Details for: ISG20

Gene ID: 3669

Symbol: ISG20

Ensembl ID: ENSG00000172183

Description: interferon stimulated exonuclease gene 20

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 137.7734
    Cell Significance Index: -21.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 112.3231
    Cell Significance Index: -28.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 95.8999
    Cell Significance Index: -38.9600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 81.4953
    Cell Significance Index: -41.9200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 73.5932
    Cell Significance Index: -34.7500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 51.8239
    Cell Significance Index: -34.7800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.8277
    Cell Significance Index: -38.9800
  • Cell Name: centroblast (CL0009112)
    Fold Change: 28.9748
    Cell Significance Index: 67.6000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.6391
    Cell Significance Index: -26.6800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 10.8105
    Cell Significance Index: 28.9600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.2334
    Cell Significance Index: -28.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.4464
    Cell Significance Index: -33.3300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 5.8578
    Cell Significance Index: 42.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.7356
    Cell Significance Index: 109.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.5422
    Cell Significance Index: 417.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.9453
    Cell Significance Index: 219.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.8743
    Cell Significance Index: 371.3300
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.5224
    Cell Significance Index: 11.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.4137
    Cell Significance Index: 113.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.0791
    Cell Significance Index: 134.1300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.6327
    Cell Significance Index: 37.7200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 1.5972
    Cell Significance Index: 27.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4237
    Cell Significance Index: 140.8400
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.4130
    Cell Significance Index: 8.7500
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.1903
    Cell Significance Index: 3.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0250
    Cell Significance Index: 559.8000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9779
    Cell Significance Index: 58.7100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.8986
    Cell Significance Index: 5.5300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.7829
    Cell Significance Index: 7.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7763
    Cell Significance Index: 84.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5835
    Cell Significance Index: 94.9100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3460
    Cell Significance Index: 6.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2965
    Cell Significance Index: 56.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2853
    Cell Significance Index: 8.2200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.2751
    Cell Significance Index: 1.5000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2042
    Cell Significance Index: 3.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1680
    Cell Significance Index: 11.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1366
    Cell Significance Index: 16.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0691
    Cell Significance Index: 9.5000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0480
    Cell Significance Index: 0.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0278
    Cell Significance Index: 12.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0249
    Cell Significance Index: 3.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0095
    Cell Significance Index: 7.1900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0088
    Cell Significance Index: 0.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0060
    Cell Significance Index: -1.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0164
    Cell Significance Index: -30.8300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0180
    Cell Significance Index: -0.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0199
    Cell Significance Index: -36.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0233
    Cell Significance Index: -35.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0280
    Cell Significance Index: -38.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0298
    Cell Significance Index: -20.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0412
    Cell Significance Index: -8.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0429
    Cell Significance Index: -31.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0547
    Cell Significance Index: -30.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0562
    Cell Significance Index: -41.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0632
    Cell Significance Index: -40.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0823
    Cell Significance Index: -37.3600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0827
    Cell Significance Index: -9.6400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0841
    Cell Significance Index: -3.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0851
    Cell Significance Index: -30.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0919
    Cell Significance Index: -26.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1126
    Cell Significance Index: -3.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1235
    Cell Significance Index: -12.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1343
    Cell Significance Index: -22.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1421
    Cell Significance Index: -28.5000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1461
    Cell Significance Index: -1.6600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1585
    Cell Significance Index: -2.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1797
    Cell Significance Index: -37.8500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2146
    Cell Significance Index: -2.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2326
    Cell Significance Index: -5.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2364
    Cell Significance Index: -27.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2426
    Cell Significance Index: -11.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2550
    Cell Significance Index: -37.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2572
    Cell Significance Index: -13.3600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2794
    Cell Significance Index: -4.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3049
    Cell Significance Index: -13.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3071
    Cell Significance Index: -6.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3084
    Cell Significance Index: -7.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3084
    Cell Significance Index: -8.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3182
    Cell Significance Index: -33.1300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.3212
    Cell Significance Index: -2.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3228
    Cell Significance Index: -8.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3709
    Cell Significance Index: -5.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3723
    Cell Significance Index: -26.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3989
    Cell Significance Index: -10.6500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4358
    Cell Significance Index: -6.5300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4517
    Cell Significance Index: -11.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4585
    Cell Significance Index: -23.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4715
    Cell Significance Index: -36.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5040
    Cell Significance Index: -33.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5123
    Cell Significance Index: -32.2900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5214
    Cell Significance Index: -41.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5433
    Cell Significance Index: -17.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5451
    Cell Significance Index: -33.4200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.5951
    Cell Significance Index: -3.8800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5993
    Cell Significance Index: -16.0300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.6019
    Cell Significance Index: -9.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6260
    Cell Significance Index: -38.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6515
    Cell Significance Index: -36.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7318
    Cell Significance Index: -38.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ISG20 is a member of the interferon-stimulated gene family, which is activated in response to viral infections and other forms of cellular stress. The gene encodes a 20-kDa protein that exhibits 3'-5' exonuclease activity, allowing it to degrade single-stranded DNA and RNA. ISG20 also interacts with various RNA-binding proteins, including U1, U2, and U3 small nuclear ribonucleoproteins (snRNPs), which are involved in RNA processing and splicing. The protein's ability to bind to metal ions suggests its involvement in metal-dependent enzymatic activities. **Pathways and Functions:** ISG20 is involved in several key pathways that regulate the immune response against viral infections: 1. **Interferon Signaling:** ISG20 is induced by interferons and plays a critical role in the regulation of interferon-alpha/beta signaling pathways. 2. **Viral Genome Replication:** ISG20 inhibits viral genome replication by degrading viral RNA and DNA, thereby limiting the spread of viral infections. 3. **RNA Degradation:** ISG20 degrades single-stranded RNA, including viral RNA, to prevent its translation and replication. 4. **Exonuclease Activity:** ISG20 exhibits 3'-5' exonuclease activity, allowing it to degrade DNA and RNA in an exonuclease-dependent manner. 5. **Metal Ion Binding:** ISG20 binds to metal ions, which may be required for its enzymatic activity. **Clinical Significance:** The ISG20 gene plays a crucial role in the innate immune response against viral infections, including influenza, HIV, and herpesviruses. Dysregulation of ISG20 has been implicated in various diseases, including cancer and autoimmune disorders. The gene's expression is highly regulated, and its dysregulation can lead to impaired immune function and increased susceptibility to viral infections. In conclusion, the ISG20 gene is a critical component of the innate immune response against viral infections, and its dysregulation can have significant clinical consequences. Further research is needed to fully understand the mechanisms of ISG20 and its role in regulating immune responses against viral infections. **Implications for Therapeutic Interventions:** The study of ISG20 has significant implications for the development of therapeutic interventions aimed at regulating the immune response against viral infections. Potential strategies include: 1. **ISG20 Induction:** Inducing ISG20 expression may enhance the innate immune response against viral infections. 2. **ISG20 Inhibition:** Inhibiting ISG20 activity may prevent its antiviral effects and allow viral replication to occur. 3. **ISG20 Targeting:** Targeting ISG20 with small molecules or RNA interference may provide a novel therapeutic approach for treating viral infections. Overall, the ISG20 gene is a critical component of the innate immune response against viral infections, and its dysregulation can have significant clinical consequences. Further research is needed to fully understand the mechanisms of ISG20 and its role in regulating immune responses against viral infections.

Genular Protein ID: 3609348115

Symbol: ISG20_HUMAN

Name: Interferon-stimulated gene 20 kDa protein

UniProtKB Accession Codes:

Q96AZ6 O00441 O00586

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 6 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9235947

Title: Molecular cloning of a new interferon-induced PML nuclear bodies-associated protein.

PubMed ID: 9235947

DOI: 10.1074/jbc.272.31.19457

PubMed ID: 9569007

Title: Expression and estrogen regulation of the HEM45 mRNA in human tumor lines and in the rat uterus.

PubMed ID: 9569007

DOI: 10.1016/s0960-0760(97)00140-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11401564

Title: The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro.

PubMed ID: 11401564

DOI: 10.1021/bi010141t

PubMed ID: 12594219

Title: ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses.

PubMed ID: 12594219

DOI: 10.1074/jbc.m209628200

PubMed ID: 16033969

Title: Interferon-induced exonuclease ISG20 exhibits an antiviral activity against human immunodeficiency virus type 1.

PubMed ID: 16033969

DOI: 10.1099/vir.0.81074-0

PubMed ID: 16514659

Title: The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein-containing complexes.

PubMed ID: 16514659

DOI: 10.1002/jcb.20869

PubMed ID: 17445960

Title: ISG20, an actor of the innate immune response.

PubMed ID: 17445960

DOI: 10.1016/j.biochi.2007.03.006

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21036379

Title: Antiviral activities of ISG20 in positive-strand RNA virus infections.

PubMed ID: 21036379

DOI: 10.1016/j.virol.2010.10.008

PubMed ID: 15527770

Title: Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease.

PubMed ID: 15527770

DOI: 10.1016/j.febslet.2004.09.074

PubMed ID: 31600344

Title: The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation.

PubMed ID: 31600344

DOI: 10.1371/journal.ppat.1008093

Sequence Information:

  • Length: 181
  • Mass: 20363
  • Checksum: 24519CB52CEA5581
  • Sequence:
    • MAGSREVVAM DCEMVGLGPH RESGLARCSL VNVHGAVLYD KFIRPEGEIT DYRTRVSGVT 
PQHMVGATPF AVARLEILQL LKGKLVVGHD LKHDFQALKE DMSGYTIYDT STDRLLWREA 
KLDHCRRVSL RVLSERLLHK SIQNSLLGHS SVEDARATME LYQISQRIRA RRGLPRLAVS 
D

Genular Protein ID: 1824468521

Symbol: H0YMM4_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0YMM4

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 2 Proteomes 2 ProteomicsDB 2 RefSeq 2 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 161
  • Mass: 18080
  • Checksum: 97C1151A8AB31267
  • Sequence:
    • MAGSREVVAM DCEMVGLGPH RESGLARCSL VNVHGAVLYD KFIRPEGEIT DYRTRVSGVT 
PQHMVGATPF AVARLEALKE DMSGYTIYDT STDRLLWREA KLDHCRRVSL RVLSERLLHK 
SIQNSLLGHS SVEDARATME LYQISQRIRA RRGLPRLAVS D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.