KPNB1 | ENSG00000108424 | NCBI 3837

Details for: KPNB1

Gene ID: 3837

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: KPNB1

Ensembl ID: ENSG00000108424

Description: karyopherin subunit beta 1

Cell Significance Landscape

Display Count:

Associated with

Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Apoptosis
(R-HSA-109581)
Apoptosis induced dna fragmentation
(R-HSA-140342)
Apoptotic execution phase
(R-HSA-75153)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
Bacterial infection pathways
(R-HSA-9824439)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infection with mycobacterium tuberculosis
(R-HSA-9635486)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Inhibition of nitric oxide production
(R-HSA-9636249)
Initiation of nuclear envelope (ne) reformation
(R-HSA-2995383)
Innate immune system
(R-HSA-168249)
Interactions of rev with host cellular proteins
(R-HSA-177243)
Interferon alpha/beta signaling
(R-HSA-909733)
Interferon signaling
(R-HSA-913531)
Isg15 antiviral mechanism
(R-HSA-1169408)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of steroids
(R-HSA-8957322)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neutrophil degranulation
(R-HSA-6798695)
Ns1 mediated effects on host pathways
(R-HSA-168276)
Nuclear envelope (ne) reassembly
(R-HSA-2995410)
Nuclear import of rev protein
(R-HSA-180746)
Postmitotic nuclear pore complex (npc) reformation
(R-HSA-9615933)
Programmed cell death
(R-HSA-5357801)
Regulation of cholesterol biosynthesis by srebp (srebf)
(R-HSA-1655829)
Response of mtb to phagocytosis
(R-HSA-9637690)
Sars-cov-1 activates/modulates innate immune responses
(R-HSA-9692916)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov infections
(R-HSA-9679506)
Suppression of phagosomal maturation
(R-HSA-9637687)
Transport of ribonucleoproteins into the host nucleus
(R-HSA-168271)
Viral infection pathways
(R-HSA-9824446)
Astral microtubule organization
(GO:0030953)
Cytoplasm
(GO:0005737)
Cytoplasmic stress granule
(GO:0010494)
Cytosol
(GO:0005829)
Endoplasmic reticulum tubular network
(GO:0071782)
Enzyme binding
(GO:0019899)
Establishment of mitotic spindle localization
(GO:0040001)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Ficolin-1-rich granule lumen
(GO:1904813)
Hsp90 protein binding
(GO:0051879)
Importin-alpha family protein binding
(GO:0061676)
Membrane
(GO:0016020)
Mitotic chromosome movement towards spindle pole
(GO:0007079)
Mitotic metaphase chromosome alignment
(GO:0007080)
Mitotic spindle assembly
(GO:0090307)
Nls-bearing protein import into nucleus
(GO:0006607)
Nls-dependent protein nuclear import complex
(GO:0042564)
Nuclear envelope
(GO:0005635)
Nuclear import signal receptor activity
(GO:0061608)
Nuclear localization sequence binding
(GO:0008139)
Nuclear membrane
(GO:0031965)
Nuclear pore
(GO:0005643)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein import into nucleus
(GO:0006606)
Ribosomal protein import into nucleus
(GO:0006610)
Rna binding
(GO:0003723)
Rna import into nucleus
(GO:0006404)
Small gtpase binding
(GO:0031267)
Specific granule lumen
(GO:0035580)
Zinc ion binding
(GO:0008270)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

megakaryocyte-erythroid progenitor cell CL0000050

CSI 73.63

rCSI 66.49%

PRS 15.63
hematopoietic stem cell CL0000037

CSI 58.8

rCSI 39.09%

PRS 20.96
common myeloid progenitor CL0000049

CSI 56.75

rCSI 45.88%

PRS 17.4
fallopian tube secretory epithelial cell CL4030006

CSI 44.76

rCSI 43.09%

PRS 18
granulocyte monocyte progenitor cell CL0000557

CSI 43.59

rCSI 37.74%

PRS 19.54
fraction A pre-pro B cell CL0002045

CSI 39.85

rCSI 45.62%

PRS 35.36
transit amplifying cell of colon CL0009011

CSI 37.43

rCSI 43.96%

PRS 20.29
common dendritic progenitor CL0001029

CSI 37.24

rCSI 46.74%

PRS 22.47
placental villous trophoblast CL2000060

CSI 31.42

rCSI 48.55%

PRS 16.28
promyelocyte CL0000836

CSI 28.73

rCSI 41.44%

PRS 24.34
early lymphoid progenitor CL0000936

CSI 27.45

rCSI 24.11%

PRS 19.92
conjunctival epithelial cell CL1000432

CSI 25.83

rCSI 39.46%

PRS 17.48
stem cell CL0000034

CSI 23.65

rCSI 22.8%

PRS 12.41
large pre-B-II cell CL0000957

CSI 21.1

rCSI 60.25%

PRS 30.01
lymphoid lineage restricted progenitor cell CL0000838

CSI 20.43

rCSI 79.54%

PRS 28.58
myeloid lineage restricted progenitor cell CL0000839

CSI 16.14

rCSI 83.33%

PRS 33.83
mesangial cell CL0000650

CSI 15.69

rCSI 63.95%

PRS 23.57
enteric smooth muscle cell CL0002504

CSI 15.59

rCSI 22.24%

PRS 19.55
retinal ganglion cell CL0000740

CSI 15

rCSI 33.14%

PRS 12.43
transit amplifying cell CL0009010

CSI 14.8

rCSI 22.64%

PRS 28.2
pancreatic A cell CL0000171

CSI 14.48

rCSI 15.17%

PRS 18.56
endothelial cell of placenta CL0009092

CSI 14.22

rCSI 70.09%

PRS 23.53
intestinal crypt stem cell of small intestine CL0009017

CSI 14.18

rCSI 38.23%

PRS 22.46
pancreatic ductal cell CL0002079

CSI 14.14

rCSI 27.51%

PRS 17.77
extravillous trophoblast CL0008036

CSI 14

rCSI 17.32%

PRS 15.22
promonocyte CL0000559

CSI 13.74

rCSI 23.55%

PRS 23.59
intestinal epithelial cell CL0002563

CSI 13.16

rCSI 13.75%

PRS 18.17
mammary gland epithelial cell CL0002327

CSI 13.04

rCSI 45.76%

PRS 30.75
transit amplifying cell of small intestine CL0009012

CSI 12.91

rCSI 56.67%

PRS 32.22
pro-B cell CL0000826

CSI 12.46

rCSI 10.32%

PRS 17.6
stromal cell of ovary CL0002132

CSI 11.77

rCSI 32.35%

PRS 28.53
L6b glutamatergic cortical neuron CL4023038

CSI 11.49

rCSI 35.9%

PRS 10.94
keratinocyte CL0000312

CSI 10.22

rCSI 8.57%

PRS 20.76
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 9.89

rCSI 24.04%

PRS 10.04
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 9.78

rCSI 35.18%

PRS 9.6
neural crest cell CL0011012

CSI 9.32

rCSI 7.37%

PRS 11.93
primitive red blood cell CL0002355

CSI 9.05

rCSI 48.85%

PRS 31.19
basophil mast progenitor cell CL0002028

CSI 8.66

rCSI 46.19%

PRS 58.77
epithelial cell of lung CL0000082

CSI 8.22

rCSI 6.81%

PRS 16.43
multi-ciliated epithelial cell CL0005012

CSI 8.17

rCSI 8.15%

PRS 14.85
mesodermal cell CL0000222

CSI 8.04

rCSI 9.65%

PRS 17.08
germinal center B cell CL0000844

CSI 8

rCSI 23.85%

PRS 40.88
microcirculation associated smooth muscle cell CL0008035

CSI 7.8

rCSI 22.59%

PRS 19.68
unswitched memory B cell CL0000970

CSI 7.8

rCSI 6.56%

PRS 27.83
colon goblet cell CL0009039

CSI 7.74

rCSI 18.41%

PRS 26.02
pancreatic PP cell CL0002275

CSI 7.39

rCSI 29.42%

PRS 30.07
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 7.08

rCSI 8.18%

PRS 15.24
pancreatic acinar cell CL0002064

CSI 6.82

rCSI 9.06%

PRS 19.02
pancreatic stellate cell CL0002410

CSI 6.81

rCSI 39.62%

PRS 25.92
neutrophil CL0000775

CSI 6.79

rCSI 37.99%

PRS 33.45
common lymphoid progenitor CL0000051

CSI 6.75

rCSI 9.02%

PRS 33.04
Hofbauer cell CL3000001

CSI 6.49

rCSI 12.26%

PRS 21.86
forebrain radial glial cell CL0013000

CSI 6.47

rCSI 20.76%

PRS 25.12
glandular epithelial cell CL0000150

CSI 6.34

rCSI 16.7%

PRS 33.67
cerebral cortex GABAergic interneuron CL0010011

CSI 6.31

rCSI 18.63%

PRS 21
paneth cell of epithelium of small intestine CL1000343

CSI 6.25

rCSI 17.51%

PRS 26.87
epithelial cell CL0000066

CSI 6.12

rCSI 9.4%

PRS 24.13
CD4-positive helper T cell CL0000492

CSI 6.09

rCSI 4.61%

PRS 23.93
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 5.66

rCSI 33.31%

PRS 10.72
lung endothelial cell CL1001567

CSI 5.6

rCSI 13.06%

PRS 40.34
activated type II NK T cell CL0000931

CSI 5.44

rCSI 6.12%

PRS 27.98
thymocyte CL0000893

CSI 5.38

rCSI 19.11%

PRS 51.83
endothelial cell of vascular tree CL0002139

CSI 5.25

rCSI 28.7%

PRS 27.83
regular atrial cardiac myocyte CL0002129

CSI 5.15

rCSI 16.57%

PRS 18.14
kidney epithelial cell CL0002518

CSI 5

rCSI 9.55%

PRS 38.75
radial glial cell CL0000681

CSI 4.94

rCSI 6.86%

PRS 17.82
respiratory epithelial cell CL0002368

CSI 4.76

rCSI 29.42%

PRS 52.85
M cell of gut CL0000682

CSI 4.75

rCSI 5.05%

PRS 30.12
plasmablast CL0000980

CSI 4.64

rCSI 3.65%

PRS 21.01
progenitor cell CL0011026

CSI 4.55

rCSI 9.67%

PRS 28.14
erythroid progenitor cell CL0000038

CSI 4.4

rCSI 25.2%

PRS 26.53
intestinal crypt stem cell of colon CL0009043

CSI 4.16

rCSI 31.27%

PRS 31.59
near-projecting glutamatergic cortical neuron CL4023012

CSI 4.12

rCSI 15.56%

PRS 10.52
blood vessel smooth muscle cell CL0019018

CSI 3.96

rCSI 32.21%

PRS 17.62
pre-conventional dendritic cell CL0002010

CSI 3.96

rCSI 52.33%

PRS 52.28
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 3.84

rCSI 2.7%

PRS 41.55
type EC enteroendocrine cell CL0000577

CSI 3.74

rCSI 13.27%

PRS 28.24
IgG plasma cell CL0000985

CSI 3.74

rCSI 4.48%

PRS 30.14
precursor B cell CL0000817

CSI 3.72

rCSI 3.26%

PRS 23.16
megakaryocyte progenitor cell CL0000553

CSI 3.72

rCSI 67.99%

PRS 49.53
podocyte CL0000653

CSI 3.66

rCSI 16.25%

PRS 17
mature alpha-beta T cell CL0000791

CSI 3.39

rCSI 12.27%

PRS 29.81
vein endothelial cell of respiratory system CL4033008

CSI 3.37

rCSI 23.14%

PRS 33.57
double negative thymocyte CL0002489

CSI 3.29

rCSI 2.29%

PRS 20.7
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 3.25

rCSI 4.6%

PRS 16.12
direct pathway medium spiny neuron CL4023026

CSI 3.24

rCSI 77.66%

PRS 8.49
myeloid leukocyte CL0000766

CSI 3.22

rCSI 2.97%

PRS 17.95
myofibroblast cell CL0000186

CSI 3.18

rCSI 4.4%

PRS 24.74
CD4-positive, alpha-beta memory T cell CL0000897

CSI 3.13

rCSI 2.25%

PRS 23.83
activated CD8-positive, alpha-beta T cell CL0000906

CSI 3.12

rCSI 3.06%

PRS 47.44
indirect pathway medium spiny neuron CL4023029

CSI 3.11

rCSI 74.95%

PRS 9.43
bronchus fibroblast of lung CL2000093

CSI 3.01

rCSI 2.45%

PRS 18.37
naive T cell CL0000898

CSI 2.98

rCSI 2.08%

PRS 24.72
lamp5 GABAergic cortical interneuron CL4023011

CSI 2.94

rCSI 4.93%

PRS 10.23
hematopoietic multipotent progenitor cell CL0000837

CSI 2.82

rCSI 6.79%

PRS 27.58
enteroendocrine cell of colon CL0009042

CSI 2.8

rCSI 13.13%

PRS 43.85
keratocyte CL0002363

CSI 2.76

rCSI 6.63%

PRS 25.75
mucous neck cell CL0000651

CSI 2.73

rCSI 3.94%

PRS 27.58
colon epithelial cell CL0011108

CSI 2.73

rCSI 2.86%

PRS 16.2
goblet cell CL0000160

CSI 2.68

rCSI 2.53%

PRS 18.18

alpha-beta T cell CL0000789

CSI -4.4

rCSI -5.2%

PRS 23.4%
neural progenitor cell CL0011020

CSI -2.6

rCSI -11.4%

PRS 16.6%
cerebral cortex endothelial cell CL1001602

CSI -1.8

rCSI -3.1%

PRS 13.2%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI -1.3

rCSI -3.3%

PRS 16.2%
lung neuroendocrine cell CL1000223

CSI -1.0

rCSI -1.4%

PRS 19.9%
forebrain neuroblast CL1000042

CSI -1.0

rCSI -10.4%

PRS 88.1%
cardiac neuron CL0010022

CSI -0.9

rCSI -2.7%

PRS 13.2%
astrocyte of the cerebral cortex CL0002605

CSI -0.3

rCSI -0.6%

PRS 10.8%
mesenchymal cell CL0008019

CSI -0.2

rCSI -0.6%

PRS 17.6%
serotonergic neuron CL0000850

CSI -0.1

rCSI -0.6%

PRS 9.4%
renal principal cell CL0005009

CSI -0.1

rCSI -0.3%

PRS 22.5%
pulmonary artery endothelial cell CL1001568

CSI -0.1

rCSI -0.2%

PRS 26.2%
regular ventricular cardiac myocyte CL0002131

CSI 0.0

rCSI 0.2%

PRS 13.5%
B-2 B cell CL0000822

CSI 0.1

rCSI 1.1%

PRS 71.4%
exhausted T cell CL0011025

CSI 0.1

rCSI 1.1%

PRS 58.1%
dopaminergic neuron CL0000700

CSI 0.1

rCSI 0.4%

PRS 8.7%
renal interstitial pericyte CL1001318

CSI 0.1

rCSI 0.2%

PRS 16.0%
mucus secreting cell CL0000319

CSI 0.1

rCSI 0.1%

PRS 22.4%
cerebral cortex pyramidal neuron CL4023111

CSI 0.1

rCSI 0.6%

PRS 43.2%
cytotoxic T cell CL0000910

CSI 0.1

rCSI 0.6%

PRS 25.5%
parietal epithelial cell CL1000452

CSI 0.1

rCSI 0.4%

PRS 14.4%
luminal cell of prostate epithelium CL0002340

CSI 0.1

rCSI 0.8%

PRS 30.9%
small pre-B-II cell CL0000954

CSI 0.2

rCSI 0.1%

PRS 35.5%
double negative T regulatory cell CL0011024

CSI 0.2

rCSI 2.8%

PRS 73.0%
erythroblast CL0000765

CSI 0.2

rCSI 0.4%

PRS 28.1%
T-helper 17 cell CL0000899

CSI 0.2

rCSI 0.1%

PRS 30.9%
hair follicular keratinocyte CL2000092

CSI 0.2

rCSI 2.8%

PRS 60.8%
neuroendocrine cell CL0000165

CSI 0.2

rCSI 0.6%

PRS 34.5%
pulmonary alveolar type 1 cell CL0002062

CSI 0.2

rCSI 1.0%

PRS 22.3%
eye photoreceptor cell CL0000287

CSI 0.2

rCSI 2.1%

PRS 41.5%
kidney connecting tubule epithelial cell CL1000768

CSI 0.2

rCSI 0.5%

PRS 13.1%
group 2 innate lymphoid cell CL0001069

CSI 0.2

rCSI 1.1%

PRS 55.2%
bronchiolar smooth muscle cell CL4033017

CSI 0.2

rCSI 3.2%

PRS 49.2%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 0.2

rCSI 0.5%

PRS 10.5%
brush cell CL0002204

CSI 0.2

rCSI 0.4%

PRS 42.6%
memory T cell CL0000813

CSI 0.2

rCSI 0.5%

PRS 38.9%
endothelial cell of venule CL1000414

CSI 0.3

rCSI 2.2%

PRS 58.2%
Bergmann glial cell CL0000644

CSI 0.3

rCSI 0.3%

PRS 17.3%
peptic cell CL0000155

CSI 0.3

rCSI 2.4%

PRS 46.6%
natural T-regulatory cell CL0000903

CSI 0.3

rCSI 0.5%

PRS 46.2%
basal cell of epithelium of trachea CL1000348

CSI 0.3

rCSI 1.8%

PRS 49.2%
skeletal muscle satellite cell CL0000594

CSI 0.3

rCSI 0.7%

PRS 50.9%
ventricular cardiac muscle cell CL2000046

CSI 0.3

rCSI 0.9%

PRS 60.0%
enterocyte of epithelium of small intestine CL1000334

CSI 0.3

rCSI 4.2%

PRS 42.0%
GABAergic amacrine cell CL4030027

CSI 0.3

rCSI 1.0%

PRS 14.9%
IgM plasma cell CL0000986

CSI 0.3

rCSI 1.3%

PRS 67.2%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.3

rCSI 0.4%

PRS 22.0%
cell of skeletal muscle CL0000188

CSI 0.3

rCSI 3.4%

PRS 69.9%
lung microvascular endothelial cell CL2000016

CSI 0.3

rCSI 6.2%

PRS 49.7%
alveolar adventitial fibroblast CL4028006

CSI 0.3

rCSI 0.5%

PRS 17.5%
retinal bipolar neuron CL0000748

CSI 0.3

rCSI 0.6%

PRS 12.5%
type L enteroendocrine cell CL0002279

CSI 0.3

rCSI 0.6%

PRS 34.0%
CD14-positive, CD16-positive monocyte CL0002397

CSI 0.3

rCSI 0.4%

PRS 24.7%
P/D1 enteroendocrine cell CL0002268

CSI 0.4

rCSI 1.9%

PRS 41.2%
epithelial cell of urethra CL1000296

CSI 0.4

rCSI 9.1%

PRS 50.0%
myelocyte CL0002193

CSI 0.4

rCSI 2.4%

PRS 51.9%
type B pancreatic cell CL0000169

CSI 0.4

rCSI 0.8%

PRS 16.1%
prostate gland microvascular endothelial cell CL2000059

CSI 0.4

rCSI 10.0%

PRS 53.1%
muscle cell CL0000187

CSI 0.4

rCSI 0.9%

PRS 38.4%
retinal cone cell CL0000573

CSI 0.4

rCSI 0.7%

PRS 13.3%
endocardial cell CL0002350

CSI 0.4

rCSI 2.1%

PRS 21.3%
H1 horizontal cell CL0004217

CSI 0.4

rCSI 1.7%

PRS 23.4%
pancreatic epsilon cell CL0005019

CSI 0.4

rCSI 2.1%

PRS 39.4%
lung goblet cell CL1000143

CSI 0.5

rCSI 5.0%

PRS 52.8%
enteroendocrine cell of small intestine CL0009006

CSI 0.5

rCSI 1.0%

PRS 26.4%
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 0.5

rCSI 0.6%

PRS 35.1%
T-helper 1 cell CL0000545

CSI 0.5

rCSI 0.9%

PRS 43.5%
pvalb GABAergic cortical interneuron CL4023018

CSI 0.5

rCSI 0.6%

PRS 9.5%
acinar cell CL0000622

CSI 0.5

rCSI 0.7%

PRS 22.8%
amacrine cell CL0000561

CSI 0.5

rCSI 1.5%

PRS 13.3%
CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915

CSI 0.5

rCSI 2.4%

PRS 56.0%
T follicular helper cell CL0002038

CSI 0.5

rCSI 0.4%

PRS 27.9%
chondrocyte CL0000138

CSI 0.5

rCSI 0.8%

PRS 14.7%
OFF-bipolar cell CL0000750

CSI 0.5

rCSI 0.7%

PRS 27.5%
sncg GABAergic cortical interneuron CL4023015

CSI 0.5

rCSI 0.9%

PRS 11.1%
tracheobronchial smooth muscle cell CL0019019

CSI 0.5

rCSI 1.0%

PRS 22.9%
centrilobular region hepatocyte CL0019029

CSI 0.6

rCSI 1.5%

PRS 26.8%
megakaryocyte CL0000556

CSI 0.6

rCSI 2.4%

PRS 30.6%
alveolar macrophage CL0000583

CSI 0.6

rCSI 0.9%

PRS 20.5%
lung secretory cell CL1000272

CSI 0.6

rCSI 1.4%

PRS 16.0%
cardiac muscle cell CL0000746

CSI 0.6

rCSI 0.8%

PRS 13.4%
choroid plexus epithelial cell CL0000706

CSI 0.6

rCSI 1.0%

PRS 13.4%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 0.6

rCSI 0.7%

PRS 30.4%
myeloid dendritic cell CL0000782

CSI 0.6

rCSI 0.9%

PRS 26.0%
respiratory basal cell CL0002633

CSI 0.6

rCSI 0.6%

PRS 20.4%
periportal region hepatocyte CL0019026

CSI 0.6

rCSI 2.3%

PRS 23.6%
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 0.6

rCSI 1.3%

PRS 11.1%
retinal rod cell CL0000604

CSI 0.6

rCSI 1.1%

PRS 17.0%
lung pericyte CL0009089

CSI 0.6

rCSI 1.7%

PRS 20.8%
class switched memory B cell CL0000972

CSI 0.7

rCSI 0.5%

PRS 29.4%
mesenchymal stem cell of adipose tissue CL0002570

CSI 0.7

rCSI 3.7%

PRS 45.1%
epicardial adipocyte CL1000309

CSI 0.7

rCSI 2.2%

PRS 21.0%
innate lymphoid cell CL0001065

CSI 0.7

rCSI 1.4%

PRS 26.1%
skeletal muscle satellite stem cell CL0008011

CSI 0.7

rCSI 3.0%

PRS 45.4%
glial cell CL0000125

CSI 0.7

rCSI 2.6%

PRS 17.0%
intermediate monocyte CL0002393

CSI 0.7

rCSI 1.0%

PRS 17.5%
neuroplacodal cell CL0000032

CSI 0.7

rCSI 6.4%

PRS 45.8%
tracheobronchial serous cell CL0019001

CSI 0.7

rCSI 3.0%

PRS 32.3%
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 0.7

rCSI 0.4%

PRS 24.2%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 0.7

rCSI 1.4%

PRS 29.3%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
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- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [KPNB1](/details-gene/3837) (karyopherin subunit beta 1), also known as importin subunit beta-1, is a crucial transport receptor responsible for the translocation of proteins from the cytoplasm into the nucleus. It functions by recognizing and binding to nuclear localization signals (NLS) on cargo proteins, often in complex with an importin alpha subunit, and mediating their passage through the nuclear pore complex [[Link](https://doi.org/10.1016/s0960-9822(95)00079-0)]. The **Overall** expression profile reveals that [KPNB1](/details-gene/3837) is most significant in highly proliferative and metabolically active cells, particularly hematopoietic stem and progenitor cells, as well as various epithelial progenitor populations. This expression pattern, combined with its well-documented role in mitotic spindle assembly and cell cycle progression, underscores its fundamental importance in cell division, differentiation, and the maintenance of progenitor cell populations. The gene has been associated with human disease ([602738](https://omim.org/entry/602738)). ## Cellular Roles and Expression Landscape **Overall**, the expression landscape of [KPNB1](/details-gene/3837) strongly highlights its role in cellular proliferation and development. It exhibits the highest significance in various hematopoietic progenitor populations, including [megakaryocyte-erythroid progenitor cells](/details-cell/CL0000050) (CSI: 73.63), [hematopoietic stem cells](/details-cell/CL0000037) (CSI: 58.80), [common myeloid progenitors](/details-cell/CL0000049) (CSI: 56.75), and [granulocyte monocyte progenitor cells](/details-cell/CL0000557) (CSI: 43.59). This suggests a critical function in the continuous process of blood cell formation. High significance is also observed in other actively dividing cell types, such as [fallopian tube secretory epithelial cells](/details-cell/CL4030006), [transit amplifying cells of the colon](/details-cell/CL0009011), and [placental villous trophoblasts](/details-cell/CL2000060), further cementing its association with rapid cell turnover and tissue maintenance. Conversely, [KPNB1](/details-gene/3837) shows minimal to negative significance in terminally differentiated, often post-mitotic cells. Its low scores in mature [alpha-beta T cells](/details-cell/CL0000789), as well as various neuronal subtypes like [forebrain neuroblasts](/details-cell/CL1000042) and [cardiac neurons](/details-cell/CL0010022), indicate that its function is less critical for the maintenance of quiescent or terminally differentiated cellular states. This stark contrast between progenitor and mature cell types underscores its specialized role in processes requiring high levels of nucleocytoplasmic transport, such as cell cycle progression and replication, rather than homeostatic cellular function. ## Pathways and Molecular Function The functional annotations for [KPNB1](/details-gene/3837) are highly consistent with its cellular expression profile. Its primary annotated function is central to cellular logistics, specifically `Protein import into nucleus` ([GO:0006606](https://www.ebi.ac.uk/QuickGO/term/GO:0006606)) and `Nls-bearing protein import into nucleus` ([GO:0006607](https://www.ebi.ac.uk/QuickGO/term/GO:0006607)). This is achieved through its `Nuclear import signal receptor activity` ([GO:0061608](https://www.ebi.ac.uk/QuickGO/term/GO:0061608)) and binding to partners like importin-alpha proteins and small GTPases. Crucially, its function extends beyond simple protein transport. The gene is deeply implicated in cell division, as evidenced by its roles in `Mitotic spindle assembly` ([GO:0090307](https://www.ebi.ac.uk/QuickGO/term/GO:0090307)) and `Mitotic metaphase chromosome alignment` ([GO:0007080](https://www.ebi.ac.uk/QuickGO/term/GO:0007080)). This is strongly supported by its involvement in the `Cell cycle, mitotic` ([R-HSA-69278](https://reactome.org/content/detail/R-HSA-69278)) and `Dna replication` ([R-HSA-69306](https://reactome.org/content/detail/R-HSA-69306)) pathways. Furthermore, [KPNB1](/details-gene/3837) appears to be a key host factor in numerous infectious disease pathways, including `Hiv infection` ([R-HSA-162906](https://reactome.org/content/detail/R-HSA-162906)), `Influenza infection` ([R-HSA-168255](https://reactome.org/content/detail/R-HSA-168255)), and `Sars-cov infections` ([R-HSA-9679506](https://reactome.org/content/detail/R-HSA-9679506)). This suggests that many viruses co-opt the [KPNB1](/details-gene/3837)-mediated nuclear import machinery to transport their own proteins into the host nucleus for replication, a mechanism that has been specifically demonstrated for the HIV Rev protein [[Link](https://doi.org/10.1006/jmbi.1997.1420)]. ## Research Directions The data suggest that [KPNB1](/details-gene/3837) is not merely a housekeeping gene for nuclear import but a critical regulator of cell state, particularly the transition from proliferation to differentiation. ### Proposed Hypotheses: 1. **Role in Cell Fate Determination:** Given its high expression in hematopoietic progenitors and low expression in their terminally differentiated descendants, the downregulation of [KPNB1](/details-gene/3837) may be a prerequisite for cellular differentiation. Constitutive expression of [KPNB1](/details-gene/3837) could trap progenitor cells in a proliferative state, thereby blocking their maturation. 2. **Broad-Spectrum Antiviral Target:** The extensive involvement of [KPNB1](/details-gene/3837) in pathways for diverse viral infections suggests it is a common host dependency factor. Pharmacological inhibition of [KPNB1](/details-gene/3837) function could represent a broad-spectrum antiviral strategy by preventing the nuclear import of essential viral components across multiple virus families. ### Key Experimental Approach: To test the first hypothesis regarding [KPNB1](/details-gene/3837)'s role in cell fate, one could perform a targeted knockdown experiment in primary human [hematopoietic stem cells](/details-cell/CL0000037). These cells would be transduced with lentiviral vectors carrying shRNA against [KPNB1](/details-gene/3837) or a non-targeting control. Following selection, cells would be cultured in cytokine cocktails that promote differentiation toward myeloid and lymphoid lineages. The progression of differentiation could be quantitatively assessed over time via flow cytometry analysis of lineage-specific surface markers (e.g., CD33 for myeloid, CD19 for B-lymphoid) and colony-forming unit (CFU) assays. A significant delay or block in the appearance of mature cell markers in the knockdown group compared to controls would support the hypothesis that [KPNB1](/details-gene/3837) downregulation is necessary for hematopoietic differentiation. ### Therapeutic Potential: As a central mediator of nuclear transport required for cell cycle progression, [KPNB1](/details-gene/3837) represents a potential therapeutic target for hyperproliferative disorders, such as cancer. **Inhibition**, likely via small molecule inhibitors that disrupt its binding to cargo or the nuclear pore complex, would be the therapeutic strategy. However, its essential role in all dividing cells, including healthy progenitor populations in the bone marrow and gut, poses a substantial risk of on-target toxicity. Therefore, a therapeutic window would be narrow and might be restricted to cancers that exhibit a particularly high dependency on nuclear transport, a concept known as "non-oncogene addiction."

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Importin subunit beta-1
B7Z752_HUMAN

Genular Protein ID: 2106567679

Symbol: IMB1_HUMAN

Name: Importin subunit beta-1

UniProtKB Accession Codes:

Q14974 B7ZAV6 D3DTT3 Q14637 Q53XN2 Q96J27

Database IDs:

Citations:

PubMed ID: 7615630

Title: Sequence and characterization of cytoplasmic nuclear protein import factor p97.

PubMed ID: 7615630

DOI: 10.1083/jcb.130.2.265

PubMed ID: 7627554

Title: Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope.

PubMed ID: 7627554

DOI: 10.1016/s0960-9822(95)00079-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8617227

Title: The conserved amino-terminal domain of hSRP1 alpha is essential for nuclear protein import.

PubMed ID: 8617227

DOI: 10.1002/j.1460-2075.1996.tb00531.x

PubMed ID: 8692944

Title: Nuclear protein import: Ran-GTP dissociates the karyopherin alphabeta heterodimer by displacing alpha from an overlapping binding site on beta.

PubMed ID: 8692944

DOI: 10.1073/pnas.93.14.7059

PubMed ID: 9405152

Title: Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta.

PubMed ID: 9405152

DOI: 10.1006/jmbi.1997.1420

PubMed ID: 9670026

Title: Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure.

PubMed ID: 9670026

DOI: 10.1093/emboj/17.14.4114

PubMed ID: 9687515

Title: Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells.

PubMed ID: 9687515

DOI: 10.1093/emboj/17.15.4491

PubMed ID: 10228156

Title: The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1.

PubMed ID: 10228156

DOI: 10.1093/emboj/18.9.2411

PubMed ID: 10209022

Title: CRM1-mediated recycling of snurportin 1 to the cytoplasm.

PubMed ID: 10209022

DOI: 10.1083/jcb.145.2.255

PubMed ID: 9891055

Title: The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals.

PubMed ID: 9891055

DOI: 10.1128/mcb.19.2.1210

PubMed ID: 9891056

Title: Importin beta can mediate the nuclear import of an arginine-rich nuclear localization signal in the absence of importin alpha.

PubMed ID: 9891056

DOI: 10.1128/mcb.19.2.1218

PubMed ID: 11682607

Title: Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin.

PubMed ID: 11682607

DOI: 10.1242/jcs.114.19.3479

PubMed ID: 11229403

Title: Role of importin-beta in coupling Ran to downstream targets in microtubule assembly.

PubMed ID: 11229403

DOI: 10.1126/science.1057661

PubMed ID: 12095920

Title: SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta.

PubMed ID: 12095920

DOI: 10.1093/hmg/11.15.1785

PubMed ID: 11891849

Title: Phosphorylation of tyrosine 256 facilitates nuclear import of atypical protein kinase C.

PubMed ID: 11891849

DOI: 10.1002/jcb.10101.abs

PubMed ID: 12764225

Title: Defective importin beta recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations.

PubMed ID: 12764225

DOI: 10.1073/pnas.1137864100

PubMed ID: 15297880

Title: Regulation of human SRY subcellular distribution by its acetylation/deacetylation.

PubMed ID: 15297880

DOI: 10.1038/sj.emboj.7600352

PubMed ID: 16171404

Title: Nuclear import of the respiratory syncytial virus matrix protein is mediated by importin beta1 independent of importin alpha.

PubMed ID: 16171404

DOI: 10.1021/bi050701e

PubMed ID: 15836774

Title: Zinc finger domain of Snail functions as a nuclear localization signal for importin beta-mediated nuclear import pathway.

PubMed ID: 15836774

DOI: 10.1111/j.1365-2443.2005.00850.x

PubMed ID: 15629770

Title: Respiratory syncytial virus M2-1 protein induces the activation of nuclear factor kappa B.

PubMed ID: 15629770

DOI: 10.1016/j.virol.2004.10.031

PubMed ID: 16704975

Title: Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1.

PubMed ID: 16704975

DOI: 10.1074/jbc.m602189200

PubMed ID: 17209048

Title: Human DNA replication-related element binding factor (hDREF) self-association via hATC domain is necessary for its nuclear accumulation and DNA binding.

PubMed ID: 17209048

DOI: 10.1074/jbc.m607180200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19386897

Title: Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors.

PubMed ID: 19386897

DOI: 10.1242/jcs.041749

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20701745

Title: Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors.

PubMed ID: 20701745

DOI: 10.1186/1471-2121-11-63

PubMed ID: 20818336

Title: An actin-regulated importin alpha/beta-dependent extended bipartite NLS directs nuclear import of MRTF-A.

PubMed ID: 20818336

DOI: 10.1038/emboj.2010.216

PubMed ID: 20147401

Title: Venezuelan equine encephalitis virus capsid protein forms a tetrameric complex with CRM1 and importin alpha/beta that obstructs nuclear pore complex function.

PubMed ID: 20147401

DOI: 10.1128/jvi.02554-09

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22500989

Title: Characterization of nuclear import and export signals determining the subcellular localization of WD repeat-containing protein 42A (WDR42A).

PubMed ID: 22500989

DOI: 10.1016/j.febslet.2012.02.053

PubMed ID: 22084111

Title: POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters.

PubMed ID: 22084111

DOI: 10.1073/pnas.1117231108

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22701565

Title: PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-beta1.

PubMed ID: 22701565

DOI: 10.1371/journal.pone.0037352

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10367892

Title: Structural view of the Ran-Importin beta interaction at 2.3 A resolution.

PubMed ID: 10367892

DOI: 10.1016/s0092-8674(00)80774-6

PubMed ID: 10353244

Title: Structure of importin-beta bound to the IBB domain of importin-alpha.

PubMed ID: 10353244

DOI: 10.1038/20367

PubMed ID: 10929717

Title: Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking.

PubMed ID: 10929717

DOI: 10.1016/s0092-8674(00)00014-3

PubMed ID: 12504010

Title: Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta.

PubMed ID: 12504010

DOI: 10.1016/s1097-2765(02)00727-x

PubMed ID: 18187419

Title: Molecular basis for the recognition of snurportin 1 by importin beta.

PubMed ID: 18187419

DOI: 10.1074/jbc.m709093200

PubMed ID: 20476751

Title: Conformational selection in the recognition of the snurportin importin beta binding domain by importin beta.

PubMed ID: 20476751

DOI: 10.1021/bi100292y

PubMed ID: 24699649

Title: Structural basis for the selective nuclear import of the C2H2 zinc-finger protein Snail by importin beta.

PubMed ID: 24699649

DOI: 10.1107/s1399004714000972

Sequence Information:

Length: 876
Mass: 97170
Checksum: F3BB8B73E7E51639
Sequence:

MELITILEKT VSPDRLELEA AQKFLERAAV ENLPTFLVEL SRVLANPGNS QVARVAAGLQ 
IKNSLTSKDP DIKAQYQQRW LAIDANARRE VKNYVLQTLG TETYRPSSAS QCVAGIACAE 
IPVNQWPELI PQLVANVTNP NSTEHMKEST LEAIGYICQD IDPEQLQDKS NEILTAIIQG 
MRKEEPSNNV KLAATNALLN SLEFTKANFD KESERHFIMQ VVCEATQCPD TRVRVAALQN 
LVKIMSLYYQ YMETYMGPAL FAITIEAMKS DIDEVALQGI EFWSNVCDEE MDLAIEASEA 
AEQGRPPEHT SKFYAKGALQ YLVPILTQTL TKQDENDDDD DWNPCKAAGV CLMLLATCCE 
DDIVPHVLPF IKEHIKNPDW RYRDAAVMAF GCILEGPEPS QLKPLVIQAM PTLIELMKDP 
SVVVRDTAAW TVGRICELLP EAAINDVYLA PLLQCLIEGL SAEPRVASNV CWAFSSLAEA 
AYEAADVADD QEEPATYCLS SSFELIVQKL LETTDRPDGH QNNLRSSAYE SLMEIVKNSA 
KDCYPAVQKT TLVIMERLQQ VLQMESHIQS TSDRIQFNDL QSLLCATLQN VLRKVQHQDA 
LQISDVVMAS LLRMFQSTAG SGGVQEDALM AVSTLVEVLG GEFLKYMEAF KPFLGIGLKN 
YAEYQVCLAA VGLVGDLCRA LQSNIIPFCD EVMQLLLENL GNENVHRSVK PQILSVFGDI 
ALAIGGEFKK YLEVVLNTLQ QASQAQVDKS DYDMVDYLNE LRESCLEAYT GIVQGLKGDQ 
ENVHPDVMLV QPRVEFILSF IDHIAGDEDH TDGVVACAAG LIGDLCTAFG KDVLKLVEAR 
PMIHELLTEG RRSKTNKAKT LATWATKELR KLKNQA

Genular Protein ID: 3595725493

Symbol: B7Z752_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z752

Database IDs:

Sequence Information:

Length: 731
Mass: 81163
Checksum: D3F3D648CA5FE4E2
Sequence:

MKESTLEAIG YICQDIDPEQ LQDKSNEILT AIIQGMRKEE PSNNVKLAAT NALLNSLEFT 
KANFDKESER HFIMQVVCEA TQCPDTRVRV AALQNLVKIM SLYYQYMETY MGPALFAITI 
EAMKSDIDEV ALQGIEFWSN VCDEEMDLAI EASEAAEQGR PPEHTSKFYA KGALQYLVPI 
LTQTLTKQDE NDDDDDWNPC KAAGVCLMLL ATCCEDDIVP HVLPFIKEHI KNPDWRYRDA 
AVMAFGCILE GPEPSQLKPL VIQAMPTLIE LMKDPSVVVR DTAAWTVGRI CELLPEAAIN 
DVYLAPLLQC LIEGLSAEPR VASNVCWAFS SLAEAAYEAA DVADDQEEPA TYCLSSSFEL 
IVQKLPETTD RPDGHQNNLR SSAYESLMEI VKNSAKDCYP AVQKTTLVIM ERLQQVLQME 
SHIQSTSDRI QFNDLQSLLC ATLQNVLRKV QHQDALQISD VVMASLLRMF QSTAGSGGVQ 
EDALMAVSTL VEVLGGEFLK YMEAFKPFLG IGLKNYAEYQ VCLAAVGLVG DLCRALQSNI 
IPFCDEVMQL LLENLGNENV HRSVKPQILS VFGDIALAIG GEFKKYLEVV LNTLQQASQA 
QVDKSDYDMV DYLNELRESC LEAYTGIVQG LKGDQENVHP DVMLVQPRVE FILSFIDHIA 
GDEDHTDGVV ACAAGLIGDL CTAFGKDVLK LVEARPMIHE LLTEGRRSKT NKAKTLATWA 
TKELRKLKNQ A

Details for: KPNB1

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Sequence and characterization of cytoplasmic nuclear protein import factor p97. PubMed ID: 7615630

Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope. PubMed ID: 7627554

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The conserved amino-terminal domain of hSRP1 alpha is essential for nuclear protein import. PubMed ID: 8617227

Nuclear protein import: Ran-GTP dissociates the karyopherin alphabeta heterodimer by displacing alpha from an overlapping binding site on beta. PubMed ID: 8692944

Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta. PubMed ID: 9405152

Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure. PubMed ID: 9670026

Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells. PubMed ID: 9687515

The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1. PubMed ID: 10228156

CRM1-mediated recycling of snurportin 1 to the cytoplasm. PubMed ID: 10209022

The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signals. PubMed ID: 9891055

Importin beta can mediate the nuclear import of an arginine-rich nuclear localization signal in the absence of importin alpha. PubMed ID: 9891056

Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin. PubMed ID: 11682607

Role of importin-beta in coupling Ran to downstream targets in microtubule assembly. PubMed ID: 11229403

SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta. PubMed ID: 12095920

Phosphorylation of tyrosine 256 facilitates nuclear import of atypical protein kinase C. PubMed ID: 11891849

Defective importin beta recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations. PubMed ID: 12764225

Regulation of human SRY subcellular distribution by its acetylation/deacetylation. PubMed ID: 15297880

Nuclear import of the respiratory syncytial virus matrix protein is mediated by importin beta1 independent of importin alpha. PubMed ID: 16171404

Zinc finger domain of Snail functions as a nuclear localization signal for importin beta-mediated nuclear import pathway. PubMed ID: 15836774

Respiratory syncytial virus M2-1 protein induces the activation of nuclear factor kappa B. PubMed ID: 15629770

Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1. PubMed ID: 16704975

Human DNA replication-related element binding factor (hDREF) self-association via hATC domain is necessary for its nuclear accumulation and DNA binding. PubMed ID: 17209048

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors. PubMed ID: 19386897

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors. PubMed ID: 20701745

An actin-regulated importin alpha/beta-dependent extended bipartite NLS directs nuclear import of MRTF-A. PubMed ID: 20818336

Venezuelan equine encephalitis virus capsid protein forms a tetrameric complex with CRM1 and importin alpha/beta that obstructs nuclear pore complex function. PubMed ID: 20147401

Initial characterization of the human central proteome. PubMed ID: 21269460

Characterization of nuclear import and export signals determining the subcellular localization of WD repeat-containing protein 42A (WDR42A). PubMed ID: 22500989

POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters. PubMed ID: 22084111

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-beta1. PubMed ID: 22701565

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Structural view of the Ran-Importin beta interaction at 2.3 A resolution. PubMed ID: 10367892

Structure of importin-beta bound to the IBB domain of importin-alpha. PubMed ID: 10353244

Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking. PubMed ID: 10929717

Molecular basis for the recognition of a nonclassical nuclear localization signal by importin beta. PubMed ID: 12504010

Molecular basis for the recognition of snurportin 1 by importin beta. PubMed ID: 18187419

Conformational selection in the recognition of the snurportin importin beta binding domain by importin beta. PubMed ID: 20476751

Structural basis for the selective nuclear import of the C2H2 zinc-finger protein Snail by importin beta. PubMed ID: 24699649