Details for: CENPVL1

Gene ID: 389857

Symbol: CENPVL1

Ensembl ID: ENSG00000223591

Description: centromere protein V like 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Unknown (CL0000003)
    Fold Change: 33.07
    Marker Score: 102202
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.83
    Marker Score: 160529
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 7.99
    Marker Score: 51512
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 5.73
    Marker Score: 7088
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 5.57
    Marker Score: 1570
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 3.75
    Marker Score: 1566
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 3.65
    Marker Score: 1418
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 3.22
    Marker Score: 1571
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 3.21
    Marker Score: 1572
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.1
    Marker Score: 5654
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.96
    Marker Score: 1558
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 2.86
    Marker Score: 1573
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.83
    Marker Score: 1568
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.77
    Marker Score: 1573
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.51
    Marker Score: 2529
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 2.25
    Marker Score: 1545
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 2.25
    Marker Score: 1166
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.16
    Marker Score: 1287
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.12
    Marker Score: 3661
  • Cell Name: mast cell (CL0000097)
    Fold Change: 1.85
    Marker Score: 1070
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.65
    Marker Score: 1844
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.42
    Marker Score: 1570
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.32
    Marker Score: 1183
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.28
    Marker Score: 1221
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 1.28
    Marker Score: 1018
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.13
    Marker Score: 1563
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.11
    Marker Score: 1569
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.09
    Marker Score: 7250
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 0.98
    Marker Score: 70277
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.97
    Marker Score: 46806
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.96
    Marker Score: 29696
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.91
    Marker Score: 2315
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1475
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.91
    Marker Score: 828
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.89
    Marker Score: 864
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.82
    Marker Score: 2460
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.81
    Marker Score: 4612
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.8
    Marker Score: 1571
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8
    Marker Score: 4846
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.75
    Marker Score: 1571
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1205
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.67
    Marker Score: 1570
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.39
    Marker Score: 1572
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.26
    Marker Score: 1567
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.25
    Marker Score: 1324
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.03
    Marker Score: 1573

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Other Information

**Key Characteristics:** CENPVL1 is a centromere protein V like 1, a member of a family of proteins involved in the regulation of chromosome segregation and cell division. The gene exhibits a unique expression profile, being significantly expressed in cells that are involved in neuronal function, immune response, and hematopoiesis. The protein itself has been implicated in metal ion binding and carbon-sulfur lyase activity, suggesting a potential role in redox regulation and enzymatic processes. **Pathways and Functions:** The pathways and functions of CENPVL1 are not yet fully elucidated, but several hypotheses have been proposed based on its expression profile and enzymatic activities. One possible hypothesis is that CENPVL1 plays a role in the regulation of redox balance in cells, particularly in glutamatergic neurons and hematopoietic multipotent progenitor cells. The protein's ability to bind metal ions may also contribute to its enzymatic activities, potentially influencing cellular processes such as DNA repair, transcription, and cell signaling. Furthermore, CENPVL1's expression in oligodendrocyte precursor cells and microglial cells suggests a potential role in the development and maintenance of the central nervous system. The protein's involvement in the regulation of cell proliferation and differentiation in these cells may be critical for normal brain function and development. **Clinical Significance:** While the clinical significance of CENPVL1 is still largely unknown, its expression in various cell types and its enzymatic activities suggest potential implications for human disease. For example, alterations in CENPVL1 expression or function may contribute to the development of neurological disorders, such as Alzheimer's disease or Parkinson's disease, which are characterized by impaired neuronal function and redox balance. Additionally, CENPVL1's role in hematopoiesis and immune response may also have implications for the treatment of hematological malignancies or autoimmune disorders. Further research is needed to fully elucidate the clinical significance of CENPVL1 and its potential as a therapeutic target. In conclusion, CENPVL1 is a gene of significant interest in the realm of immunology and cell biology, with a unique expression profile and enzymatic activities that suggest potential implications for human disease. Further research is needed to fully elucidate the functional significance of CENPVL1 and its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.