Details for: INCENP

Gene ID: 3619

Symbol: INCENP

Ensembl ID: ENSG00000149503

Description: inner centromere protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 36.3238
    Cell Significance Index: -5.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 29.4902
    Cell Significance Index: -7.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 16.7628
    Cell Significance Index: -6.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.1397
    Cell Significance Index: -7.5700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.7575
    Cell Significance Index: 45.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8055
    Cell Significance Index: 153.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6252
    Cell Significance Index: 8.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5393
    Cell Significance Index: 53.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5192
    Cell Significance Index: 84.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4940
    Cell Significance Index: 53.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4474
    Cell Significance Index: 404.0100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3934
    Cell Significance Index: 8.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2978
    Cell Significance Index: 35.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2892
    Cell Significance Index: 57.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2813
    Cell Significance Index: 32.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2805
    Cell Significance Index: 56.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2385
    Cell Significance Index: 14.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2341
    Cell Significance Index: 12.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2214
    Cell Significance Index: 6.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2043
    Cell Significance Index: 5.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2020
    Cell Significance Index: 13.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1884
    Cell Significance Index: 10.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0991
    Cell Significance Index: 35.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0909
    Cell Significance Index: 1.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0784
    Cell Significance Index: 42.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0740
    Cell Significance Index: 13.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0712
    Cell Significance Index: 1.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0689
    Cell Significance Index: 2.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0645
    Cell Significance Index: 4.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0476
    Cell Significance Index: 3.0000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0374
    Cell Significance Index: 1.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0311
    Cell Significance Index: 1.9100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0301
    Cell Significance Index: 0.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0249
    Cell Significance Index: 3.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0235
    Cell Significance Index: 10.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0230
    Cell Significance Index: 1.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0184
    Cell Significance Index: 0.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0122
    Cell Significance Index: 0.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0036
    Cell Significance Index: 0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0034
    Cell Significance Index: 6.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0017
    Cell Significance Index: 3.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0014
    Cell Significance Index: 2.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0012
    Cell Significance Index: 0.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0005
    Cell Significance Index: 0.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0037
    Cell Significance Index: -2.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0041
    Cell Significance Index: -0.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0075
    Cell Significance Index: -3.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0081
    Cell Significance Index: -5.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0102
    Cell Significance Index: -7.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0111
    Cell Significance Index: -8.2300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0116
    Cell Significance Index: -0.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0138
    Cell Significance Index: -7.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0141
    Cell Significance Index: -4.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0148
    Cell Significance Index: -2.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0153
    Cell Significance Index: -2.2300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0235
    Cell Significance Index: -0.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0239
    Cell Significance Index: -2.4400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0277
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0290
    Cell Significance Index: -4.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0318
    Cell Significance Index: -2.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0335
    Cell Significance Index: -4.3000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0368
    Cell Significance Index: -0.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0379
    Cell Significance Index: -2.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0399
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0411
    Cell Significance Index: -8.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0431
    Cell Significance Index: -4.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0480
    Cell Significance Index: -6.2000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0517
    Cell Significance Index: -1.2400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0527
    Cell Significance Index: -0.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0551
    Cell Significance Index: -3.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0586
    Cell Significance Index: -2.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0675
    Cell Significance Index: -2.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0690
    Cell Significance Index: -7.1800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0775
    Cell Significance Index: -1.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0865
    Cell Significance Index: -6.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0882
    Cell Significance Index: -5.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0896
    Cell Significance Index: -4.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0924
    Cell Significance Index: -7.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0931
    Cell Significance Index: -4.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1024
    Cell Significance Index: -1.7600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1100
    Cell Significance Index: -2.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1137
    Cell Significance Index: -5.9700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1250
    Cell Significance Index: -0.8300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1260
    Cell Significance Index: -3.7000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1262
    Cell Significance Index: -3.6000
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.1313
    Cell Significance Index: -1.6300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1315
    Cell Significance Index: -1.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1333
    Cell Significance Index: -2.7900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1460
    Cell Significance Index: -2.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1495
    Cell Significance Index: -4.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1519
    Cell Significance Index: -5.3200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1544
    Cell Significance Index: -3.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1598
    Cell Significance Index: -2.6800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1602
    Cell Significance Index: -5.8800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1625
    Cell Significance Index: -5.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1694
    Cell Significance Index: -4.6100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1708
    Cell Significance Index: -8.6300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1763
    Cell Significance Index: -3.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1819
    Cell Significance Index: -3.8600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1877
    Cell Significance Index: -2.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** INCENP is a large protein (approximately 350 kDa) that localizes to the centromere region of chromosomes during mitosis. It is characterized by its unique structure, which includes multiple protein-protein interaction domains, including a coiled-coil domain, a CUL4-RBX1-DDB1 (CRIB) domain, and a SUMOylation motif. INCENP is expressed in a wide range of cell types, including those of neural, cardiac, and immune origins. Its expression is tightly regulated, with a significant increase observed during the G2/M phase of the cell cycle. **Pathways and Functions:** INCENP is a central component of the chromosome passenger complex (CPC), which is responsible for the proper segregation of chromosomes during mitosis. The CPC is composed of INCENP, the kinase Aurora B, and the SUMOylation machinery. INCENP interacts with Aurora B to regulate the assembly of the mitotic spindle, while also binding to and modifying the histone variant CENP-A, which is essential for centromere formation. INCENP also plays a critical role in the regulation of protein degradation, with its SUMOylation motif interacting with E3 ligases to target proteins for degradation. INCENP's role in mitotic spindle assembly and chromosome segregation is mediated through its interactions with various proteins, including: 1. Aurora B: INCENP interacts with Aurora B to regulate the assembly of the mitotic spindle. 2. CENP-A: INCENP binds to and modifies CENP-A, which is essential for centromere formation. 3. SUMOylation machinery: INCENP interacts with E3 ligases to target proteins for SUMOylation. 4. Formins: INCENP interacts with formins to regulate the formation of the mitotic spindle. **Clinical Significance:** Dysregulation of INCENP expression has been implicated in various human diseases, including: 1. Cancer: INCENP overexpression has been observed in several types of cancer, including breast, lung, and colon cancer. 2. Neurodegenerative disorders: INCENP has been implicated in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 3. Congenital disorders: INCENP mutations have been identified in patients with congenital disorders, including intellectual disability and epilepsy. In conclusion, INCENP is a critical regulator of mitotic spindle assembly and chromosome segregation. Its dysregulation has been implicated in various human diseases, highlighting the importance of this protein in maintaining genome stability. Further studies are needed to elucidate the molecular mechanisms underlying INCENP's role in human disease and to explore potential therapeutic strategies for targeting INCENP in cancer and other diseases.

Genular Protein ID: 3196327141

Symbol: INCE_HUMAN

Name: Inner centromere protein

UniProtKB Accession Codes:

Q9NQS7 A8MQD2 Q5Y192

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEMBL 2 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 7 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11453556

Title: Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells.

PubMed ID: 11453556

DOI: 10.1007/s004120100130

PubMed ID: 15316025

Title: Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C.

PubMed ID: 15316025

DOI: 10.1074/jbc.m403029200

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9864353

Title: INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1.

PubMed ID: 9864353

DOI: 10.1083/jcb.143.7.1763

PubMed ID: 11139336

Title: INCENP binds directly to tubulin and requires dynamic microtubules to target to the cleavage furrow.

PubMed ID: 11139336

DOI: 10.1006/excr.2000.5088

PubMed ID: 12925766

Title: Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis.

PubMed ID: 12925766

DOI: 10.1091/mbc.e02-11-0769

PubMed ID: 14610074

Title: Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo.

PubMed ID: 14610074

DOI: 10.1074/jbc.m311299200

PubMed ID: 15249581

Title: Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.

PubMed ID: 15249581

DOI: 10.1083/jcb.200404001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16764853

Title: EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis.

PubMed ID: 16764853

DOI: 10.1016/j.yexcr.2006.03.032

PubMed ID: 16760428

Title: Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1.

PubMed ID: 16760428

DOI: 10.1091/mbc.e06-03-0240

PubMed ID: 16571674

Title: Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of borealin, survivin, and the N-terminal domain of INCENP.

PubMed ID: 16571674

DOI: 10.1091/mbc.e05-12-1133

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20562864

Title: Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.

PubMed ID: 20562864

DOI: 10.1038/ncb2075

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21225229

Title: PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins.

PubMed ID: 21225229

DOI: 10.3892/ijo.2011.900

PubMed ID: 21346195

Title: Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells.

PubMed ID: 21346195

DOI: 10.1091/mbc.e11-01-0009

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27332895

Title: Aurora-C interactions with survivin and INCENP reveal shared and distinct features compared with Aurora-B chromosome passenger protein complex.

PubMed ID: 27332895

DOI: 10.1371/journal.pone.0157305

PubMed ID: 17956729

Title: Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.

PubMed ID: 17956729

DOI: 10.1016/j.cell.2007.07.045

PubMed ID: 22920039

Title: Crystal structure of human aurora B in complex with INCENP and VX-680.

PubMed ID: 22920039

DOI: 10.1021/jm3008954

Sequence Information:

  • Length: 918
  • Mass: 105429
  • Checksum: 644D081DCC9035E8
  • Sequence:
    • MGTTAPGPIH LLELCDQKLM EFLCNMDNKD LVWLEEIQEE AERMFTREFS KEPELMPKTP 
SQKNRRKKRR ISYVQDENRD PIRRRLSRRK SRSSQLSSRR LRSKDSVEKL ATVVGENGSV 
LRRVTRAAAA AAAATMALAA PSSPTPESPT MLTKKPEDNH TQCQLVPVVE IGISERQNAE 
QHVTQLMSTE PLPRTLSPTP ASATAPTSQG IPTSDEESTP KKSKARILES ITVSSLMATP 
QDPKGQGVGT GRSASKLRIA QVSPGPRDSP AFPDSPWRER VLAPILPDNF STPTGSRTDS 
QSVRHSPIAP SSPSPQVLAQ KYSLVAKQES VVRRASRRLA KKTAEEPAAS GRIICHSYLE 
RLLNVEVPQK VGSEQKEPPE EAEPVAAAEP EVPENNGNNS WPHNDTEIAN STPNPKPAAS 
SPETPSAGQQ EAKTDQADGP REPPQSARRK RSYKQAVSEL DEEQHLEDEE LQPPRSKTPS 
SPCPASKVVR PLRTFLHTVQ RNQMLMTPTS APRSVMKSFI KRNTPLRMDP KCSFVEKERQ 
RLENLRRKEE AEQLRRQKVE EDKRRRLEEV KLKREERLRK VLQARERVEQ MKEEKKKQIE 
QKFAQIDEKT EKAKEERLAE EKAKKKAAAK KMEEVEARRK QEEEARRLRW LQQEEEERRH 
QELLQKKKEE EQERLRKAAE AKRLAEQREQ ERREQERREQ ERREQERREQ ERREQERQLA 
EQERRREQER LQAERELQER EKALRLQKEQ LQRELEEKKK KEEQQRLAER QLQEEQEKKA 
KEAAGASKAL NVTVDVQSPA CTSYQMTPQG HRAPPKINPD NYGMDLNSDD STDDEAHPRK 
PIPTWARGTP LSQAIIHQYY HPPNLLELFG TILPLDLEDI FKKSKPRYHK RTSSAVWNSP 
PLQGARVPSS LAYSLKKH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.