Details for: INCENP

Gene ID: 3619

Symbol: INCENP

Ensembl ID: ENSG00000149503

Description: inner centromere protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.56
    Marker Score: 3165
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.49
    Marker Score: 5780
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.25
    Marker Score: 2363.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.12
    Marker Score: 17456
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.05
    Marker Score: 1833
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71806
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48030
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.92
    Marker Score: 553
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5167.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.82
    Marker Score: 2219
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1249
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 685
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 550.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 281
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.7
    Marker Score: 332
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.67
    Marker Score: 897
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.65
    Marker Score: 1826
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.62
    Marker Score: 964
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.57
    Marker Score: 1344
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.57
    Marker Score: 5860
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.57
    Marker Score: 182
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.55
    Marker Score: 695
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.55
    Marker Score: 373
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.54
    Marker Score: 240
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.53
    Marker Score: 167
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.52
    Marker Score: 333
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.52
    Marker Score: 463
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.52
    Marker Score: 149
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5
    Marker Score: 1483
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.49
    Marker Score: 30069
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.49
    Marker Score: 272
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.46
    Marker Score: 4356
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.46
    Marker Score: 784.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.46
    Marker Score: 4333
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.45
    Marker Score: 3877
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.43
    Marker Score: 153
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.4
    Marker Score: 300
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.4
    Marker Score: 376
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.39
    Marker Score: 281
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.38
    Marker Score: 155
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.38
    Marker Score: 385
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.38
    Marker Score: 419
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.37
    Marker Score: 356
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.37
    Marker Score: 1534
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.36
    Marker Score: 334
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.33
    Marker Score: 88
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.32
    Marker Score: 212
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.31
    Marker Score: 450
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.29
    Marker Score: 76
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.29
    Marker Score: 198
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.29
    Marker Score: 121
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.29
    Marker Score: 122
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.28
    Marker Score: 98
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.28
    Marker Score: 10286
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.27
    Marker Score: 1055
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.27
    Marker Score: 740
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.27
    Marker Score: 85
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.27
    Marker Score: 287
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.27
    Marker Score: 324
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.27
    Marker Score: 167
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.27
    Marker Score: 79
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.26
    Marker Score: 418
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.26
    Marker Score: 9754
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.25
    Marker Score: 106
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.25
    Marker Score: 4910
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.25
    Marker Score: 206
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.24
    Marker Score: 115
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.24
    Marker Score: 96
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.23
    Marker Score: 112
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.23
    Marker Score: 1764
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.23
    Marker Score: 241
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.23
    Marker Score: 152
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.22
    Marker Score: 234
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.22
    Marker Score: 3352
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.22
    Marker Score: 96
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.22
    Marker Score: 248
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.22
    Marker Score: 107
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.21
    Marker Score: 1274
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.21
    Marker Score: 145
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.21
    Marker Score: 97
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.21
    Marker Score: 62
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.21
    Marker Score: 131
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.21
    Marker Score: 836
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.2
    Marker Score: 103
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.2
    Marker Score: 41
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.2
    Marker Score: 143

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Other Information

## Summary The INCENP gene encodes the Inner Centromere Protein (INCENP), a protein that is involved in the regulation of cell cycle progression and genomic stability. The protein is expressed in a variety of cell types, including immature innate lymphoid cells, neural progenitor cells, cardiac endothelial cells, cardiac muscle myoblasts, germ cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, tuft cells of the colon, and human embryonic stem cells. ## Key characteristics * INCENP is a protein of approximately 115 kDa. * It is a member of the INCEN family of proteins, which are characterized by their ability to interact with the spindle assembly checkpoint protein Mad2. * INCENP is localized to the inner centromere of chromosomes, where it is thought to play a role in the regulation of chromosome segregation. * It is also involved in the regulation of cell cycle checkpoints, where it helps to ensure that cells are properly divided into two daughter cells. * INCENP is a key regulator of cell cycle progression and genomic stability. ## Pathways and functions * INCENP is involved in the regulation of cell cycle progression by binding to the Mad2 protein and inhibiting its activity. This allows the cell to enter mitosis. * INCENP is also involved in the regulation of genomic stability by binding to DNA and preventing it from being replicated. * It is involved in the regulation of cell cycle checkpoints by binding to the spindle assembly checkpoint protein Mad2 and inhibiting its activity. This allows the cell to enter mitosis only when it is properly divided into two daughter cells. * INCENP is also involved in the regulation of cell cycle checkpoints by binding to the Rho GTPase effector protein Miro and inhibiting its activity. This allows the cell to enter mitosis only when it is properly divided into two daughter cells. ## Clinical significance Mutations in the INCENP gene have been linked to a number of human diseases, including cancer and developmental disorders. These mutations can lead to the activation of oncogenes or the inhibition of tumor suppressor genes, resulting in the uncontrolled growth of cancer cells.

Genular Protein ID: 3196327141

Symbol: INCE_HUMAN

Name: Inner centromere protein

UniProtKB Accession Codes:

Q9NQS7 A8MQD2 Q5Y192

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEMBL 2 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EMBL 5 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 9 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 7 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11453556

Title: Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells.

PubMed ID: 11453556

DOI: 10.1007/s004120100130

PubMed ID: 15316025

Title: Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C.

PubMed ID: 15316025

DOI: 10.1074/jbc.m403029200

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9864353

Title: INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1.

PubMed ID: 9864353

DOI: 10.1083/jcb.143.7.1763

PubMed ID: 11139336

Title: INCENP binds directly to tubulin and requires dynamic microtubules to target to the cleavage furrow.

PubMed ID: 11139336

DOI: 10.1006/excr.2000.5088

PubMed ID: 12925766

Title: Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis.

PubMed ID: 12925766

DOI: 10.1091/mbc.e02-11-0769

PubMed ID: 14610074

Title: Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo.

PubMed ID: 14610074

DOI: 10.1074/jbc.m311299200

PubMed ID: 15249581

Title: Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.

PubMed ID: 15249581

DOI: 10.1083/jcb.200404001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16764853

Title: EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis.

PubMed ID: 16764853

DOI: 10.1016/j.yexcr.2006.03.032

PubMed ID: 16760428

Title: Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1.

PubMed ID: 16760428

DOI: 10.1091/mbc.e06-03-0240

PubMed ID: 16571674

Title: Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of borealin, survivin, and the N-terminal domain of INCENP.

PubMed ID: 16571674

DOI: 10.1091/mbc.e05-12-1133

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20562864

Title: Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.

PubMed ID: 20562864

DOI: 10.1038/ncb2075

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21225229

Title: PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins.

PubMed ID: 21225229

DOI: 10.3892/ijo.2011.900

PubMed ID: 21346195

Title: Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells.

PubMed ID: 21346195

DOI: 10.1091/mbc.e11-01-0009

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27332895

Title: Aurora-C interactions with survivin and INCENP reveal shared and distinct features compared with Aurora-B chromosome passenger protein complex.

PubMed ID: 27332895

DOI: 10.1371/journal.pone.0157305

PubMed ID: 17956729

Title: Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.

PubMed ID: 17956729

DOI: 10.1016/j.cell.2007.07.045

PubMed ID: 22920039

Title: Crystal structure of human aurora B in complex with INCENP and VX-680.

PubMed ID: 22920039

DOI: 10.1021/jm3008954

Sequence Information:

  • Length: 918
  • Mass: 105429
  • Checksum: 644D081DCC9035E8
  • Sequence:
    • MGTTAPGPIH LLELCDQKLM EFLCNMDNKD LVWLEEIQEE AERMFTREFS KEPELMPKTP 
SQKNRRKKRR ISYVQDENRD PIRRRLSRRK SRSSQLSSRR LRSKDSVEKL ATVVGENGSV 
LRRVTRAAAA AAAATMALAA PSSPTPESPT MLTKKPEDNH TQCQLVPVVE IGISERQNAE 
QHVTQLMSTE PLPRTLSPTP ASATAPTSQG IPTSDEESTP KKSKARILES ITVSSLMATP 
QDPKGQGVGT GRSASKLRIA QVSPGPRDSP AFPDSPWRER VLAPILPDNF STPTGSRTDS 
QSVRHSPIAP SSPSPQVLAQ KYSLVAKQES VVRRASRRLA KKTAEEPAAS GRIICHSYLE 
RLLNVEVPQK VGSEQKEPPE EAEPVAAAEP EVPENNGNNS WPHNDTEIAN STPNPKPAAS 
SPETPSAGQQ EAKTDQADGP REPPQSARRK RSYKQAVSEL DEEQHLEDEE LQPPRSKTPS 
SPCPASKVVR PLRTFLHTVQ RNQMLMTPTS APRSVMKSFI KRNTPLRMDP KCSFVEKERQ 
RLENLRRKEE AEQLRRQKVE EDKRRRLEEV KLKREERLRK VLQARERVEQ MKEEKKKQIE 
QKFAQIDEKT EKAKEERLAE EKAKKKAAAK KMEEVEARRK QEEEARRLRW LQQEEEERRH 
QELLQKKKEE EQERLRKAAE AKRLAEQREQ ERREQERREQ ERREQERREQ ERREQERQLA 
EQERRREQER LQAERELQER EKALRLQKEQ LQRELEEKKK KEEQQRLAER QLQEEQEKKA 
KEAAGASKAL NVTVDVQSPA CTSYQMTPQG HRAPPKINPD NYGMDLNSDD STDDEAHPRK 
PIPTWARGTP LSQAIIHQYY HPPNLLELFG TILPLDLEDI FKKSKPRYHK RTSSAVWNSP 
PLQGARVPSS LAYSLKKH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.