Details for: LMNB1

Gene ID: 4001

Symbol: LMNB1

Ensembl ID: ENSG00000113368

Description: lamin B1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 62.4899
    Cell Significance Index: -9.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 57.6794
    Cell Significance Index: -14.6300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 44.9086
    Cell Significance Index: -18.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 41.0331
    Cell Significance Index: -16.6700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.4916
    Cell Significance Index: -16.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.1635
    Cell Significance Index: -16.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.2751
    Cell Significance Index: -16.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.3613
    Cell Significance Index: -17.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.0287
    Cell Significance Index: -4.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.0228
    Cell Significance Index: 21.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.8742
    Cell Significance Index: 185.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.7278
    Cell Significance Index: 60.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.5984
    Cell Significance Index: 188.5000
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.3810
    Cell Significance Index: 7.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2989
    Cell Significance Index: 141.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2543
    Cell Significance Index: 75.3000
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.2059
    Cell Significance Index: 5.8700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.1697
    Cell Significance Index: 7.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1509
    Cell Significance Index: 187.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1236
    Cell Significance Index: 63.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0964
    Cell Significance Index: 22.9500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.9467
    Cell Significance Index: 9.5500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.8654
    Cell Significance Index: 25.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8418
    Cell Significance Index: 167.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7990
    Cell Significance Index: 93.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7118
    Cell Significance Index: 642.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6727
    Cell Significance Index: 43.4000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5573
    Cell Significance Index: 10.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5093
    Cell Significance Index: 12.7300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4673
    Cell Significance Index: 13.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4542
    Cell Significance Index: 31.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4331
    Cell Significance Index: 13.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4053
    Cell Significance Index: 81.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3993
    Cell Significance Index: 11.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2939
    Cell Significance Index: 105.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2754
    Cell Significance Index: 150.4000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2651
    Cell Significance Index: 3.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2598
    Cell Significance Index: 15.9700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2275
    Cell Significance Index: 43.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2082
    Cell Significance Index: 13.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2068
    Cell Significance Index: 143.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1628
    Cell Significance Index: 4.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1385
    Cell Significance Index: 3.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0903
    Cell Significance Index: 39.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0540
    Cell Significance Index: 0.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0323
    Cell Significance Index: 0.7000
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.0279
    Cell Significance Index: 0.4800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.0121
    Cell Significance Index: 0.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0052
    Cell Significance Index: 0.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0040
    Cell Significance Index: 5.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0016
    Cell Significance Index: 0.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0096
    Cell Significance Index: -17.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0097
    Cell Significance Index: -0.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0112
    Cell Significance Index: -17.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0152
    Cell Significance Index: -9.6300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0183
    Cell Significance Index: -13.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0194
    Cell Significance Index: -0.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0195
    Cell Significance Index: -2.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0243
    Cell Significance Index: -17.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0255
    Cell Significance Index: -18.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0281
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0315
    Cell Significance Index: -19.6600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0321
    Cell Significance Index: -0.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0340
    Cell Significance Index: -19.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0342
    Cell Significance Index: -1.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0350
    Cell Significance Index: -15.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0377
    Cell Significance Index: -4.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0411
    Cell Significance Index: -5.0500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0425
    Cell Significance Index: -0.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0440
    Cell Significance Index: -12.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0505
    Cell Significance Index: -5.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0578
    Cell Significance Index: -10.4200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0740
    Cell Significance Index: -1.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0864
    Cell Significance Index: -3.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0923
    Cell Significance Index: -6.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0939
    Cell Significance Index: -16.0400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0955
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0956
    Cell Significance Index: -20.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1162
    Cell Significance Index: -2.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1212
    Cell Significance Index: -15.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1241
    Cell Significance Index: -4.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1290
    Cell Significance Index: -6.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1524
    Cell Significance Index: -17.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1567
    Cell Significance Index: -9.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1600
    Cell Significance Index: -16.6600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1642
    Cell Significance Index: -2.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1798
    Cell Significance Index: -12.0900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.1927
    Cell Significance Index: -1.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1966
    Cell Significance Index: -5.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1986
    Cell Significance Index: -15.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2090
    Cell Significance Index: -10.9800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2192
    Cell Significance Index: -2.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2277
    Cell Significance Index: -18.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2293
    Cell Significance Index: -17.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2325
    Cell Significance Index: -3.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2526
    Cell Significance Index: -11.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2786
    Cell Significance Index: -6.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2838
    Cell Significance Index: -9.2900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2951
    Cell Significance Index: -3.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LMNB1 is a member of the lamin family, which consists of proteins that play crucial roles in maintaining the structure and function of the nucleus. Unlike its lamin B2 counterpart, which is primarily localized to the nuclear envelope, LMNB1 is widely expressed throughout the cell, including the cytoplasm and nuclear envelope. This unique distribution suggests that LMNB1 may have distinct functions compared to other lamin proteins. LMNB1 has been implicated in various cellular processes, including cell cycle regulation, apoptosis, and immune response. Its involvement in apoptosis has been highlighted by its role in the breakdown of the nuclear lamina, which is a hallmark of programmed cell death. Moreover, LMNB1 has been shown to interact with various signaling pathways, including those involved in cytokine signaling and Rho GTPase cycles, which are crucial for immune cell function. **Pathways and Functions:** LMNB1's involvement in multiple cellular processes can be attributed to its interactions with various signaling pathways. Some of the key pathways and functions associated with LMNB1 include: 1. **Apoptosis:** LMNB1's role in the breakdown of the nuclear lamina and its interaction with pro-apoptotic proteins suggest that it may play a critical role in regulating apoptosis. 2. **Cell Cycle Regulation:** LMNB1's localization to the nuclear envelope and its interaction with cyclin-dependent kinases (CDKs) suggest that it may regulate cell cycle progression. 3. **Immune Response:** LMNB1's expression in immune cells and its interaction with cytokine signaling pathways suggest that it may play a role in regulating immune cell function and response to stimuli. 4. **Cytoskeleton Organization:** LMNB1's involvement in cytoskeleton organization and its interaction with Rho GTPases suggest that it may play a role in regulating cell migration and adhesion. **Clinical Significance:** LMNB1's involvement in various cellular processes and its expression in distinct cell types make it a potential candidate for investigation in various diseases. Some potential clinical applications of LMNB1 include: 1. **Cancer:** LMNB1's role in regulating apoptosis and cell cycle progression make it a potential target for cancer therapy. 2. **Neurodegenerative Diseases:** LMNB1's involvement in neurodegenerative diseases, such as Alzheimer's disease, suggests that it may play a role in regulating neuronal function and survival. 3. **Immune-Mediated Diseases:** LMNB1's expression in immune cells and its interaction with cytokine signaling pathways suggest that it may play a role in regulating immune cell function and response to stimuli. In conclusion, LMNB1 is a complex gene that plays a multifaceted role in regulating cell cycle progression, apoptosis, and immune response. Further investigation into the functions and clinical significance of LMNB1 is warranted, particularly in the context of various diseases.

Genular Protein ID: 3779653985

Symbol: LMNB1_HUMAN

Name: Lamin-B1

UniProtKB Accession Codes:

P20700 B2R6J6 Q3SYN7 Q96EI6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 3 CPTC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 10 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2325650

Title: In vitro posttranslational modification of lamin B cloned from a human T-cell line.

PubMed ID: 2325650

DOI: 10.1128/mcb.10.5.2164-2175.1990

PubMed ID: 7557986

Title: Structural organization of the human gene (LMNB1) encoding nuclear lamin B1.

PubMed ID: 7557986

DOI: 10.1006/geno.1995.1036

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2684976

Title: Human lamin B contains a farnesylated cysteine residue.

PubMed ID: 2684976

DOI: 10.1016/s0021-9258(19)47079-8

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16951681

Title: Lamin B1 duplications cause autosomal dominant leukodystrophy.

PubMed ID: 16951681

DOI: 10.1038/ng1872

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25775403

Title: SEPT12/SPAG4/LAMINB1 complexes are required for maintaining the integrity of the nuclear envelope in postmeiotic male germ cells.

PubMed ID: 25775403

DOI: 10.1371/journal.pone.0120722

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 22265972

Title: Crystal structures of the coil 2B fragment and the globular tail domain of human lamin B1.

PubMed ID: 22265972

DOI: 10.1016/j.febslet.2012.01.007

PubMed ID: 26237509

Title: The active site of O-GlcNAc transferase imposes constraints on substrate sequence.

PubMed ID: 26237509

DOI: 10.1038/nsmb.3063

PubMed ID: 28939839

Title: Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase.

PubMed ID: 28939839

DOI: 10.1038/s41467-017-00865-1

PubMed ID: 33706103

Title: Beta-strand-mediated dimeric formation of the Ig-like domains of human lamin A/C and B1.

PubMed ID: 33706103

DOI: 10.1016/j.bbrc.2021.02.102

PubMed ID: 24686783

Title: Mutations in the matrin 3 gene cause familial amyotrophic lateral sclerosis.

PubMed ID: 24686783

DOI: 10.1038/nn.3688

PubMed ID: 28716252

Title: LMNB1 mutation causes cerebellar involvement and a genome instability defect.

PubMed ID: 28716252

DOI: 10.1016/j.jns.2017.06.027

PubMed ID: 32910914

Title: De Novo Variants in LMNB1 Cause Pronounced Syndromic Microcephaly and Disruption of Nuclear Envelope Integrity.

PubMed ID: 32910914

DOI: 10.1016/j.ajhg.2020.08.015

PubMed ID: 33033404

Title: Heterozygous lamin B1 and lamin B2 variants cause primary microcephaly and define a novel laminopathy.

PubMed ID: 33033404

DOI: 10.1038/s41436-020-00980-3

Sequence Information:

  • Length: 586
  • Mass: 66408
  • Checksum: 73292877745722C4
  • Sequence:
    • MATATPVPPR MGSRAGGPTT PLSPTRLSRL QEKEELRELN DRLAVYIDKV RSLETENSAL 
QLQVTEREEV RGRELTGLKA LYETELADAR RALDDTARER AKLQIELGKC KAEHDQLLLN 
YAKKESDLNG AQIKLREYEA ALNSKDAALA TALGDKKSLE GDLEDLKDQI AQLEASLAAA 
KKQLADETLL KVDLENRCQS LTEDLEFRKS MYEEEINETR RKHETRLVEV DSGRQIEYEY 
KLAQALHEMR EQHDAQVRLY KEELEQTYHA KLENARLSSE MNTSTVNSAR EELMESRMRI 
ESLSSQLSNL QKESRACLER IQELEDLLAK EKDNSRRMLT DKEREMAEIR DQMQQQLNDY 
EQLLDVKLAL DMEISAYRKL LEGEEERLKL SPSPSSRVTV SRASSSRSVR TTRGKRKRVD 
VEESEASSSV SISHSASATG NVCIEEIDVD GKFIRLKNTS EQDQPMGGWE MIRKIGDTSV 
SYKYTSRYVL KAGQTVTIWA ANAGVTASPP TDLIWKNQNS WGTGEDVKVI LKNSQGEEVA 
QRSTVFKTTI PEEEEEEEEA AGVVVEEELF HQQGTPRASN RSCAIM

Genular Protein ID: 2269307674

Symbol: B4DZT3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DZT3

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 2 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SAM 2 SUPFAM 2

Sequence Information:

  • Length: 376
  • Mass: 43034
  • Checksum: 7AE8F395AF286EB9
  • Sequence:
    • MYEEEINETR RKHETRLVEV DPGRQIEYEY KLAQALHEMR EQHDAQVRLY KEELEQTYHA 
KLENARLSSE MNTSTVNSAR EELMESRMRI ESLSSQLSNL QKESRACLER IQELEDLLAK 
EKDNSRRMLT DKEREMAEIR DQMQQQLNDY EQLLDVKLAL DMEISAYRKL LEGEEERLKL 
SPSPSSRVTV SRASSSRSVR TTRGKRKRVD VEESEASSSV SISHSASATG NVCIEEIDVD 
GKFIRLKNTS EQDQPMGGWE MIRKIGDTSV SYKYTSRYVL KAGQTVTIWA ANAGVTASPP 
TDLIWKNQNS WGTGEDVKVI LKNSQGEEVA QRSTVFKTTI PEEEEEEEEA AGVVVEEELF 
HQQGTPRASN RSCAIM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.