Details for: CENPVL1

Gene ID: 389857

Symbol: CENPVL1

Ensembl ID: ENSG00000223591

Description: centromere protein V like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.4962
    Cell Significance Index: 4.6700
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.4821
    Cell Significance Index: 6.1100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2108
    Cell Significance Index: 5.2600
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.0503
    Cell Significance Index: 0.4300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.0093
    Cell Significance Index: 0.0800
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.0084
    Cell Significance Index: 0.0900
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.0036
    Cell Significance Index: 0.0300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0035
    Cell Significance Index: 0.0700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.0028
    Cell Significance Index: 0.0600
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0013
    Cell Significance Index: -0.0400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0014
    Cell Significance Index: -0.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0035
    Cell Significance Index: -0.1100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0039
    Cell Significance Index: -0.0800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0044
    Cell Significance Index: -0.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0044
    Cell Significance Index: -0.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0050
    Cell Significance Index: -0.1300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0051
    Cell Significance Index: -0.1100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0057
    Cell Significance Index: -0.0600
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -0.0060
    Cell Significance Index: -0.0600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0060
    Cell Significance Index: -0.1000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0062
    Cell Significance Index: -0.0800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0063
    Cell Significance Index: -0.0900
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0066
    Cell Significance Index: -0.0700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0066
    Cell Significance Index: -0.0800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0069
    Cell Significance Index: -0.0900
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0074
    Cell Significance Index: -0.0800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0074
    Cell Significance Index: -0.0800
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0075
    Cell Significance Index: -0.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0078
    Cell Significance Index: -0.1300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0080
    Cell Significance Index: -0.1300
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.0082
    Cell Significance Index: -0.0800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0085
    Cell Significance Index: -0.0800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0085
    Cell Significance Index: -0.1100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0087
    Cell Significance Index: -0.0900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0095
    Cell Significance Index: -0.1300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0097
    Cell Significance Index: -0.1300
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0100
    Cell Significance Index: -0.1200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0103
    Cell Significance Index: -0.1200
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0106
    Cell Significance Index: -0.1300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0106
    Cell Significance Index: -0.1500
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.0111
    Cell Significance Index: -0.1200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0112
    Cell Significance Index: -0.1200
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0127
    Cell Significance Index: -0.1400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0129
    Cell Significance Index: -0.1200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0135
    Cell Significance Index: -0.1400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0135
    Cell Significance Index: -0.1600
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0135
    Cell Significance Index: -0.1400
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.0146
    Cell Significance Index: -0.1200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0154
    Cell Significance Index: -0.1300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.0163
    Cell Significance Index: -0.1000
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0167
    Cell Significance Index: -0.1300
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: -0.0167
    Cell Significance Index: -0.1500
  • Cell Name: group 2 innate lymphoid cell (CL0001069)
    Fold Change: -0.0171
    Cell Significance Index: -0.1200
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: -0.0185
    Cell Significance Index: -0.1200
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0191
    Cell Significance Index: -0.1200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0200
    Cell Significance Index: -0.1300
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: -0.0203
    Cell Significance Index: -0.1200
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: -0.0205
    Cell Significance Index: -0.1100
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: -0.0207
    Cell Significance Index: -0.1300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0209
    Cell Significance Index: -0.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Profile:** CENPVL1 is significantly expressed in diverse cell types, including glutamatergic neurons, progenitor cells, oligodendrocyte precursor cells, lung neuroendocrine cells, megakaryocyte-erythroid progenitor cells, hematopoietic multipotent progenitor cells, early lymphoid progenitors, and microglial cells. This widespread expression suggests a multifaceted role in cell development and regulation. 2. **Enzymatic Activity:** CENPVL1 possesses carbon-sulfur lyase activity, a rare enzymatic function that implies a potential role in metabolic processes. 3. **Metal Ion Binding:** The gene's ability to bind metal ions suggests a possible involvement in redox reactions or metal-dependent signaling pathways. **Pathways and Functions:** 1. **Cell Development and Regulation:** CENPVL1's expression in progenitor cells, oligodendrocyte precursor cells, and hematopoietic multipotent progenitor cells implies a role in cell fate determination and differentiation. Its involvement in the regulation of cell growth, proliferation, and survival is also plausible. 2. **Neurological Disorders:** The gene's expression in glutamatergic neurons and neuroendocrine cells raises questions about its potential involvement in neurological disorders, such as neurodegenerative diseases or cancer. 3. **Immune Cell Development:** CENPVL1's expression in early lymphoid progenitors and microglial cells suggests a role in the development and function of immune cells, including T cells, B cells, and macrophages. 4. **Metabolic Processes:** The gene's carbon-sulfur lyase activity and metal ion binding capabilities imply a potential role in metabolic pathways, including energy production, redox reactions, and metal-dependent signaling. **Clinical Significance:** 1. **Cancer Research:** CENPVL1's expression in lung neuroendocrine cells and hematopoietic multipotent progenitor cells raises the possibility of its involvement in cancer development and progression. Further investigation is needed to determine its potential as a diagnostic or therapeutic target. 2. **Neurological Disorders:** The gene's expression in glutamatergic neurons and neuroendocrine cells suggests a potential role in neurological disorders, such as Alzheimer's disease, Parkinson's disease, or multiple sclerosis. Further research is necessary to elucidate its involvement in these conditions. 3. **Immunological Disorders:** CENPVL1's expression in early lymphoid progenitors and microglial cells implies a potential role in immune cell development and function. Its involvement in immunological disorders, such as autoimmune diseases or immunodeficiency syndromes, is a promising area of investigation. 4. **Personalized Medicine:** The gene's expression in various cell types highlights the need for personalized medicine approaches, where CENPVL1 expression levels can be used to tailor therapeutic strategies to individual patients. In conclusion, CENPVL1 is a gene with a complex and multifaceted role in cell development, regulation, and disease. Further research is necessary to elucidate its involvement in various disease states and to explore its potential as a therapeutic target or diagnostic biomarker. As an expert immunologist, I emphasize the importance of continued investigation into the immunological significance of CENPVL1, with a focus on its role in immune cell development, regulation, and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.