Details for: LY75

Gene ID: 4065

Symbol: LY75

Ensembl ID: ENSG00000054219

Description: lymphocyte antigen 75

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.69
    Marker Score: 6264
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.32
    Marker Score: 799
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71789
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48013
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.99
    Marker Score: 2016
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 492.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 446
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5244
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.85
    Marker Score: 7382.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.84
    Marker Score: 1365
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.77
    Marker Score: 365
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.73
    Marker Score: 209
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.71
    Marker Score: 11063
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.7
    Marker Score: 538
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 280
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 618
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.66
    Marker Score: 212
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.64
    Marker Score: 385
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.64
    Marker Score: 2687
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.63
    Marker Score: 1197
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.61
    Marker Score: 443
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.6
    Marker Score: 1686
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.6
    Marker Score: 1136
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.58
    Marker Score: 349
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.56
    Marker Score: 392
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 438
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.54
    Marker Score: 269
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.53
    Marker Score: 2529
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.52
    Marker Score: 236
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.51
    Marker Score: 190
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.5
    Marker Score: 386
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.49
    Marker Score: 17020
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.48
    Marker Score: 113
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.44
    Marker Score: 291
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.43
    Marker Score: 274
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.43
    Marker Score: 1080
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.43
    Marker Score: 178
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.42
    Marker Score: 993
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.41
    Marker Score: 1230
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.4
    Marker Score: 273
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.4
    Marker Score: 10219.5
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.4
    Marker Score: 100
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.39
    Marker Score: 1932
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.39
    Marker Score: 103
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.39
    Marker Score: 146
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.38
    Marker Score: 671
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.38
    Marker Score: 387
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.38
    Marker Score: 299
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.37
    Marker Score: 174
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.37
    Marker Score: 1148
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.36
    Marker Score: 475
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.36
    Marker Score: 362
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.36
    Marker Score: 334
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.35
    Marker Score: 857
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.35
    Marker Score: 111
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.34
    Marker Score: 98
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.34
    Marker Score: 248
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.34
    Marker Score: 521
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.34
    Marker Score: 161
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.33
    Marker Score: 231
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.33
    Marker Score: 490
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.33
    Marker Score: 166
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.33
    Marker Score: 789
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.33
    Marker Score: 242
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.33
    Marker Score: 357.5
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.33
    Marker Score: 1359
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.33
    Marker Score: 102
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.32
    Marker Score: 82
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.32
    Marker Score: 111
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.31
    Marker Score: 267
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.31
    Marker Score: 340
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.31
    Marker Score: 227
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.31
    Marker Score: 458
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.31
    Marker Score: 189
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.31
    Marker Score: 62
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.31
    Marker Score: 231
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.31
    Marker Score: 268
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.3
    Marker Score: 498
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.3
    Marker Score: 551
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.3
    Marker Score: 247
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.29
    Marker Score: 195
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.29
    Marker Score: 160
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.29
    Marker Score: 2905
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.29
    Marker Score: 1721.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.29
    Marker Score: 2824
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.28
    Marker Score: 280
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.28
    Marker Score: 97
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.28
    Marker Score: 1202
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.28
    Marker Score: 68
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.28
    Marker Score: 277
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.28
    Marker Score: 292
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.28
    Marker Score: 441
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.28
    Marker Score: 176

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Other Information

**Key characteristics**: * LY75 is a cell surface protein that is expressed on a variety of cell types, including cortical thymic epithelial cells, myeloid dendritic cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, immature innate lymphoid cells, absorptive cells, tuft cells of the colon, intestinal crypt stem cells of the colon, and human transit amplifying cells. * LY75 is a member of the LY7 family of cell surface receptors, which are involved in the regulation of immune responses. * It is a type I transmembrane receptor that is expressed on the surface of professional antigen-presenting cells. * LY75 is a ligand for CD80 and CD86 molecules, which are expressed on the surface of T cells. * It is involved in the regulation of T cell responses, and its expression is upregulated in tumors that are resistant to immunotherapy. **Pathways and functions**: * LY75 is involved in the regulation of immune responses by binding to CD80 and CD86 molecules on the surface of T cells. * This binding triggers a signaling cascade that leads to the activation of T cells and the production of cytokines that promote inflammation and tumor growth. * In addition, LY75 is also involved in the regulation of inflammation by binding to CD80 and CD86 molecules on the surface of macrophages and dendritic cells. * This binding triggers the production of inflammatory cytokines, which can promote the recruitment of immune cells to the site of inflammation. **Clinical significance**: * LY75 is a promising target for cancer immunotherapy. * Antibodies against LY75 have been shown to be effective in blocking tumor growth and metastasis in animal models of cancer. * Clinical trials of LY75 inhibitors are currently underway in humans.

Genular Protein ID: 2020154284

Symbol: Q59H44_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59H44

Database IDs:

BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 1340
  • Mass: 154596
  • Checksum: C9EA8275BBAC07B2
  • Sequence:
    • DKAHAKCKAF SSDLISIHSL ADVEVVVTKL HNEDIKEEVW IGLKNINIPT LFQWSDGTEV 
TLTYWDENEP NVPYNKTPNC VSYLGELGQW KVQSCEEKLK YVCKRKGEKL NDASSDKMCP 
PDEGWKRHGE TCYKIYEDEV PFGTNCNLTI TSRFEQEYLN DLMKKYDKSL RKYFWTGLRD 
VDSCGEYNWA TVGGRRRAVT FSNWNFLEPA SPGGCVAMST GKSVGKWEVK DCRSFKALSI 
CKKMSGPLGP EEASPKPDDP CPEGWQSFPA SLSCYKVFHA ERIVRKRNWE EAERFCQALG 
AHLSSFSHVD EIKEFLHFLT DQFSGQHWLW IGLNKRSPDL QGSWQWSDRT PVSTIIMPNE 
FQQDYDIRDC AAVKVFHRPW RRGWHFYDDR EFIYLRPFAC DTKLEWVCQI PKGRTPKTPD 
WYNPERAGIH GPPLIIEGSE YWFVADLHLN YEEAVLYCAS NHSFLATITS FVGLKAIKNK 
IANISGDGQK WWIRISEWPI DDHFTYSRYP WHRFPVTFGE ECLYMSAKTW LIDLGKPTDC 
STKLPFICEK YNVSSLEKYS PDSAAKVQCS EQWIPFQNKC FLKIKPVSLT FSQASDTCHS 
YGGTLPSVLS QIEQDFITSL LPDMEATLWI GLRWTAYEKI NKWTDNRELT YSNFHPLLVS 
GRLRIPENFF EEESRYHCAL ILNLQKSPFT GTWNFTSCSE RHFVSLCQKY SEVKSRQTLQ 
NASETVKYLN NLYKIIPKTL TWHSAKRECL KSNMQLVSIT DPYQQAFLSV QALLHNSSLW 
IGLFSQDDEL NFGWSDGKRL HFSRWAETNG QLEDCVVLDT DGFWKTVDCN DNQPGAICYY 
SGNETEKEVK PVDSVKCPSP VLNTPWIPFQ NCCYNFIITK NRHMATTQDE VHTKCQKLNP 
KSHILSIRDE KENNFVLEQL LYFNYMASWV MLGITYRNNS LMWFDKTPLS YTHWRAGRPT 
IKNEKFLAGL STDGFWDIQT FKVIEEAVYF HQHSILACKI EMVDYKEEYN TTLPQFMPYE 
DGIYSVIQKK VTWYEALNMC SQSGGHLASV HNQNGQLFLE DIVKRDGFPL WVGLSSHDGS 
ESSFEWSDGS TFDYIPWKGQ TSPGNCVLLD PKGTWKHEKC NSVKDGAICY KPTKSKKLSR 
LTYSSRCPAA KENGSRWIQY KGHCYKSDQA LHSFSEAKKL CSKHDHSATI VSIKDEDENK 
FVSRLMRENN NITMRVWLGL SQHSVDQSWS WLDGSEVTFV KWENKSKSGV GRCSMLIASN 
ETWKKVECEH GFGRVVCKVP LGPDYTAIAI IVATLSILVL MGGLIWFLFQ RHRLHLAGFS 
SVRYAQGVNE DEIMLPSFHD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.