KPNB1 | ENSG00000108424 | NCBI 3837

Details for: KPNB1

Gene ID: 3837

Symbol: KPNB1

Ensembl ID: ENSG00000108424

Description: karyopherin subunit beta 1

Associated with

Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Apoptosis
(R-HSA-109581)
Apoptosis induced dna fragmentation
(R-HSA-140342)
Apoptotic execution phase
(R-HSA-75153)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
Bacterial infection pathways
(R-HSA-9824439)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infection with mycobacterium tuberculosis
(R-HSA-9635486)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Inhibition of nitric oxide production
(R-HSA-9636249)
Initiation of nuclear envelope (ne) reformation
(R-HSA-2995383)
Innate immune system
(R-HSA-168249)
Interactions of rev with host cellular proteins
(R-HSA-177243)
Interferon alpha/beta signaling
(R-HSA-909733)
Interferon signaling
(R-HSA-913531)
Isg15 antiviral mechanism
(R-HSA-1169408)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of steroids
(R-HSA-8957322)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neutrophil degranulation
(R-HSA-6798695)
Ns1 mediated effects on host pathways
(R-HSA-168276)
Nuclear envelope (ne) reassembly
(R-HSA-2995410)
Nuclear import of rev protein
(R-HSA-180746)
Postmitotic nuclear pore complex (npc) reformation
(R-HSA-9615933)
Programmed cell death
(R-HSA-5357801)
Regulation of cholesterol biosynthesis by srebp (srebf)
(R-HSA-1655829)
Response of mtb to phagocytosis
(R-HSA-9637690)
Sars-cov-1 activates/modulates innate immune responses
(R-HSA-9692916)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov infections
(R-HSA-9679506)
Suppression of phagosomal maturation
(R-HSA-9637687)
Transport of ribonucleoproteins into the host nucleus
(R-HSA-168271)
Viral infection pathways
(R-HSA-9824446)
Astral microtubule organization
(GO:0030953)
Cytoplasm
(GO:0005737)
Cytoplasmic stress granule
(GO:0010494)
Cytosol
(GO:0005829)
Endoplasmic reticulum tubular network
(GO:0071782)
Enzyme binding
(GO:0019899)
Establishment of mitotic spindle localization
(GO:0040001)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Ficolin-1-rich granule lumen
(GO:1904813)
Hsp90 protein binding
(GO:0051879)
Importin-alpha family protein binding
(GO:0061676)
Membrane
(GO:0016020)
Mitotic chromosome movement towards spindle pole
(GO:0007079)
Mitotic metaphase chromosome alignment
(GO:0007080)
Mitotic spindle assembly
(GO:0090307)
Nls-bearing protein import into nucleus
(GO:0006607)
Nls-dependent protein nuclear import complex
(GO:0042564)
Nuclear envelope
(GO:0005635)
Nuclear import signal receptor activity
(GO:0061608)
Nuclear localization sequence binding
(GO:0008139)
Nuclear membrane
(GO:0031965)
Nuclear pore
(GO:0005643)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein import into nucleus
(GO:0006606)
Ribosomal protein import into nucleus
(GO:0006610)
Rna binding
(GO:0003723)
Rna import into nucleus
(GO:0006404)
Small gtpase binding
(GO:0031267)
Specific granule lumen
(GO:0035580)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 434.6003
Cell Significance Index: -67.6000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 253.2690
Cell Significance Index: -64.2400
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 196.1900
Cell Significance Index: -80.8200
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 174.6474
Cell Significance Index: -82.4600
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 171.6401
Cell Significance Index: -69.7300
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 152.2011
Cell Significance Index: -78.2900
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 123.1629
Cell Significance Index: -82.6500
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 73.4648
Cell Significance Index: -70.1400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 62.2731
Cell Significance Index: -76.7800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 27.3680
Cell Significance Index: -73.3200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 19.9998
Cell Significance Index: -78.9200
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 19.4403
Cell Significance Index: -59.7100
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 16.0012
Cell Significance Index: -35.0200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.9526
Cell Significance Index: 78.8400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.0137
Cell Significance Index: 399.6200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.8419
Cell Significance Index: 252.9500
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.8159
Cell Significance Index: 197.5200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.8107
Cell Significance Index: 363.2300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.6740
Cell Significance Index: 205.8300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.6668
Cell Significance Index: 46.5800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.6538
Cell Significance Index: 298.1400
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.5075
Cell Significance Index: 823.2800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.4979
Cell Significance Index: 70.4000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.4405
Cell Significance Index: 92.9400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.4346
Cell Significance Index: 39.0500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.4189
Cell Significance Index: 167.3400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.2653
Cell Significance Index: 43.9700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.1215
Cell Significance Index: 30.0000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.0566
Cell Significance Index: 378.9900
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.9972
Cell Significance Index: 26.2200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.9717
Cell Significance Index: 429.5900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.9264
Cell Significance Index: 65.5200
Cell Name: lactocyte (CL0002325)
Fold Change: 0.8861
Cell Significance Index: 114.4800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.8777
Cell Significance Index: 49.2500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.7582
Cell Significance Index: 35.3500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6919
Cell Significance Index: 19.9400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.5943
Cell Significance Index: 44.2900
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.5274
Cell Significance Index: 27.4700
Cell Name: odontoblast (CL0000060)
Fold Change: 0.5265
Cell Significance Index: 67.5000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.4631
Cell Significance Index: 8.5600
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4369
Cell Significance Index: 394.4500
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4175
Cell Significance Index: 41.3000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3647
Cell Significance Index: 18.9500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3559
Cell Significance Index: 60.7800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.3171
Cell Significance Index: 16.6500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2594
Cell Significance Index: 11.7600
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2471
Cell Significance Index: 170.8900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1500
Cell Significance Index: 203.8900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1185
Cell Significance Index: 9.1000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1158
Cell Significance Index: 217.9600
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.1151
Cell Significance Index: 2.4100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1092
Cell Significance Index: 20.7800
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0869
Cell Significance Index: 160.2600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0705
Cell Significance Index: 108.5200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0703
Cell Significance Index: 4.7300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0615
Cell Significance Index: 3.7800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0273
Cell Significance Index: 17.3700
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0199
Cell Significance Index: 0.7000
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0058
Cell Significance Index: -4.2700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0077
Cell Significance Index: -3.4900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0117
Cell Significance Index: -8.8700
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0237
Cell Significance Index: -0.6400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0390
Cell Significance Index: -28.9100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0469
Cell Significance Index: -29.2900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0675
Cell Significance Index: -1.1300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0855
Cell Significance Index: -8.7400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1109
Cell Significance Index: -62.5700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.1679
Cell Significance Index: -27.3100
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1726
Cell Significance Index: -5.0700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1885
Cell Significance Index: -39.7000
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.2183
Cell Significance Index: -2.0100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2422
Cell Significance Index: -69.7000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2791
Cell Significance Index: -40.5700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2859
Cell Significance Index: -18.0200
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2867
Cell Significance Index: -12.6800
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.3459
Cell Significance Index: -3.7600
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.3509
Cell Significance Index: -2.1200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3906
Cell Significance Index: -44.7500
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4086
Cell Significance Index: -46.6400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4192
Cell Significance Index: -5.7200
Cell Name: peg cell (CL4033014)
Fold Change: -0.4510
Cell Significance Index: -10.4200
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.4575
Cell Significance Index: -9.4900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4643
Cell Significance Index: -54.1100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4678
Cell Significance Index: -13.4100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4893
Cell Significance Index: -18.5300
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.5766
Cell Significance Index: -14.7300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5981
Cell Significance Index: -62.2800
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.7363
Cell Significance Index: -14.3700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7412
Cell Significance Index: -23.7400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.7925
Cell Significance Index: -17.1700
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.8138
Cell Significance Index: -64.4500
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.8327
Cell Significance Index: -14.2700
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.8950
Cell Significance Index: -25.5400
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.9026
Cell Significance Index: -10.7600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.9165
Cell Significance Index: -22.9100
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -1.0316
Cell Significance Index: -11.7200
Cell Name: Purkinje cell (CL0000121)
Fold Change: -1.1655
Cell Significance Index: -25.5200
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.1998
Cell Significance Index: -30.8400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.2727
Cell Significance Index: -78.0300
Cell Name: cortical interneuron (CL0008031)
Fold Change: -1.3585
Cell Significance Index: -32.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** * KPNB1 is a nuclear importin subunit that facilitates the transport of proteins into the nucleus. * The protein is involved in apoptosis, particularly in the execution phase, and is required for the assembly of the orca complex at the origin of replication. * KPNB1 is also involved in the regulation of cholesterol biosynthesis, working in conjunction with the sterol regulatory element-binding protein (SREBP). * The protein interacts with various signaling pathways, including interferon alpha/beta signaling, cytokine signaling in the immune system, and the response to viral infections. * KPNB1 is expressed in multiple cell types, including immune cells, and has been implicated in the pathogenesis of various diseases, including HIV infection and SARS-CoV-1. **Pathways and Functions** KPNB1 is involved in a wide range of cellular processes, including: * **Nuclear Import**: KPNB1 functions as a nuclear importin, facilitating the transport of proteins into the nucleus. * **Apoptosis**: KPNB1 is involved in the execution phase of apoptosis, working in conjunction with other proteins to regulate programmed cell death. * **Cholesterol Biosynthesis**: KPNB1 interacts with SREBP to regulate cholesterol biosynthesis. * **Immune Response**: KPNB1 is expressed in immune cells and has been implicated in the response to viral infections, including HIV and SARS-CoV-1. * **Viral Infection**: KPNB1 plays a role in the assembly of viral particles and the regulation of viral replication. * **Cell Cycle**: KPNB1 is involved in the regulation of the cell cycle, particularly in the assembly of the mitotic spindle and the regulation of mitotic metaphase. **Clinical Significance** KPNB1 has been implicated in the pathogenesis of various diseases, including: * **HIV Infection**: KPNB1 is expressed in HIV-infected cells and has been shown to be involved in the regulation of viral replication. * **SARS-CoV-1 Infection**: KPNB1 plays a role in the response to SARS-CoV-1 infection, working in conjunction with other proteins to regulate viral replication. * **Immune System Disorders**: KPNB1 has been implicated in the regulation of immune responses and has been shown to be expressed in cells involved in immune system disorders, such as multiple sclerosis. * **Cancer**: KPNB1 has been shown to be involved in the regulation of apoptosis and has been implicated in the pathogenesis of various cancers. In conclusion, KPNB1 is a gene that encodes a protein involved in various cellular processes, including nuclear import, apoptosis, and immune response. The protein's functions and pathways are diverse, involving interactions with other proteins, signaling pathways, and cellular compartments. KPNB1 has been implicated in the pathogenesis of various diseases, including HIV infection, SARS-CoV-1 infection, and immune system disorders. Further research is needed to fully understand the role of KPNB1 in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Importin subunit beta-1
B7Z752_HUMAN

Genular Protein ID: 2106567679

Symbol: IMB1_HUMAN

Name: Importin subunit beta-1

UniProtKB Accession Codes:

Q14974 B7ZAV6 D3DTT3 Q14637 Q53XN2 Q96J27

Database IDs:

Citations:

PubMed ID: 7615630

Title: Sequence and characterization of cytoplasmic nuclear protein import factor p97.

PubMed ID: 7615630

DOI: 10.1083/jcb.130.2.265

PubMed ID: 7627554

Title: Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope.

PubMed ID: 7627554

DOI: 10.1016/s0960-9822(95)00079-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8617227

Title: The conserved amino-terminal domain of hSRP1 alpha is essential for nuclear protein import.

PubMed ID: 8617227

DOI: 10.1002/j.1460-2075.1996.tb00531.x

PubMed ID: 8692944

Title: Nuclear protein import: Ran-GTP dissociates the karyopherin alphabeta heterodimer by displacing alpha from an overlapping binding site on beta.

PubMed ID: 8692944

DOI: 10.1073/pnas.93.14.7059

PubMed ID: 9405152

Title: Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta.

PubMed ID: 9405152

DOI: 10.1006/jmbi.1997.1420

PubMed ID: 9670026

Title: Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure.

PubMed ID: 9670026

DOI: 10.1093/emboj/17.14.4114

PubMed ID: 9687515

Title: Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells.

PubMed ID: 9687515

DOI: 10.1093/emboj/17.15.4491

PubMed ID: 10228156

Title: The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1.

PubMed ID: 10228156

DOI: 10.1093/emboj/18.9.2411

PubMed ID: 10209022

Title: CRM1-mediated recycling of snurportin 1 to the cytoplasm.

PubMed ID: 10209022

DOI: 10.1083/jcb.145.2.255

PubMed ID: 9891055

Title: The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals.

PubMed ID: 9891055

DOI: 10.1128/mcb.19.2.1210

PubMed ID: 9891056

Title: Importin beta can mediate the nuclear import of an arginine-rich nuclear localization signal in the absence of importin alpha.

PubMed ID: 9891056

DOI: 10.1128/mcb.19.2.1218

PubMed ID: 11682607

Title: Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin.

PubMed ID: 11682607

DOI: 10.1242/jcs.114.19.3479

PubMed ID: 11229403

Title: Role of importin-beta in coupling Ran to downstream targets in microtubule assembly.

PubMed ID: 11229403

DOI: 10.1126/science.1057661

PubMed ID: 12095920

Title: SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta.

PubMed ID: 12095920

DOI: 10.1093/hmg/11.15.1785

PubMed ID: 11891849

Title: Phosphorylation of tyrosine 256 facilitates nuclear import of atypical protein kinase C.

PubMed ID: 11891849

DOI: 10.1002/jcb.10101.abs

PubMed ID: 12764225

Title: Defective importin beta recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations.

PubMed ID: 12764225

DOI: 10.1073/pnas.1137864100

PubMed ID: 15297880

Title: Regulation of human SRY subcellular distribution by its acetylation/deacetylation.

PubMed ID: 15297880

DOI: 10.1038/sj.emboj.7600352

PubMed ID: 16171404

Title: Nuclear import of the respiratory syncytial virus matrix protein is mediated by importin beta1 independent of importin alpha.

PubMed ID: 16171404

DOI: 10.1021/bi050701e

PubMed ID: 15836774

Title: Zinc finger domain of Snail functions as a nuclear localization signal for importin beta-mediated nuclear import pathway.

PubMed ID: 15836774

DOI: 10.1111/j.1365-2443.2005.00850.x

PubMed ID: 15629770

Title: Respiratory syncytial virus M2-1 protein induces the activation of nuclear factor kappa B.

PubMed ID: 15629770

DOI: 10.1016/j.virol.2004.10.031

PubMed ID: 16704975

Title: Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1.

PubMed ID: 16704975

DOI: 10.1074/jbc.m602189200

PubMed ID: 17209048

Title: Human DNA replication-related element binding factor (hDREF) self-association via hATC domain is necessary for its nuclear accumulation and DNA binding.

PubMed ID: 17209048

DOI: 10.1074/jbc.m607180200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19386897

Title: Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors.

PubMed ID: 19386897

DOI: 10.1242/jcs.041749

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20701745

Title: Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors.

PubMed ID: 20701745

DOI: 10.1186/1471-2121-11-63

PubMed ID: 20818336

Title: An actin-regulated importin alpha/beta-dependent extended bipartite NLS directs nuclear import of MRTF-A.

PubMed ID: 20818336

DOI: 10.1038/emboj.2010.216

PubMed ID: 20147401

Title: Venezuelan equine encephalitis virus capsid protein forms a tetrameric complex with CRM1 and importin alpha/beta that obstructs nuclear pore complex function.

PubMed ID: 20147401

DOI: 10.1128/jvi.02554-09

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22500989

Title: Characterization of nuclear import and export signals determining the subcellular localization of WD repeat-containing protein 42A (WDR42A).

PubMed ID: 22500989

DOI: 10.1016/j.febslet.2012.02.053

PubMed ID: 22084111

Title: POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters.

PubMed ID: 22084111

DOI: 10.1073/pnas.1117231108

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22701565

Title: PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-beta1.

PubMed ID: 22701565

DOI: 10.1371/journal.pone.0037352

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10367892

Title: Structural view of the Ran-Importin beta interaction at 2.3 A resolution.

PubMed ID: 10367892

DOI: 10.1016/s0092-8674(00)80774-6

PubMed ID: 10353244

Title: Structure of importin-beta bound to the IBB domain of importin-alpha.

PubMed ID: 10353244

DOI: 10.1038/20367

PubMed ID: 10929717

Title: Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking.

PubMed ID: 10929717

DOI: 10.1016/s0092-8674(00)00014-3

PubMed ID: 12504010

Title: Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta.

PubMed ID: 12504010

DOI: 10.1016/s1097-2765(02)00727-x

PubMed ID: 18187419

Title: Molecular basis for the recognition of snurportin 1 by importin beta.

PubMed ID: 18187419

DOI: 10.1074/jbc.m709093200

PubMed ID: 20476751

Title: Conformational selection in the recognition of the snurportin importin beta binding domain by importin beta.

PubMed ID: 20476751

DOI: 10.1021/bi100292y

PubMed ID: 24699649

Title: Structural basis for the selective nuclear import of the C2H2 zinc-finger protein Snail by importin beta.

PubMed ID: 24699649

DOI: 10.1107/s1399004714000972

Sequence Information:

Length: 876
Mass: 97170
Checksum: F3BB8B73E7E51639
Sequence:

MELITILEKT VSPDRLELEA AQKFLERAAV ENLPTFLVEL SRVLANPGNS QVARVAAGLQ 
IKNSLTSKDP DIKAQYQQRW LAIDANARRE VKNYVLQTLG TETYRPSSAS QCVAGIACAE 
IPVNQWPELI PQLVANVTNP NSTEHMKEST LEAIGYICQD IDPEQLQDKS NEILTAIIQG 
MRKEEPSNNV KLAATNALLN SLEFTKANFD KESERHFIMQ VVCEATQCPD TRVRVAALQN 
LVKIMSLYYQ YMETYMGPAL FAITIEAMKS DIDEVALQGI EFWSNVCDEE MDLAIEASEA 
AEQGRPPEHT SKFYAKGALQ YLVPILTQTL TKQDENDDDD DWNPCKAAGV CLMLLATCCE 
DDIVPHVLPF IKEHIKNPDW RYRDAAVMAF GCILEGPEPS QLKPLVIQAM PTLIELMKDP 
SVVVRDTAAW TVGRICELLP EAAINDVYLA PLLQCLIEGL SAEPRVASNV CWAFSSLAEA 
AYEAADVADD QEEPATYCLS SSFELIVQKL LETTDRPDGH QNNLRSSAYE SLMEIVKNSA 
KDCYPAVQKT TLVIMERLQQ VLQMESHIQS TSDRIQFNDL QSLLCATLQN VLRKVQHQDA 
LQISDVVMAS LLRMFQSTAG SGGVQEDALM AVSTLVEVLG GEFLKYMEAF KPFLGIGLKN 
YAEYQVCLAA VGLVGDLCRA LQSNIIPFCD EVMQLLLENL GNENVHRSVK PQILSVFGDI 
ALAIGGEFKK YLEVVLNTLQ QASQAQVDKS DYDMVDYLNE LRESCLEAYT GIVQGLKGDQ 
ENVHPDVMLV QPRVEFILSF IDHIAGDEDH TDGVVACAAG LIGDLCTAFG KDVLKLVEAR 
PMIHELLTEG RRSKTNKAKT LATWATKELR KLKNQA

Genular Protein ID: 3595725493

Symbol: B7Z752_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z752

Database IDs:

Sequence Information:

Length: 731
Mass: 81163
Checksum: D3F3D648CA5FE4E2
Sequence:

MKESTLEAIG YICQDIDPEQ LQDKSNEILT AIIQGMRKEE PSNNVKLAAT NALLNSLEFT 
KANFDKESER HFIMQVVCEA TQCPDTRVRV AALQNLVKIM SLYYQYMETY MGPALFAITI 
EAMKSDIDEV ALQGIEFWSN VCDEEMDLAI EASEAAEQGR PPEHTSKFYA KGALQYLVPI 
LTQTLTKQDE NDDDDDWNPC KAAGVCLMLL ATCCEDDIVP HVLPFIKEHI KNPDWRYRDA 
AVMAFGCILE GPEPSQLKPL VIQAMPTLIE LMKDPSVVVR DTAAWTVGRI CELLPEAAIN 
DVYLAPLLQC LIEGLSAEPR VASNVCWAFS SLAEAAYEAA DVADDQEEPA TYCLSSSFEL 
IVQKLPETTD RPDGHQNNLR SSAYESLMEI VKNSAKDCYP AVQKTTLVIM ERLQQVLQME 
SHIQSTSDRI QFNDLQSLLC ATLQNVLRKV QHQDALQISD VVMASLLRMF QSTAGSGGVQ 
EDALMAVSTL VEVLGGEFLK YMEAFKPFLG IGLKNYAEYQ VCLAAVGLVG DLCRALQSNI 
IPFCDEVMQL LLENLGNENV HRSVKPQILS VFGDIALAIG GEFKKYLEVV LNTLQQASQA 
QVDKSDYDMV DYLNELRESC LEAYTGIVQG LKGDQENVHP DVMLVQPRVE FILSFIDHIA 
GDEDHTDGVV ACAAGLIGDL CTAFGKDVLK LVEARPMIHE LLTEGRRSKT NKAKTLATWA 
TKELRKLKNQ A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: KPNB1

Associated with

Cells (max top 100)

Other Information

Sequence and characterization of cytoplasmic nuclear protein import factor p97. PubMed ID: 7615630

Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope. PubMed ID: 7627554

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The conserved amino-terminal domain of hSRP1 alpha is essential for nuclear protein import. PubMed ID: 8617227

Nuclear protein import: Ran-GTP dissociates the karyopherin alphabeta heterodimer by displacing alpha from an overlapping binding site on beta. PubMed ID: 8692944

Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta. PubMed ID: 9405152

Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure. PubMed ID: 9670026

Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. PubMed ID: 9687515

The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1. PubMed ID: 10228156

CRM1-mediated recycling of snurportin 1 to the cytoplasm. PubMed ID: 10209022

The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals. PubMed ID: 9891055

Importin beta can mediate the nuclear import of an arginine-rich nuclear localization signal in the absence of importin alpha. PubMed ID: 9891056

Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin. PubMed ID: 11682607

Role of importin-beta in coupling Ran to downstream targets in microtubule assembly. PubMed ID: 11229403

SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta. PubMed ID: 12095920

Phosphorylation of tyrosine 256 facilitates nuclear import of atypical protein kinase C. PubMed ID: 11891849

Defective importin beta recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations. PubMed ID: 12764225

Regulation of human SRY subcellular distribution by its acetylation/deacetylation. PubMed ID: 15297880

Nuclear import of the respiratory syncytial virus matrix protein is mediated by importin beta1 independent of importin alpha. PubMed ID: 16171404

Zinc finger domain of Snail functions as a nuclear localization signal for importin beta-mediated nuclear import pathway. PubMed ID: 15836774

Respiratory syncytial virus M2-1 protein induces the activation of nuclear factor kappa B. PubMed ID: 15629770

Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1. PubMed ID: 16704975

Human DNA replication-related element binding factor (hDREF) self-association via hATC domain is necessary for its nuclear accumulation and DNA binding. PubMed ID: 17209048

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors. PubMed ID: 19386897

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors. PubMed ID: 20701745

An actin-regulated importin alpha/beta-dependent extended bipartite NLS directs nuclear import of MRTF-A. PubMed ID: 20818336

Venezuelan equine encephalitis virus capsid protein forms a tetrameric complex with CRM1 and importin alpha/beta that obstructs nuclear pore complex function. PubMed ID: 20147401

Initial characterization of the human central proteome. PubMed ID: 21269460

Characterization of nuclear import and export signals determining the subcellular localization of WD repeat-containing protein 42A (WDR42A). PubMed ID: 22500989

POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters. PubMed ID: 22084111

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-beta1. PubMed ID: 22701565

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Structural view of the Ran-Importin beta interaction at 2.3 A resolution. PubMed ID: 10367892

Structure of importin-beta bound to the IBB domain of importin-alpha. PubMed ID: 10353244

Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking. PubMed ID: 10929717

Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta. PubMed ID: 12504010

Molecular basis for the recognition of snurportin 1 by importin beta. PubMed ID: 18187419

Conformational selection in the recognition of the snurportin importin beta binding domain by importin beta. PubMed ID: 20476751

Structural basis for the selective nuclear import of the C2H2 zinc-finger protein Snail by importin beta. PubMed ID: 24699649