availability of IGFs. 3. **Intracellular signaling**: IGFBP5 can interact with various intracellular signaling molecules, including growth factor receptors, and regulate signaling pathways, such as the PI3K/Akt pathway. 4. **Regulation of translation**: IGFBP5 can regulate protein translation by binding to ribosomes and inhibiting the translation of certain mRNAs. **Clinical Significance** IGFBP5 has been implicated in various diseases and disorders, including: 1. **Cancer**: IGFBP5 has been shown to inhibit the growth of certain cancer cells, suggesting its potential as a therapeutic target for cancer treatment. 2. **Muscle wasting**: IGFBP5 has been implicated in muscle wasting diseases, such as muscular dystrophy, where it may play a role in regulating muscle growth and differentiation. 3. **Cardiovascular disease**: IGFBP5 has been shown to regulate vascular smooth muscle cell migration and proliferation, suggesting its potential as a therapeutic target for cardiovascular disease. 4. **Obesity**: IGFBP5 has been implicated in obesity, where it may play a role in regulating energy metabolism and glucose homeostasis. In conclusion, IGFBP5 is a multifunctional protein that plays a critical role in regulating IGF signaling pathways, cell growth, and differentiation. Its dysregulation has been implicated in various diseases and disorders, highlighting its potential as a therapeutic target for the treatment of these conditions.

Genular Protein ID: 3314915111

Symbol: IBP5_HUMAN

Name: Insulin-like growth factor-binding protein 5

UniProtKB Accession Codes:

P24593 Q5U0A3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 11 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRINTS 2 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1850258

Title: Molecular cloning of a new human insulin-like growth factor binding protein.

PubMed ID: 1850258

DOI: 10.1016/0006-291x(91)90912-q

PubMed ID: 1709938

Title: Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human.

PubMed ID: 1709938

DOI: 10.1016/s0021-9258(18)99272-0

PubMed ID: 7511611

Title: Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5.

PubMed ID: 7511611

DOI: 10.1016/s0021-9258(17)34142-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1850257

Title: A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells.

PubMed ID: 1850257

DOI: 10.1016/0006-291x(91)90911-p

PubMed ID: 9883900

Title: Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5.

PubMed ID: 9883900

DOI: 10.1016/s0014-5793(98)01497-5

PubMed ID: 22117064

Title: Defining the disulfide bonds of insulin-like growth factor-binding protein-5 by tandem mass spectrometry with electron transfer dissociation and collision-induced dissociation.

PubMed ID: 22117064

DOI: 10.1074/jbc.m111.285528

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 9822601

Title: Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions.

PubMed ID: 9822601

DOI: 10.1093/emboj/17.22.6558

Sequence Information:

  • Length: 272
  • Mass: 30570
  • Checksum: 0A7AD37C6EEA3A81
  • Sequence:
    • MVLLTAVLLL LAAYAGPAQS LGSFVHCEPC DEKALSMCPP SPLGCELVKE PGCGCCMTCA 
LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC LNEKSYREQV KIERDSREHE 
EPTTSEMAEE TYSPKIFRPK HTRISELKAE AVKKDRRKKL TQSKFVGGAE NTAHPRIISA 
PEMRQESEQG PCRRHMEASL QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI 
CWCVDKYGMK LPGMEYVDGD FQCHTFDSSN VE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.