Details for: MAGOH

Gene ID: 4116

Symbol: MAGOH

Ensembl ID: ENSG00000162385

Description: mago homolog, exon junction complex subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 260.3101
    Cell Significance Index: -40.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 154.8631
    Cell Significance Index: -39.2800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 131.0604
    Cell Significance Index: -53.9900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 115.6056
    Cell Significance Index: -54.5800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 104.6103
    Cell Significance Index: -53.8100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 81.6217
    Cell Significance Index: -54.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.5749
    Cell Significance Index: -51.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.9329
    Cell Significance Index: -54.9800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.1642
    Cell Significance Index: -35.2700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.2915
    Cell Significance Index: -31.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.2539
    Cell Significance Index: 379.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.2225
    Cell Significance Index: 58.4400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.1396
    Cell Significance Index: 17.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.0732
    Cell Significance Index: 56.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9826
    Cell Significance Index: 322.4500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.8498
    Cell Significance Index: 20.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.7409
    Cell Significance Index: 205.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.5622
    Cell Significance Index: 32.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.5355
    Cell Significance Index: 72.1700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.4826
    Cell Significance Index: 42.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4225
    Cell Significance Index: 91.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.4192
    Cell Significance Index: 627.4800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.4070
    Cell Significance Index: 99.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.3344
    Cell Significance Index: 46.3700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.2938
    Cell Significance Index: 10.3300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2519
    Cell Significance Index: 17.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2253
    Cell Significance Index: 168.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1508
    Cell Significance Index: 141.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1479
    Cell Significance Index: 626.8700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9568
    Cell Significance Index: 10.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9399
    Cell Significance Index: 169.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8818
    Cell Significance Index: 65.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8234
    Cell Significance Index: 56.9500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.7773
    Cell Significance Index: 13.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7516
    Cell Significance Index: 97.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7450
    Cell Significance Index: 21.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7207
    Cell Significance Index: 16.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6709
    Cell Significance Index: 193.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6251
    Cell Significance Index: 16.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6138
    Cell Significance Index: 31.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5731
    Cell Significance Index: 26.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5699
    Cell Significance Index: 56.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4965
    Cell Significance Index: 63.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4277
    Cell Significance Index: 85.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3791
    Cell Significance Index: 10.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3527
    Cell Significance Index: 22.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3253
    Cell Significance Index: 64.5500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2171
    Cell Significance Index: 2.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1276
    Cell Significance Index: 24.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1083
    Cell Significance Index: 38.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0437
    Cell Significance Index: 33.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0137
    Cell Significance Index: 0.2300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0018
    Cell Significance Index: -0.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0039
    Cell Significance Index: -2.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0060
    Cell Significance Index: -0.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0089
    Cell Significance Index: -6.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0120
    Cell Significance Index: -22.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0256
    Cell Significance Index: -47.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0312
    Cell Significance Index: -48.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0381
    Cell Significance Index: -3.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0386
    Cell Significance Index: -52.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0469
    Cell Significance Index: -29.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0596
    Cell Significance Index: -44.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0683
    Cell Significance Index: -11.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0836
    Cell Significance Index: -47.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0887
    Cell Significance Index: -40.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0956
    Cell Significance Index: -59.6800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1648
    Cell Significance Index: -3.5100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1660
    Cell Significance Index: -4.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2221
    Cell Significance Index: -11.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2440
    Cell Significance Index: -6.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2442
    Cell Significance Index: -27.9800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2466
    Cell Significance Index: -1.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2617
    Cell Significance Index: -38.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2780
    Cell Significance Index: -12.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2793
    Cell Significance Index: -58.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3996
    Cell Significance Index: -12.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4124
    Cell Significance Index: -25.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4450
    Cell Significance Index: -24.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4519
    Cell Significance Index: -13.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4636
    Cell Significance Index: -35.5800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4809
    Cell Significance Index: -38.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5179
    Cell Significance Index: -53.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5613
    Cell Significance Index: -14.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6547
    Cell Significance Index: -44.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7598
    Cell Significance Index: -46.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7848
    Cell Significance Index: -23.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8401
    Cell Significance Index: -37.1600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8599
    Cell Significance Index: -10.2500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.8826
    Cell Significance Index: -12.3800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.9008
    Cell Significance Index: -9.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9061
    Cell Significance Index: -23.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0053
    Cell Significance Index: -38.0700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.0094
    Cell Significance Index: -9.3000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -1.0499
    Cell Significance Index: -6.8500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.0978
    Cell Significance Index: -16.4500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.1079
    Cell Significance Index: -45.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1779
    Cell Significance Index: -43.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.1870
    Cell Significance Index: -59.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.2151
    Cell Significance Index: -32.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MAGO is a 40-kDa protein that belongs to the Mago-Nashi homolog family. It is a substrate of the EJC and is characterized by its ability to bind to and regulate the activity of other EJC components, including Y14 and NMD proteins. MAGO is highly phosphorylated and ubiquitinated, which modulates its interaction with other proteins and affects its function. The MAGO protein is also a substrate of the NMD pathway, which is involved in nonsense-mediated decay. **Pathways and Functions** MAGO is involved in several key biological pathways, including: 1. **Alternative mRNA splicing**: MAGO regulates the activity of the EJC, which is essential for the recognition and inclusion of alternative exons in mature mRNA. 2. **mRNA export**: MAGO facilitates the export of mature mRNA from the nucleus by interacting with the EJC and other export factors. 3. **Translation regulation**: MAGO modulates the translation of specific mRNAs by interacting with ribosomes and other translation factors. 4. **Nonsense-mediated decay**: MAGO is a substrate of the NMD pathway, which is involved in the degradation of aberrant mRNAs containing nonsense mutations. 5. **Regulation of gene expression**: MAGO regulates the expression of specific genes by influencing the activity of the EJC and other transcriptional regulators. **Clinical Significance** Dysregulation of MAGO has been implicated in various diseases, including: 1. **Neurodevelopmental disorders**: Mutations in the MAGO gene have been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Cancer**: Alterations in MAGO expression have been observed in various types of cancer, including breast, lung, and colon cancer. 3. **Neurodegenerative diseases**: MAGO has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In summary, MAGO is a critical component of the EJC that plays a pivotal role in regulating alternative mRNA splicing, mRNA export, and translation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying MAGO function and its clinical significance.

Genular Protein ID: 3852735636

Symbol: MGN_HUMAN

Name: Protein mago nashi homolog

UniProtKB Accession Codes:

P61326 B1ARP8 B2R5A2 O35169 P50606 Q5SW69

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 5 Ensembl 2 EvolutionaryTrace 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9479507

Title: The mammalian homologue of mago nashi encodes a serum-inducible protein.

PubMed ID: 9479507

DOI: 10.1006/geno.1997.5126

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10662555

Title: MAGOH interacts with a novel RNA-binding protein.

PubMed ID: 10662555

DOI: 10.1006/geno.1999.6064

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 12730685

Title: A novel mode of RBD-protein recognition in the Y14-Mago complex.

PubMed ID: 12730685

DOI: 10.1038/nsb926

PubMed ID: 14968132

Title: Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex.

PubMed ID: 14968132

DOI: 10.1038/sj.embor.7400091

PubMed ID: 16209946

Title: Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements.

PubMed ID: 16209946

DOI: 10.1016/j.molcel.2005.08.012

PubMed ID: 16170325

Title: The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity.

PubMed ID: 16170325

DOI: 10.1038/nsmb990

PubMed ID: 16314458

Title: Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.

PubMed ID: 16314458

DOI: 10.1261/rna.2155905

PubMed ID: 18026120

Title: PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs.

PubMed ID: 18026120

DOI: 10.1038/nsmb1321

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19410547

Title: Disassembly of exon junction complexes by PYM.

PubMed ID: 19410547

DOI: 10.1016/j.cell.2009.02.042

PubMed ID: 19324961

Title: Assembly and mobility of exon-exon junction complexes in living cells.

PubMed ID: 19324961

DOI: 10.1261/rna.1387009

PubMed ID: 22203037

Title: Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators.

PubMed ID: 22203037

DOI: 10.1128/mcb.06130-11

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23917022

Title: Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay.

PubMed ID: 23917022

DOI: 10.4161/rna.25827

PubMed ID: 12781131

Title: Structure of the Y14-Magoh core of the exon junction complex.

PubMed ID: 12781131

DOI: 10.1016/s0960-9822(03)00328-2

PubMed ID: 16923391

Title: The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA.

PubMed ID: 16923391

DOI: 10.1016/j.cell.2006.08.006

PubMed ID: 16931718

Title: Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA.

PubMed ID: 16931718

DOI: 10.1126/science.1131981

PubMed ID: 19033377

Title: Mechanism of ATP turnover inhibition in the EJC.

PubMed ID: 19033377

DOI: 10.1261/rna.1283109

PubMed ID: 20479275

Title: Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex.

PubMed ID: 20479275

DOI: 10.1073/pnas.1000993107

PubMed ID: 37020021

Title: mRNA recognition and packaging by the human transcription-export complex.

PubMed ID: 37020021

DOI: 10.1038/s41586-023-05904-0

Sequence Information:

  • Length: 146
  • Mass: 17164
  • Checksum: FFAD0B075E045875
  • Sequence:
    • MESDFYLRYY VGHKGKFGHE FLEFEFRPDG KLRYANNSNY KNDVMIRKEA YVHKSVMEEL 
KRIIDDSEIT KEDDALWPPP DRVGRQELEI VIGDEHISFT TSKIGSLIDV NQSKDPEGLR 
VFYYLVQDLK CLVFSLIGLH FKIKPI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.