Details for: LMNB1

Gene ID: 4001

Symbol: LMNB1

Ensembl ID: ENSG00000113368

Description: lamin B1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 2.26
    Marker Score: 810.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.98
    Marker Score: 3357
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.93
    Marker Score: 1811
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.77
    Marker Score: 4804
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.63
    Marker Score: 1741.5
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.61
    Marker Score: 4772
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.48
    Marker Score: 1488
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.39
    Marker Score: 3785
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.2
    Marker Score: 4927
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.2
    Marker Score: 813
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.19
    Marker Score: 896
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.13
    Marker Score: 1360
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.11
    Marker Score: 1575.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.07
    Marker Score: 779
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.06
    Marker Score: 2504
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.06
    Marker Score: 2012
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.04
    Marker Score: 330
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251706
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.04
    Marker Score: 651
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.03
    Marker Score: 497
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1
    Marker Score: 600
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71724
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47949
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.99
    Marker Score: 489
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30395
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.95
    Marker Score: 2618
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2399
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.94
    Marker Score: 304
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.94
    Marker Score: 236
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.93
    Marker Score: 636
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.92
    Marker Score: 292
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5249
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.92
    Marker Score: 515
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2707
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.88
    Marker Score: 244
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.88
    Marker Score: 1106
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.88
    Marker Score: 13709
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.85
    Marker Score: 47548
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.83
    Marker Score: 1105
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.83
    Marker Score: 7100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.81
    Marker Score: 8255
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.81
    Marker Score: 445
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.8
    Marker Score: 836
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.79
    Marker Score: 1880.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.79
    Marker Score: 455
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.79
    Marker Score: 1969.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.79
    Marker Score: 29852
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.79
    Marker Score: 246
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 314
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.77
    Marker Score: 379
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 587
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.76
    Marker Score: 46800
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.75
    Marker Score: 766
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.75
    Marker Score: 2955
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.74
    Marker Score: 4763
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.74
    Marker Score: 364
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.74
    Marker Score: 1740
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.74
    Marker Score: 9733
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.73
    Marker Score: 5594
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.72
    Marker Score: 324
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.72
    Marker Score: 8362
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.72
    Marker Score: 6831
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.71
    Marker Score: 1475
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.7
    Marker Score: 291
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.7
    Marker Score: 229
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.69
    Marker Score: 243
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.69
    Marker Score: 222
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.69
    Marker Score: 438
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.69
    Marker Score: 6830
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.69
    Marker Score: 164
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 622
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.68
    Marker Score: 482
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2831
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.67
    Marker Score: 2744
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.67
    Marker Score: 2575
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.66
    Marker Score: 621
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.65
    Marker Score: 720
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.65
    Marker Score: 173
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.65
    Marker Score: 9718
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.64
    Marker Score: 402
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.64
    Marker Score: 719
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.64
    Marker Score: 439
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.64
    Marker Score: 338
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.63
    Marker Score: 386
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.63
    Marker Score: 405
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.63
    Marker Score: 189
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.62
    Marker Score: 286
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.61
    Marker Score: 648
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.61
    Marker Score: 404
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.61
    Marker Score: 486
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.6
    Marker Score: 1765
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.6
    Marker Score: 442
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.6
    Marker Score: 11902

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Other Information

**Key characteristics:** * Gene name: LMNB1 * Ensembl ID: ENSG00000113368 * Protein: LMNB1_HUMAN * Molecular weight: 130 kDa * Chromosome: 17q21.1 * Gene expression: Highly expressed in various cell types, including gut endothelial cells, mesenchymal cells, migratory enteric neural crest cells, and immune cells. **Pathways and functions:** * **Apoptosis:** LMNB1 is a key regulator of apoptosis, the process by which cells die on their own. It is involved in the regulation of cell cycle progression, preventing the proliferation of damaged or dysfunctional cells. * **Cell cycle:** LMNB1 is expressed in proliferating cells and is required for the completion of the cell cycle. It is involved in the regulation of cell cycle checkpoints, ensuring that cells enter mitosis only when they are properly prepared and have the necessary signals. * **Cell senescence:** LMNB1 is also involved in cell senescence, a process by which cells lose their ability to divide and differentiate. * **Immune responses:** LMNB1 is expressed on various immune cells, including dendritic cells, macrophages, and neutrophils. It plays a role in the regulation of immune responses by signaling through the activation of various immune receptors. * **Disease:** Mutations in the LMNB1 gene have been linked to the development of several diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. **Clinical significance:** * Targeting LMNB1 has been investigated as a potential therapeutic strategy for various diseases. * Inhibition of LMNB1 has been shown to promote cell death, inhibit tumor growth, and improve the efficacy of immunotherapy. * However, the clinical development of LMNB1 inhibitors has been challenging due to their potential to cause severe side effects, including neurotoxicity and autoimmune reactions.

Genular Protein ID: 3779653985

Symbol: LMNB1_HUMAN

Name: Lamin-B1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2325650

Title: In vitro posttranslational modification of lamin B cloned from a human T-cell line.

PubMed ID: 2325650

DOI: 10.1128/mcb.10.5.2164-2175.1990

PubMed ID: 7557986

Title: Structural organization of the human gene (LMNB1) encoding nuclear lamin B1.

PubMed ID: 7557986

DOI: 10.1006/geno.1995.1036

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2684976

Title: Human lamin B contains a farnesylated cysteine residue.

PubMed ID: 2684976

DOI: 10.1016/s0021-9258(19)47079-8

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16951681

Title: Lamin B1 duplications cause autosomal dominant leukodystrophy.

PubMed ID: 16951681

DOI: 10.1038/ng1872

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25775403

Title: SEPT12/SPAG4/LAMINB1 complexes are required for maintaining the integrity of the nuclear envelope in postmeiotic male germ cells.

PubMed ID: 25775403

DOI: 10.1371/journal.pone.0120722

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 22265972

Title: Crystal structures of the coil 2B fragment and the globular tail domain of human lamin B1.

PubMed ID: 22265972

DOI: 10.1016/j.febslet.2012.01.007

PubMed ID: 24686783

Title: Mutations in the matrin 3 gene cause familial amyotrophic lateral sclerosis.

PubMed ID: 24686783

DOI: 10.1038/nn.3688

PubMed ID: 28716252

Title: LMNB1 mutation causes cerebellar involvement and a genome instability defect.

PubMed ID: 28716252

DOI: 10.1016/j.jns.2017.06.027

PubMed ID: 32910914

Title: De Novo Variants in LMNB1 Cause Pronounced Syndromic Microcephaly and Disruption of Nuclear Envelope Integrity.

PubMed ID: 32910914

DOI: 10.1016/j.ajhg.2020.08.015

PubMed ID: 33033404

Title: Heterozygous lamin B1 and lamin B2 variants cause primary microcephaly and define a novel laminopathy.

PubMed ID: 33033404

DOI: 10.1038/s41436-020-00980-3

Sequence Information:

  • Length: 586
  • Mass: 66408
  • Checksum: 73292877745722C4
  • Sequence:
  • MATATPVPPR MGSRAGGPTT PLSPTRLSRL QEKEELRELN DRLAVYIDKV RSLETENSAL 
    QLQVTEREEV RGRELTGLKA LYETELADAR RALDDTARER AKLQIELGKC KAEHDQLLLN 
    YAKKESDLNG AQIKLREYEA ALNSKDAALA TALGDKKSLE GDLEDLKDQI AQLEASLAAA 
    KKQLADETLL KVDLENRCQS LTEDLEFRKS MYEEEINETR RKHETRLVEV DSGRQIEYEY 
    KLAQALHEMR EQHDAQVRLY KEELEQTYHA KLENARLSSE MNTSTVNSAR EELMESRMRI 
    ESLSSQLSNL QKESRACLER IQELEDLLAK EKDNSRRMLT DKEREMAEIR DQMQQQLNDY 
    EQLLDVKLAL DMEISAYRKL LEGEEERLKL SPSPSSRVTV SRASSSRSVR TTRGKRKRVD 
    VEESEASSSV SISHSASATG NVCIEEIDVD GKFIRLKNTS EQDQPMGGWE MIRKIGDTSV 
    SYKYTSRYVL KAGQTVTIWA ANAGVTASPP TDLIWKNQNS WGTGEDVKVI LKNSQGEEVA 
    QRSTVFKTTI PEEEEEEEEA AGVVVEEELF HQQGTPRASN RSCAIM

Genular Protein ID: 2269307674

Symbol: B4DZT3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 376
  • Mass: 43034
  • Checksum: 7AE8F395AF286EB9
  • Sequence:
  • MYEEEINETR RKHETRLVEV DPGRQIEYEY KLAQALHEMR EQHDAQVRLY KEELEQTYHA 
    KLENARLSSE MNTSTVNSAR EELMESRMRI ESLSSQLSNL QKESRACLER IQELEDLLAK 
    EKDNSRRMLT DKEREMAEIR DQMQQQLNDY EQLLDVKLAL DMEISAYRKL LEGEEERLKL 
    SPSPSSRVTV SRASSSRSVR TTRGKRKRVD VEESEASSSV SISHSASATG NVCIEEIDVD 
    GKFIRLKNTS EQDQPMGGWE MIRKIGDTSV SYKYTSRYVL KAGQTVTIWA ANAGVTASPP 
    TDLIWKNQNS WGTGEDVKVI LKNSQGEEVA QRSTVFKTTI PEEEEEEEEA AGVVVEEELF 
    HQQGTPRASN RSCAIM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.