KRAS | ENSG00000133703 | NCBI 3845

Details for: KRAS

Gene ID: 3845

Symbol: KRAS

Ensembl ID: ENSG00000133703

Description: KRAS proto-oncogene, GTPase

Associated with

Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adaptive immune system
(R-HSA-1280218)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Ca2+ pathway
(R-HSA-4086398)
Cd209 (dc-sign) signaling
(R-HSA-5621575)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Constitutive signaling by overexpressed erbb2
(R-HSA-9634285)
Cytokine signaling in immune system
(R-HSA-1280215)
Dap12 interactions
(R-HSA-2172127)
Dap12 signaling
(R-HSA-2424491)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream signal transduction
(R-HSA-186763)
Erythropoietin activates ras
(R-HSA-9027284)
Esr-mediated signaling
(R-HSA-8939211)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated mapk activation
(R-HSA-2871796)
Flt3 signaling
(R-HSA-9607240)
Flt3 signaling in disease
(R-HSA-9682385)
G alpha (q) signalling events
(R-HSA-416476)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gpcr downstream signalling
(R-HSA-388396)
Grb2 events in egfr signaling
(R-HSA-179812)
Grb2 events in erbb2 signaling
(R-HSA-1963640)
Hemostasis
(R-HSA-109582)
Igf1r signaling cascade
(R-HSA-2428924)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Insulin receptor signalling cascade
(R-HSA-74751)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Met activates ras signaling
(R-HSA-8851805)
Ncam signaling for neurite out-growth
(R-HSA-375165)
Nervous system development
(R-HSA-9675108)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Oncogenic mapk signaling
(R-HSA-6802957)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Ptk6 regulates rho gtpases, ras gtpase and map kinases
(R-HSA-8849471)
Raf/map kinase cascade
(R-HSA-5673001)
Ras signaling downstream of nf1 loss-of-function variants
(R-HSA-6802953)
Rna polymerase ii transcription
(R-HSA-73857)
Shc1 events in egfr signaling
(R-HSA-180336)
Shc1 events in erbb2 signaling
(R-HSA-1250196)
Shc1 events in erbb4 signaling
(R-HSA-1250347)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by csf1 (m-csf) in myeloid cells
(R-HSA-9680350)
Signaling by csf3 (g-csf)
(R-HSA-9674555)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by egfrviii in cancer
(R-HSA-5637812)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb2 in cancer
(R-HSA-1227990)
Signaling by erbb4
(R-HSA-1236394)
Signaling by erythropoietin
(R-HSA-9006335)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr3 in disease
(R-HSA-5655332)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by fgfr4 in disease
(R-HSA-5655291)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by gpcr
(R-HSA-372790)
Signaling by high-kinase activity braf mutants
(R-HSA-6802948)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by kit in disease
(R-HSA-9669938)
Signaling by ligand-responsive egfr variants in cancer
(R-HSA-5637815)
Signaling by met
(R-HSA-6806834)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrk2 (trkb)
(R-HSA-9006115)
Signaling by ntrk3 (trkc)
(R-HSA-9034015)
Signaling by ntrks
(R-HSA-166520)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by pdgf
(R-HSA-186797)
Signaling by pdgfr in disease
(R-HSA-9671555)
Signaling by ptk6
(R-HSA-8848021)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by scf-kit
(R-HSA-1433557)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signaling by vegf
(R-HSA-194138)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Tie2 signaling
(R-HSA-210993)
Transcriptional regulation by runx3
(R-HSA-8878159)
Transmission across chemical synapses
(R-HSA-112315)
Vegfa-vegfr2 pathway
(R-HSA-4420097)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 298.1769
Cell Significance Index: -46.3800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 185.4572
Cell Significance Index: -47.0400
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 142.0812
Cell Significance Index: -58.5300
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 118.3379
Cell Significance Index: -55.8700
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 111.3827
Cell Significance Index: -45.2500
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 101.6845
Cell Significance Index: -52.3100
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 83.3952
Cell Significance Index: -55.9600
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 47.9082
Cell Significance Index: -45.7400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 41.5424
Cell Significance Index: -51.2200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.8807
Cell Significance Index: -47.9000
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 13.1828
Cell Significance Index: -52.0200
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 11.5743
Cell Significance Index: -35.5500
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 9.6912
Cell Significance Index: -21.2100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.7624
Cell Significance Index: 47.0600
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.6918
Cell Significance Index: 184.0200
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.6567
Cell Significance Index: 106.8900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.1666
Cell Significance Index: 234.0100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.9548
Cell Significance Index: 60.1800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.9060
Cell Significance Index: 163.3200
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.9027
Cell Significance Index: 26.5100
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.8548
Cell Significance Index: 466.8200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.8444
Cell Significance Index: 22.9900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.8334
Cell Significance Index: 102.4800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.8322
Cell Significance Index: 43.2300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.7818
Cell Significance Index: 155.1600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7507
Cell Significance Index: 21.6300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7261
Cell Significance Index: 15.7300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.6600
Cell Significance Index: 77.8400
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.6504
Cell Significance Index: 9.7500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.6292
Cell Significance Index: 29.5700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6115
Cell Significance Index: 99.4600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5873
Cell Significance Index: 26.6200
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.5552
Cell Significance Index: 383.9700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.5312
Cell Significance Index: 234.8700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.5280
Cell Significance Index: 24.6200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5066
Cell Significance Index: 181.7200
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.4886
Cell Significance Index: 5.8300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4438
Cell Significance Index: 60.9500
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.4390
Cell Significance Index: 9.1900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4238
Cell Significance Index: 29.3100
Cell Name: odontoblast (CL0000060)
Fold Change: 0.4039
Cell Significance Index: 51.7800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3424
Cell Significance Index: 309.2100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.3399
Cell Significance Index: 17.7100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3389
Cell Significance Index: 33.5200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.3345
Cell Significance Index: 17.5600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.3054
Cell Significance Index: 18.7700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1963
Cell Significance Index: 13.8800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.1766
Cell Significance Index: 13.1700
Cell Name: lactocyte (CL0002325)
Fold Change: 0.1761
Cell Significance Index: 22.7500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1637
Cell Significance Index: 31.1600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1187
Cell Significance Index: 20.2700
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.1039
Cell Significance Index: 1.1800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0834
Cell Significance Index: 4.6800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0112
Cell Significance Index: 15.2400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0067
Cell Significance Index: 12.6800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0037
Cell Significance Index: 2.7200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.0005
Cell Significance Index: 0.0100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0015
Cell Significance Index: -0.6600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0068
Cell Significance Index: -0.1900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0148
Cell Significance Index: -10.9900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0170
Cell Significance Index: -26.1500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0173
Cell Significance Index: -11.0000
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0186
Cell Significance Index: -34.2300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0202
Cell Significance Index: -12.6200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0385
Cell Significance Index: -29.1100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0556
Cell Significance Index: -5.6800
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0665
Cell Significance Index: -1.1400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0686
Cell Significance Index: -38.7000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0909
Cell Significance Index: -13.2200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1038
Cell Significance Index: -6.9800
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1090
Cell Significance Index: -3.8300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1379
Cell Significance Index: -29.0400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1482
Cell Significance Index: -42.6300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1745
Cell Significance Index: -19.9900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1923
Cell Significance Index: -14.7600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1965
Cell Significance Index: -6.8300
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2019
Cell Significance Index: -1.2200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2235
Cell Significance Index: -4.7600
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2385
Cell Significance Index: -27.7900
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2467
Cell Significance Index: -6.6000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2648
Cell Significance Index: -7.8000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2737
Cell Significance Index: -4.5800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2829
Cell Significance Index: -3.8600
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3001
Cell Significance Index: -7.8900
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.3106
Cell Significance Index: -2.8600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4056
Cell Significance Index: -42.2300
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4067
Cell Significance Index: -46.4200
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.5095
Cell Significance Index: -14.6100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5104
Cell Significance Index: -40.4200
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5779
Cell Significance Index: -18.5100
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.6050
Cell Significance Index: -14.5100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.6158
Cell Significance Index: -27.2400
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.6680
Cell Significance Index: -17.1700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.6913
Cell Significance Index: -17.2800
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.6980
Cell Significance Index: -26.4300
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.7476
Cell Significance Index: -19.1000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8909
Cell Significance Index: -54.6200
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -1.0096
Cell Significance Index: -14.5200
Cell Name: peg cell (CL4033014)
Fold Change: -1.0332
Cell Significance Index: -23.8700
Cell Name: preadipocyte (CL0002334)
Fold Change: -1.0765
Cell Significance Index: -21.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** KRAS is a member of the RAS family of small GTPases, which are guanine nucleotide-binding proteins that regulate various cellular signaling pathways. The KRAS protein is a GTPase that cycles between an active GTP-bound state and an inactive GDP-bound state. This cycling mechanism allows KRAS to modulate downstream signaling pathways, including those involved in cell proliferation, survival, and migration. KRAS is highly conserved across species, with high sequence identity between human and mouse. The gene is located on the long arm of chromosome 12 in humans and is highly expressed in various tissues, including epithelial cells, neurons, and immune cells. **Pathways and Functions** KRAS is involved in numerous signaling pathways, including: 1. **MAPK/ERK pathway**: KRAS activates the MAPK/ERK pathway, which regulates cell proliferation, differentiation, and survival. 2. **PI3K/AKT pathway**: KRAS activates the PI3K/AKT pathway, which regulates cell survival, metabolism, and migration. 3. **Wnt/β-catenin pathway**: KRAS activates the Wnt/β-catenin pathway, which regulates cell proliferation, differentiation, and survival. 4. **G-protein coupled receptor signaling**: KRAS regulates the activity of G-protein coupled receptors, including EGFR and FGFR. KRAS plays a critical role in various cellular processes, including: 1. **Cell growth and proliferation**: KRAS regulates cell growth and proliferation by activating the MAPK/ERK pathway. 2. **Differentiation**: KRAS regulates differentiation by modulating the activity of transcription factors, such as NF-κB and AP-1. 3. **Survival**: KRAS regulates cell survival by activating the PI3K/AKT pathway. 4. **Migration**: KRAS regulates cell migration by modulating the activity of cytoskeletal proteins, such as actin and myosin. **Clinical Significance** Mutations in the KRAS gene are commonly found in various cancers, including: 1. **Colorectal cancer**: KRAS mutations are found in up to 50% of colorectal cancers. 2. **Lung cancer**: KRAS mutations are found in up to 30% of lung cancers. 3. **Pancreatic cancer**: KRAS mutations are found in up to 90% of pancreatic cancers. 4. **Other cancers**: KRAS mutations are also found in other cancers, including breast, brain, and skin cancers. KRAS mutations can be used as biomarkers for cancer diagnosis and treatment. Targeted therapies, such as KRAS inhibitors, are being developed to specifically inhibit KRAS signaling in cancer cells.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

GTPase KRas
I1SRC5_HUMAN

Genular Protein ID: 2122947741

Symbol: RASK_HUMAN

Name: GTPase KRas

UniProtKB Accession Codes:

P01116 A8K8Z5 B0LPF9 P01118 Q96D10

Database IDs:

Citations:

PubMed ID: 6308466

Title: Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene.

PubMed ID: 6308466

DOI: 10.1038/304501a0

PubMed ID: 6308465

Title: Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1.

PubMed ID: 6308465

DOI: 10.1038/304497a0

PubMed ID: 6308467

Title: Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations.

PubMed ID: 6308467

DOI: 10.1038/304507a0

PubMed ID: 6092920

Title: Human colon carcinoma Ki-ras2 oncogene and its corresponding proto-oncogene.

PubMed ID: 6092920

DOI: 10.1128/mcb.4.8.1577-1582.1984

PubMed ID: 3310850

Title: The c-K-ras gene and human cancer (review).

PubMed ID: 3310850

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6320174

Title: Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes.

PubMed ID: 6320174

DOI: 10.1073/pnas.81.1.71

PubMed ID: 3855240

Title: Activation of the c-K-ras oncogene in a human pancreas carcinoma.

PubMed ID: 3855240

DOI: 10.1016/s0006-291x(85)80140-6

PubMed ID: 3034404

Title: Activated c-Ha-ras oncogene with a guanine to thymine transversion at the twelfth codon in a human stomach cancer cell line.

PubMed ID: 3034404

PubMed ID: 6695174

Title: Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient.

PubMed ID: 6695174

DOI: 10.1126/science.6695174

PubMed ID: 3932274

Title: Essential region for transforming activity of human c-Ha-ras-1.

PubMed ID: 3932274

PubMed ID: 6096811

Title: Activation of a human c-K-ras oncogene.

PubMed ID: 6096811

DOI: 10.1093/nar/12.23.8873

PubMed ID: 19744486

Title: Distinct kinetics of (H/K/N)Ras glucosylation and Rac1 glucosylation catalysed by Clostridium sordellii lethal toxin.

PubMed ID: 19744486

DOI: 10.1016/j.febslet.2009.09.006

PubMed ID: 20709748

Title: Splice variants of SmgGDS control small GTPase prenylation and membrane localization.

PubMed ID: 20709748

DOI: 10.1074/jbc.m110.129916

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22711838

Title: Regulation of RAS oncogenicity by acetylation.

PubMed ID: 22711838

DOI: 10.1073/pnas.1201487109

PubMed ID: 23698361

Title: Small molecule inhibition of the KRAS-PDE? interaction impairs oncogenic KRAS signalling.

PubMed ID: 23698361

DOI: 10.1038/nature12205

PubMed ID: 24623306

Title: A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.

PubMed ID: 24623306

DOI: 10.7554/elife.02313

PubMed ID: 24415755

Title: The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif.

PubMed ID: 24415755

DOI: 10.1074/jbc.m113.527192

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29239724

Title: SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a.

PubMed ID: 29239724

DOI: 10.7554/elife.32436

PubMed ID: 28619714

Title: The G protein-coupled receptor GPR31 promotes membrane association of KRAS.

PubMed ID: 28619714

DOI: 10.1083/jcb.201609096

PubMed ID: 30442762

Title: Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination.

PubMed ID: 30442762

DOI: 10.1126/science.aap7607

PubMed ID: 30442766

Title: LZTR1 is a regulator of RAS ubiquitination and signaling.

PubMed ID: 30442766

DOI: 10.1126/science.aap8210

PubMed ID: 22566140

Title: Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation.

PubMed ID: 22566140

DOI: 10.1002/anie.201201358

PubMed ID: 22431598

Title: Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity.

PubMed ID: 22431598

DOI: 10.1073/pnas.1116510109

PubMed ID: 27791178

Title: Structural basis of recognition of farnesylated and methylated KRAS4b by PDEdelta.

PubMed ID: 27791178

DOI: 10.1073/pnas.1615316113

PubMed ID: 3627975

Title: The human c-Kirsten ras gene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231.

PubMed ID: 3627975

DOI: 10.1093/nar/15.15.5963

PubMed ID: 1553789

Title: Detection of a rare point mutation in Ki-ras of a human bladder cancer xenograft by polymerase chain reaction and direct sequencing.

PubMed ID: 1553789

DOI: 10.1007/bf00296523

PubMed ID: 8439212

Title: Detection of point mutations in the Kirsten-ras oncogene provides evidence for the multicentricity of pancreatic carcinoma.

PubMed ID: 8439212

DOI: 10.1097/00000658-199302000-00007

PubMed ID: 7773929

Title: Clinicopathologic significance of the K-ras gene codon 12 point mutation in stomach cancer. An analysis of 140 cases.

PubMed ID: 7773929

DOI: 10.1002/1097-0142(19950615)75:12<2794::aid-cncr2820751203>3.0.co;2-f

PubMed ID: 8955068

Title: Biochemical characterization of a novel KRAS insertion mutation from a human leukemia.

PubMed ID: 8955068

DOI: 10.1074/jbc.271.51.32491

PubMed ID: 14534542

Title: BRAF and KRAS mutations in stomach cancer.

PubMed ID: 14534542

DOI: 10.1038/sj.onc.1206749

PubMed ID: 16247081

Title: RAS pathway activation and an oncogenic RAS mutation in sporadic pilocytic astrocytoma.

PubMed ID: 16247081

DOI: 10.1212/01.wnl.0000180409.78098.d7

PubMed ID: 16773572

Title: Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype.

PubMed ID: 16773572

DOI: 10.1086/504394

PubMed ID: 16533793

Title: Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features.

PubMed ID: 16533793

DOI: 10.1158/1078-0432.ccr-05-1981

PubMed ID: 16474404

Title: Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome.

PubMed ID: 16474404

DOI: 10.1038/ng1749

PubMed ID: 16474405

Title: Germline KRAS mutations cause Noonan syndrome.

PubMed ID: 16474405

DOI: 10.1038/ng1748

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17332249

Title: Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations.

PubMed ID: 17332249

DOI: 10.1182/blood-2006-09-046649

PubMed ID: 17468812

Title: Further evidence of genetic heterogeneity in Costello syndrome: involvement of the KRAS gene.

PubMed ID: 17468812

DOI: 10.1007/s10038-007-0146-1

PubMed ID: 17056636

Title: Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations.

PubMed ID: 17056636

DOI: 10.1136/jmg.2006.046300

PubMed ID: 19396835

Title: Craniosynostosis in patients with Noonan syndrome caused by germline KRAS mutations.

PubMed ID: 19396835

DOI: 10.1002/ajmg.a.32786

PubMed ID: 20949621

Title: Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders.

PubMed ID: 20949621

DOI: 10.1002/humu.21377

PubMed ID: 21797849

Title: Two novel germline KRAS mutations: expanding the molecular and clinical phenotype.

PubMed ID: 21797849

DOI: 10.1111/j.1399-0004.2011.01754.x

PubMed ID: 25808193

Title: Oculoectodermal syndrome is a mosaic RASopathy associated with KRAS alterations.

PubMed ID: 25808193

DOI: 10.1002/ajmg.a.37048

PubMed ID: 26970110

Title: Specific mosaic KRAS mutations affecting codon 146 cause oculoectodermal syndrome and encephalocraniocutaneous lipomatosis.

PubMed ID: 26970110

DOI: 10.1111/cge.12775

PubMed ID: 30891959

Title: Expansion of the phenotypic spectrum and description of molecular findings in a cohort of patients with oculocutaneous mosaic RASopathies.

PubMed ID: 30891959

DOI: 10.1002/mgg3.625

PubMed ID: 34820593

Title: KRAS A146 mutations are associated with distinct clinical behavior in patients with colorectal liver metastases.

PubMed ID: 34820593

DOI: 10.1200/po.21.00223

Sequence Information:

Length: 189
Mass: 21656
Checksum: 973547B2E11C2C81
Sequence:

MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG 
QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI KRVKDSEDVP MVLVGNKCDL 
PSRTVDTKQA QDLARSYGIP FIETSAKTRQ RVEDAFYTLV REIRQYRLKK ISKEEKTPGC 
VKIKKCIIM

Genular Protein ID: 1004964975

Symbol: I1SRC5_HUMAN

Name: N/A

UniProtKB Accession Codes:

I1SRC5

Database IDs:

Sequence Information:

Length: 296
Mass: 33983
Checksum: 564873E7568723AF
Sequence:

MAASRRLMKE LEEIRKCGMK NFRNIQVDEA NLLTWQGLIV PDNPPYDKGA FRIEINFPAE 
YPFKPPKITF KTKIYHPNID EKGQVCLPVI SAENWKPATK TDQGLLKMTE YKLVVVGAGG 
VGKSALTIQL IQNHFVDEYD PTIEDSYRKQ VVIDGETCLL DILDTAGQEE YSAMRDQYMR 
TGEGFLCVFA INNTKSFEDI HHYREQIKRV KDSEDVPMVL VGNKCDLPSR TVDTKQAQDL 
ARSYGIPFIE TSAKTRQRVE DAFYTLVREI RQYRLKKISK EEKTPGCVKI KKCIIM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: KRAS

Associated with

Cells (max top 100)

Other Information

Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene. PubMed ID: 6308466

Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1. PubMed ID: 6308465

Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations. PubMed ID: 6308467

Human colon carcinoma Ki-ras2 oncogene and its corresponding proto-oncogene. PubMed ID: 6092920

The c-K-ras gene and human cancer (review). PubMed ID: 3310850

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes. PubMed ID: 6320174

Activation of the c-K-ras oncogene in a human pancreas carcinoma. PubMed ID: 3855240

Activated c-Ha-ras oncogene with a guanine to thymine transversion at the twelfth codon in a human stomach cancer cell line. PubMed ID: 3034404

Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient. PubMed ID: 6695174

Essential region for transforming activity of human c-Ha-ras-1. PubMed ID: 3932274

Activation of a human c-K-ras oncogene. PubMed ID: 6096811

Distinct kinetics of (H/K/N)Ras glucosylation and Rac1 glucosylation catalysed by Clostridium sordellii lethal toxin. PubMed ID: 19744486

Splice variants of SmgGDS control small GTPase prenylation and membrane localization. PubMed ID: 20709748

Initial characterization of the human central proteome. PubMed ID: 21269460

Regulation of RAS oncogenicity by acetylation. PubMed ID: 22711838

Small molecule inhibition of the KRAS-PDE? interaction impairs oncogenic KRAS signalling. PubMed ID: 23698361

A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype. PubMed ID: 24623306

The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif. PubMed ID: 24415755

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a. PubMed ID: 29239724

The G protein-coupled receptor GPR31 promotes membrane association of KRAS. PubMed ID: 28619714

Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination. PubMed ID: 30442762

LZTR1 is a regulator of RAS ubiquitination and signaling. PubMed ID: 30442766

Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. PubMed ID: 22566140

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. PubMed ID: 22431598

Structural basis of recognition of farnesylated and methylated KRAS4b by PDEdelta. PubMed ID: 27791178

The human c-Kirsten ras gene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231. PubMed ID: 3627975

Detection of a rare point mutation in Ki-ras of a human bladder cancer xenograft by polymerase chain reaction and direct sequencing. PubMed ID: 1553789

Detection of point mutations in the Kirsten-ras oncogene provides evidence for the multicentricity of pancreatic carcinoma. PubMed ID: 8439212

Clinicopathologic significance of the K-ras gene codon 12 point mutation in stomach cancer. An analysis of 140 cases. PubMed ID: 7773929

Biochemical characterization of a novel KRAS insertion mutation from a human leukemia. PubMed ID: 8955068

BRAF and KRAS mutations in stomach cancer. PubMed ID: 14534542

RAS pathway activation and an oncogenic RAS mutation in sporadic pilocytic astrocytoma. PubMed ID: 16247081

Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype. PubMed ID: 16773572

Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features. PubMed ID: 16533793

Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome. PubMed ID: 16474404

Germline KRAS mutations cause Noonan syndrome. PubMed ID: 16474405

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations. PubMed ID: 17332249

Further evidence of genetic heterogeneity in Costello syndrome: involvement of the KRAS gene. PubMed ID: 17468812

Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations. PubMed ID: 17056636

Craniosynostosis in patients with Noonan syndrome caused by germline KRAS mutations. PubMed ID: 19396835

Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders. PubMed ID: 20949621

Two novel germline KRAS mutations: expanding the molecular and clinical phenotype. PubMed ID: 21797849

Oculoectodermal syndrome is a mosaic RASopathy associated with KRAS alterations. PubMed ID: 25808193

Specific mosaic KRAS mutations affecting codon 146 cause oculoectodermal syndrome and encephalocraniocutaneous lipomatosis. PubMed ID: 26970110

Expansion of the phenotypic spectrum and description of molecular findings in a cohort of patients with oculocutaneous mosaic RASopathies. PubMed ID: 30891959

KRAS A146 mutations are associated with distinct clinical behavior in patients with colorectal liver metastases. PubMed ID: 34820593