Details for: LY75

Gene ID: 4065

Symbol: LY75

Ensembl ID: ENSG00000054219

Description: lymphocyte antigen 75

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 48.0889
    Cell Significance Index: -7.4800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 23.8130
    Cell Significance Index: -6.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.0748
    Cell Significance Index: -7.4900
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.5090
    Cell Significance Index: 20.7500
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 2.1510
    Cell Significance Index: 16.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.1203
    Cell Significance Index: 403.5100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.9158
    Cell Significance Index: -7.5600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.5492
    Cell Significance Index: 16.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4114
    Cell Significance Index: 84.7300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.2502
    Cell Significance Index: 18.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9394
    Cell Significance Index: 102.1800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7368
    Cell Significance Index: 6.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5674
    Cell Significance Index: 92.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5265
    Cell Significance Index: 52.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5203
    Cell Significance Index: 63.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5056
    Cell Significance Index: 91.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3559
    Cell Significance Index: 18.4900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.3391
    Cell Significance Index: 3.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3183
    Cell Significance Index: 287.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3112
    Cell Significance Index: 8.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2742
    Cell Significance Index: 149.7200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.2686
    Cell Significance Index: 2.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2682
    Cell Significance Index: 5.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2670
    Cell Significance Index: 12.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2602
    Cell Significance Index: 30.6900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2542
    Cell Significance Index: 6.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2276
    Cell Significance Index: 26.5200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1904
    Cell Significance Index: 8.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1769
    Cell Significance Index: 11.4200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1619
    Cell Significance Index: 3.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1348
    Cell Significance Index: 2.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0799
    Cell Significance Index: 1.7500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0719
    Cell Significance Index: 1.0300
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.0611
    Cell Significance Index: 0.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0487
    Cell Significance Index: 1.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0446
    Cell Significance Index: 1.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0396
    Cell Significance Index: 17.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0354
    Cell Significance Index: 1.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0321
    Cell Significance Index: 6.4400
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.0256
    Cell Significance Index: 0.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0162
    Cell Significance Index: 0.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0046
    Cell Significance Index: 0.6000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0024
    Cell Significance Index: -0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0040
    Cell Significance Index: -7.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0048
    Cell Significance Index: -0.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0057
    Cell Significance Index: -8.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0070
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0081
    Cell Significance Index: -5.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0087
    Cell Significance Index: -3.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0092
    Cell Significance Index: -6.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0106
    Cell Significance Index: -7.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0129
    Cell Significance Index: -7.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0143
    Cell Significance Index: -4.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0143
    Cell Significance Index: -8.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0191
    Cell Significance Index: -8.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0284
    Cell Significance Index: -4.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0382
    Cell Significance Index: -8.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0394
    Cell Significance Index: -7.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0407
    Cell Significance Index: -5.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0462
    Cell Significance Index: -0.6300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0467
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0478
    Cell Significance Index: -5.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0486
    Cell Significance Index: -3.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0500
    Cell Significance Index: -5.1100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0520
    Cell Significance Index: -0.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0578
    Cell Significance Index: -4.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0606
    Cell Significance Index: -1.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0634
    Cell Significance Index: -1.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0650
    Cell Significance Index: -2.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0703
    Cell Significance Index: -5.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0775
    Cell Significance Index: -3.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0827
    Cell Significance Index: -2.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0890
    Cell Significance Index: -5.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0981
    Cell Significance Index: -4.3400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0991
    Cell Significance Index: -7.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1006
    Cell Significance Index: -6.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1082
    Cell Significance Index: -6.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1117
    Cell Significance Index: -3.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1246
    Cell Significance Index: -6.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1352
    Cell Significance Index: -7.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1422
    Cell Significance Index: -5.8300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1545
    Cell Significance Index: -6.7200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1645
    Cell Significance Index: -6.0400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1750
    Cell Significance Index: -6.1300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1850
    Cell Significance Index: -2.8100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1887
    Cell Significance Index: -1.2300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1898
    Cell Significance Index: -4.9900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1902
    Cell Significance Index: -2.4100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.2104
    Cell Significance Index: -2.1700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2124
    Cell Significance Index: -6.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2183
    Cell Significance Index: -5.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2236
    Cell Significance Index: -7.7700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2245
    Cell Significance Index: -7.1500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2258
    Cell Significance Index: -4.6000
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.2353
    Cell Significance Index: -2.3300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2355
    Cell Significance Index: -4.0600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2363
    Cell Significance Index: -3.5400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2395
    Cell Significance Index: -7.0600
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.2419
    Cell Significance Index: -2.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LY75 is a gene that is significantly expressed in various cell types, including cortical thymic epithelial cells, myeloid dendritic cells, and intestinal epithelial cells. Its protein product exhibits a unique combination of carbohydrate binding and signaling receptor activity, suggesting a multifaceted role in immune regulation. Notably, LY75 is also expressed in the central nervous system, where it may contribute to the modulation of immune responses in the brain. **Pathways and Functions:** LY75's involvement in various cellular processes can be attributed to its participation in multiple signaling pathways. These include: 1. **Carbohydrate binding:** LY75's carbohydrate binding capabilities may play a crucial role in modulating immune responses, particularly in the context of carbohydrate-mediated antigen presentation. 2. **Endocytosis:** The protein's ability to participate in endocytic processes suggests a role in the internalization and degradation of antigens, thereby influencing immune surveillance. 3. **Signaling receptor activity:** LY75's signaling receptor activity may contribute to the modulation of immune responses, potentially influencing the activation of immune cells and the production of cytokines. 4. **Immune response and inflammatory response:** LY75's involvement in these pathways suggests a role in regulating immune responses, including the activation of immune cells and the production of pro-inflammatory cytokines. **Clinical Significance:** The clinical significance of LY75 lies in its potential role in various immune-related disorders. For instance: 1. **Autoimmune diseases:** Alterations in LY75 expression or function may contribute to the development or progression of autoimmune diseases, such as rheumatoid arthritis or multiple sclerosis. 2. **Inflammatory disorders:** LY75's involvement in inflammatory responses suggests a potential role in the pathogenesis of inflammatory disorders, such as inflammatory bowel disease or psoriasis. 3. **Neurological disorders:** LY75's expression in the central nervous system raises the possibility of its involvement in neurological disorders, such as multiple sclerosis or Alzheimer's disease. In conclusion, LY75 is a gene with a complex and multifaceted role in the immune system. Its involvement in various signaling pathways and its expression in diverse cell types underscore its potential significance in immune-related disorders. Further research is necessary to elucidate the full extent of LY75's clinical significance and to explore its therapeutic potential.

Genular Protein ID: 2020154284

Symbol: Q59H44_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59H44

Database IDs:

BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 1340
  • Mass: 154596
  • Checksum: C9EA8275BBAC07B2
  • Sequence:
    • DKAHAKCKAF SSDLISIHSL ADVEVVVTKL HNEDIKEEVW IGLKNINIPT LFQWSDGTEV 
TLTYWDENEP NVPYNKTPNC VSYLGELGQW KVQSCEEKLK YVCKRKGEKL NDASSDKMCP 
PDEGWKRHGE TCYKIYEDEV PFGTNCNLTI TSRFEQEYLN DLMKKYDKSL RKYFWTGLRD 
VDSCGEYNWA TVGGRRRAVT FSNWNFLEPA SPGGCVAMST GKSVGKWEVK DCRSFKALSI 
CKKMSGPLGP EEASPKPDDP CPEGWQSFPA SLSCYKVFHA ERIVRKRNWE EAERFCQALG 
AHLSSFSHVD EIKEFLHFLT DQFSGQHWLW IGLNKRSPDL QGSWQWSDRT PVSTIIMPNE 
FQQDYDIRDC AAVKVFHRPW RRGWHFYDDR EFIYLRPFAC DTKLEWVCQI PKGRTPKTPD 
WYNPERAGIH GPPLIIEGSE YWFVADLHLN YEEAVLYCAS NHSFLATITS FVGLKAIKNK 
IANISGDGQK WWIRISEWPI DDHFTYSRYP WHRFPVTFGE ECLYMSAKTW LIDLGKPTDC 
STKLPFICEK YNVSSLEKYS PDSAAKVQCS EQWIPFQNKC FLKIKPVSLT FSQASDTCHS 
YGGTLPSVLS QIEQDFITSL LPDMEATLWI GLRWTAYEKI NKWTDNRELT YSNFHPLLVS 
GRLRIPENFF EEESRYHCAL ILNLQKSPFT GTWNFTSCSE RHFVSLCQKY SEVKSRQTLQ 
NASETVKYLN NLYKIIPKTL TWHSAKRECL KSNMQLVSIT DPYQQAFLSV QALLHNSSLW 
IGLFSQDDEL NFGWSDGKRL HFSRWAETNG QLEDCVVLDT DGFWKTVDCN DNQPGAICYY 
SGNETEKEVK PVDSVKCPSP VLNTPWIPFQ NCCYNFIITK NRHMATTQDE VHTKCQKLNP 
KSHILSIRDE KENNFVLEQL LYFNYMASWV MLGITYRNNS LMWFDKTPLS YTHWRAGRPT 
IKNEKFLAGL STDGFWDIQT FKVIEEAVYF HQHSILACKI EMVDYKEEYN TTLPQFMPYE 
DGIYSVIQKK VTWYEALNMC SQSGGHLASV HNQNGQLFLE DIVKRDGFPL WVGLSSHDGS 
ESSFEWSDGS TFDYIPWKGQ TSPGNCVLLD PKGTWKHEKC NSVKDGAICY KPTKSKKLSR 
LTYSSRCPAA KENGSRWIQY KGHCYKSDQA LHSFSEAKKL CSKHDHSATI VSIKDEDENK 
FVSRLMRENN NITMRVWLGL SQHSVDQSWS WLDGSEVTFV KWENKSKSGV GRCSMLIASN 
ETWKKVECEH GFGRVVCKVP LGPDYTAIAI IVATLSILVL MGGLIWFLFQ RHRLHLAGFS 
SVRYAQGVNE DEIMLPSFHD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.