Details for: LAMC1

Gene ID: 3915

Symbol: LAMC1

Ensembl ID: ENSG00000135862

Description: laminin subunit gamma 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 7.17
    Marker Score: 4721
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 3.69
    Marker Score: 15391
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 3.42
    Marker Score: 1900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.4
    Marker Score: 2938
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 3.18
    Marker Score: 3959
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.87
    Marker Score: 6309
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.68
    Marker Score: 981
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.61
    Marker Score: 677
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.5
    Marker Score: 1352
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.45
    Marker Score: 2817
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.38
    Marker Score: 2546
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.34
    Marker Score: 1922
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.28
    Marker Score: 1273
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.27
    Marker Score: 1293
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.09
    Marker Score: 1182
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.07
    Marker Score: 71772
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.01
    Marker Score: 1892
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.89
    Marker Score: 1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.8
    Marker Score: 61156
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.77
    Marker Score: 408
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.73
    Marker Score: 856
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.72
    Marker Score: 4228.5
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.7
    Marker Score: 3262.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.69
    Marker Score: 17402
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.68
    Marker Score: 530.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.66
    Marker Score: 6516
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.64
    Marker Score: 479
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.64
    Marker Score: 404
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.6
    Marker Score: 1068
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.59
    Marker Score: 4157
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.57
    Marker Score: 25222
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.53
    Marker Score: 5935
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.53
    Marker Score: 13139
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.53
    Marker Score: 1473
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.52
    Marker Score: 7465.5
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.5
    Marker Score: 946
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.5
    Marker Score: 1612
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.49
    Marker Score: 1322
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.44
    Marker Score: 88746
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.42
    Marker Score: 5793
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.41
    Marker Score: 940
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.4
    Marker Score: 5845
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.39
    Marker Score: 13230
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.38
    Marker Score: 1492
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.38
    Marker Score: 2598
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.38
    Marker Score: 667
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.36
    Marker Score: 50120
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.36
    Marker Score: 2094
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.36
    Marker Score: 435
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.32
    Marker Score: 5705
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.31
    Marker Score: 1363
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.31
    Marker Score: 1481
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.3
    Marker Score: 12263
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.29
    Marker Score: 1595
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.29
    Marker Score: 1773
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.29
    Marker Score: 5336
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.28
    Marker Score: 3020
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.28
    Marker Score: 1297
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.28
    Marker Score: 8315
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.26
    Marker Score: 2520
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.24
    Marker Score: 1456
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.24
    Marker Score: 326
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.22
    Marker Score: 26043
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.22
    Marker Score: 1346
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.21
    Marker Score: 452
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.2
    Marker Score: 504
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.2
    Marker Score: 26791
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.2
    Marker Score: 3020
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.19
    Marker Score: 9122
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.19
    Marker Score: 18589
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.18
    Marker Score: 707
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.18
    Marker Score: 908
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.17
    Marker Score: 1058
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.16
    Marker Score: 2425
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.15
    Marker Score: 15150
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.15
    Marker Score: 258
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.14
    Marker Score: 12896
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.14
    Marker Score: 43246
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.14
    Marker Score: 626
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.14
    Marker Score: 289
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.13
    Marker Score: 289
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.12
    Marker Score: 739
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.12
    Marker Score: 652
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.11
    Marker Score: 218
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.11
    Marker Score: 539
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.1
    Marker Score: 256
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.1
    Marker Score: 639
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.09
    Marker Score: 981
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.09
    Marker Score: 1589
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.09
    Marker Score: 308
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.09
    Marker Score: 219
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.08
    Marker Score: 375
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.08
    Marker Score: 627
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.07
    Marker Score: 258
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.07
    Marker Score: 3956
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.07
    Marker Score: 2607
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.06
    Marker Score: 659
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.04
    Marker Score: 741
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.04
    Marker Score: 404
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.04
    Marker Score: 4020

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Other Information

**Key characteristics**: - The laminin subunit gamma 1 is a transmembrane protein that is expressed in the ECM of tissues such as the skin, cartilage, and blood vessels. - It is a major component of the structural framework of tissues, providing strength and integrity to the extracellular matrix. - It is a key regulator of cell migration, proliferation, and differentiation. **Pathways and functions**: - LamC1 is a key component of the cell adhesion complex, which is responsible for the organization and stability of the ECM. - It interacts with other ECM proteins, such as collagen and elastin, to form the structural framework of tissues. - It is also involved in cell migration, adhesion, and signaling. - LamC1 is a key regulator of cell migration, proliferation, and differentiation. - It is involved in the development and maintenance of the nervous system, including the formation of the central nervous system and the peripheral nervous system. - It is also involved in wound healing and tissue regeneration. **Clinical significance**: - Mutations in the LAMC1 gene have been linked to a number of human diseases, including cerebral palsy, muscular dystrophy, and kidney disease. - LamC1 is a potential therapeutic target for these diseases, as it is a common target for mutations that cause these conditions. - Studies of the role of LAMC1 in disease models have led to the development of new treatments for these disorders.

Genular Protein ID: 2823062116

Symbol: LAMC1_HUMAN

Name: Laminin subunit gamma-1

UniProtKB Accession Codes:

P11047 Q5VYE7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 11 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 31 EMDB 2 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 24 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 6 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 9 RefSeq 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3360804

Title: Human laminin B2 chain. Comparison of the complete amino acid sequence with the B1 chain reveals variability in sequence homology between different structural domains.

PubMed ID: 3360804

DOI: 10.1016/s0021-9258(18)68707-1

PubMed ID: 1985895

Title: Structure of the human laminin B2 chain gene reveals extensive divergence from the laminin B1 chain gene.

PubMed ID: 1985895

DOI: 10.1016/s0021-9258(18)52424-8

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 1806043

Title: Differences in human laminin B2 sequences.

PubMed ID: 1806043

DOI: 10.3109/10425179109020782

PubMed ID: 3234037

Title: Isolation of a human laminin B2 (LAMB2) cDNA clone and assignment of the gene to chromosome region 1q25-->q31.

PubMed ID: 3234037

DOI: 10.1159/000132610

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 28397838

Title: Mapping autosomal recessive intellectual disability: combined microarray and exome sequencing identifies 26 novel candidate genes in 192 consanguineous families.

PubMed ID: 28397838

DOI: 10.1038/mp.2017.60

Sequence Information:

  • Length: 1609
  • Mass: 177603
  • Checksum: 42D9A9958EEBBB01
  • Sequence:
    • MRGSHRAAPA LRPRGRLWPV LAVLAAAAAA GCAQAAMDEC TDEGGRPQRC MPEFVNAAFN 
VTVVATNTCG TPPEEYCVQT GVTGVTKSCH LCDAGQPHLQ HGAAFLTDYN NQADTTWWQS 
QTMLAGVQYP SSINLTLHLG KAFDITYVRL KFHTSRPESF AIYKRTREDG PWIPYQYYSG 
SCENTYSKAN RGFIRTGGDE QQALCTDEFS DISPLTGGNV AFSTLEGRPS AYNFDNSPVL 
QEWVTATDIR VTLNRLNTFG DEVFNDPKVL KSYYYAISDF AVGGRCKCNG HASECMKNEF 
DKLVCNCKHN TYGVDCEKCL PFFNDRPWRR ATAESASECL PCDCNGRSQE CYFDPELYRS 
TGHGGHCTNC QDNTDGAHCE RCRENFFRLG NNEACSSCHC SPVGSLSTQC DSYGRCSCKP 
GVMGDKCDRC QPGFHSLTEA GCRPCSCDPS GSIDECNIET GRCVCKDNVE GFNCERCKPG 
FFNLESSNPR GCTPCFCFGH SSVCTNAVGY SVYSISSTFQ IDEDGWRAEQ RDGSEASLEW 
SSERQDIAVI SDSYFPRYFI APAKFLGKQV LSYGQNLSFS FRVDRRDTRL SAEDLVLEGA 
GLRVSVPLIA QGNSYPSETT VKYVFRLHEA TDYPWRPALT PFEFQKLLNN LTSIKIRGTY 
SERSAGYLDD VTLASARPGP GVPATWVESC TCPVGYGGQF CEMCLSGYRR ETPNLGPYSP 
CVLCACNGHS ETCDPETGVC NCRDNTAGPH CEKCSDGYYG DSTAGTSSDC QPCPCPGGSS 
CAVVPKTKEV VCTNCPTGTT GKRCELCDDG YFGDPLGRNG PVRLCRLCQC SDNIDPNAVG 
NCNRLTGECL KCIYNTAGFY CDRCKDGFFG NPLAPNPADK CKACNCNLYG TMKQQSSCNP 
VTGQCECLPH VTGQDCGACD PGFYNLQSGQ GCERCDCHAL GSTNGQCDIR TGQCECQPGI 
TGQHCERCEV NHFGFGPEGC KPCDCHPEGS LSLQCKDDGR CECREGFVGN RCDQCEENYF 
YNRSWPGCQE CPACYRLVKD KVADHRVKLQ ELESLIANLG TGDEMVTDQA FEDRLKEAER 
EVMDLLREAQ DVKDVDQNLM DRLQRVNNTL SSQISRLQNI RNTIEETGNL AEQARAHVEN 
TERLIEIASR ELEKAKVAAA NVSVTQPEST GDPNNMTLLA EEARKLAERH KQEADDIVRV 
AKTANDTSTE AYNLLLRTLA GENQTAFEIE ELNRKYEQAK NISQDLEKQA ARVHEEAKRA 
GDKAVEIYAS VAQLSPLDSE TLENEANNIK MEAENLEQLI DQKLKDYEDL REDMRGKELE 
VKNLLEKGKT EQQTADQLLA RADAAKALAE EAAKKGRDTL QEANDILNNL KDFDRRVNDN 
KTAAEEALRK IPAINQTITE ANEKTREAQQ ALGSAAADAT EAKNKAHEAE RIASAVQKNA 
TSTKAEAERT FAEVTDLDNE VNNMLKQLQE AEKELKRKQD DADQDMMMAG MASQAAQEAE 
INARKAKNSV TSLLSIINDL LEQLGQLDTV DLNKLNEIEG TLNKAKDEMK VSDLDRKVSD 
LENEAKKQEA AIMDYNRDIE EIMKDIRNLE DIRKTLPSGC FNTPSIEKP

Genular Protein ID: 3130512742

Symbol: Q6NVY8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6NVY8

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SMR 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 248
  • Mass: 27079
  • Checksum: E42903FF0505C03D
  • Sequence:
    • MRGSHRAAPA LRPRGRLWPV LAVLAAAAAA GCAQAAMDEC TDEGGRPQRC MPEFVNAAFN 
VTVVATNTCG TPPEEYCVQT GVTGVTKSCH LCDAGQPHLQ HGAAFLTDYN NQADTTWWQS 
QTMLAGVQYP SSINLTLHLG KAFDITYVRL KFHTSRPESF AIYKRTREDG PWIPYQYYSG 
SCENTYSKAN RGFIRTGGDE QQALCTDEFS DISPLTGGNV AFSTLEGRPS AYNFDNSPVL 
QVNSHRLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.