Details for: KCNA3

Gene ID: 3738

Symbol: KCNA3

Ensembl ID: ENSG00000177272

Description: potassium voltage-gated channel subfamily A member 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.19
    Marker Score: 5120
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.16
    Marker Score: 2195
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.13
    Marker Score: 2760
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.06
    Marker Score: 635
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.04
    Marker Score: 54778
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.01
    Marker Score: 671
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71807
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48032
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.99
    Marker Score: 2771
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.97
    Marker Score: 1969.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5335
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.91
    Marker Score: 666
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.89
    Marker Score: 784
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.89
    Marker Score: 2815
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.86
    Marker Score: 1185
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.85
    Marker Score: 522
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 601
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.76
    Marker Score: 446
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.76
    Marker Score: 11863
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.72
    Marker Score: 220
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.72
    Marker Score: 199
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.67
    Marker Score: 176
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.61
    Marker Score: 6055
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.6
    Marker Score: 888
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.58
    Marker Score: 226
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.53
    Marker Score: 3391
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.53
    Marker Score: 705
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.51
    Marker Score: 722
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.51
    Marker Score: 3381
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.48
    Marker Score: 572
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.47
    Marker Score: 446
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.47
    Marker Score: 993
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.47
    Marker Score: 236
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.46
    Marker Score: 793
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.46
    Marker Score: 160
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 274
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.45
    Marker Score: 329.5
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.44
    Marker Score: 199
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.43
    Marker Score: 335
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.42
    Marker Score: 4368
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.42
    Marker Score: 301
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.42
    Marker Score: 743.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.41
    Marker Score: 109
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.41
    Marker Score: 309
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.41
    Marker Score: 175
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.4
    Marker Score: 10341
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.4
    Marker Score: 446
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.38
    Marker Score: 413
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.37
    Marker Score: 331
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.37
    Marker Score: 204
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.37
    Marker Score: 238
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.37
    Marker Score: 722
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.36
    Marker Score: 141
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.36
    Marker Score: 346
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.35
    Marker Score: 340
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.35
    Marker Score: 386
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.34
    Marker Score: 104
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.33
    Marker Score: 1295
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.33
    Marker Score: 149
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.33
    Marker Score: 84
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.31
    Marker Score: 206
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.3
    Marker Score: 816
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.3
    Marker Score: 3444
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.29
    Marker Score: 164
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.29
    Marker Score: 249
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.29
    Marker Score: 138
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.29
    Marker Score: 243
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.28
    Marker Score: 119
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.28
    Marker Score: 1184
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.28
    Marker Score: 635
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.28
    Marker Score: 262
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.28
    Marker Score: 96
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.28
    Marker Score: 185
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.27
    Marker Score: 234
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.27
    Marker Score: 119
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.26
    Marker Score: 151
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.26
    Marker Score: 107
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.24
    Marker Score: 62
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.24
    Marker Score: 313
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.24
    Marker Score: 196
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.24
    Marker Score: 210
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.23
    Marker Score: 195
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.23
    Marker Score: 236
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.23
    Marker Score: 167
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.23
    Marker Score: 102
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.23
    Marker Score: 232
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.23
    Marker Score: 4479
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.22
    Marker Score: 147
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.22
    Marker Score: 246
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.22
    Marker Score: 267
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.21
    Marker Score: 1871

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - It is a transmembrane protein that is expressed in various cell types, including T-helper 22 cells, cardiac endothelial cells, central memory CD8-positive T cells, lymphoid lineage restricted progenitor cells, mature alpha-beta T cells, hematopoietic cells, and cerebral cortex GABAergic interneurons. - It is a potassium channel that is responsible for the regulation of potassium ion concentrations in the cell. - It is a key component of the voltage-gated potassium channel complex, which is responsible for the generation and propagation of action potentials in nerve cells. **Pathways and functions:** - It is involved in the regulation of immune responses by controlling the flow of potassium ions into and out of immune cells. - It is involved in the development of the nervous system by regulating the growth and differentiation of neurons. - It is involved in synaptic plasticity, which is the ability of synapses to change their strength over time. **Clinical significance:** - Mutations in the KCNA3 gene have been linked to several autoimmune diseases, including rheumatoid arthritis, Crohn's disease, and multiple sclerosis. - Targeting the KCNA3 gene has been investigated as a therapeutic strategy for these diseases. **Additional notes:** - It is a highly conserved protein, with a similar sequence in mice and humans. - It is a member of the voltage-gated potassium channel family of proteins. - It is a key target for the treatment of autoimmune diseases.

Genular Protein ID: 2462600059

Symbol: KCNA3_HUMAN

Name: Potassium voltage-gated channel subfamily A member 3

UniProtKB Accession Codes:

P22001 Q5VWN2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EMBL 7 EMDB 4 Ensembl 5 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 8 PIR 1 PRINTS 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7829094

Title: Confirmation of the assignment of the gene encoding Kv1.3, a voltage-gated potassium channel (KCNA3) to the proximal short arm of human chromosome 1.

PubMed ID: 7829094

DOI: 10.1006/geno.1994.1500

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1986382

Title: Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel.

PubMed ID: 1986382

DOI: 10.1073/pnas.88.1.53

PubMed ID: 1373731

Title: Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.

PubMed ID: 1373731

DOI: 10.1016/s0021-9258(18)42492-1

PubMed ID: 1547020

Title: Characterization and functional expression of genomic DNA encoding the human lymphocyte type n potassium channel.

PubMed ID: 1547020

DOI: 10.1089/dna.1992.11.163

Sequence Information:

  • Length: 575
  • Mass: 63842
  • Checksum: 0E98905187A85F48
  • Sequence:
    • MDERLSLLRS PPPPSARHRA HPPQRPASSG GAHTLVNHGY AEPAAGRELP PDMTVVPGDH 
LLEPEVADGG GAPPQGGCGG GGCDRYEPLP PSLPAAGEQD CCGERVVINI SGLRFETQLK 
TLCQFPETLL GDPKRRMRYF DPLRNEYFFD RNRPSFDAIL YYYQSGGRIR RPVNVPIDIF 
SEEIRFYQLG EEAMEKFRED EGFLREEERP LPRRDFQRQV WLLFEYPESS GPARGIAIVS 
VLVILISIVI FCLETLPEFR DEKDYPASTS QDSFEAAGNS TSGSRAGASS FSDPFFVVET 
LCIIWFSFEL LVRFFACPSK ATFSRNIMNL IDIVAIIPYF ITLGTELAER QGNGQQAMSL 
AILRVIRLVR VFRIFKLSRH SKGLQILGQT LKASMRELGL LIFFLFIGVI LFSSAVYFAE 
ADDPTSGFSS IPDAFWWAVV TMTTVGYGDM HPVTIGGKIV GSLCAIAGVL TIALPVPVIV 
SNFNYFYHRE TEGEEQSQYM HVGSCQHLSS SAEELRKARS NSTLSKSEYM VIEEGGMNHS 
AFPQTPFKTG NSTATCTTNN NPNSCVNIKK IFTDV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.