Details for: KPNB1

Gene ID: 3837

Symbol: KPNB1

Ensembl ID: ENSG00000108424

Description: karyopherin subunit beta 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.46
    Marker Score: 2624.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.43
    Marker Score: 43050
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.13
    Marker Score: 2239
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.12
    Marker Score: 1240
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.11
    Marker Score: 117899.5
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.11
    Marker Score: 2964
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.07
    Marker Score: 2981
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.07
    Marker Score: 2085
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.06
    Marker Score: 2198
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.05
    Marker Score: 1933
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.05
    Marker Score: 23784
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.03
    Marker Score: 485
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 2.01
    Marker Score: 1257
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.01
    Marker Score: 69693
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.97
    Marker Score: 5354.5
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.96
    Marker Score: 1012
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.94
    Marker Score: 10198
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.94
    Marker Score: 7925.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.93
    Marker Score: 2493
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.93
    Marker Score: 6094
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.92
    Marker Score: 101686
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.92
    Marker Score: 64907.5
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.91
    Marker Score: 5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.91
    Marker Score: 19230
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.89
    Marker Score: 1636
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.89
    Marker Score: 4445
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.89
    Marker Score: 769
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.88
    Marker Score: 3338
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.88
    Marker Score: 7840
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.88
    Marker Score: 2768
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.88
    Marker Score: 19005.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.87
    Marker Score: 21068
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.87
    Marker Score: 12156.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.84
    Marker Score: 1338
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.84
    Marker Score: 3833
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.83
    Marker Score: 2592
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.81
    Marker Score: 5367
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.8
    Marker Score: 1939.5
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.79
    Marker Score: 1023
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.79
    Marker Score: 1405
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.79
    Marker Score: 624
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.79
    Marker Score: 10609
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.78
    Marker Score: 3031.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.77
    Marker Score: 4042.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.77
    Marker Score: 1705
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.76
    Marker Score: 1875
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.76
    Marker Score: 1866
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.75
    Marker Score: 23129
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.75
    Marker Score: 1325
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.75
    Marker Score: 2194.5
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.75
    Marker Score: 432
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.74
    Marker Score: 1093
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.74
    Marker Score: 2314
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.74
    Marker Score: 1185
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.74
    Marker Score: 2851
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.74
    Marker Score: 1811
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.73
    Marker Score: 1961.5
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.73
    Marker Score: 1220
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.72
    Marker Score: 2998
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.72
    Marker Score: 2013
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.72
    Marker Score: 6743.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.71
    Marker Score: 16961
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.71
    Marker Score: 1168
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.71
    Marker Score: 1714
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.71
    Marker Score: 22928.5
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.7
    Marker Score: 829
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.7
    Marker Score: 1847
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.68
    Marker Score: 2325
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.68
    Marker Score: 1580
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.67
    Marker Score: 811.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.67
    Marker Score: 4071.5
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.66
    Marker Score: 2239
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.66
    Marker Score: 674
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.66
    Marker Score: 938
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.65
    Marker Score: 379
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.65
    Marker Score: 808
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.65
    Marker Score: 592
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.65
    Marker Score: 16990
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.64
    Marker Score: 469
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.64
    Marker Score: 6695
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.64
    Marker Score: 100846.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.64
    Marker Score: 7573
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.64
    Marker Score: 617
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.63
    Marker Score: 870
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.63
    Marker Score: 1085
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 1.63
    Marker Score: 1050
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.63
    Marker Score: 948
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.63
    Marker Score: 1452
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.62
    Marker Score: 3291
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.62
    Marker Score: 1564
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 1.62
    Marker Score: 451
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.62
    Marker Score: 3150
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.61
    Marker Score: 465
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.61
    Marker Score: 571
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.61
    Marker Score: 1479
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.6
    Marker Score: 1073
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.6
    Marker Score: 3522
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.6
    Marker Score: 844
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.6
    Marker Score: 13765.5
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 1.6
    Marker Score: 454

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Other Information

## Summary KPNB1 is a protein that is involved in the regulation of cell cycle progression and apoptosis. It is a key component of the pre-replicative complex, which is responsible for initiating DNA replication. KPNB1 is also involved in the assembly of the cell cycle regulatory protein p53, which is a key regulator of cell cycle arrest and apoptosis. ## Key characteristics * KPNB1 is a protein of the immunoglobulin superfamily. * It is expressed in a variety of cell types, including skeletal muscle satellite stem cells, cortical cells of the adrenal gland, conjunctival epithelial cells, secondary lens fibers, CD14-positive and CD16-negative classical monocytes, chromaffin cells, oogonial cells, fraction A pre-pro B cells, neural crest cells, and migratory enteric neural crest cells. * It is a highly conserved protein, with a sequence that is found in mammals, birds, and fish. ## Pathways and functions * KPNB1 is involved in the regulation of cell cycle progression and apoptosis. * It is a key component of the pre-replicative complex, which is responsible for initiating DNA replication. * It also plays a role in the assembly of the cell cycle regulatory protein p53, which is a key regulator of cell cycle arrest and apoptosis. * KPNB1 is also involved in the regulation of inflammation and immune responses. * It is expressed in high levels in skeletal muscle and cardiac cells, where it plays a role in the regulation of muscle growth and development. * It is also expressed in immune cells, where it plays a role in the regulation of inflammation and immune responses. ## Clinical significance KPNB1 gene variants have been linked to a number of human diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. These variants are often associated with the development of cancer cells, and they can lead to the development of tumors. KPNB1 is a promising target for the development of new therapies for cancer and other diseases that are caused by mutations in this gene.

Genular Protein ID: 2106567679

Symbol: IMB1_HUMAN

Name: Importin subunit beta-1

UniProtKB Accession Codes:

Q14974 B7ZAV6 D3DTT3 Q14637 Q53XN2 Q96J27

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 8 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EMDB 2 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 14 PIR 1 PRIDE 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 13 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7615630

Title: Sequence and characterization of cytoplasmic nuclear protein import factor p97.

PubMed ID: 7615630

DOI: 10.1083/jcb.130.2.265

PubMed ID: 7627554

Title: Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope.

PubMed ID: 7627554

DOI: 10.1016/s0960-9822(95)00079-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8617227

Title: The conserved amino-terminal domain of hSRP1 alpha is essential for nuclear protein import.

PubMed ID: 8617227

DOI: 10.1002/j.1460-2075.1996.tb00531.x

PubMed ID: 8692944

Title: Nuclear protein import: Ran-GTP dissociates the karyopherin alphabeta heterodimer by displacing alpha from an overlapping binding site on beta.

PubMed ID: 8692944

DOI: 10.1073/pnas.93.14.7059

PubMed ID: 9405152

Title: Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta.

PubMed ID: 9405152

DOI: 10.1006/jmbi.1997.1420

PubMed ID: 9670026

Title: Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure.

PubMed ID: 9670026

DOI: 10.1093/emboj/17.14.4114

PubMed ID: 9687515

Title: Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells.

PubMed ID: 9687515

DOI: 10.1093/emboj/17.15.4491

PubMed ID: 10228156

Title: The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1.

PubMed ID: 10228156

DOI: 10.1093/emboj/18.9.2411

PubMed ID: 10209022

Title: CRM1-mediated recycling of snurportin 1 to the cytoplasm.

PubMed ID: 10209022

DOI: 10.1083/jcb.145.2.255

PubMed ID: 9891055

Title: The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals.

PubMed ID: 9891055

DOI: 10.1128/mcb.19.2.1210

PubMed ID: 9891056

Title: Importin beta can mediate the nuclear import of an arginine-rich nuclear localization signal in the absence of importin alpha.

PubMed ID: 9891056

DOI: 10.1128/mcb.19.2.1218

PubMed ID: 11682607

Title: Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin.

PubMed ID: 11682607

DOI: 10.1242/jcs.114.19.3479

PubMed ID: 11229403

Title: Role of importin-beta in coupling Ran to downstream targets in microtubule assembly.

PubMed ID: 11229403

DOI: 10.1126/science.1057661

PubMed ID: 12095920

Title: SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta.

PubMed ID: 12095920

DOI: 10.1093/hmg/11.15.1785

PubMed ID: 11891849

Title: Phosphorylation of tyrosine 256 facilitates nuclear import of atypical protein kinase C.

PubMed ID: 11891849

DOI: 10.1002/jcb.10101.abs

PubMed ID: 12764225

Title: Defective importin beta recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations.

PubMed ID: 12764225

DOI: 10.1073/pnas.1137864100

PubMed ID: 15297880

Title: Regulation of human SRY subcellular distribution by its acetylation/deacetylation.

PubMed ID: 15297880

DOI: 10.1038/sj.emboj.7600352

PubMed ID: 16171404

Title: Nuclear import of the respiratory syncytial virus matrix protein is mediated by importin beta1 independent of importin alpha.

PubMed ID: 16171404

DOI: 10.1021/bi050701e

PubMed ID: 15836774

Title: Zinc finger domain of Snail functions as a nuclear localization signal for importin beta-mediated nuclear import pathway.

PubMed ID: 15836774

DOI: 10.1111/j.1365-2443.2005.00850.x

PubMed ID: 15629770

Title: Respiratory syncytial virus M2-1 protein induces the activation of nuclear factor kappa B.

PubMed ID: 15629770

DOI: 10.1016/j.virol.2004.10.031

PubMed ID: 16704975

Title: Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1.

PubMed ID: 16704975

DOI: 10.1074/jbc.m602189200

PubMed ID: 17209048

Title: Human DNA replication-related element binding factor (hDREF) self-association via hATC domain is necessary for its nuclear accumulation and DNA binding.

PubMed ID: 17209048

DOI: 10.1074/jbc.m607180200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19386897

Title: Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors.

PubMed ID: 19386897

DOI: 10.1242/jcs.041749

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20701745

Title: Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors.

PubMed ID: 20701745

DOI: 10.1186/1471-2121-11-63

PubMed ID: 20147401

Title: Venezuelan equine encephalitis virus capsid protein forms a tetrameric complex with CRM1 and importin alpha/beta that obstructs nuclear pore complex function.

PubMed ID: 20147401

DOI: 10.1128/jvi.02554-09

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22500989

Title: Characterization of nuclear import and export signals determining the subcellular localization of WD repeat-containing protein 42A (WDR42A).

PubMed ID: 22500989

DOI: 10.1016/j.febslet.2012.02.053

PubMed ID: 22084111

Title: POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters.

PubMed ID: 22084111

DOI: 10.1073/pnas.1117231108

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22701565

Title: PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-beta1.

PubMed ID: 22701565

DOI: 10.1371/journal.pone.0037352

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10367892

Title: Structural view of the Ran-Importin beta interaction at 2.3 A resolution.

PubMed ID: 10367892

DOI: 10.1016/s0092-8674(00)80774-6

PubMed ID: 10353244

Title: Structure of importin-beta bound to the IBB domain of importin-alpha.

PubMed ID: 10353244

DOI: 10.1038/20367

PubMed ID: 10929717

Title: Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking.

PubMed ID: 10929717

DOI: 10.1016/s0092-8674(00)00014-3

PubMed ID: 12504010

Title: Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta.

PubMed ID: 12504010

DOI: 10.1016/s1097-2765(02)00727-x

PubMed ID: 18187419

Title: Molecular basis for the recognition of snurportin 1 by importin beta.

PubMed ID: 18187419

DOI: 10.1074/jbc.m709093200

PubMed ID: 20476751

Title: Conformational selection in the recognition of the snurportin importin beta binding domain by importin beta.

PubMed ID: 20476751

DOI: 10.1021/bi100292y

PubMed ID: 24699649

Title: Structural basis for the selective nuclear import of the C2H2 zinc-finger protein Snail by importin beta.

PubMed ID: 24699649

DOI: 10.1107/s1399004714000972

Sequence Information:

  • Length: 876
  • Mass: 97170
  • Checksum: F3BB8B73E7E51639
  • Sequence:
    • MELITILEKT VSPDRLELEA AQKFLERAAV ENLPTFLVEL SRVLANPGNS QVARVAAGLQ 
IKNSLTSKDP DIKAQYQQRW LAIDANARRE VKNYVLQTLG TETYRPSSAS QCVAGIACAE 
IPVNQWPELI PQLVANVTNP NSTEHMKEST LEAIGYICQD IDPEQLQDKS NEILTAIIQG 
MRKEEPSNNV KLAATNALLN SLEFTKANFD KESERHFIMQ VVCEATQCPD TRVRVAALQN 
LVKIMSLYYQ YMETYMGPAL FAITIEAMKS DIDEVALQGI EFWSNVCDEE MDLAIEASEA 
AEQGRPPEHT SKFYAKGALQ YLVPILTQTL TKQDENDDDD DWNPCKAAGV CLMLLATCCE 
DDIVPHVLPF IKEHIKNPDW RYRDAAVMAF GCILEGPEPS QLKPLVIQAM PTLIELMKDP 
SVVVRDTAAW TVGRICELLP EAAINDVYLA PLLQCLIEGL SAEPRVASNV CWAFSSLAEA 
AYEAADVADD QEEPATYCLS SSFELIVQKL LETTDRPDGH QNNLRSSAYE SLMEIVKNSA 
KDCYPAVQKT TLVIMERLQQ VLQMESHIQS TSDRIQFNDL QSLLCATLQN VLRKVQHQDA 
LQISDVVMAS LLRMFQSTAG SGGVQEDALM AVSTLVEVLG GEFLKYMEAF KPFLGIGLKN 
YAEYQVCLAA VGLVGDLCRA LQSNIIPFCD EVMQLLLENL GNENVHRSVK PQILSVFGDI 
ALAIGGEFKK YLEVVLNTLQ QASQAQVDKS DYDMVDYLNE LRESCLEAYT GIVQGLKGDQ 
ENVHPDVMLV QPRVEFILSF IDHIAGDEDH TDGVVACAAG LIGDLCTAFG KDVLKLVEAR 
PMIHELLTEG RRSKTNKAKT LATWATKELR KLKNQA

Genular Protein ID: 3595725493

Symbol: B7Z752_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z752

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 731
  • Mass: 81163
  • Checksum: D3F3D648CA5FE4E2
  • Sequence:
    • MKESTLEAIG YICQDIDPEQ LQDKSNEILT AIIQGMRKEE PSNNVKLAAT NALLNSLEFT 
KANFDKESER HFIMQVVCEA TQCPDTRVRV AALQNLVKIM SLYYQYMETY MGPALFAITI 
EAMKSDIDEV ALQGIEFWSN VCDEEMDLAI EASEAAEQGR PPEHTSKFYA KGALQYLVPI 
LTQTLTKQDE NDDDDDWNPC KAAGVCLMLL ATCCEDDIVP HVLPFIKEHI KNPDWRYRDA 
AVMAFGCILE GPEPSQLKPL VIQAMPTLIE LMKDPSVVVR DTAAWTVGRI CELLPEAAIN 
DVYLAPLLQC LIEGLSAEPR VASNVCWAFS SLAEAAYEAA DVADDQEEPA TYCLSSSFEL 
IVQKLPETTD RPDGHQNNLR SSAYESLMEI VKNSAKDCYP AVQKTTLVIM ERLQQVLQME 
SHIQSTSDRI QFNDLQSLLC ATLQNVLRKV QHQDALQISD VVMASLLRMF QSTAGSGGVQ 
EDALMAVSTL VEVLGGEFLK YMEAFKPFLG IGLKNYAEYQ VCLAAVGLVG DLCRALQSNI 
IPFCDEVMQL LLENLGNENV HRSVKPQILS VFGDIALAIG GEFKKYLEVV LNTLQQASQA 
QVDKSDYDMV DYLNELRESC LEAYTGIVQG LKGDQENVHP DVMLVQPRVE FILSFIDHIA 
GDEDHTDGVV ACAAGLIGDL CTAFGKDVLK LVEARPMIHE LLTEGRRSKT NKAKTLATWA 
TKELRKLKNQ A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.