Details for: LAMP2

Gene ID: 3920

Symbol: LAMP2

Ensembl ID: ENSG00000005893

Description: lysosomal associated membrane protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.01
    Marker Score: 7214
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.9
    Marker Score: 3099
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.76
    Marker Score: 6299
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.49
    Marker Score: 84794
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.39
    Marker Score: 61084
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.37
    Marker Score: 9188
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.33
    Marker Score: 11447.5
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.19
    Marker Score: 18879
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.03
    Marker Score: 2138
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.01
    Marker Score: 8367.5
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.98
    Marker Score: 1768.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.98
    Marker Score: 5301
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.98
    Marker Score: 8526
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.93
    Marker Score: 1934
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.92
    Marker Score: 6821.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.91
    Marker Score: 7514
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.91
    Marker Score: 4813
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.9
    Marker Score: 757
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.89
    Marker Score: 1103
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.85
    Marker Score: 3280
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.85
    Marker Score: 745
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.85
    Marker Score: 1574.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.83
    Marker Score: 2097
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.79
    Marker Score: 751
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.79
    Marker Score: 984
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.75
    Marker Score: 1816
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.73
    Marker Score: 2869
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.72
    Marker Score: 804
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.69
    Marker Score: 1154
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.69
    Marker Score: 4209
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.68
    Marker Score: 3058
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.67
    Marker Score: 694.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.66
    Marker Score: 1947
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.66
    Marker Score: 57539
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.66
    Marker Score: 2141
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.64
    Marker Score: 812.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.64
    Marker Score: 12810
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.64
    Marker Score: 1659
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.63
    Marker Score: 1244
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.63
    Marker Score: 2264
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.63
    Marker Score: 2965
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.62
    Marker Score: 469
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.62
    Marker Score: 373.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.62
    Marker Score: 6002
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.62
    Marker Score: 34575
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6
    Marker Score: 18062
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.6
    Marker Score: 89294
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.6
    Marker Score: 4177
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.58
    Marker Score: 6108
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.58
    Marker Score: 501
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.57
    Marker Score: 1340
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.56
    Marker Score: 1221
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.55
    Marker Score: 383
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.54
    Marker Score: 1053
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.52
    Marker Score: 2243
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.52
    Marker Score: 958
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.51
    Marker Score: 1600
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.51
    Marker Score: 2070
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.5
    Marker Score: 373.5
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.49
    Marker Score: 9046
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.49
    Marker Score: 373.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.48
    Marker Score: 2093
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.46
    Marker Score: 779
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.46
    Marker Score: 3313
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.44
    Marker Score: 165608
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.44
    Marker Score: 820
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.43
    Marker Score: 1194
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.41
    Marker Score: 610
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.4
    Marker Score: 878
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.39
    Marker Score: 2283.5
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.38
    Marker Score: 391
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.38
    Marker Score: 1994
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.36
    Marker Score: 829.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.35
    Marker Score: 5663
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.34
    Marker Score: 2678
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.33
    Marker Score: 2808
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.33
    Marker Score: 1552
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.33
    Marker Score: 299
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.33
    Marker Score: 471
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.32
    Marker Score: 949
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.29
    Marker Score: 1430
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.29
    Marker Score: 860
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.29
    Marker Score: 663
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.28
    Marker Score: 852
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.27
    Marker Score: 297
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.26
    Marker Score: 473
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.26
    Marker Score: 512
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.26
    Marker Score: 1127
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.25
    Marker Score: 1349.5
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.25
    Marker Score: 1077
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.24
    Marker Score: 1531
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.24
    Marker Score: 2162
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.23
    Marker Score: 294
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.23
    Marker Score: 1950
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.22
    Marker Score: 2985.5
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.21
    Marker Score: 294
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.21
    Marker Score: 494.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.21
    Marker Score: 12495
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.21
    Marker Score: 525
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2
    Marker Score: 73499

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Other Information

**Key characteristics:** - The gene is located on chromosome 15q21.1. - It is a large gene with a size of approximately 30.5 kb. - It encodes a protein that is approximately 350 amino acids long. - The protein is a member of the LAMP family of lysosomal membrane proteins. **Pathways and functions:** - LAMP2 is involved in autophagy, a process by which cells degrade their own components. - It is also involved in cellular response to starvation, where it is expressed in cells that are adapting to a lack of nutrients. - LAMP2 is also involved in the immune system, where it is expressed in immune cells. - It is a protein that is involved in platelet activation and degranulation, and in the regulation of protein stability. **Clinical significance:** - Mutations in the LAMP2 gene have been linked to a number of human diseases, including amyotrophic lateral sclerosis, Alzheimer's disease, and cancer. - These mutations can result in the production of a protein that is misfolded or degraded, which can lead to disease symptoms. - Therefore, LAMP2 is a promising target for the development of new drugs for these diseases.

Genular Protein ID: 890772727

Symbol: LAMP2_HUMAN

Name: CD107 antigen-like family member B

UniProtKB Accession Codes:

P13473 A8K4X5 D3DTF0 Q16641 Q6Q3G8 Q96J30 Q99534 Q9UD93

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CPTAC 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 22 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 37 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3198605

Title: Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences.

PubMed ID: 3198605

DOI: 10.1016/s0021-9258(18)37370-8

PubMed ID: 8517882

Title: The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes.

PubMed ID: 8517882

DOI: 10.1016/s0021-9258(18)52972-0

PubMed ID: 8407947

Title: Molecular and cellular characterization of Mex-/methylation-resistant phenotype. Gene and cDNA cloning, serum dependence, and tumor suppression of transfectant strains.

PubMed ID: 8407947

DOI: 10.1016/s0021-9258(19)36899-1

PubMed ID: 7999007

Title: Complete cDNA sequence of human lysosome-associated membrane protein-2.

PubMed ID: 7999007

DOI: 10.1006/bbrc.1994.2620

PubMed ID: 7488019

Title: An alternatively spliced form of the human lysosome-associated membrane protein-2 gene is expressed in a tissue-specific manner.

PubMed ID: 7488019

DOI: 10.1006/bbrc.1995.2528

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2912382

Title: Purification and characterization of human lysosomal membrane glycoproteins.

PubMed ID: 2912382

DOI: 10.1016/0003-9861(89)90597-3

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 2243102

Title: The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones.

PubMed ID: 2243102

DOI: 10.1016/s0021-9258(17)30530-6

PubMed ID: 8323299

Title: Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2.

PubMed ID: 8323299

DOI: 10.1006/abbi.1993.1322

PubMed ID: 8662539

Title: A receptor for the selective uptake and degradation of proteins by lysosomes.

PubMed ID: 8662539

DOI: 10.1126/science.273.5274.501

PubMed ID: 11082038

Title: Unique properties of lamp2a compared to other lamp2 isoforms.

PubMed ID: 11082038

DOI: 10.1242/jcs.113.24.4441

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 15894275

Title: Lamp-2a facilitates MHC class II presentation of cytoplasmic antigens.

PubMed ID: 15894275

DOI: 10.1016/j.immuni.2005.03.009

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16190986

Title: Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2.

PubMed ID: 16190986

DOI: 10.1111/j.1600-0854.2005.00337.x

PubMed ID: 17897319

Title: Integral and associated lysosomal membrane proteins.

PubMed ID: 17897319

DOI: 10.1111/j.1600-0854.2007.00643.x

PubMed ID: 18644871

Title: The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane.

PubMed ID: 18644871

DOI: 10.1128/mcb.02070-07

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 20518820

Title: LAMP-2-deficient human B cells exhibit altered MHC class II presentation of exogenous antigens.

PubMed ID: 20518820

DOI: 10.1111/j.1365-2567.2010.03309.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22641697

Title: The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2.

PubMed ID: 22641697

DOI: 10.1242/jcs.087346

PubMed ID: 24880125

Title: Degradation of AF1Q by chaperone-mediated autophagy.

PubMed ID: 24880125

DOI: 10.1016/j.yexcr.2014.05.013

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27628032

Title: LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes.

PubMed ID: 27628032

DOI: 10.1242/bio.018648

PubMed ID: 26856698

Title: LAMP-2C inhibits MHC class II presentation of cytoplasmic antigens by disrupting chaperone-mediated autophagy.

PubMed ID: 26856698

DOI: 10.4049/jimmunol.1501476

PubMed ID: 32295904

Title: Lysosome-Associated Membrane Proteins Support the Furin-Mediated Processing of the Mumps Virus Fusion Protein.

PubMed ID: 32295904

DOI: 10.1128/jvi.00050-20

PubMed ID: 36586411

Title: Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy.

PubMed ID: 36586411

DOI: 10.1016/j.molcel.2022.12.002

PubMed ID: 36481789

Title: Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice.

PubMed ID: 36481789

DOI: 10.1038/s41418-022-01098-6

PubMed ID: 37390818

Title: Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.

PubMed ID: 37390818

DOI: 10.1016/j.molcel.2023.06.004

PubMed ID: 25342746

Title: Structure of transmembrane domain of lysosome-associated membrane protein type 2a (LAMP-2A) reveals key features for substrate specificity in chaperone-mediated autophagy.

PubMed ID: 25342746

DOI: 10.1074/jbc.m114.609446

PubMed ID: 15673802

Title: Glycogen storage diseases presenting as hypertrophic cardiomyopathy.

PubMed ID: 15673802

DOI: 10.1056/nejmoa033349

PubMed ID: 15907287

Title: Asymptomatic hyperCKemia in a case of Danon disease due to a missense mutation in Lamp-2 gene.

PubMed ID: 15907287

DOI: 10.1016/j.nmd.2005.02.008

Sequence Information:

  • Length: 410
  • Mass: 44961
  • Checksum: 9E08E3B62D58F454
  • Sequence:
    • MVCFRLFPVP GSGLVLVCLV LGAVRSYALE LNLTDSENAT CLYAKWQMNF TVRYETTNKT 
YKTVTISDHG TVTYNGSICG DDQNGPKIAV QFGPGFSWIA NFTKAASTYS IDSVSFSYNT 
GDNTTFPDAE DKGILTVDEL LAIRIPLNDL FRCNSLSTLE KNDVVQHYWD VLVQAFVQNG 
TVSTNEFLCD KDKTSTVAPT IHTTVPSPTT TPTPKEKPEA GTYSVNNGND TCLLATMGLQ 
LNITQDKVAS VININPNTTH STGSCRSHTA LLRLNSSTIK YLDFVFAVKN ENRFYLKEVN 
ISMYLVNGSV FSIANNNLSY WDAPLGSSYM CNKEQTVSVS GAFQINTFDL RVQPFNVTQG 
KYSTAQDCSA DDDNFLVPIA VGAALAGVLI LVLLAYFIGL KHHHAGYEQF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.