Details for: KCNN3

Gene ID: 3782

Symbol: KCNN3

Ensembl ID: ENSG00000143603

Description: potassium calcium-activated channel subfamily N member 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.04
    Marker Score: 25686
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.96
    Marker Score: 63256
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.58
    Marker Score: 1698
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.93
    Marker Score: 19930
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.91
    Marker Score: 1659
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.62
    Marker Score: 507
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1165
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.52
    Marker Score: 57806
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5
    Marker Score: 1496
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.49
    Marker Score: 8946
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168836
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.47
    Marker Score: 21982
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.35
    Marker Score: 11589
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.34
    Marker Score: 2732
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.26
    Marker Score: 19650
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.23
    Marker Score: 1652
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4802
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.12
    Marker Score: 371
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.12
    Marker Score: 1730
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1
    Marker Score: 4253
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.06
    Marker Score: 671
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.04
    Marker Score: 64018
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251787
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.01
    Marker Score: 2884
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71806
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48030
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.99
    Marker Score: 597
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.98
    Marker Score: 7504
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.97
    Marker Score: 659
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.97
    Marker Score: 1140.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.97
    Marker Score: 1170.5
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.96
    Marker Score: 439.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.95
    Marker Score: 3875
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5295
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.93
    Marker Score: 384
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.91
    Marker Score: 975
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5282
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.86
    Marker Score: 394
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.85
    Marker Score: 3303
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.84
    Marker Score: 271
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.82
    Marker Score: 549
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.82
    Marker Score: 3404
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.81
    Marker Score: 312
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 614
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.78
    Marker Score: 736
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.78
    Marker Score: 594
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.78
    Marker Score: 1552
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 684
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.74
    Marker Score: 287
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.73
    Marker Score: 170
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.72
    Marker Score: 1694
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.71
    Marker Score: 340
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.67
    Marker Score: 351
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.65
    Marker Score: 729
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.65
    Marker Score: 168
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.61
    Marker Score: 516
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.6
    Marker Score: 140
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.58
    Marker Score: 362
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.57
    Marker Score: 272
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.57
    Marker Score: 5398
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.55
    Marker Score: 243
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.53
    Marker Score: 1829.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.53
    Marker Score: 476
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.53
    Marker Score: 4613
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.53
    Marker Score: 17896
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.53
    Marker Score: 6949
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.53
    Marker Score: 765
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.51
    Marker Score: 252
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.51
    Marker Score: 674
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.49
    Marker Score: 516
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.48
    Marker Score: 813
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.48
    Marker Score: 195
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.47
    Marker Score: 774
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.46
    Marker Score: 9205
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.45
    Marker Score: 207
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.45
    Marker Score: 786
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.44
    Marker Score: 1114
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.43
    Marker Score: 537
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.42
    Marker Score: 799
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.42
    Marker Score: 145
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.41
    Marker Score: 350
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.41
    Marker Score: 229
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.4
    Marker Score: 209
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.4
    Marker Score: 176
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.4
    Marker Score: 3736
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.39
    Marker Score: 107
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.39
    Marker Score: 1796

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Other Information

**Key characteristics:** - KCNN3 is a member of the potassium channel superfamily, which is a large family of ion channels that are involved in a variety of cellular processes, including membrane potential, action potential generation, and synaptic transmission. - The KCNN3 gene is located on chromosome 19p13.2. - The protein is a transmembrane protein with a molecular weight of approximately 140 kDa. - The protein is a calcium-dependent potassium channel, which means that it opens when calcium ions bind to its receptor site. **Pathways and functions:** - The KCNN3 gene is involved in a variety of cellular processes, including: - Membrane potential: KCNN3 is expressed in the plasma membrane of neurons and other cells. It is a key component of the neuronal potassium channel, which is responsible for maintaining the resting membrane potential of neurons. - Action potential generation: KCNN3 is also expressed in astrocytes, which are the cells that surround neurons. It is a key component of the astrocyte action potential channel, which is responsible for generating and propagating action potentials in neurons. - Synaptic transmission: KCNN3 is also expressed in sympathetic and parasympathetic neurons. It is a key component of the presynaptic potassium channel, which is responsible for initiating synaptic transmission. **Clinical significance:** - Mutations in the KCNN3 gene have been linked to a number of human diseases, including: - Congenital stationary epilepsy: Mutations in the KCNN3 gene are a common cause of congenital stationary epilepsy, a genetic disorder that affects the brain and causes recurrent seizures. - Pseudotumor cerebri: Mutations in the KCNN3 gene are also a common cause of pseudotumor cerebri, a rare brain tumor that is characterized by the growth of benign tumors in the brain. - Autism: Mutations in the KCNN3 gene have also been linked to autism, a neurodevelopmental disorder that affects social interaction and communication.

Genular Protein ID: 399626918

Symbol: KCNN3_HUMAN

Name: Small conductance calcium-activated potassium channel protein 3

UniProtKB Accession Codes:

Q9UGI6 B1ANX0 O43517 Q86VF9 Q8WXG7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EMBL 11 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9491810

Title: Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder?

PubMed ID: 9491810

DOI: 10.1038/sj.mp.4000353

PubMed ID: 11501944

Title: Genomic organization and promoter analysis of human KCNN3 gene.

PubMed ID: 11501944

DOI: 10.1007/s100380170046

PubMed ID: 12808432

Title: Novel truncated isoform of SK3 potassium channel is a potent dominant-negative regulator of SK currents: implications in schizophrenia.

PubMed ID: 12808432

DOI: 10.1038/sj.mp.4001271

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20562108

Title: Allosteric block of KCa2 channels by apamin.

PubMed ID: 20562108

DOI: 10.1074/jbc.m110.110072

PubMed ID: 31155282

Title: Gain-of-function mutations in KCNN3 encoding the small-conductance Ca2+-activated K+ channel SK3 cause Zimmermann-Laband syndrome.

PubMed ID: 31155282

DOI: 10.1016/j.ajhg.2019.04.012

PubMed ID: 26658685

Title: A de novo mutation in KCNN3 associated with autosomal dominant idiopathic non-cirrhotic portal hypertension.

PubMed ID: 26658685

DOI: 10.1016/j.jhep.2015.11.027

Sequence Information:

  • Length: 731
  • Mass: 81385
  • Checksum: 02E5E79D7EAAAC29
  • Sequence:
    • MDTSGHFHDS GVGDLDEDPK CPCPSSGDEQ QQQQQQQQQQ QPPPPAPPAA PQQPLGPSLQ 
PQPPQLQQQQ QQQQQQQQQQ PPHPLSQLAQ LQSQPVHPGL LHSSPTAFRA PPSSNSTAIL 
HPSSRQGSQL NLNDHLLGHS PSSTATSGPG GGSRHRQASP LVHRRDSNPF TEIAMSSCKY 
SGGVMKPLSR LSASRRNLIE AETEGQPLQL FSPSNPPEIV ISSREDNHAH QTLLHHPNAT 
HNHQHAGTTA SSTTFPKANK RKNQNIGYKL GHRRALFEKR KRLSDYALIF GMFGIVVMVI 
ETELSWGLYS KDSMFSLALK CLISLSTIIL LGLIIAYHTR EVQLFVIDNG ADDWRIAMTY 
ERILYISLEM LVCAIHPIPG EYKFFWTARL AFSYTPSRAE ADVDIILSIP MFLRLYLIAR 
VMLLHSKLFT DASSRSIGAL NKINFNTRFV MKTLMTICPG TVLLVFSISL WIIAAWTVRV 
CERYHDQQDV TSNFLGAMWL ISITFLSIGY GDMVPHTYCG KGVCLLTGIM GAGCTALVVA 
VVARKLELTK AEKHVHNFMM DTQLTKRIKN AAANVLRETW LIYKHTKLLK KIDHAKVRKH 
QRKFLQAIHQ LRSVKMEQRK LSDQANTLVD LSKMQNVMYD LITELNDRSE DLEKQIGSLE 
SKLEHLTASF NSLPLLIADT LRQQQQQLLS AIIEARGVSV AVGTTHTPIS DSPIGVSSTS 
FPTPYTSSSS C

Genular Protein ID: 3670895700

Symbol: A0A087WYJ0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WYJ0

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 3 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 746
  • Mass: 82809
  • Checksum: DBAEBC1D1762C237
  • Sequence:
    • MDTSGHFHDS GVGDLDEDPK CPCPSSGDEQ QQQQQQQQQQ QPPPPAPPAA PQQPLGPSLQ 
PQPPQLQQQQ QQQQQQQQQQ PPHPLSQLAQ LQSQPVHPGL LHSSPTAFRA PPSSNSTAIL 
HPSSRQGSQL NLNDHLLGHS PSSTATSGPG GGSRHRQASP LVHRRDSNPF TEIAMSSCKY 
SGGVMKPLSR LSASRRNLIE AETEGQPLQL FSPSNPPEIV ISSREDNHAH QTLLHHPNAT 
HNHQHAGTTA SSTTFPKANK RKNQNIGYKL GHRRALFEKR KRLSDYALIF GMFGIVVMVI 
ETELSWGLYS KDSMFSLALK CLISLSTIIL LGLIIAYHTR EVQLFVIDNG ADDWRIAMTY 
ERILYISLEM LVCAIHPIPG EYKFFWTARL AFSYTPSRAE ADVDIILSIP MFLRLYLIAR 
VMLLHSKLFT DASSRSIGAL NKINFNTRFV MKTLMTICPG TVLLVFSISL WIIAAWTVRV 
CESPESPAQP SGSSLPAWYH DQQDVTSNFL GAMWLISITF LSIGYGDMVP HTYCGKGVCL 
LTGIMGAGCT ALVVAVVARK LELTKAEKHV HNFMMDTQLT KRIKNAAANV LRETWLIYKH 
TKLLKKIDHA KVRKHQRKFL QAIHQLRSVK MEQRKLSDQA NTLVDLSKMQ NVMYDLITEL 
NDRSEDLEKQ IGSLESKLEH LTASFNSLPL LIADTLRQQQ QQLLSAIIEA RGVSVAVGTT 
HTPISDSPIG VSSTSFPTPY TSSSSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.