Gene KRAS - ENSG00000133703 | NCBI Gene ID: 3845

Details for: KRAS

Gene ID: 3845

Symbol: KRAS

Ensembl ID: ENSG00000133703

Description: KRAS proto-oncogene, GTPase

Associated with

Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adaptive immune system
(R-HSA-1280218)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Ca2+ pathway
(R-HSA-4086398)
Cd209 (dc-sign) signaling
(R-HSA-5621575)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Constitutive signaling by overexpressed erbb2
(R-HSA-9634285)
Cytokine signaling in immune system
(R-HSA-1280215)
Dap12 interactions
(R-HSA-2172127)
Dap12 signaling
(R-HSA-2424491)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream signal transduction
(R-HSA-186763)
Erythropoietin activates ras
(R-HSA-9027284)
Esr-mediated signaling
(R-HSA-8939211)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated mapk activation
(R-HSA-2871796)
Flt3 signaling
(R-HSA-9607240)
Flt3 signaling in disease
(R-HSA-9682385)
G alpha (q) signalling events
(R-HSA-416476)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gpcr downstream signalling
(R-HSA-388396)
Grb2 events in egfr signaling
(R-HSA-179812)
Grb2 events in erbb2 signaling
(R-HSA-1963640)
Hemostasis
(R-HSA-109582)
Igf1r signaling cascade
(R-HSA-2428924)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Insulin receptor signalling cascade
(R-HSA-74751)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Met activates ras signaling
(R-HSA-8851805)
Ncam signaling for neurite out-growth
(R-HSA-375165)
Nervous system development
(R-HSA-9675108)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Oncogenic mapk signaling
(R-HSA-6802957)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Ptk6 regulates rho gtpases, ras gtpase and map kinases
(R-HSA-8849471)
Raf/map kinase cascade
(R-HSA-5673001)
Ras signaling downstream of nf1 loss-of-function variants
(R-HSA-6802953)
Rna polymerase ii transcription
(R-HSA-73857)
Shc1 events in egfr signaling
(R-HSA-180336)
Shc1 events in erbb2 signaling
(R-HSA-1250196)
Shc1 events in erbb4 signaling
(R-HSA-1250347)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by csf1 (m-csf) in myeloid cells
(R-HSA-9680350)
Signaling by csf3 (g-csf)
(R-HSA-9674555)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by egfrviii in cancer
(R-HSA-5637812)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb2 in cancer
(R-HSA-1227990)
Signaling by erbb4
(R-HSA-1236394)
Signaling by erythropoietin
(R-HSA-9006335)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr3 in disease
(R-HSA-5655332)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by fgfr4 in disease
(R-HSA-5655291)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by gpcr
(R-HSA-372790)
Signaling by high-kinase activity braf mutants
(R-HSA-6802948)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by kit in disease
(R-HSA-9669938)
Signaling by ligand-responsive egfr variants in cancer
(R-HSA-5637815)
Signaling by met
(R-HSA-6806834)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrk2 (trkb)
(R-HSA-9006115)
Signaling by ntrk3 (trkc)
(R-HSA-9034015)
Signaling by ntrks
(R-HSA-166520)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by pdgf
(R-HSA-186797)
Signaling by pdgfr in disease
(R-HSA-9671555)
Signaling by ptk6
(R-HSA-8848021)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by scf-kit
(R-HSA-1433557)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signaling by vegf
(R-HSA-194138)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Tie2 signaling
(R-HSA-210993)
Transcriptional regulation by runx3
(R-HSA-8878159)
Transmission across chemical synapses
(R-HSA-112315)
Vegfa-vegfr2 pathway
(R-HSA-4420097)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.03
Marker Score: 6378
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.87
Marker Score: 1968.5
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.8
Marker Score: 18234
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.72
Marker Score: 1354
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.71
Marker Score: 2523
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.7
Marker Score: 1818
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.62
Marker Score: 13947
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.61
Marker Score: 2317
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.56
Marker Score: 6142
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.55
Marker Score: 2201
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.55
Marker Score: 462
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.54
Marker Score: 446
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.53
Marker Score: 9800
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.52
Marker Score: 3081
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 1.51
Marker Score: 912
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.51
Marker Score: 1892
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 1.49
Marker Score: 737
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.49
Marker Score: 1793
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.48
Marker Score: 1494
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.45
Marker Score: 346
Cell Name: mural cell (CL0008034)
Fold Change: 1.45
Marker Score: 165816
Cell Name: Unknown (CL0000548)
Fold Change: 1.44
Marker Score: 1053
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.44
Marker Score: 10694
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.43
Marker Score: 976
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.42
Marker Score: 9071
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 1.41
Marker Score: 498
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.39
Marker Score: 48166
Cell Name: neuron (CL0000540)
Fold Change: 1.39
Marker Score: 5656
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.39
Marker Score: 2703
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.39
Marker Score: 648
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.38
Marker Score: 3765
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 1.38
Marker Score: 2469
Cell Name: basal cell (CL0000646)
Fold Change: 1.35
Marker Score: 1743
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.34
Marker Score: 82488
Cell Name: enterocyte (CL0000584)
Fold Change: 1.34
Marker Score: 6428
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.34
Marker Score: 384
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 1.33
Marker Score: 905
Cell Name: malignant cell (CL0001064)
Fold Change: 1.33
Marker Score: 17844
Cell Name: secretory cell (CL0000151)
Fold Change: 1.33
Marker Score: 2422.5
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.32
Marker Score: 4901
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.32
Marker Score: 1246
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 1.32
Marker Score: 456
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.32
Marker Score: 12412
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.32
Marker Score: 3215
Cell Name: hepatocyte (CL0000182)
Fold Change: 1.31
Marker Score: 895
Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.3
Marker Score: 2950
Cell Name: ependymal cell (CL0000065)
Fold Change: 1.3
Marker Score: 453
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.3
Marker Score: 940
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.3
Marker Score: 1293
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.3
Marker Score: 1371
Cell Name: mature T cell (CL0002419)
Fold Change: 1.29
Marker Score: 12821
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.28
Marker Score: 707
Cell Name: male germ cell (CL0000015)
Fold Change: 1.28
Marker Score: 370
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 1.28
Marker Score: 522.5
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.27
Marker Score: 1964
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1.27
Marker Score: 621
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 1.27
Marker Score: 67084
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 1.26
Marker Score: 1371.5
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.26
Marker Score: 627
Cell Name: mature B cell (CL0000785)
Fold Change: 1.25
Marker Score: 920
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.25
Marker Score: 2213
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 1.24
Marker Score: 325
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.24
Marker Score: 11737
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 1.23
Marker Score: 274
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 1.23
Marker Score: 1231
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 1.23
Marker Score: 281
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.22
Marker Score: 1097
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.22
Marker Score: 2785
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.22
Marker Score: 1102
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.22
Marker Score: 815
Cell Name: neural cell (CL0002319)
Fold Change: 1.22
Marker Score: 587
Cell Name: club cell (CL0000158)
Fold Change: 1.22
Marker Score: 1419
Cell Name: memory B cell (CL0000787)
Fold Change: 1.21
Marker Score: 917
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.21
Marker Score: 2413
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.21
Marker Score: 3388
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 1.21
Marker Score: 1775
Cell Name: epithelial fate stem cell (CL0000036)
Fold Change: 1.2
Marker Score: 345.5
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.2
Marker Score: 3565
Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 1.2
Marker Score: 295
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.2
Marker Score: 2889
Cell Name: plasmablast (CL0000980)
Fold Change: 1.19
Marker Score: 1588
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.19
Marker Score: 12294
Cell Name: mesothelial fibroblast (CL4023054)
Fold Change: 1.19
Marker Score: 351
Cell Name: peptic cell (CL0000155)
Fold Change: 1.19
Marker Score: 497
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.19
Marker Score: 278
Cell Name: keratinocyte (CL0000312)
Fold Change: 1.18
Marker Score: 989
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 1.18
Marker Score: 1134
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.18
Marker Score: 293
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.18
Marker Score: 1711
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.18
Marker Score: 65846
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 1.18
Marker Score: 2019
Cell Name: myoepithelial cell (CL0000185)
Fold Change: 1.18
Marker Score: 329
Cell Name: stem cell (CL0000034)
Fold Change: 1.17
Marker Score: 2790
Cell Name: pro-B cell (CL0000826)
Fold Change: 1.17
Marker Score: 1133.5
Cell Name: epidermal cell (CL0000362)
Fold Change: 1.17
Marker Score: 329.5
Cell Name: dendritic cell (CL0000451)
Fold Change: 1.17
Marker Score: 803
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 1.17
Marker Score: 308
Cell Name: tendon cell (CL0000388)
Fold Change: 1.17
Marker Score: 287
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 1.17
Marker Score: 1024.5
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 1.16
Marker Score: 330

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## Summary The KRAS proto-oncogene is a serine/threonine kinase that plays a critical role in various cellular processes, including cell growth, proliferation, differentiation, and apoptosis. It is commonly known as the "oncogene of cancer" due to its frequent mutations and role in various human cancers. ## Key characteristics * **Location:** Chromosome 7 * **Gene type:** Proto-oncogene * **Ensembl ID:** ENSG00000133703 * **Protein:** RASK_HUMAN (GTPase KRas) * **Protein type:** Kinase * **Expression:** Significantly expressed in various cell types, particularly in epithelial cells, immune cells, and proliferating cells. ## Pathways and functions * **Adaptive immune system:** KRAS is involved in the regulation of immune responses, including activation of CD8+ cytotoxic T cells and regulation of immune cell proliferation. * **Cell surface interactions at the vascular wall:** KRAS signaling is crucial for cell migration, invasion, and angiogenesis in various tissues, including the tumor microenvironment. * **Cytokine signaling in immune system:** KRAS is a key regulator of cytokine production and signaling in the immune system. * **Developmental biology:** KRAS plays a role in embryonic development and tissue homeostasis. * **Disease:** KRAS mutations are frequently observed in various cancers, leading to uncontrolled cell growth and tumor formation. ## Clinical significance * **Cancer therapy:** KRAS inhibitors are among the most commonly used cancer drugs. * **Cardiovascular disease:** KRAS mutations have been linked to cardiovascular diseases, such as hypertension and heart failure. * **Cancer immunotherapy:** KRAS inhibitors have shown promising results in clinical trials for various cancers. ## Additional notes * KRAS is a highly conserved gene with significant expression in various cell types. * It is frequently mutated in human cancer, leading to the development of drug-resistant tumors. * Targeting KRAS signaling has become a major therapeutic approach for cancer treatment.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

GTPase KRas
I1SRC5_HUMAN

Genular Protein ID: 2122947741

Symbol: RASK_HUMAN

Name: GTPase KRas

UniProtKB Accession Codes:

P01116 A8K8Z5 B0LPF9 P01118 Q96D10

Database IDs:

Citations:

PubMed ID: 6308466

Title: Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene.

PubMed ID: 6308466

DOI: 10.1038/304501a0

PubMed ID: 6308465

Title: Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1.

PubMed ID: 6308465

DOI: 10.1038/304497a0

PubMed ID: 6308467

Title: Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations.

PubMed ID: 6308467

DOI: 10.1038/304507a0

PubMed ID: 6092920

Title: Human colon carcinoma Ki-ras2 oncogene and its corresponding proto-oncogene.

PubMed ID: 6092920

DOI: 10.1128/mcb.4.8.1577-1582.1984

PubMed ID: 3310850

Title: The c-K-ras gene and human cancer (review).

PubMed ID: 3310850

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6320174

Title: Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes.

PubMed ID: 6320174

DOI: 10.1073/pnas.81.1.71

PubMed ID: 3855240

Title: Activation of the c-K-ras oncogene in a human pancreas carcinoma.

PubMed ID: 3855240

DOI: 10.1016/s0006-291x(85)80140-6

PubMed ID: 3034404

Title: Activated c-Ha-ras oncogene with a guanine to thymine transversion at the twelfth codon in a human stomach cancer cell line.

PubMed ID: 3034404

PubMed ID: 6695174

Title: Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient.

PubMed ID: 6695174

DOI: 10.1126/science.6695174

PubMed ID: 3932274

Title: Essential region for transforming activity of human c-Ha-ras-1.

PubMed ID: 3932274

PubMed ID: 6096811

Title: Activation of a human c-K-ras oncogene.

PubMed ID: 6096811

DOI: 10.1093/nar/12.23.8873

PubMed ID: 19744486

Title: Distinct kinetics of (H/K/N)Ras glucosylation and Rac1 glucosylation catalysed by Clostridium sordellii lethal toxin.

PubMed ID: 19744486

DOI: 10.1016/j.febslet.2009.09.006

PubMed ID: 20709748

Title: Splice variants of SmgGDS control small GTPase prenylation and membrane localization.

PubMed ID: 20709748

DOI: 10.1074/jbc.m110.129916

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22711838

Title: Regulation of RAS oncogenicity by acetylation.

PubMed ID: 22711838

DOI: 10.1073/pnas.1201487109

PubMed ID: 23698361

Title: Small molecule inhibition of the KRAS-PDE? interaction impairs oncogenic KRAS signalling.

PubMed ID: 23698361

DOI: 10.1038/nature12205

PubMed ID: 24623306

Title: A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.

PubMed ID: 24623306

DOI: 10.7554/elife.02313

PubMed ID: 24415755

Title: The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif.

PubMed ID: 24415755

DOI: 10.1074/jbc.m113.527192

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29239724

Title: SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a.

PubMed ID: 29239724

DOI: 10.7554/elife.32436

PubMed ID: 28619714

Title: The G protein-coupled receptor GPR31 promotes membrane association of KRAS.

PubMed ID: 28619714

DOI: 10.1083/jcb.201609096

PubMed ID: 30442762

Title: Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination.

PubMed ID: 30442762

DOI: 10.1126/science.aap7607

PubMed ID: 30442766

Title: LZTR1 is a regulator of RAS ubiquitination and signaling.

PubMed ID: 30442766

DOI: 10.1126/science.aap8210

PubMed ID: 22566140

Title: Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation.

PubMed ID: 22566140

DOI: 10.1002/anie.201201358

PubMed ID: 22431598

Title: Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.

PubMed ID: 22431598

DOI: 10.1073/pnas.1116510109

PubMed ID: 27791178

Title: Structural basis of recognition of farnesylated and methylated KRAS4b by PDEdelta.

PubMed ID: 27791178

DOI: 10.1073/pnas.1615316113

PubMed ID: 3627975

Title: The human c-Kirsten ras gene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231.

PubMed ID: 3627975

DOI: 10.1093/nar/15.15.5963

PubMed ID: 1553789

Title: Detection of a rare point mutation in Ki-ras of a human bladder cancer xenograft by polymerase chain reaction and direct sequencing.

PubMed ID: 1553789

DOI: 10.1007/bf00296523

PubMed ID: 8439212

Title: Detection of point mutations in the Kirsten-ras oncogene provides evidence for the multicentricity of pancreatic carcinoma.

PubMed ID: 8439212

DOI: 10.1097/00000658-199302000-00007

PubMed ID: 7773929

Title: Clinicopathologic significance of the K-ras gene codon 12 point mutation in stomach cancer. An analysis of 140 cases.

PubMed ID: 7773929

DOI: 10.1002/1097-0142(19950615)75:12<2794::aid-cncr2820751203>3.0.co;2-f

PubMed ID: 8955068

Title: Biochemical characterization of a novel KRAS insertion mutation from a human leukemia.

PubMed ID: 8955068

DOI: 10.1074/jbc.271.51.32491

PubMed ID: 14534542

Title: BRAF and KRAS mutations in stomach cancer.

PubMed ID: 14534542

DOI: 10.1038/sj.onc.1206749

PubMed ID: 16247081

Title: RAS pathway activation and an oncogenic RAS mutation in sporadic pilocytic astrocytoma.

PubMed ID: 16247081

DOI: 10.1212/01.wnl.0000180409.78098.d7

PubMed ID: 16773572

Title: Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype.

PubMed ID: 16773572

DOI: 10.1086/504394

PubMed ID: 16533793

Title: Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features.

PubMed ID: 16533793

DOI: 10.1158/1078-0432.ccr-05-1981

PubMed ID: 16474404

Title: Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome.

PubMed ID: 16474404

DOI: 10.1038/ng1749

PubMed ID: 16474405

Title: Germline KRAS mutations cause Noonan syndrome.

PubMed ID: 16474405

DOI: 10.1038/ng1748

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17332249

Title: Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations.

PubMed ID: 17332249

DOI: 10.1182/blood-2006-09-046649

PubMed ID: 17468812

Title: Further evidence of genetic heterogeneity in Costello syndrome: involvement of the KRAS gene.

PubMed ID: 17468812

DOI: 10.1007/s10038-007-0146-1

PubMed ID: 17056636

Title: Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations.

PubMed ID: 17056636

DOI: 10.1136/jmg.2006.046300

PubMed ID: 19396835

Title: Craniosynostosis in patients with Noonan syndrome caused by germline KRAS mutations.

PubMed ID: 19396835

DOI: 10.1002/ajmg.a.32786

PubMed ID: 20949621

Title: Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders.

PubMed ID: 20949621

DOI: 10.1002/humu.21377

PubMed ID: 21797849

Title: Two novel germline KRAS mutations: expanding the molecular and clinical phenotype.

PubMed ID: 21797849

DOI: 10.1111/j.1399-0004.2011.01754.x

PubMed ID: 25808193

Title: Oculoectodermal syndrome is a mosaic RASopathy associated with KRAS alterations.

PubMed ID: 25808193

DOI: 10.1002/ajmg.a.37048

PubMed ID: 26970110

Title: Specific mosaic KRAS mutations affecting codon 146 cause oculoectodermal syndrome and encephalocraniocutaneous lipomatosis.

PubMed ID: 26970110

DOI: 10.1111/cge.12775

PubMed ID: 30891959

Title: Expansion of the phenotypic spectrum and description of molecular findings in a cohort of patients with oculocutaneous mosaic RASopathies.

PubMed ID: 30891959

DOI: 10.1002/mgg3.625

PubMed ID: 34820593

Title: KRAS A146 mutations are associated with distinct clinical behavior in patients with colorectal liver metastases.

PubMed ID: 34820593

DOI: 10.1200/po.21.00223

Sequence Information:

Length: 189
Mass: 21656
Checksum: 973547B2E11C2C81
Sequence:

MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG 
QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI KRVKDSEDVP MVLVGNKCDL 
PSRTVDTKQA QDLARSYGIP FIETSAKTRQ RVEDAFYTLV REIRQYRLKK ISKEEKTPGC 
VKIKKCIIM

Genular Protein ID: 1004964975

Symbol: I1SRC5_HUMAN

Name: N/A

UniProtKB Accession Codes:

I1SRC5

Database IDs:

Sequence Information:

Length: 296
Mass: 33983
Checksum: 564873E7568723AF
Sequence:

MAASRRLMKE LEEIRKCGMK NFRNIQVDEA NLLTWQGLIV PDNPPYDKGA FRIEINFPAE 
YPFKPPKITF KTKIYHPNID EKGQVCLPVI SAENWKPATK TDQGLLKMTE YKLVVVGAGG 
VGKSALTIQL IQNHFVDEYD PTIEDSYRKQ VVIDGETCLL DILDTAGQEE YSAMRDQYMR 
TGEGFLCVFA INNTKSFEDI HHYREQIKRV KDSEDVPMVL VGNKCDLPSR TVDTKQAQDL 
ARSYGIPFIE TSAKTRQRVE DAFYTLVREI RQYRLKKISK EEKTPGCVKI KKCIIM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: KRAS

Associated with

Cells (max top 100)

Other Information

Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene. PubMed ID: 6308466

Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1. PubMed ID: 6308465

Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations. PubMed ID: 6308467

Human colon carcinoma Ki-ras2 oncogene and its corresponding proto-oncogene. PubMed ID: 6092920

The c-K-ras gene and human cancer (review). PubMed ID: 3310850

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes. PubMed ID: 6320174

Activation of the c-K-ras oncogene in a human pancreas carcinoma. PubMed ID: 3855240

Activated c-Ha-ras oncogene with a guanine to thymine transversion at the twelfth codon in a human stomach cancer cell line. PubMed ID: 3034404

Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient. PubMed ID: 6695174

Essential region for transforming activity of human c-Ha-ras-1. PubMed ID: 3932274

Activation of a human c-K-ras oncogene. PubMed ID: 6096811

Distinct kinetics of (H/K/N)Ras glucosylation and Rac1 glucosylation catalysed by Clostridium sordellii lethal toxin. PubMed ID: 19744486

Splice variants of SmgGDS control small GTPase prenylation and membrane localization. PubMed ID: 20709748

Initial characterization of the human central proteome. PubMed ID: 21269460

Regulation of RAS oncogenicity by acetylation. PubMed ID: 22711838

Small molecule inhibition of the KRAS-PDE? interaction impairs oncogenic KRAS signalling. PubMed ID: 23698361

A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. PubMed ID: 24623306

The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif. PubMed ID: 24415755

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a. PubMed ID: 29239724

The G protein-coupled receptor GPR31 promotes membrane association of KRAS. PubMed ID: 28619714

Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination. PubMed ID: 30442762

LZTR1 is a regulator of RAS ubiquitination and signaling. PubMed ID: 30442766

Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. PubMed ID: 22566140

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. PubMed ID: 22431598

Structural basis of recognition of farnesylated and methylated KRAS4b by PDEdelta. PubMed ID: 27791178

The human c-Kirsten ras gene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231. PubMed ID: 3627975

Detection of a rare point mutation in Ki-ras of a human bladder cancer xenograft by polymerase chain reaction and direct sequencing. PubMed ID: 1553789

Detection of point mutations in the Kirsten-ras oncogene provides evidence for the multicentricity of pancreatic carcinoma. PubMed ID: 8439212

Clinicopathologic significance of the K-ras gene codon 12 point mutation in stomach cancer. An analysis of 140 cases. PubMed ID: 7773929

Biochemical characterization of a novel KRAS insertion mutation from a human leukemia. PubMed ID: 8955068

BRAF and KRAS mutations in stomach cancer. PubMed ID: 14534542

RAS pathway activation and an oncogenic RAS mutation in sporadic pilocytic astrocytoma. PubMed ID: 16247081

Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype. PubMed ID: 16773572

Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features. PubMed ID: 16533793

Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome. PubMed ID: 16474404

Germline KRAS mutations cause Noonan syndrome. PubMed ID: 16474405

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations. PubMed ID: 17332249

Further evidence of genetic heterogeneity in Costello syndrome: involvement of the KRAS gene. PubMed ID: 17468812

Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations. PubMed ID: 17056636

Craniosynostosis in patients with Noonan syndrome caused by germline KRAS mutations. PubMed ID: 19396835

Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders. PubMed ID: 20949621

Two novel germline KRAS mutations: expanding the molecular and clinical phenotype. PubMed ID: 21797849

Oculoectodermal syndrome is a mosaic RASopathy associated with KRAS alterations. PubMed ID: 25808193

Specific mosaic KRAS mutations affecting codon 146 cause oculoectodermal syndrome and encephalocraniocutaneous lipomatosis. PubMed ID: 26970110

Expansion of the phenotypic spectrum and description of molecular findings in a cohort of patients with oculocutaneous mosaic RASopathies. PubMed ID: 30891959

KRAS A146 mutations are associated with distinct clinical behavior in patients with colorectal liver metastases. PubMed ID: 34820593