Details for: MAX
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 309.0419
Cell Significance Index: -48.0700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 153.6803
Cell Significance Index: -38.9800 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 123.9235
Cell Significance Index: -51.0500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 115.1488
Cell Significance Index: -46.7800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 111.5388
Cell Significance Index: -52.6600 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 101.1110
Cell Significance Index: -52.0100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 49.4924
Cell Significance Index: -47.2500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 40.1799
Cell Significance Index: -49.5400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 14.9952
Cell Significance Index: -40.1700 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 14.2213
Cell Significance Index: -43.6800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 13.8583
Cell Significance Index: -30.3300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.8990
Cell Significance Index: -50.9000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.9907
Cell Significance Index: 27.1600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.7412
Cell Significance Index: 349.2800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.4628
Cell Significance Index: 40.8800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.3373
Cell Significance Index: 265.3900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.1202
Cell Significance Index: 121.8400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.0482
Cell Significance Index: 80.4400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.9923
Cell Significance Index: 27.0100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.9016
Cell Significance Index: 323.3800 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.8644
Cell Significance Index: 16.8700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.8105
Cell Significance Index: 13.8900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.7490
Cell Significance Index: 135.0200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.7155
Cell Significance Index: 33.6300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6865
Cell Significance Index: 84.4200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.6822
Cell Significance Index: 93.6900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.6646
Cell Significance Index: 42.8800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.6486
Cell Significance Index: 286.7400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6318
Cell Significance Index: 570.4700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.6187
Cell Significance Index: 23.4300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.5929
Cell Significance Index: 26.2300 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.5540
Cell Significance Index: 16.2700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.5375
Cell Significance Index: 28.2200 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.4739
Cell Significance Index: 61.2200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.4542
Cell Significance Index: 33.8500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4127
Cell Significance Index: 19.2400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.3632
Cell Significance Index: 24.4300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.3433
Cell Significance Index: 9.8400 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.3285
Cell Significance Index: 4.0700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.3207
Cell Significance Index: 37.8200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3160
Cell Significance Index: 9.1100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.3082
Cell Significance Index: 8.2300 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2909
Cell Significance Index: 158.8500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2873
Cell Significance Index: 46.7200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2672
Cell Significance Index: 12.1100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.2624
Cell Significance Index: 356.7600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2437
Cell Significance Index: 458.8100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2419
Cell Significance Index: 167.3400 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.2400
Cell Significance Index: 2.2100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.2327
Cell Significance Index: 358.1800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2289
Cell Significance Index: 43.5600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.2243
Cell Significance Index: 11.6900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1792
Cell Significance Index: 330.5300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1674
Cell Significance Index: 16.5600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1585
Cell Significance Index: 8.2400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1513
Cell Significance Index: 96.0600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1435
Cell Significance Index: 10.1500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.1349
Cell Significance Index: 7.5700 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0608
Cell Significance Index: 7.7900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0337
Cell Significance Index: 15.3100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0100
Cell Significance Index: 1.7100 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 0.0090
Cell Significance Index: 0.1400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0161
Cell Significance Index: -10.0400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0184
Cell Significance Index: -13.6100 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0230
Cell Significance Index: -0.6100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0288
Cell Significance Index: -21.8100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0479
Cell Significance Index: -35.1000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0581
Cell Significance Index: -5.9300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0619
Cell Significance Index: -34.9000 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0698
Cell Significance Index: -1.2900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1394
Cell Significance Index: -29.3700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1554
Cell Significance Index: -44.7000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1760
Cell Significance Index: -25.5900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1877
Cell Significance Index: -21.8700 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.2029
Cell Significance Index: -4.9500 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2278
Cell Significance Index: -6.1100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2504
Cell Significance Index: -28.5800 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2517
Cell Significance Index: -6.4300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2569
Cell Significance Index: -4.3000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2891
Cell Significance Index: -30.1000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3043
Cell Significance Index: -34.8600 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.3343
Cell Significance Index: -2.0200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3371
Cell Significance Index: -7.1800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3827
Cell Significance Index: -24.1200 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.4149
Cell Significance Index: -6.1300 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.5263
Cell Significance Index: -9.3000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.5432
Cell Significance Index: -15.5000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5888
Cell Significance Index: -46.6300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.5917
Cell Significance Index: -20.5600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.5969
Cell Significance Index: -14.9200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.6718
Cell Significance Index: -14.5600 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.7999
Cell Significance Index: -11.5100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.8287
Cell Significance Index: -50.9400 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.8437
Cell Significance Index: -12.1200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8457
Cell Significance Index: -51.8500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.8485
Cell Significance Index: -17.7600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.8535
Cell Significance Index: -21.9400 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: -0.8561
Cell Significance Index: -10.7800 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.8843
Cell Significance Index: -7.8500 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.8916
Cell Significance Index: -13.3600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2783465866
Symbol: MAX_HUMAN
Name: Class D basic helix-loop-helix protein 4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2006410
Title: Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc.
PubMed ID: 2006410
PubMed ID: 8426752
Title: Alternative mRNA forms and open reading frames of the max gene.
PubMed ID: 8426752
PubMed ID: 1566084
Title: Alternative forms of Max as enhancers or suppressors of Myc-ras cotransformation.
PubMed ID: 1566084
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12004135
Title: A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells.
PubMed ID: 12004135
PubMed ID: 14759258
PubMed ID: 15960975
Title: Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
PubMed ID: 15960975
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 17217336
Title: Max is acetylated by p300 at several nuclear localization residues.
PubMed ID: 17217336
DOI: 10.1042/bj20061593
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21685915
Title: Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma.
PubMed ID: 21685915
DOI: 10.1038/ng.861
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 22452945
Title: MAX mutations cause hereditary and sporadic pheochromocytoma and paraganglioma.
PubMed ID: 22452945
PubMed ID: 26070438
Title: Functional and in silico assessment of MAX variants of unknown significance.
PubMed ID: 26070438
PubMed ID: 8479534
Title: Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain.
PubMed ID: 8479534
DOI: 10.1038/363038a0
PubMed ID: 9115440
Title: The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control.
PubMed ID: 9115440
PubMed ID: 38141607
Title: A recurrent de novo MAX p.Arg60Gln variant causes a syndromic overgrowth disorder through differential expression of c-Myc target genes.
PubMed ID: 38141607
Sequence Information:
- Length: 160
- Mass: 18275
- Checksum: EB10F3137727A56F
- Sequence:
MSDNDDIEVE SDEEQPRFQS AADKRAHHNA LERKRRDHIK DSFHSLRDSV PSLQGEKASR AQILDKATEY IQYMRRKNHT HQQDIDDLKR QNALLEQQVR ALEKARSSAQ LQTNYPSSDN SLYTNAKGST ISAFDGGSDS SSESEPEEPQ SRKKLRMEAS
Genular Protein ID: 2605604838
Symbol: Q8TAX8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 151
- Mass: 17248
- Checksum: 9B2DF6F5F39793FD
- Sequence:
MSDNDDIEVE SDADKRAHHN ALERKRRDHI KDSFHSLRDS VPSLQGEKAS RAQILDKATE YIQYMRRKNH THQQDIDDLK RQNALLEQQV RALEKARSSA QLQTNYPSSD NSLYTNAKGS TISAFDGCSD SSSESEPEEP QSRKKLRMEA S
Genular Protein ID: 4032976110
Symbol: G3V302_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
Sequence Information:
- Length: 97
- Mass: 10702
- Checksum: B3C82CACD22A91BE
- Sequence:
MLFWSSKGKA RADQVLCSWG IHFSSSLMED ASKRKFRALE KARSSAQLQT NYPSSDNSLY TNAKGSTISA FDGGSDSSSE SEPEEPQSRK KLRMEAS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.