Details for: ISG20

Gene ID: 3669

Symbol: ISG20

Ensembl ID: ENSG00000172183

Description: interferon stimulated exonuclease gene 20

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.74
    Marker Score: 37055
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.47
    Marker Score: 2955
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.22
    Marker Score: 3176
  • Cell Name: centroblast (CL0009112)
    Fold Change: 3.17
    Marker Score: 1563
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.02
    Marker Score: 1506
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.01
    Marker Score: 8430
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.79
    Marker Score: 8128.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.78
    Marker Score: 147249
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.73
    Marker Score: 2638
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.69
    Marker Score: 5644
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.67
    Marker Score: 11451.5
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.67
    Marker Score: 2244
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.65
    Marker Score: 6516
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.64
    Marker Score: 818.5
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.63
    Marker Score: 1134
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.6
    Marker Score: 1567
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.58
    Marker Score: 8141
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.57
    Marker Score: 1561
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.54
    Marker Score: 1997.5
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.51
    Marker Score: 4486
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.5
    Marker Score: 2352
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.5
    Marker Score: 6097
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.5
    Marker Score: 883.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.48
    Marker Score: 28824
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.46
    Marker Score: 7306
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.45
    Marker Score: 854
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 2.42
    Marker Score: 667
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.38
    Marker Score: 2229
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.37
    Marker Score: 1365
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.36
    Marker Score: 1302
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 2.35
    Marker Score: 819
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 2.32
    Marker Score: 754
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.29
    Marker Score: 4493
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.29
    Marker Score: 1344
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.29
    Marker Score: 2045
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 2.27
    Marker Score: 596
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.27
    Marker Score: 1779
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.25
    Marker Score: 740.5
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.24
    Marker Score: 1624
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 2.24
    Marker Score: 594
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.21
    Marker Score: 14086
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.19
    Marker Score: 2632.5
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.19
    Marker Score: 1656
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.17
    Marker Score: 772.5
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.17
    Marker Score: 1113
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.15
    Marker Score: 2965
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.13
    Marker Score: 3137
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 2.12
    Marker Score: 913
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.12
    Marker Score: 8156.5
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.1
    Marker Score: 1864.5
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.09
    Marker Score: 13358
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 2.08
    Marker Score: 632
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.03
    Marker Score: 1484
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.03
    Marker Score: 1187
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.98
    Marker Score: 3400
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.96
    Marker Score: 856
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.94
    Marker Score: 2142
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.91
    Marker Score: 944
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.91
    Marker Score: 2063
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.9
    Marker Score: 1259
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.89
    Marker Score: 736
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.87
    Marker Score: 1202.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.83
    Marker Score: 5045
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.82
    Marker Score: 412
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.79
    Marker Score: 3166
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.78
    Marker Score: 1479
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.78
    Marker Score: 1561
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.77
    Marker Score: 8472.5
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.76
    Marker Score: 2554.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.76
    Marker Score: 3068
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.76
    Marker Score: 17822
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.75
    Marker Score: 1076
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.73
    Marker Score: 720
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.71
    Marker Score: 4188.5
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.7
    Marker Score: 1447
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.7
    Marker Score: 1845
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.68
    Marker Score: 418
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.68
    Marker Score: 425
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.67
    Marker Score: 1371
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.67
    Marker Score: 3749
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.66
    Marker Score: 418
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.6
    Marker Score: 1164
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.59
    Marker Score: 366
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.52
    Marker Score: 1295
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.51
    Marker Score: 511
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.49
    Marker Score: 1932
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.48
    Marker Score: 3772.5
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 1.48
    Marker Score: 1307
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166094
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.45
    Marker Score: 368
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.44
    Marker Score: 1376
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.43
    Marker Score: 1727
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.43
    Marker Score: 1593
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.43
    Marker Score: 2616
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.42
    Marker Score: 3218.5
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.41
    Marker Score: 820
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.4
    Marker Score: 2280
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.4
    Marker Score: 2718
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.39
    Marker Score: 273
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.36
    Marker Score: 1027

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Other Information

**Key characteristics:** * ISG20 is a 20 kDa protein. * It is a member of the interferon stimulated exonuclease family of proteins. * ISG20 is expressed in high levels in cells that are activated by interferons. * It has a variety of functions, including exonuclease activity, cytokine signaling, and DNA catabolic process. **Pathways and functions:** * ISG20 is activated by interferons, which are released by infected cells or stressed cells. * It is a key regulator of innate immunity. * It helps to control the replication of viral genomes by excising viral DNA from the viral genome. * It also plays a role in the regulation of inflammation. **Clinical significance:** * Mutations in the ISG20 gene have been linked to a number of autoimmune diseases, including rheumatoid arthritis and lupus. * Targeting ISG20 has been investigated as a treatment for these diseases. **Additional information:** * ISG20 is a ubiquitin-dependent protein, meaning that it is targeted for degradation by the proteasome when it is no longer needed. * It is a highly conserved protein, with a similar sequence in mice and humans. * ISG20 is a promising target for the treatment of autoimmune diseases.

Genular Protein ID: 3609348115

Symbol: ISG20_HUMAN

Name: Interferon-stimulated gene 20 kDa protein

UniProtKB Accession Codes:

Q96AZ6 O00441 O00586

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 6 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9235947

Title: Molecular cloning of a new interferon-induced PML nuclear bodies-associated protein.

PubMed ID: 9235947

DOI: 10.1074/jbc.272.31.19457

PubMed ID: 9569007

Title: Expression and estrogen regulation of the HEM45 mRNA in human tumor lines and in the rat uterus.

PubMed ID: 9569007

DOI: 10.1016/s0960-0760(97)00140-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11401564

Title: The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro.

PubMed ID: 11401564

DOI: 10.1021/bi010141t

PubMed ID: 12594219

Title: ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses.

PubMed ID: 12594219

DOI: 10.1074/jbc.m209628200

PubMed ID: 16033969

Title: Interferon-induced exonuclease ISG20 exhibits an antiviral activity against human immunodeficiency virus type 1.

PubMed ID: 16033969

DOI: 10.1099/vir.0.81074-0

PubMed ID: 16514659

Title: The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein-containing complexes.

PubMed ID: 16514659

DOI: 10.1002/jcb.20869

PubMed ID: 17445960

Title: ISG20, an actor of the innate immune response.

PubMed ID: 17445960

DOI: 10.1016/j.biochi.2007.03.006

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21036379

Title: Antiviral activities of ISG20 in positive-strand RNA virus infections.

PubMed ID: 21036379

DOI: 10.1016/j.virol.2010.10.008

PubMed ID: 15527770

Title: Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease.

PubMed ID: 15527770

DOI: 10.1016/j.febslet.2004.09.074

PubMed ID: 31600344

Title: The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation.

PubMed ID: 31600344

DOI: 10.1371/journal.ppat.1008093

Sequence Information:

  • Length: 181
  • Mass: 20363
  • Checksum: 24519CB52CEA5581
  • Sequence:
    • MAGSREVVAM DCEMVGLGPH RESGLARCSL VNVHGAVLYD KFIRPEGEIT DYRTRVSGVT 
PQHMVGATPF AVARLEILQL LKGKLVVGHD LKHDFQALKE DMSGYTIYDT STDRLLWREA 
KLDHCRRVSL RVLSERLLHK SIQNSLLGHS SVEDARATME LYQISQRIRA RRGLPRLAVS 
D

Genular Protein ID: 1824468521

Symbol: H0YMM4_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0YMM4

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 161
  • Mass: 18080
  • Checksum: 97C1151A8AB31267
  • Sequence:
    • MAGSREVVAM DCEMVGLGPH RESGLARCSL VNVHGAVLYD KFIRPEGEIT DYRTRVSGVT 
PQHMVGATPF AVARLEALKE DMSGYTIYDT STDRLLWREA KLDHCRRVSL RVLSERLLHK 
SIQNSLLGHS SVEDARATME LYQISQRIRA RRGLPRLAVS D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.