Details for: KCNA3

Gene ID: 3738

Symbol: KCNA3

Ensembl ID: ENSG00000177272

Description: potassium voltage-gated channel subfamily A member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 37.6739
    Cell Significance Index: -5.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 21.5263
    Cell Significance Index: -5.4600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 16.4428
    Cell Significance Index: -6.6800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.2061
    Cell Significance Index: -6.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.7366
    Cell Significance Index: -5.8400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.4977
    Cell Significance Index: -5.9100
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.2255
    Cell Significance Index: 3.7400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.7520
    Cell Significance Index: 7.5400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.6588
    Cell Significance Index: 15.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5769
    Cell Significance Index: 35.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4690
    Cell Significance Index: 13.7800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2786
    Cell Significance Index: 3.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2576
    Cell Significance Index: 178.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1593
    Cell Significance Index: 8.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0676
    Cell Significance Index: 1.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0450
    Cell Significance Index: 16.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0306
    Cell Significance Index: 6.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0013
    Cell Significance Index: 0.0700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0020
    Cell Significance Index: -0.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0072
    Cell Significance Index: -5.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0080
    Cell Significance Index: -5.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0095
    Cell Significance Index: -5.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0102
    Cell Significance Index: -7.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0140
    Cell Significance Index: -4.0400
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0145
    Cell Significance Index: -0.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0226
    Cell Significance Index: -2.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0239
    Cell Significance Index: -3.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0275
    Cell Significance Index: -3.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0286
    Cell Significance Index: -6.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0290
    Cell Significance Index: -1.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0318
    Cell Significance Index: -6.3100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0321
    Cell Significance Index: -0.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0329
    Cell Significance Index: -4.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0353
    Cell Significance Index: -6.0200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0377
    Cell Significance Index: -0.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0422
    Cell Significance Index: -5.4500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0485
    Cell Significance Index: -1.0300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0486
    Cell Significance Index: -0.9800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0505
    Cell Significance Index: -1.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0518
    Cell Significance Index: -6.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0553
    Cell Significance Index: -6.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0594
    Cell Significance Index: -4.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0609
    Cell Significance Index: -2.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0635
    Cell Significance Index: -0.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0662
    Cell Significance Index: -6.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0666
    Cell Significance Index: -3.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0704
    Cell Significance Index: -5.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0735
    Cell Significance Index: -5.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0791
    Cell Significance Index: -4.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0820
    Cell Significance Index: -5.2900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0848
    Cell Significance Index: -1.6700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0851
    Cell Significance Index: -3.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0871
    Cell Significance Index: -2.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0905
    Cell Significance Index: -4.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0916
    Cell Significance Index: -3.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0921
    Cell Significance Index: -5.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0932
    Cell Significance Index: -4.8400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0968
    Cell Significance Index: -3.3900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0986
    Cell Significance Index: -2.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1101
    Cell Significance Index: -4.8700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1112
    Cell Significance Index: -1.1000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1166
    Cell Significance Index: -2.9800
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1223
    Cell Significance Index: -0.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1268
    Cell Significance Index: -4.0400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1281
    Cell Significance Index: -2.5600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1283
    Cell Significance Index: -1.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1331
    Cell Significance Index: -5.0400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1380
    Cell Significance Index: -2.8800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1490
    Cell Significance Index: -2.3100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1514
    Cell Significance Index: -1.9100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1544
    Cell Significance Index: -2.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1562
    Cell Significance Index: -3.2700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1601
    Cell Significance Index: -1.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1678
    Cell Significance Index: -4.8400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1701
    Cell Significance Index: -2.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1723
    Cell Significance Index: -4.9400
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1765
    Cell Significance Index: -2.2800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1818
    Cell Significance Index: -3.7000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1914
    Cell Significance Index: -1.7900
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1925
    Cell Significance Index: -1.6400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1962
    Cell Significance Index: -5.6000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2014
    Cell Significance Index: -3.4200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2047
    Cell Significance Index: -1.9400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2062
    Cell Significance Index: -2.4400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2066
    Cell Significance Index: -5.1600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.2115
    Cell Significance Index: -1.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2142
    Cell Significance Index: -5.8300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2150
    Cell Significance Index: -3.1500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2188
    Cell Significance Index: -2.2200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.2238
    Cell Significance Index: -3.8500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2240
    Cell Significance Index: -5.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2242
    Cell Significance Index: -5.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2296
    Cell Significance Index: -6.1300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2308
    Cell Significance Index: -2.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2347
    Cell Significance Index: -6.2900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2366
    Cell Significance Index: -2.3900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2426
    Cell Significance Index: -6.1800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2432
    Cell Significance Index: -2.9500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2437
    Cell Significance Index: -5.2100
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.2540
    Cell Significance Index: -3.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Potassium Channel Function:** KCNA3 encodes a voltage-gated potassium channel that is involved in regulating potassium ion flux across the plasma membrane. 2. **Cell Type-Specific Expression:** The gene is significantly expressed in T-helper 22 cells, cardiac endothelial cells, and various subsets of T cells, highlighting its importance in immune function. 3. **Neuronal Expression:** KCNA3 is expressed in GABAergic interneurons and radial glial cells, suggesting its involvement in neuronal development and function. 4. **Voltage-Gated Kinetics:** The channel exhibits voltage-gated kinetics, allowing it to regulate potassium ion flux in response to changes in membrane potential. **Pathways and Functions:** 1. **Immune Response:** KCNA3 plays a crucial role in regulating the immune response by modulating potassium ion flux in T-helper 22 cells and other subsets of T cells. This, in turn, influences the activation and function of these cells. 2. **Neuronal Development:** The gene's expression in GABAergic interneurons and radial glial cells suggests its involvement in neuronal development and function. KCNA3 may regulate potassium ion flux in these cells, influencing their differentiation and migration. 3. **Cardiac Function:** KCNA3 is expressed in cardiac endothelial cells, and its dysfunction may contribute to cardiac arrhythmias and other cardiovascular disorders. 4. **Synaptic Transmission:** The channel's expression in presynaptic membranes and postsynaptic membranes suggests its involvement in regulating synaptic transmission. **Clinical Significance:** 1. **Immune-Mediated Disorders:** KCNA3 dysfunction may contribute to immune-mediated disorders, such as autoimmune diseases and allergies. 2. **Cardiovascular Disorders:** Mutations in the KCNA3 gene have been associated with cardiac arrhythmias and other cardiovascular disorders. 3. **Neurological Disorders:** KCNA3 dysfunction may contribute to neurological disorders, such as epilepsy and schizophrenia. 4. **Cancer:** The gene's expression in hematopoietic cells suggests its potential role in cancer development and progression. In conclusion, KCNA3 is a critical regulator of potassium channels in the immune system and the nervous system. Its dysfunction may contribute to a range of clinical disorders, highlighting the need for further research into the gene's role in maintaining immune homeostasis and neuronal function.

Genular Protein ID: 2462600059

Symbol: KCNA3_HUMAN

Name: Potassium voltage-gated channel subfamily A member 3

UniProtKB Accession Codes:

P22001 B2RA23 Q5VWN2 Q6P2D3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 2 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EMBL 10 EMDB 4 Ensembl 5 EvolutionaryTrace 1 GO 20 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PRINTS 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7829094

Title: Confirmation of the assignment of the gene encoding Kv1.3, a voltage-gated potassium channel (KCNA3) to the proximal short arm of human chromosome 1.

PubMed ID: 7829094

DOI: 10.1006/geno.1994.1500

PubMed ID: 1986382

Title: Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel.

PubMed ID: 1986382

DOI: 10.1073/pnas.88.1.53

PubMed ID: 1373731

Title: Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.

PubMed ID: 1373731

DOI: 10.1016/s0021-9258(18)42492-1

PubMed ID: 1547020

Title: Characterization and functional expression of genomic DNA encoding the human lymphocyte type n potassium channel.

PubMed ID: 1547020

DOI: 10.1089/dna.1992.11.163

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 36852591

Title: Characterization of endogenous Kv1.3 channel isoforms in T cells.

PubMed ID: 36852591

DOI: 10.1002/jcp.30984

Sequence Information:

  • Length: 575
  • Mass: 63842
  • Checksum: 0E98905187A85F48
  • Sequence:
    • MDERLSLLRS PPPPSARHRA HPPQRPASSG GAHTLVNHGY AEPAAGRELP PDMTVVPGDH 
LLEPEVADGG GAPPQGGCGG GGCDRYEPLP PSLPAAGEQD CCGERVVINI SGLRFETQLK 
TLCQFPETLL GDPKRRMRYF DPLRNEYFFD RNRPSFDAIL YYYQSGGRIR RPVNVPIDIF 
SEEIRFYQLG EEAMEKFRED EGFLREEERP LPRRDFQRQV WLLFEYPESS GPARGIAIVS 
VLVILISIVI FCLETLPEFR DEKDYPASTS QDSFEAAGNS TSGSRAGASS FSDPFFVVET 
LCIIWFSFEL LVRFFACPSK ATFSRNIMNL IDIVAIIPYF ITLGTELAER QGNGQQAMSL 
AILRVIRLVR VFRIFKLSRH SKGLQILGQT LKASMRELGL LIFFLFIGVI LFSSAVYFAE 
ADDPTSGFSS IPDAFWWAVV TMTTVGYGDM HPVTIGGKIV GSLCAIAGVL TIALPVPVIV 
SNFNYFYHRE TEGEEQSQYM HVGSCQHLSS SAEELRKARS NSTLSKSEYM VIEEGGMNHS 
AFPQTPFKTG NSTATCTTNN NPNSCVNIKK IFTDV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.