Details for: IGFBP5

Gene ID: 3488

Symbol: IGFBP5

Ensembl ID: ENSG00000115461

Description: insulin like growth factor binding protein 5

Associated with

  • Metabolism of proteins
    (R-HSA-392499)
  • Post-translational protein modification
    (R-HSA-597592)
  • Post-translational protein phosphorylation
    (R-HSA-8957275)
  • Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
    (R-HSA-381426)
  • Cellular response to camp
    (GO:0071320)
  • Cellular response to organic cyclic compound
    (GO:0071407)
  • Endoplasmic reticulum lumen
    (GO:0005788)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Female pregnancy
    (GO:0007565)
  • Fibronectin binding
    (GO:0001968)
  • Glucose homeostasis
    (GO:0042593)
  • Hair follicle morphogenesis
    (GO:0031069)
  • Insulin-like growth factor binding protein complex
    (GO:0016942)
  • Insulin-like growth factor i binding
    (GO:0031994)
  • Insulin-like growth factor ii binding
    (GO:0031995)
  • Insulin-like growth factor receptor signaling pathway
    (GO:0048009)
  • Insulin-like growth factor ternary complex
    (GO:0042567)
  • Intracellular signal transduction
    (GO:0035556)
  • Lung alveolus development
    (GO:0048286)
  • Mammary gland involution
    (GO:0060056)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of growth
    (GO:0045926)
  • Negative regulation of insulin-like growth factor receptor signaling pathway
    (GO:0043569)
  • Negative regulation of muscle tissue development
    (GO:1901862)
  • Negative regulation of osteoblast differentiation
    (GO:0045668)
  • Negative regulation of skeletal muscle hypertrophy
    (GO:1904205)
  • Negative regulation of smooth muscle cell migration
    (GO:0014912)
  • Negative regulation of smooth muscle cell proliferation
    (GO:0048662)
  • Negative regulation of translation
    (GO:0017148)
  • Osteoblast differentiation
    (GO:0001649)
  • Positive regulation of insulin-like growth factor receptor signaling pathway
    (GO:0043568)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of vascular associated smooth muscle cell migration
    (GO:1904754)
  • Positive regulation of vascular associated smooth muscle cell proliferation
    (GO:1904707)
  • Protein binding
    (GO:0005515)
  • Regulation of cell growth
    (GO:0001558)
  • Regulation of insulin-like growth factor receptor signaling pathway
    (GO:0043567)
  • Response to growth hormone
    (GO:0060416)
  • Signal transduction
    (GO:0007165)
  • Striated muscle cell differentiation
    (GO:0051146)
  • Type b pancreatic cell proliferation
    (GO:0044342)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.12
    Marker Score: 4403
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.08
    Marker Score: 5314
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.8
    Marker Score: 3619
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.47
    Marker Score: 6518
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.38
    Marker Score: 2406
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.26
    Marker Score: 43031
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 3.22
    Marker Score: 835
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.18
    Marker Score: 1323
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.11
    Marker Score: 999
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.07
    Marker Score: 2616
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 3.05
    Marker Score: 710
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 3.04
    Marker Score: 1575
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.99
    Marker Score: 4950
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.91
    Marker Score: 18954
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.77
    Marker Score: 1499
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.74
    Marker Score: 11834
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.53
    Marker Score: 4865
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.44
    Marker Score: 21168
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.4
    Marker Score: 598
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.39
    Marker Score: 1571
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.38
    Marker Score: 598
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.38
    Marker Score: 1706
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.31
    Marker Score: 520
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.3
    Marker Score: 2841
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 2.3
    Marker Score: 584
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.29
    Marker Score: 528
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.28
    Marker Score: 1106
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.21
    Marker Score: 1727
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.2
    Marker Score: 3048
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.19
    Marker Score: 2947
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.18
    Marker Score: 2107
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.14
    Marker Score: 2938
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.08
    Marker Score: 3409
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.03
    Marker Score: 3129.5
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.03
    Marker Score: 574
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.01
    Marker Score: 2152
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.97
    Marker Score: 847
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.96
    Marker Score: 742
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.95
    Marker Score: 890
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.89
    Marker Score: 534
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.84
    Marker Score: 4825
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.8
    Marker Score: 1202
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.79
    Marker Score: 526
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.75
    Marker Score: 1645
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.74
    Marker Score: 1142
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.73
    Marker Score: 426
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.71
    Marker Score: 5884
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.69
    Marker Score: 19078
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.69
    Marker Score: 1287
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.67
    Marker Score: 918
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.65
    Marker Score: 1041
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.64
    Marker Score: 1741
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.63
    Marker Score: 563
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.59
    Marker Score: 785
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.58
    Marker Score: 842.5
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.52
    Marker Score: 388
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.49
    Marker Score: 937
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167244
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.45
    Marker Score: 49196
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.42
    Marker Score: 801
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.41
    Marker Score: 1554
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.4
    Marker Score: 3286
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.37
    Marker Score: 1477
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.36
    Marker Score: 51823
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.32
    Marker Score: 349
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.3
    Marker Score: 798
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.27
    Marker Score: 401
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.26
    Marker Score: 709
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.26
    Marker Score: 19703
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.25
    Marker Score: 3141
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.23
    Marker Score: 2333
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.22
    Marker Score: 642
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.21
    Marker Score: 6350
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.21
    Marker Score: 12135.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.2
    Marker Score: 2637
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.19
    Marker Score: 10465
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.18
    Marker Score: 2159
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.18
    Marker Score: 561
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.18
    Marker Score: 1739
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.17
    Marker Score: 1376
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.15
    Marker Score: 336
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.12
    Marker Score: 652
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.09
    Marker Score: 436
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.09
    Marker Score: 4525
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.08
    Marker Score: 8011
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.07
    Marker Score: 1156
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.07
    Marker Score: 264
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.07
    Marker Score: 3959
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.05
    Marker Score: 330
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.04
    Marker Score: 386
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.03
    Marker Score: 270
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.01
    Marker Score: 342
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71727
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47951
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.99
    Marker Score: 1108
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.98
    Marker Score: 1224
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30398
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.97
    Marker Score: 1121
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.97
    Marker Score: 265
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.95
    Marker Score: 454

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Other Information

**Key characteristics:** * IGFBP5 is a secreted protein that is produced by cells and transported to other cells. * It is a member of the IGFBP family of proteins, which are involved in cell growth, differentiation, and metabolism. * IGFBP5 is a key regulator of insulin-like growth factor (igf) signaling. * It is involved in the regulation of female pregnancy, fibronectin binding, glucose homeostasis, hair follicle morphogenesis, insulin-like growth factor i and ii binding, intracellular signal transduction, metabolism of proteins, and negative regulation of cell migration. **Pathways and functions:** * IGFBP5 is a key regulator of insulin-like growth factor (igf) signaling. * It is involved in the regulation of female pregnancy by promoting the growth of the embryo and maintaining pregnancy. * It is involved in the regulation of fibronectin binding by promoting the formation of fibronectin microfibrils. * It is involved in the regulation of glucose homeostasis by promoting the uptake of glucose into cells. * It is involved in the regulation of hair follicle morphogenesis by promoting the growth and development of hair follicles. * It is involved in the regulation of insulin-like growth factor (igf) i and ii binding by promoting the binding of these proteins to their receptors. * It is involved in the regulation of intracellular signal transduction by binding to its receptor, IGF-1R. * It is involved in the regulation of metabolism of proteins by promoting the degradation of damaged or misfolded proteins. * It is involved in the negative regulation of cell migration by interacting with the IGF-1 receptor and inhibiting its signaling. * It is involved in the negative regulation of smooth muscle cell migration by interacting with the IGF-1 receptor and inhibiting its signaling. * It is involved in the negative regulation of translation by interacting with the eukaryotic translation initiation factor 2 (eIF2). **Clinical significance:** * Mutations in IGFBP5 have been linked to a number of human diseases, including cancer, cardiovascular disease, and diabetes. * IGFBP5 is a potential therapeutic target for these diseases. * Inhibitors of IGFBP5 have been shown to be effective in treating cancer and other diseases that are characterized by abnormal cell growth.

Genular Protein ID: 3314915111

Symbol: IBP5_HUMAN

Name: Insulin-like growth factor-binding protein 5

UniProtKB Accession Codes:

P24593 Q5U0A3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 11 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRINTS 2 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1850258

Title: Molecular cloning of a new human insulin-like growth factor binding protein.

PubMed ID: 1850258

DOI: 10.1016/0006-291x(91)90912-q

PubMed ID: 1709938

Title: Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human.

PubMed ID: 1709938

DOI: 10.1016/s0021-9258(18)99272-0

PubMed ID: 7511611

Title: Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5.

PubMed ID: 7511611

DOI: 10.1016/s0021-9258(17)34142-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1850257

Title: A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells.

PubMed ID: 1850257

DOI: 10.1016/0006-291x(91)90911-p

PubMed ID: 9883900

Title: Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5.

PubMed ID: 9883900

DOI: 10.1016/s0014-5793(98)01497-5

PubMed ID: 22117064

Title: Defining the disulfide bonds of insulin-like growth factor-binding protein-5 by tandem mass spectrometry with electron transfer dissociation and collision-induced dissociation.

PubMed ID: 22117064

DOI: 10.1074/jbc.m111.285528

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 9822601

Title: Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions.

PubMed ID: 9822601

DOI: 10.1093/emboj/17.22.6558

Sequence Information:

  • Length: 272
  • Mass: 30570
  • Checksum: 0A7AD37C6EEA3A81
  • Sequence:
    • MVLLTAVLLL LAAYAGPAQS LGSFVHCEPC DEKALSMCPP SPLGCELVKE PGCGCCMTCA 
LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC LNEKSYREQV KIERDSREHE 
EPTTSEMAEE TYSPKIFRPK HTRISELKAE AVKKDRRKKL TQSKFVGGAE NTAHPRIISA 
PEMRQESEQG PCRRHMEASL QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI 
CWCVDKYGMK LPGMEYVDGD FQCHTFDSSN VE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.