Details for: CAPRIN1

Gene ID: 4076

Symbol: CAPRIN1

Ensembl ID: ENSG00000135387

Description: cell cycle associated protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 377.4465
    Cell Significance Index: -58.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 222.9902
    Cell Significance Index: -56.5600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 168.9292
    Cell Significance Index: -69.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 143.9668
    Cell Significance Index: -67.9700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 132.1823
    Cell Significance Index: -53.7000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 122.8846
    Cell Significance Index: -63.2100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 101.5168
    Cell Significance Index: -68.1200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 56.4969
    Cell Significance Index: -53.9400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 51.8753
    Cell Significance Index: -63.9600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.9202
    Cell Significance Index: -61.4000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.4747
    Cell Significance Index: -65.0100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.7329
    Cell Significance Index: -42.1800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.8922
    Cell Significance Index: -21.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.7486
    Cell Significance Index: 553.4000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 4.7237
    Cell Significance Index: 75.7900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.8025
    Cell Significance Index: 48.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6229
    Cell Significance Index: 292.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6159
    Cell Significance Index: 320.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5462
    Cell Significance Index: 190.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4998
    Cell Significance Index: 84.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3395
    Cell Significance Index: 268.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1135
    Cell Significance Index: 608.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0796
    Cell Significance Index: 31.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0279
    Cell Significance Index: 141.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9269
    Cell Significance Index: 25.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8461
    Cell Significance Index: 763.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8337
    Cell Significance Index: 23.3000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7956
    Cell Significance Index: 51.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7858
    Cell Significance Index: 40.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7820
    Cell Significance Index: 280.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7563
    Cell Significance Index: 39.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7025
    Cell Significance Index: 76.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6171
    Cell Significance Index: 272.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6149
    Cell Significance Index: 28.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5972
    Cell Significance Index: 27.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5942
    Cell Significance Index: 70.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5817
    Cell Significance Index: 110.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5470
    Cell Significance Index: 11.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5023
    Cell Significance Index: 38.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4917
    Cell Significance Index: 34.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4853
    Cell Significance Index: 29.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4541
    Cell Significance Index: 11.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4192
    Cell Significance Index: 289.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4135
    Cell Significance Index: 19.2800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3898
    Cell Significance Index: 3.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3791
    Cell Significance Index: 64.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3339
    Cell Significance Index: 33.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3151
    Cell Significance Index: 10.9500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3013
    Cell Significance Index: 38.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1630
    Cell Significance Index: 21.0600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1514
    Cell Significance Index: 3.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0911
    Cell Significance Index: 171.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0894
    Cell Significance Index: 3.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0236
    Cell Significance Index: 36.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0225
    Cell Significance Index: 14.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0136
    Cell Significance Index: 18.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0128
    Cell Significance Index: 23.6900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0165
    Cell Significance Index: -12.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0171
    Cell Significance Index: -7.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0174
    Cell Significance Index: -12.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0213
    Cell Significance Index: -1.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0463
    Cell Significance Index: -35.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0568
    Cell Significance Index: -35.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0745
    Cell Significance Index: -7.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0788
    Cell Significance Index: -5.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0800
    Cell Significance Index: -5.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0886
    Cell Significance Index: -49.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1135
    Cell Significance Index: -1.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1506
    Cell Significance Index: -31.7300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1593
    Cell Significance Index: -2.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1873
    Cell Significance Index: -53.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1874
    Cell Significance Index: -4.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1960
    Cell Significance Index: -8.6700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2048
    Cell Significance Index: -1.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2228
    Cell Significance Index: -32.3800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3132
    Cell Significance Index: -35.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3238
    Cell Significance Index: -12.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3268
    Cell Significance Index: -37.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3475
    Cell Significance Index: -9.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3793
    Cell Significance Index: -9.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.3803
    Cell Significance Index: -61.8500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4222
    Cell Significance Index: -4.5900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4365
    Cell Significance Index: -11.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4459
    Cell Significance Index: -23.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4471
    Cell Significance Index: -6.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4900
    Cell Significance Index: -14.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5032
    Cell Significance Index: -52.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5549
    Cell Significance Index: -9.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5725
    Cell Significance Index: -14.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6018
    Cell Significance Index: -47.6700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6380
    Cell Significance Index: -15.3000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7423
    Cell Significance Index: -13.7200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7812
    Cell Significance Index: -4.7200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7844
    Cell Significance Index: -9.3500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.9291
    Cell Significance Index: -64.2500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9791
    Cell Significance Index: -27.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9892
    Cell Significance Index: -26.5100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.0003
    Cell Significance Index: -12.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0313
    Cell Significance Index: -63.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0659
    Cell Significance Index: -31.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CAPRIN1 is a cytoplasmic protein that interacts with various molecular partners, including RNA-binding proteins, signaling adaptors, and other proteins involved in cellular signaling pathways. Its expression is tightly regulated during the cell cycle, and it is involved in the positive regulation of dendrite morphogenesis and dendritic spine morphogenesis. CAPRIN1 also plays a role in the assembly and regulation of stress granules, which are cytoplasmic structures involved in mRNA translation and stability. **Pathways and Functions:** CAPRIN1 is involved in several signaling pathways, including: 1. **Cell cycle regulation:** CAPRIN1 is required for the proper progression of the cell cycle, particularly during the G2/M phase. 2. **Dendrite morphogenesis:** CAPRIN1 is involved in the regulation of dendrite growth and branching, which is essential for neuronal function and synaptic plasticity. 3. **Stress granule assembly:** CAPRIN1 interacts with RNA-binding proteins to regulate the assembly and stability of stress granules, which are involved in mRNA translation and stability. 4. **Negative regulation of translation:** CAPRIN1 can inhibit translation by binding to mRNA and preventing its translation. **Clinical Significance:** The dysregulation of CAPRIN1 has been implicated in various diseases, including: 1. **Neurological disorders:** Alterations in CAPRIN1 expression have been observed in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer:** CAPRIN1 is overexpressed in certain types of cancer, including breast cancer and ovarian cancer. 3. **Immune disorders:** CAPRIN1 is involved in the regulation of immune responses, and its dysregulation has been implicated in autoimmune diseases, such as multiple sclerosis. In conclusion, CAPRIN1 is a multifunctional protein that plays a crucial role in various cellular processes, including cell cycle regulation, dendrite morphogenesis, and stress granule assembly. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and mechanisms of CAPRIN1. **Future Directions:** 1. **Investigating the molecular mechanisms of CAPRIN1 regulation:** Further studies are needed to elucidate the molecular mechanisms underlying CAPRIN1 regulation, including its interactions with other proteins and signaling pathways. 2. **Exploring the therapeutic potential of CAPRIN1:** The identification of CAPRIN1 as a potential therapeutic target for various diseases, including neurological disorders and cancer, highlights the need for further research into its therapeutic potential. 3. **Investigating the role of CAPRIN1 in disease models:** The use of disease models, such as animal models and cell culture systems, can provide valuable insights into the role of CAPRIN1 in disease pathogenesis and the development of therapeutic strategies.

Genular Protein ID: 1586374210

Symbol: CAPR1_HUMAN

Name: Cell cycle-associated protein 1

UniProtKB Accession Codes:

Q14444 A6NMY7 D3DR06 Q15074 Q6IMN4 Q6IMN7 Q9BV09

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 10 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7657653

Title: Identification and characterization of a novel protein (p137) which transcytoses bidirectionally in Caco-2 cells.

PubMed ID: 7657653

DOI: 10.1074/jbc.270.35.20717

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8786113

Title: The gene encoding the GPI-anchored membrane protein p137GPI (M11S1) maps to human chromosome 11p13 and is highly conserved in the mouse.

PubMed ID: 8786113

DOI: 10.1006/geno.1996.0099

PubMed ID: 14764709

Title: Activation/division of lymphocytes results in increased levels of cytoplasmic activation/proliferation-associated protein-1: prototype of a new family of proteins.

PubMed ID: 14764709

DOI: 10.4049/jimmunol.172.4.2389

PubMed ID: 17210633

Title: Distinct structural features of caprin-1 mediate its interaction with G3BP-1 and its induction of phosphorylation of eukaryotic translation initiation factor 2alpha, entry to cytoplasmic stress granules, and selective interaction with a subset of mRNAs.

PubMed ID: 17210633

DOI: 10.1128/mcb.02300-06

PubMed ID: 20516077

Title: RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain.

PubMed ID: 20516077

DOI: 10.1074/jbc.m110.108944

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21933836

Title: The X-chromosome-linked intellectual disability protein PQBP1 is a component of neuronal RNA granules and regulates the appearance of stress granules.

PubMed ID: 21933836

DOI: 10.1093/hmg/ddr430

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22967762

Title: Characterization of O-GlcNAc cycling and proteomic identification of differentially O-GlcNAcylated proteins during G1/S transition.

PubMed ID: 22967762

DOI: 10.1016/j.bbagen.2012.08.024

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23097442

Title: Japanese encephalitis virus core protein inhibits stress granule formation through an interaction with Caprin-1 and facilitates viral propagation.

PubMed ID: 23097442

DOI: 10.1128/jvi.02186-12

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27022092

Title: G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits.

PubMed ID: 27022092

DOI: 10.1083/jcb.201508028

PubMed ID: 28733330

Title: The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading.

PubMed ID: 28733330

DOI: 10.1042/bcj20170354

PubMed ID: 28592527

Title: Zika virus hijacks stress granule proteins and modulates the host stress response.

PubMed ID: 28592527

DOI: 10.1128/jvi.00474-17

PubMed ID: 28794026

Title: Mammalian Orthoreovirus Factories Modulate Stress Granule Protein Localization by Interaction with G3BP1.

PubMed ID: 28794026

DOI: 10.1128/jvi.01298-17

PubMed ID: 30258011

Title: Rotavirus Induces Formation of Remodeled Stress Granules and P Bodies and Their Sequestration in Viroplasms To Promote Progeny Virus Production.

PubMed ID: 30258011

DOI: 10.1128/jvi.01363-18

PubMed ID: 31439799

Title: Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation.

PubMed ID: 31439799

DOI: 10.1126/science.aax4240

PubMed ID: 32302570

Title: Competing protein-RNA interaction networks control multiphase intracellular organization.

PubMed ID: 32302570

DOI: 10.1016/j.cell.2020.03.050

PubMed ID: 32302571

Title: G3BP1 is a tunable switch that triggers phase separation to assemble stress granules.

PubMed ID: 32302571

DOI: 10.1016/j.cell.2020.03.046

PubMed ID: 32302572

Title: RNA-Induced conformational switching and clustering of G3BP drive stress granule assembly by condensation.

PubMed ID: 32302572

DOI: 10.1016/j.cell.2020.03.049

PubMed ID: 34074792

Title: Interaction hot spots for phase separation revealed by NMR studies of a CAPRIN1 condensed phase.

PubMed ID: 34074792

DOI: 10.1073/pnas.2104897118

PubMed ID: 36183834

Title: Tryptophan mutations in G3BP1 tune the stability of a cellular signaling hub by weakening transient interactions with Caprin1 and USP10.

PubMed ID: 36183834

DOI: 10.1016/j.jbc.2022.102552

PubMed ID: 36040869

Title: Mapping the per-residue surface electrostatic potential of CAPRIN1 along its phase-separation trajectory.

PubMed ID: 36040869

DOI: 10.1073/pnas.2210492119

PubMed ID: 35977029

Title: De novo variants in genes regulating stress granule assembly associate with neurodevelopmental disorders.

PubMed ID: 35977029

DOI: 10.1126/sciadv.abo7112

PubMed ID: 36279435

Title: Yin and yang regulation of stress granules by Caprin-1.

PubMed ID: 36279435

DOI: 10.1073/pnas.2207975119

PubMed ID: 36136249

Title: CAPRIN1P512L causes aberrant protein aggregation and associates with early-onset ataxia.

PubMed ID: 36136249

DOI: 10.1007/s00018-022-04544-3

PubMed ID: 35979925

Title: CAPRIN1 haploinsufficiency causes a neurodevelopmental disorder with language impairment, ADHD and ASD.

PubMed ID: 35979925

DOI: 10.1093/brain/awac278

Sequence Information:

  • Length: 709
  • Mass: 78366
  • Checksum: 56F5BC188CA3A2D4
  • Sequence:
    • MPSATSHSGS GSKSSGPPPP SGSSGSEAAA GAGAAAPASQ HPATGTGAVQ TEAMKQILGV 
IDKKLRNLEK KKGKLDDYQE RMNKGERLNQ DQLDAVSKYQ EVTNNLEFAK ELQRSFMALS 
QDIQKTIKKT ARREQLMREE AEQKRLKTVL ELQYVLDKLG DDEVRTDLKQ GLNGVPILSE 
EELSLLDEFY KLVDPERDMS LRLNEQYEHA SIHLWDLLEG KEKPVCGTTY KVLKEIVERV 
FQSNYFDSTH NHQNGLCEEE EAASAPAVED QVPEAEPEPA EEYTEQSEVE STEYVNRQFM 
AETQFTSGEK EQVDEWTVET VEVVNSLQQQ PQAASPSVPE PHSLTPVAQA DPLVRRQRVQ 
DLMAQMQGPY NFIQDSMLDF ENQTLDPAIV SAQPMNPTQN MDMPQLVCPP VHSESRLAQP 
NQVPVQPEAT QVPLVSSTSE GYTASQPLYQ PSHATEQRPQ KEPIDQIQAT ISLNTDQTTA 
SSSLPAASQP QVFQAGTSKP LHSSGINVNA APFQSMQTVF NMNAPVPPVN EPETLKQQNQ 
YQASYNQSFS SQPHQVEQTE LQQEQLQTVV GTYHGSPDQS HQVTGNHQQP PQQNTGFPRS 
NQPYYNSRGV SRGGSRGARG LMNGYRGPAN GFRGGYDGYR PSFSNTPNSG YTQSQFSAPR 
DYSGYQRDGY QQNFKRGSGQ SGPRGAPRGR GGPPRPNRGM PQMNTQQVN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.