Details for: ILF3

Gene ID: 3609

Symbol: ILF3

Ensembl ID: ENSG00000129351

Description: interleukin enhancer binding factor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 334.1150
    Cell Significance Index: -51.9700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 207.2989
    Cell Significance Index: -52.5800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 159.6319
    Cell Significance Index: -65.7600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 151.7085
    Cell Significance Index: -71.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 146.4097
    Cell Significance Index: -59.4800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 131.1760
    Cell Significance Index: -67.4800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 106.9339
    Cell Significance Index: -71.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 62.8756
    Cell Significance Index: -60.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 52.4512
    Cell Significance Index: -64.6700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 23.8796
    Cell Significance Index: -63.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.0778
    Cell Significance Index: -67.3900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.3636
    Cell Significance Index: -50.2600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.0489
    Cell Significance Index: -26.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 3.3728
    Cell Significance Index: 90.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.5977
    Cell Significance Index: 90.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.4515
    Cell Significance Index: 68.5100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.0439
    Cell Significance Index: 22.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9053
    Cell Significance Index: 378.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.7084
    Cell Significance Index: 201.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.6726
    Cell Significance Index: 93.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.6396
    Cell Significance Index: 34.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.5794
    Cell Significance Index: 45.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5658
    Cell Significance Index: 41.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5402
    Cell Significance Index: 211.5100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4816
    Cell Significance Index: 88.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.4634
    Cell Significance Index: 38.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3857
    Cell Significance Index: 170.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3034
    Cell Significance Index: 234.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2874
    Cell Significance Index: 83.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.2241
    Cell Significance Index: 35.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1983
    Cell Significance Index: 654.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1808
    Cell Significance Index: 32.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0943
    Cell Significance Index: 57.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9507
    Cell Significance Index: 58.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8830
    Cell Significance Index: 46.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8622
    Cell Significance Index: 59.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8519
    Cell Significance Index: 40.0400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8202
    Cell Significance Index: 17.7700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.7797
    Cell Significance Index: 9.9900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.7264
    Cell Significance Index: 5.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7240
    Cell Significance Index: 259.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7042
    Cell Significance Index: 90.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6872
    Cell Significance Index: 620.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6749
    Cell Significance Index: 298.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6457
    Cell Significance Index: 129.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6209
    Cell Significance Index: 28.9500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5714
    Cell Significance Index: 395.2200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3876
    Cell Significance Index: 4.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3594
    Cell Significance Index: 18.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3378
    Cell Significance Index: 11.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3197
    Cell Significance Index: 20.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3081
    Cell Significance Index: 58.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2725
    Cell Significance Index: 19.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2605
    Cell Significance Index: 33.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2016
    Cell Significance Index: 19.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1826
    Cell Significance Index: 31.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1513
    Cell Significance Index: 6.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1293
    Cell Significance Index: 9.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1016
    Cell Significance Index: 7.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0968
    Cell Significance Index: 182.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0750
    Cell Significance Index: 115.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0636
    Cell Significance Index: 117.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0317
    Cell Significance Index: 0.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0130
    Cell Significance Index: 8.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0010
    Cell Significance Index: -1.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0115
    Cell Significance Index: -8.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0133
    Cell Significance Index: -9.7700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0178
    Cell Significance Index: -13.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0273
    Cell Significance Index: -12.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0416
    Cell Significance Index: -25.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0427
    Cell Significance Index: -0.9100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0649
    Cell Significance Index: -0.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0726
    Cell Significance Index: -40.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0756
    Cell Significance Index: -7.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0780
    Cell Significance Index: -2.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1504
    Cell Significance Index: -31.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1974
    Cell Significance Index: -56.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2249
    Cell Significance Index: -25.7700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2263
    Cell Significance Index: -25.8300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2301
    Cell Significance Index: -33.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2385
    Cell Significance Index: -27.7900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3165
    Cell Significance Index: -7.5900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3770
    Cell Significance Index: -6.4600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4229
    Cell Significance Index: -9.7700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4560
    Cell Significance Index: -11.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5277
    Cell Significance Index: -16.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5327
    Cell Significance Index: -35.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5658
    Cell Significance Index: -58.9100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5736
    Cell Significance Index: -8.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6644
    Cell Significance Index: -12.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6904
    Cell Significance Index: -9.4200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7114
    Cell Significance Index: -56.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7470
    Cell Significance Index: -20.0200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.7737
    Cell Significance Index: -7.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7794
    Cell Significance Index: -20.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8080
    Cell Significance Index: -35.7400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.8767
    Cell Significance Index: -9.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9972
    Cell Significance Index: -61.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.0186
    Cell Significance Index: -19.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0341
    Cell Significance Index: -39.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Function:** ILF3 is a transcription factor that regulates the expression of interferon-stimulated genes (ISGs), which are crucial for antiviral defense. It also modulates the expression of cell adhesion molecules, such as CDH11, which is involved in homotypic cell-cell adhesion. 2. **Expression:** ILF3 is widely expressed in various cell types, including epithelial cells of the nephron, fibroblasts of the mammary gland, and neural crest cells. It is also highly expressed in cells involved in immune response, such as lymphocytes and macrophages. 3. **Structure:** The ILF3 protein contains a single RING finger domain, which is essential for its DNA binding activity. It also possesses a C-terminal domain that mediates protein-protein interactions. 4. **Regulation:** ILF3 is regulated by various signaling pathways, including interferon signaling, protein kinase R (PKR)-mediated signaling, and protein phosphorylation. **Pathways and Functions:** 1. **Antiviral Mechanism:** ILF3 regulates the expression of ISGs, which are essential for antiviral defense. It binds to the interferon-stimulated response element (ISRE) in the promoter region of ISGs, thereby activating their transcription. 2. **Cytokine Signaling:** ILF3 modulates the expression of cytokines, such as interferons, which are critical for immune response and inflammation. 3. **Cell-Cell Communication:** ILF3 regulates the expression of cell adhesion molecules, such as CDH11, which is involved in homotypic cell-cell adhesion. 4. **Regulation of Gene Expression:** ILF3 regulates the expression of various genes, including those involved in immune response, cell adhesion, and tissue development. **Clinical Significance:** 1. **Viral Infections:** ILF3 plays a crucial role in antiviral defense, and its dysregulation may contribute to the development of viral infections, such as HIV and influenza. 2. **Cancer:** ILF3 has been implicated in the regulation of cell adhesion and migration, which are critical processes in cancer progression. Its dysregulation may contribute to the development of cancer. 3. **Autoimmune Diseases:** ILF3 has been shown to regulate the expression of cytokines and immune cells, which are involved in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 4. **Immunodeficiency Disorders:** ILF3 mutations have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). In conclusion, the ILF3 gene is a crucial regulator of immune response and cellular adhesion, and its dysregulation may contribute to various diseases, including viral infections, cancer, autoimmune diseases, and immunodeficiency disorders. Further studies are necessary to fully understand the mechanisms of ILF3 and its role in human disease.

Genular Protein ID: 2200160217

Symbol: ILF3_HUMAN

Name: Interleukin enhancer-binding factor 3

UniProtKB Accession Codes:

Q12906 A8K6F2 G5E9M5 O43409 Q6P1X1 Q86XY7 Q99544 Q99545 Q9BZH4 Q9BZH5 Q9NQ95 Q9NQ96 Q9NQ97 Q9NQ98 Q9NQ99 Q9NQA0 Q9NQA1 Q9NQA2 Q9NRN2 Q9NRN3 Q9NRN4 Q9UMZ9 Q9UN00 Q9UN84 Q9UNA2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 2 CORUM 1 CPTAC 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 60 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 Reactome 2 RefSeq 7 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7519613

Title: Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90.

PubMed ID: 7519613

DOI: 10.1016/s0021-9258(17)32048-3

PubMed ID: 10400669

Title: DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR.

PubMed ID: 10400669

DOI: 10.1074/jbc.274.29.20432

PubMed ID: 10607473

Title: Molecular cloning and characterization of a translational inhibitory protein that binds to coding sequences of human acid beta-glucosidase and other mRNAs.

PubMed ID: 10607473

DOI: 10.1006/mgme.1999.2934

PubMed ID: 11167023

Title: Alternative splicing in the human interleukin enhancer binding factor 3 (ILF3) gene.

PubMed ID: 11167023

DOI: 10.1016/s0378-1119(00)00495-9

PubMed ID: 11438536

Title: Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR.

PubMed ID: 11438536

DOI: 10.1074/jbc.m104207200

PubMed ID: 11161820

Title: The 90- and 110-kDa human NFAR proteins are translated from two differentially spliced mRNAs encoded on chromosome 19p13.

PubMed ID: 11161820

DOI: 10.1006/geno.2000.6423

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8885239

Title: Identification of novel M phase phosphoproteins by expression cloning.

PubMed ID: 8885239

DOI: 10.1091/mbc.7.9.1455

PubMed ID: 9442054

Title: DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45.

PubMed ID: 9442054

DOI: 10.1074/jbc.273.4.2136

PubMed ID: 10574923

Title: Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity.

PubMed ID: 10574923

DOI: 10.1074/jbc.274.49.34598

PubMed ID: 10749851

Title: Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3.

PubMed ID: 10749851

DOI: 10.1074/jbc.m000023200

PubMed ID: 11777942

Title: Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins.

PubMed ID: 11777942

DOI: 10.1083/jcb.200110082

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 11739746

Title: The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells.

PubMed ID: 11739746

DOI: 10.1128/mcb.22.1.343-356.2002

PubMed ID: 14570900

Title: Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3.

PubMed ID: 14570900

DOI: 10.1074/jbc.m306808200

PubMed ID: 14731398

Title: Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU.

PubMed ID: 14731398

DOI: 10.1016/s1097-2765(03)00481-7

PubMed ID: 15254228

Title: Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5.

PubMed ID: 15254228

DOI: 10.1128/mcb.24.15.6608-6619.2004

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17890166

Title: The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G.

PubMed ID: 17890166

DOI: 10.1016/j.bbapap.2007.07.015

PubMed ID: 17932509

Title: Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.

PubMed ID: 17932509

DOI: 10.1038/sj.embor.7401088

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19029303

Title: Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs.

PubMed ID: 19029303

DOI: 10.1261/rna.1175909

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21123651

Title: Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense.

PubMed ID: 21123651

DOI: 10.1101/gad.1965010

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 26240280

Title: The NF45/NF90 Heterodimer Contributes to the Biogenesis of 60S Ribosomal Subunits and Influences Nucleolar Morphology.

PubMed ID: 26240280

DOI: 10.1128/mcb.00306-15

PubMed ID: 26891316

Title: NF45 and NF90 Bind HIV-1 RNA and Modulate HIV Gene Expression.

PubMed ID: 26891316

DOI: 10.3390/v8020047

PubMed ID: 28625552

Title: Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection.

PubMed ID: 28625552

DOI: 10.1016/j.molcel.2017.05.023

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 34110282

Title: Ubiquitination and degradation of NF90 by Tim-3 inhibits antiviral innate immunity.

PubMed ID: 34110282

DOI: 10.7554/elife.66501

Sequence Information:

  • Length: 894
  • Mass: 95338
  • Checksum: 20903ABD0331F370
  • Sequence:
    • MRPMRIFVND DRHVMAKHSS VYPTQEELEA VQNMVSHTER ALKAVSDWID EQEKGSSEQA 
ESDNMDVPPE DDSKEGAGEQ KTEHMTRTLR GVMRVGLVAK GLLLKGDLDL ELVLLCKEKP 
TTALLDKVAD NLAIQLAAVT EDKYEILQSV DDAAIVIKNT KEPPLSLTIH LTSPVVREEM 
EKVLAGETLS VNDPPDVLDR QKCLAALASL RHAKWFQARA NGLKSCVIVI RVLRDLCTRV 
PTWGPLRGWP LELLCEKSIG TANRPMGAGE ALRRVLECLA SGIVMPDGSG IYDPCEKEAT 
DAIGHLDRQQ REDITQSAQH ALRLAAFGQL HKVLGMDPLP SKMPKKPKNE NPVDYTVQIP 
PSTTYAITPM KRPMEEDGEE KSPSKKKKKI QKKEEKAEPP QAMNALMRLN QLKPGLQYKL 
VSQTGPVHAP IFTMSVEVDG NSFEASGPSK KTAKLHVAVK VLQDMGLPTG AEGRDSSKGE 
DSAEETEAKP AVVAPAPVVE AVSTPSAAFP SDATAEQGPI LTKHGKNPVM ELNEKRRGLK 
YELISETGGS HDKRFVMEVE VDGQKFQGAG SNKKVAKAYA ALAALEKLFP DTPLALDANK 
KKRAPVPVRG GPKFAAKPHN PGFGMGGPMH NEVPPPPNLR GRGRGGSIRG RGRGRGFGGA 
NHGGYMNAGA GYGSYGYGGN SATAGYSQFY SNGGHSGNAS GGGGGGGGGS SGYGSYYQGD 
NYNSPVPPKH AGKKQPHGGQ QKPSYGSGYQ SHQGQQQSYN QSPYSNYGPP QGKQKGYNHG 
QGSYSYSNSY NSPGGGGGSD YNYESKFNYS GSGGRSGGNS YGSGGASYNP GSHGGYGGGS 
GGGSSYQGKQ GGYSQSNYNS PGSGQNYSGP PSSYQSSQGG YGRNADHSMN YQYR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.