Details for: IGFBP5

Gene ID: 3488

Symbol: IGFBP5

Ensembl ID: ENSG00000115461

Description: insulin like growth factor binding protein 5

Associated with

  • Metabolism of proteins
    (R-HSA-392499)
  • Post-translational protein modification
    (R-HSA-597592)
  • Post-translational protein phosphorylation
    (R-HSA-8957275)
  • Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
    (R-HSA-381426)
  • Cell population proliferation
    (GO:0008283)
  • Cellular response to camp
    (GO:0071320)
  • Cellular response to organic cyclic compound
    (GO:0071407)
  • Endoplasmic reticulum lumen
    (GO:0005788)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Female pregnancy
    (GO:0007565)
  • Fibronectin binding
    (GO:0001968)
  • Glucose homeostasis
    (GO:0042593)
  • Hair follicle morphogenesis
    (GO:0031069)
  • Insulin-like growth factor binding protein complex
    (GO:0016942)
  • Insulin-like growth factor i binding
    (GO:0031994)
  • Insulin-like growth factor ii binding
    (GO:0031995)
  • Insulin-like growth factor receptor signaling pathway
    (GO:0048009)
  • Insulin-like growth factor ternary complex
    (GO:0042567)
  • Intracellular signal transduction
    (GO:0035556)
  • Lung alveolus development
    (GO:0048286)
  • Mammary gland involution
    (GO:0060056)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of growth
    (GO:0045926)
  • Negative regulation of insulin-like growth factor receptor signaling pathway
    (GO:0043569)
  • Negative regulation of muscle tissue development
    (GO:1901862)
  • Negative regulation of osteoblast differentiation
    (GO:0045668)
  • Negative regulation of skeletal muscle hypertrophy
    (GO:1904205)
  • Negative regulation of smooth muscle cell migration
    (GO:0014912)
  • Negative regulation of smooth muscle cell proliferation
    (GO:0048662)
  • Negative regulation of translation
    (GO:0017148)
  • Nucleus
    (GO:0005634)
  • Osteoblast differentiation
    (GO:0001649)
  • Positive regulation of insulin-like growth factor receptor signaling pathway
    (GO:0043568)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of vascular associated smooth muscle cell migration
    (GO:1904754)
  • Positive regulation of vascular associated smooth muscle cell proliferation
    (GO:1904707)
  • Protein binding
    (GO:0005515)
  • Receptor ligand activity
    (GO:0048018)
  • Regulation of cell growth
    (GO:0001558)
  • Regulation of insulin-like growth factor receptor signaling pathway
    (GO:0043567)
  • Response to growth hormone
    (GO:0060416)
  • Signal transduction
    (GO:0007165)
  • Striated muscle cell differentiation
    (GO:0051146)
  • Type b pancreatic cell proliferation
    (GO:0044342)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 150.3589
    Cell Significance Index: -61.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 121.8194
    Cell Significance Index: -49.4900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 121.8116
    Cell Significance Index: -57.5100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 52.1711
    Cell Significance Index: -49.8100
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 34.1927
    Cell Significance Index: 127.4400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.4664
    Cell Significance Index: -38.2900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 11.0519
    Cell Significance Index: 64.9300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 9.4548
    Cell Significance Index: 121.0900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 8.7303
    Cell Significance Index: 40.3100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 6.5085
    Cell Significance Index: 139.1200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 6.1023
    Cell Significance Index: 66.3400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.9791
    Cell Significance Index: 104.2200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.7491
    Cell Significance Index: 49.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 4.1850
    Cell Significance Index: 81.6800
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.8861
    Cell Significance Index: 14.8800
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.9586
    Cell Significance Index: 13.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.8918
    Cell Significance Index: 397.1300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.2856
    Cell Significance Index: 19.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.9394
    Cell Significance Index: 248.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.3382
    Cell Significance Index: 38.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.3381
    Cell Significance Index: 69.7000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.0678
    Cell Significance Index: 16.9400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.9436
    Cell Significance Index: 16.6800
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.9336
    Cell Significance Index: 5.4800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.6174
    Cell Significance Index: 3.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5968
    Cell Significance Index: 263.8400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.5372
    Cell Significance Index: 3.6400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.5336
    Cell Significance Index: 13.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3394
    Cell Significance Index: 625.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3188
    Cell Significance Index: 39.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2362
    Cell Significance Index: 129.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1755
    Cell Significance Index: 35.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1335
    Cell Significance Index: 2.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1270
    Cell Significance Index: 80.6700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0345
    Cell Significance Index: 0.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0072
    Cell Significance Index: 1.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0037
    Cell Significance Index: 6.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0015
    Cell Significance Index: 2.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0150
    Cell Significance Index: -6.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0178
    Cell Significance Index: -13.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0263
    Cell Significance Index: -9.4200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0334
    Cell Significance Index: -23.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0422
    Cell Significance Index: -57.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0424
    Cell Significance Index: -3.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0516
    Cell Significance Index: -32.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0709
    Cell Significance Index: -40.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0753
    Cell Significance Index: -55.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0800
    Cell Significance Index: -60.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0962
    Cell Significance Index: -19.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1412
    Cell Significance Index: -20.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1613
    Cell Significance Index: -33.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1734
    Cell Significance Index: -17.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1908
    Cell Significance Index: -54.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2023
    Cell Significance Index: -34.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2474
    Cell Significance Index: -12.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2720
    Cell Significance Index: -31.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2834
    Cell Significance Index: -36.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3142
    Cell Significance Index: -23.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3196
    Cell Significance Index: -16.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3548
    Cell Significance Index: -9.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4134
    Cell Significance Index: -19.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4607
    Cell Significance Index: -35.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4818
    Cell Significance Index: -55.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5120
    Cell Significance Index: -31.4700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5216
    Cell Significance Index: -59.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5535
    Cell Significance Index: -57.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5634
    Cell Significance Index: -37.8800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6610
    Cell Significance Index: -52.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7476
    Cell Significance Index: -33.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7586
    Cell Significance Index: -19.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7676
    Cell Significance Index: -40.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8098
    Cell Significance Index: -28.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.8972
    Cell Significance Index: -57.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9264
    Cell Significance Index: -58.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.9267
    Cell Significance Index: -43.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9406
    Cell Significance Index: -35.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.9494
    Cell Significance Index: -25.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9883
    Cell Significance Index: -55.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0175
    Cell Significance Index: -62.3800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.0230
    Cell Significance Index: -14.6900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.0765
    Cell Significance Index: -26.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.1024
    Cell Significance Index: -25.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.1798
    Cell Significance Index: -32.9700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -1.2848
    Cell Significance Index: -20.7300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -1.3570
    Cell Significance Index: -10.4400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -1.3599
    Cell Significance Index: -21.0400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.3599
    Cell Significance Index: -49.9200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -1.4170
    Cell Significance Index: -8.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.4389
    Cell Significance Index: -47.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.4812
    Cell Significance Index: -39.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.5000
    Cell Significance Index: -38.3200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.5248
    Cell Significance Index: -36.9400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.6153
    Cell Significance Index: -32.4300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -1.6264
    Cell Significance Index: -26.8000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.6485
    Cell Significance Index: -57.7500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -1.6534
    Cell Significance Index: -15.9400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.6718
    Cell Significance Index: -53.2500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.7171
    Cell Significance Index: -49.0000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -1.7172
    Cell Significance Index: -26.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.7751
    Cell Significance Index: -30.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IGFBP5 is a 21-kDa protein that belongs to the IGFBP family, which consists of five members: IGFBP1-5. IGFBP5 is characterized by its ability to bind to IGFs, including IGF-I and IGF-II, with high affinity. This binding capacity allows IGFBP5 to regulate the availability of IGFs for binding to their receptors, thereby modulating their biological activity. IGFBP5 is also known to interact with other proteins, such as growth factor receptors, and to regulate various signaling pathways, including the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway. **Pathways and Functions** IGFBP5 is involved in various cellular processes, including: 1. **Regulation of IGF signaling**: IGFBP5 can both positively and negatively regulate IGF signaling pathways, depending on the context and cell type. In some cases, IGFBP5 can enhance IGF signaling by increasing the availability of IGFs for binding to their receptors, while in other cases, it can inhibit IGF signaling by binding to IGFs and preventing their interaction with receptors. 2. **Cell growth and differentiation**: IGFBP5 can regulate cell growth and differentiation by modulating the availability of IGFs for binding to their receptors. IGFBP5 has been shown to inhibit the growth of certain cell types, such as cancer cells, by reducing the availability of IGFs. 3. **Intracellular signaling**: IGFBP5 can interact with various intracellular signaling molecules, including growth factor receptors, and regulate signaling pathways, such as the PI3K/Akt pathway. 4. **Regulation of translation**: IGFBP5 can regulate protein translation by binding to ribosomes and inhibiting the translation of certain mRNAs. **Clinical Significance** IGFBP5 has been implicated in various diseases and disorders, including: 1. **Cancer**: IGFBP5 has been shown to inhibit the growth of certain cancer cells, suggesting its potential as a therapeutic target for cancer treatment. 2. **Muscle wasting**: IGFBP5 has been implicated in muscle wasting diseases, such as muscular dystrophy, where it may play a role in regulating muscle growth and differentiation. 3. **Cardiovascular disease**: IGFBP5 has been shown to regulate vascular smooth muscle cell migration and proliferation, suggesting its potential as a therapeutic target for cardiovascular disease. 4. **Obesity**: IGFBP5 has been implicated in obesity, where it may play a role in regulating energy metabolism and glucose homeostasis. In conclusion, IGFBP5 is a multifunctional protein that plays a critical role in regulating IGF signaling pathways, cell growth, and differentiation. Its dysregulation has been implicated in various diseases and disorders, highlighting its potential as a therapeutic target for the treatment of these conditions.

Genular Protein ID: 3314915111

Symbol: IBP5_HUMAN

Name: Insulin-like growth factor-binding protein 5

UniProtKB Accession Codes:

P24593 Q5U0A3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 11 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1850258

Title: Molecular cloning of a new human insulin-like growth factor binding protein.

PubMed ID: 1850258

DOI: 10.1016/0006-291x(91)90912-q

PubMed ID: 1709938

Title: Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human.

PubMed ID: 1709938

DOI: 10.1016/s0021-9258(18)99272-0

PubMed ID: 7511611

Title: Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5.

PubMed ID: 7511611

DOI: 10.1016/s0021-9258(17)34142-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1850257

Title: A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells.

PubMed ID: 1850257

DOI: 10.1016/0006-291x(91)90911-p

PubMed ID: 7683690

Title: Extracellular matrix contains insulin-like growth factor binding protein-5: potentiation of the effects of IGF-I.

PubMed ID: 7683690

DOI: 10.1083/jcb.121.3.679

PubMed ID: 9883900

Title: Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5.

PubMed ID: 9883900

DOI: 10.1016/s0014-5793(98)01497-5

PubMed ID: 18930415

Title: Complement 1s is the serine protease that cleaves IGFBP-5 in human osteoarthritic joint fluid.

PubMed ID: 18930415

DOI: 10.1016/j.joca.2008.08.004

PubMed ID: 20345844

Title: Decreased caveolin-1 levels contribute to fibrosis and deposition of extracellular IGFBP-5.

PubMed ID: 20345844

DOI: 10.1111/j.1582-4934.2010.01063.x

PubMed ID: 22117064

Title: Defining the disulfide bonds of insulin-like growth factor-binding protein-5 by tandem mass spectrometry with electron transfer dissociation and collision-induced dissociation.

PubMed ID: 22117064

DOI: 10.1074/jbc.m111.285528

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 26103640

Title: IGFBP-5 Promotes Fibrosis Independently of Its Translocation to the Nucleus and Its Interaction with Nucleolin and IGF.

PubMed ID: 26103640

DOI: 10.1371/journal.pone.0130546

PubMed ID: 36949068

Title: IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis.

PubMed ID: 36949068

DOI: 10.1038/s41467-023-37306-1

PubMed ID: 9822601

Title: Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions.

PubMed ID: 9822601

DOI: 10.1093/emboj/17.22.6558

Sequence Information:

  • Length: 272
  • Mass: 30570
  • Checksum: 0A7AD37C6EEA3A81
  • Sequence:
    • MVLLTAVLLL LAAYAGPAQS LGSFVHCEPC DEKALSMCPP SPLGCELVKE PGCGCCMTCA 
LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC LNEKSYREQV KIERDSREHE 
EPTTSEMAEE TYSPKIFRPK HTRISELKAE AVKKDRRKKL TQSKFVGGAE NTAHPRIISA 
PEMRQESEQG PCRRHMEASL QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI 
CWCVDKYGMK LPGMEYVDGD FQCHTFDSSN VE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.