Details for: MAP3K1

Gene ID: 4214

Symbol: MAP3K1

Ensembl ID: ENSG00000095015

Description: mitogen-activated protein kinase kinase kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 189.5590
    Cell Significance Index: -29.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 113.8212
    Cell Significance Index: -28.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 69.6111
    Cell Significance Index: -28.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 61.0437
    Cell Significance Index: -31.4000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 47.5469
    Cell Significance Index: -31.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.2385
    Cell Significance Index: -29.8900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.6169
    Cell Significance Index: -31.1200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.5782
    Cell Significance Index: -25.3400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.1943
    Cell Significance Index: -28.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.6228
    Cell Significance Index: -30.0800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.8218
    Cell Significance Index: 23.5200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.9158
    Cell Significance Index: 11.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.7285
    Cell Significance Index: 251.2600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.5101
    Cell Significance Index: 18.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4928
    Cell Significance Index: 41.7200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.3391
    Cell Significance Index: 19.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.3347
    Cell Significance Index: 84.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.2806
    Cell Significance Index: 149.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2772
    Cell Significance Index: 253.4700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.1434
    Cell Significance Index: 17.2300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.9788
    Cell Significance Index: 18.0900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.8787
    Cell Significance Index: 7.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8515
    Cell Significance Index: 305.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7581
    Cell Significance Index: 335.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7381
    Cell Significance Index: 120.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7187
    Cell Significance Index: 43.1500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.5813
    Cell Significance Index: 4.7400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5737
    Cell Significance Index: 42.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5421
    Cell Significance Index: 296.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5029
    Cell Significance Index: 454.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4806
    Cell Significance Index: 22.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4439
    Cell Significance Index: 11.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4185
    Cell Significance Index: 41.4000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3995
    Cell Significance Index: 3.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3972
    Cell Significance Index: 71.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3924
    Cell Significance Index: 48.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3884
    Cell Significance Index: 268.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3787
    Cell Significance Index: 21.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3704
    Cell Significance Index: 697.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3694
    Cell Significance Index: 74.1000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3558
    Cell Significance Index: 7.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3505
    Cell Significance Index: 16.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3159
    Cell Significance Index: 8.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3025
    Cell Significance Index: 192.1300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2954
    Cell Significance Index: 6.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2528
    Cell Significance Index: 6.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2212
    Cell Significance Index: 16.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1922
    Cell Significance Index: 13.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1856
    Cell Significance Index: 4.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1805
    Cell Significance Index: 3.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1802
    Cell Significance Index: 277.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1776
    Cell Significance Index: 327.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1531
    Cell Significance Index: 4.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1524
    Cell Significance Index: 5.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1514
    Cell Significance Index: 4.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1453
    Cell Significance Index: 27.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1156
    Cell Significance Index: 3.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0701
    Cell Significance Index: 3.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0685
    Cell Significance Index: 9.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0673
    Cell Significance Index: 11.5000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0612
    Cell Significance Index: 1.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0408
    Cell Significance Index: 2.5100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0272
    Cell Significance Index: 0.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0212
    Cell Significance Index: 28.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0074
    Cell Significance Index: 0.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0074
    Cell Significance Index: 0.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0029
    Cell Significance Index: 0.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0057
    Cell Significance Index: -0.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0112
    Cell Significance Index: -0.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0177
    Cell Significance Index: -13.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0187
    Cell Significance Index: -13.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0194
    Cell Significance Index: -12.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0209
    Cell Significance Index: -9.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0252
    Cell Significance Index: -3.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0278
    Cell Significance Index: -15.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0364
    Cell Significance Index: -27.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0640
    Cell Significance Index: -8.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0767
    Cell Significance Index: -7.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0887
    Cell Significance Index: -25.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1048
    Cell Significance Index: -22.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1150
    Cell Significance Index: -13.1800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1334
    Cell Significance Index: -1.5900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1511
    Cell Significance Index: -4.4500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1821
    Cell Significance Index: -1.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1926
    Cell Significance Index: -12.9500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2157
    Cell Significance Index: -24.6200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2456
    Cell Significance Index: -5.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2484
    Cell Significance Index: -25.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2609
    Cell Significance Index: -3.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2911
    Cell Significance Index: -15.1200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2912
    Cell Significance Index: -6.0400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.3366
    Cell Significance Index: -4.3400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3635
    Cell Significance Index: -28.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3836
    Cell Significance Index: -11.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4045
    Cell Significance Index: -24.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4975
    Cell Significance Index: -26.1200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5012
    Cell Significance Index: -12.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5109
    Cell Significance Index: -8.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5298
    Cell Significance Index: -9.0800
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.5386
    Cell Significance Index: -5.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAP3K1 is a serine/threonine kinase that belongs to the MAP3K family, which plays a pivotal role in the regulation of cellular responses to various stimuli. The gene is highly expressed in various cell types, including immune cells, epithelial cells, and lens cells. Notably, MAP3K1 is involved in the activation of various signaling pathways, including the MAPK cascade, NF-κB pathway, and Toll-like receptor (TLR) pathways. The gene's expression is tightly regulated, and its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions. **Pathways and Functions:** MAP3K1 is a key component of the MAPK cascade, which is a critical signaling pathway involved in the regulation of cellular responses to various stimuli, including mitogens, cytokines, and stress. The MAPK cascade is composed of three main kinases: MAP2K, MAPK, and MAPK phosphatase. MAP3K1 activates the MAP2K kinase, which in turn phosphorylates and activates the MAPK kinase. This cascade ultimately leads to the activation of transcription factors, such as CREB and Elk-1, which regulate gene expression. MAP3K1 is also involved in the regulation of the NF-κB pathway, which is a crucial signaling pathway involved in the regulation of immune responses, inflammation, and cell survival. The NF-κB pathway is composed of transcription factors, including NF-κB, IκB, and p65, which are regulated by the activity of MAP3K1. The activation of MAP3K1 leads to the phosphorylation and degradation of IκB, allowing NF-κB to translocate to the nucleus and regulate gene expression. Furthermore, MAP3K1 is involved in the regulation of the TLR pathways, which are critical for the recognition of pathogen-associated molecular patterns (PAMPs) and the activation of immune responses. The TLR pathways are composed of pattern recognition receptors, including TLR2, TLR4, and TLR9, which are activated by the binding of PAMPs. The activation of TLRs leads to the recruitment of adaptor proteins, including MyD88, which in turn activates MAP3K1 and the NF-κB pathway. **Clinical Significance:** Dysregulation of MAP3K1 has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions. For example, overexpression of MAP3K1 has been observed in certain types of cancer, including breast and lung cancer, where it contributes to the development and progression of the disease. Additionally, MAP3K1 has been implicated in the pathogenesis of autoimmune disorders, such as rheumatoid arthritis and lupus, where it contributes to the activation of immune cells and the production of pro-inflammatory cytokines. In conclusion, MAP3K1 is a complex gene that plays a critical role in the regulation of immune responses, cell signaling, and inflammation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of MAP3K1 and its potential as a therapeutic target.

Genular Protein ID: 3582887510

Symbol: M3K1_HUMAN

Name: Mitogen-activated protein kinase kinase kinase 1

UniProtKB Accession Codes:

Q13233

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 9 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 4 ELM 1 EMBL 3 Ensembl 1 GO 12 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 9808624

Title: JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension.

PubMed ID: 9808624

DOI: 10.1101/gad.12.21.3369

PubMed ID: 8597633

Title: Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5.

PubMed ID: 8597633

DOI: 10.1007/bf00539003

PubMed ID: 12223491

Title: SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling.

PubMed ID: 12223491

DOI: 10.1074/jbc.m208099200

PubMed ID: 12049732

Title: The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2.

PubMed ID: 12049732

DOI: 10.1016/s1097-2765(02)00519-1

PubMed ID: 15262978

Title: The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.

PubMed ID: 15262978

DOI: 10.1074/jbc.m404598200

PubMed ID: 17761173

Title: GRASP-1 is a neuronal scaffold protein for the JNK signaling pathway.

PubMed ID: 17761173

DOI: 10.1016/j.febslet.2007.08.008

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 17906693

Title: Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38).

PubMed ID: 17906693

DOI: 10.1038/sj.onc.1210828

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 17101801

Title: MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress.

PubMed ID: 17101801

DOI: 10.1128/mcb.01355-06

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 21129722

Title: Mutations in MAP3K1 cause 46,XY disorders of sex development and implicate a common signal transduction pathway in human testis determination.

PubMed ID: 21129722

DOI: 10.1016/j.ajhg.2010.11.003

Sequence Information:

  • Length: 1512
  • Mass: 164470
  • Checksum: 5CB78242295411D9
  • Sequence:
    • MAAAAGNRAS SSGFPGARAT SPEAGGGGGA LKASSAPAAA AGLLREAGSG GRERADWRRR 
QLRKVRSVEL DQLPEQPLFL AASPPASSTS PSPEPADAAG SGTGFQPVAV PPPHGAASRG 
GAHLTESVAA PDSGASSPAA AEPGEKRAPA AEPSPAAAPA GREMENKETL KGLHKMDDRP 
EERMIREKLK ATCMPAWKHE WLERRNRRGP VVVKPIPVKG DGSEMNHLAA ESPGEVQASA 
ASPASKGRRS PSPGNSPSGR TVKSESPGVR RKRVSPVPFQ SGRITPPRRA PSPDGFSPYS 
PEETNRRVNK VMRARLYLLQ QIGPNSFLIG GDSPDNKYRV FIGPQNCSCA RGTFCIHLLF 
VMLRVFQLEP SDPMLWRKTL KNFEVESLFQ KYHSRRSSRI KAPSRNTIQK FVSRMSNSHT 
LSSSSTSTSS SENSIKDEEE QMCPICLLGM LDEESLTVCE DGCRNKLHHH CMSIWAEECR 
RNREPLICPL CRSKWRSHDF YSHELSSPVD SPSSLRAAQQ QTVQQQPLAG SRRNQESNFN 
LTHYGTQQIP PAYKDLAEPW IQVFGMELVG CLFSRNWNVR EMALRRLSHD VSGALLLANG 
ESTGNSGGSS GSSPSGGATS GSSQTSISGD VVEACCSVLS MVCADPVYKV YVAALKTLRA 
MLVYTPCHSL AERIKLQRLL QPVVDTILVK CADANSRTSQ LSISTLLELC KGQAGELAVG 
REILKAGSIG IGGVDYVLNC ILGNQTESNN WQELLGRLCL IDRLLLEFPA EFYPHIVSTD 
VSQAEPVEIR YKKLLSLLTF ALQSIDNSHS MVGKLSRRIY LSSARMVTTV PHVFSKLLEM 
LSVSSSTHFT RMRRRLMAIA DEVEIAEAIQ LGVEDTLDGQ QDSFLQASVP NNYLETTENS 
SPECTVHLEK TGKGLCATKL SASSEDISER LASISVGPSS STTTTTTTTE QPKPMVQTKG 
RPHSQCLNSS PLSHHSQLMF PALSTPSSST PSVPAGTATD VSKHRLQGFI PCRIPSASPQ 
TQRKFSLQFH RNCPENKDSD KLSPVFTQSR PLPSSNIHRP KPSRPTPGNT SKQGDPSKNS 
MTLDLNSSSK CDDSFGCSSN SSNAVIPSDE TVFTPVEEKC RLDVNTELNS SIEDLLEASM 
PSSDTTVTFK SEVAVLSPEK AENDDTYKDD VNHNQKCKEK MEAEEEEALA IAMAMSASQD 
ALPIVPQLQV ENGEDIIIIQ QDTPETLPGH TKAKQPYRED TEWLKGQQIG LGAFSSCYQA 
QDVGTGTLMA VKQVTYVRNT SSEQEEVVEA LREEIRMMSH LNHPNIIRML GATCEKSNYN 
LFIEWMAGGS VAHLLSKYGA FKESVVINYT EQLLRGLSYL HENQIIHRDV KGANLLIDST 
GQRLRIADFG AAARLASKGT GAGEFQGQLL GTIAFMAPEV LRGQQYGRSC DVWSVGCAII 
EMACAKPPWN AEKHSNHLAL IFKIASATTA PSIPSHLSPG LRDVALRCLE LQPQDRPPSR 
ELLKHPVFRT TW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.