Details for: MAZ

Gene ID: 4150

Symbol: MAZ

Ensembl ID: ENSG00000103495

Description: MYC associated zinc finger protein

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of apoptotic signaling pathway
    (GO:2001234)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna binding
    (GO:0003723)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Termination of rna polymerase ii transcription
    (GO:0006369)
  • Transcription initiation at rna polymerase ii promoter
    (GO:0006367)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 132.3731
    Cell Significance Index: -20.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 101.5993
    Cell Significance Index: -25.7700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 72.1710
    Cell Significance Index: -29.3200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 70.7443
    Cell Significance Index: -33.4000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 65.8067
    Cell Significance Index: -33.8500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.0073
    Cell Significance Index: -29.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.6832
    Cell Significance Index: -25.9400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.0418
    Cell Significance Index: -24.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.9320
    Cell Significance Index: -31.3000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.1814
    Cell Significance Index: -11.3400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 4.7339
    Cell Significance Index: 126.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.4798
    Cell Significance Index: 224.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.5527
    Cell Significance Index: 153.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7230
    Cell Significance Index: 78.1000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.6965
    Cell Significance Index: 10.8300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.5074
    Cell Significance Index: 10.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3574
    Cell Significance Index: 186.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.2723
    Cell Significance Index: 87.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0399
    Cell Significance Index: 567.8900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.0314
    Cell Significance Index: 7.9500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0012
    Cell Significance Index: 903.9800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.9245
    Cell Significance Index: 11.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8562
    Cell Significance Index: 169.9200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.8391
    Cell Significance Index: 7.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8021
    Cell Significance Index: 37.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7527
    Cell Significance Index: 47.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7324
    Cell Significance Index: 323.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7082
    Cell Significance Index: 115.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7069
    Cell Significance Index: 32.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7002
    Cell Significance Index: 86.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5946
    Cell Significance Index: 30.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5913
    Cell Significance Index: 41.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5686
    Cell Significance Index: 102.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5203
    Cell Significance Index: 99.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4916
    Cell Significance Index: 98.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4890
    Cell Significance Index: 57.6700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.4377
    Cell Significance Index: 6.1400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.4333
    Cell Significance Index: 3.6400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4093
    Cell Significance Index: 4.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3920
    Cell Significance Index: 11.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3263
    Cell Significance Index: 8.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3244
    Cell Significance Index: 17.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3183
    Cell Significance Index: 31.4900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3170
    Cell Significance Index: 4.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3108
    Cell Significance Index: 8.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2998
    Cell Significance Index: 38.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2855
    Cell Significance Index: 7.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2527
    Cell Significance Index: 5.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2371
    Cell Significance Index: 17.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2315
    Cell Significance Index: 6.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2293
    Cell Significance Index: 82.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2196
    Cell Significance Index: 13.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1196
    Cell Significance Index: 3.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0956
    Cell Significance Index: 12.3500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0947
    Cell Significance Index: 1.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0364
    Cell Significance Index: 1.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0172
    Cell Significance Index: 0.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0010
    Cell Significance Index: 0.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0075
    Cell Significance Index: -5.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0129
    Cell Significance Index: -2.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0132
    Cell Significance Index: -9.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0153
    Cell Significance Index: -28.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0170
    Cell Significance Index: -0.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0207
    Cell Significance Index: -38.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0245
    Cell Significance Index: -37.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0283
    Cell Significance Index: -38.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0295
    Cell Significance Index: -21.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0476
    Cell Significance Index: -2.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0483
    Cell Significance Index: -4.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0489
    Cell Significance Index: -31.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0501
    Cell Significance Index: -28.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0603
    Cell Significance Index: -2.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0625
    Cell Significance Index: -39.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0744
    Cell Significance Index: -33.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0802
    Cell Significance Index: -23.0900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0860
    Cell Significance Index: -3.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0880
    Cell Significance Index: -10.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1030
    Cell Significance Index: -3.3000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.1040
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1272
    Cell Significance Index: -14.5700
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -0.1302
    Cell Significance Index: -0.7400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1428
    Cell Significance Index: -1.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1592
    Cell Significance Index: -3.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1649
    Cell Significance Index: -34.7400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1722
    Cell Significance Index: -2.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1978
    Cell Significance Index: -4.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2013
    Cell Significance Index: -7.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2073
    Cell Significance Index: -13.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2201
    Cell Significance Index: -31.9900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2483
    Cell Significance Index: -1.5000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2606
    Cell Significance Index: -6.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2940
    Cell Significance Index: -7.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2960
    Cell Significance Index: -30.8200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3116
    Cell Significance Index: -23.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3232
    Cell Significance Index: -25.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3623
    Cell Significance Index: -22.2200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3829
    Cell Significance Index: -5.7700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3922
    Cell Significance Index: -4.0600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4307
    Cell Significance Index: -10.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4911
    Cell Significance Index: -25.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The MAZ gene encodes a protein that belongs to the MYC family of transcription factors, which are known for their role in regulating cell growth, differentiation, and apoptosis. The MAZ protein is characterized by its ability to bind to specific DNA sequences, thereby regulating gene expression. It is also known to interact with other transcription factors and signaling molecules to modulate cellular responses. **Pathways and Functions:** The MAZ gene is involved in various signaling pathways, including: 1. **DNA-binding transcription factor activity**: The MAZ protein binds to specific DNA sequences, regulating gene expression by interacting with RNA polymerase II and other transcription factors. 2. **Metal ion binding**: The MAZ protein contains a zinc finger motif, which allows it to bind to metal ions, modulating its activity and interactions with other proteins. 3. **Negative regulation of apoptotic signaling pathway**: The MAZ protein can inhibit apoptosis by interacting with pro-apoptotic proteins and regulating the expression of anti-apoptotic genes. 4. **Positive regulation of cell migration and proliferation**: The MAZ protein can promote cell migration and proliferation by activating signaling pathways involved in these processes. The MAZ gene plays a critical role in the development and function of various immune cells, including: 1. **Early pro-B cells**: The MAZ protein is essential for the development and maturation of B cells in the bone marrow. 2. **Effector CD4-positive, alpha-beta T cells**: The MAZ protein regulates the expression of genes involved in T cell activation and function. 3. **Cortical thymic epithelial cells**: The MAZ protein plays a role in the development and function of thymic epithelial cells, which are essential for T cell maturation. **Clinical Significance:** Dysregulation of the MAZ gene has been implicated in various immune-related disorders, including: 1. **Immunodeficiency diseases**: Mutations in the MAZ gene can lead to impaired B cell development and function, resulting in immunodeficiency. 2. **Autoimmune diseases**: The MAZ protein can also contribute to autoimmune diseases by regulating the expression of genes involved in immune responses. 3. **Cancer**: The MAZ protein has been implicated in the development and progression of various cancers, including lymphomas and leukemias. In conclusion, the MAZ gene is a critical regulator of immune cell development, cell migration, and gene expression. Its dysregulation can have significant implications for immune-related disorders, highlighting the importance of further research into the mechanisms underlying MAZ gene function and its role in disease.

Genular Protein ID: 2308920028

Symbol: MAZ_HUMAN

Name: Myc-associated zinc finger protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1502157

Title: MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating transcriptional initiation and termination.

PubMed ID: 1502157

DOI: 10.1073/pnas.89.16.7452

PubMed ID: 1567856

Title: Isolation of a novel cDNA encoding a zinc-finger protein that binds to two sites within the c-myc promoter.

PubMed ID: 1567856

DOI: 10.1021/bi00131a029

PubMed ID: 8831693

Title: Members of the MAZ family: a novel cDNA clone for MAZ from human pancreatic islet cells.

PubMed ID: 8831693

DOI: 10.1006/bbrc.1996.1432

PubMed ID: 8626793

Title: The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1.

PubMed ID: 8626793

DOI: 10.1074/jbc.271.8.4417

PubMed ID: 9685418

Title: Genomic organization and expression of a human gene for Myc-associated zinc finger protein (MAZ).

PubMed ID: 9685418

DOI: 10.1074/jbc.273.32.20603

PubMed ID: 12270922

Title: SAF-2, a splice variant of SAF-1, acts as a negative regulator of transcription.

PubMed ID: 12270922

DOI: 10.1074/jbc.m206299200

PubMed ID: 19583771

Title: SAF-3, a novel splice variant of the SAF-1/MAZ/Pur-1 family, is expressed during inflammation.

PubMed ID: 19583771

DOI: 10.1111/j.1742-4658.2009.07136.x

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 10727212

Title: Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity.

PubMed ID: 10727212

DOI: 10.1021/bi992211q

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 477
  • Mass: 48608
  • Checksum: C04C80F32C3C6825
  • Sequence:
  • MFPVFPCTLL APPFPVLGLD SRGVGGLMNS FPPPQGHAQN PLQVGAELQS RFFASQGCAQ 
    SPFQAAPAPP PTPQAPAAEP LQVDLLPVLA AAQESAAAAA AAAAAAAAVA AAPPAPAAAS 
    TVDTAALKQP PAPPPPPPPV SAPAAEAAPP ASAATIAAAA ATAVVAPTST VAVAPVASAL 
    EKKTKSKGPY ICALCAKEFK NGYNLRRHEA IHTGAKAGRV PSGAMKMPTM VPLSLLSVPQ 
    LSGAGGGGGE AGAGGGAAAV AAGGVVTTTA SGKRIRKNHA CEMCGKAFRD VYHLNRHKLS 
    HSDEKPYQCP VCQQRFKRKD RMSYHVRSHD GAVHKPYNCS HCGKSFSRPD HLNSHVRQVH 
    STERPFKCEK CEAAFATKDR LRAHTVRHEE KVPCHVCGKM LSSAYISDHM KVHSQGPHHV 
    CELCNKGTGE VCPMAAAAAA AAAAAAAAVA APPTAVGSLS GAEGVPVSSQ PLPSQPW

Genular Protein ID: 505096247

Symbol: Q59GP8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 179
  • Mass: 19063
  • Checksum: BDA520499F2993BC
  • Sequence:
  • LSVPQLSGAG GGGGEAGAGG GAAAVAAGGV VTTTASGKRI RKNHACEMCG KAFRDVYHLN 
    RHKLSHSDEK PYQCPVCQQR FKRKDRMSYH VRSHDGAVHK PYNCSHCGKS FSRCARGLGR 
    PLGRGEGGTR RRWPGRGWRG GRRLLRLGKG SHSQGGGRKP LPVTREQGVV LCRGGGPWG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.