Details for: MN1

Gene ID: 4330

Symbol: MN1

Ensembl ID: ENSG00000169184

Description: MN1 proto-oncogene, transcriptional regulator

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 102.9283
    Cell Significance Index: -16.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 57.9554
    Cell Significance Index: -14.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.9769
    Cell Significance Index: -16.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 5.1499
    Cell Significance Index: 315.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.0674
    Cell Significance Index: -16.0500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.4463
    Cell Significance Index: 38.8100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.7153
    Cell Significance Index: 21.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.5701
    Cell Significance Index: 69.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.4168
    Cell Significance Index: 53.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2733
    Cell Significance Index: 242.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2214
    Cell Significance Index: 68.5400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.0376
    Cell Significance Index: 22.1800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9791
    Cell Significance Index: 96.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9137
    Cell Significance Index: 327.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8359
    Cell Significance Index: 754.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6509
    Cell Significance Index: 40.0100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.6160
    Cell Significance Index: 15.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.5579
    Cell Significance Index: 14.3400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.4164
    Cell Significance Index: 5.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3879
    Cell Significance Index: 63.0900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3849
    Cell Significance Index: 9.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3826
    Cell Significance Index: 5.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3246
    Cell Significance Index: 10.4000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3217
    Cell Significance Index: 35.0000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.3119
    Cell Significance Index: 5.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2996
    Cell Significance Index: 207.2400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2572
    Cell Significance Index: 5.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1633
    Cell Significance Index: 32.7500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1523
    Cell Significance Index: 2.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1437
    Cell Significance Index: 9.9400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.1363
    Cell Significance Index: 2.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1078
    Cell Significance Index: 2.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0846
    Cell Significance Index: 38.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0793
    Cell Significance Index: 1.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0379
    Cell Significance Index: 58.2700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0303
    Cell Significance Index: 0.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0195
    Cell Significance Index: 8.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0131
    Cell Significance Index: 24.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0118
    Cell Significance Index: 16.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0101
    Cell Significance Index: 18.5600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0018
    Cell Significance Index: 0.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0020
    Cell Significance Index: -0.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0031
    Cell Significance Index: -0.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0100
    Cell Significance Index: -0.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0109
    Cell Significance Index: -1.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0171
    Cell Significance Index: -10.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0201
    Cell Significance Index: -0.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0203
    Cell Significance Index: -14.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0234
    Cell Significance Index: -17.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0263
    Cell Significance Index: -14.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0264
    Cell Significance Index: -19.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0285
    Cell Significance Index: -17.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0350
    Cell Significance Index: -19.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0442
    Cell Significance Index: -12.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0445
    Cell Significance Index: -5.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0448
    Cell Significance Index: -5.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0457
    Cell Significance Index: -0.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0578
    Cell Significance Index: -10.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0620
    Cell Significance Index: -12.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0840
    Cell Significance Index: -17.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0883
    Cell Significance Index: -12.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0936
    Cell Significance Index: -2.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0948
    Cell Significance Index: -16.1900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0973
    Cell Significance Index: -5.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0988
    Cell Significance Index: -7.5800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1003
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1057
    Cell Significance Index: -12.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1084
    Cell Significance Index: -13.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1236
    Cell Significance Index: -15.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1440
    Cell Significance Index: -16.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1444
    Cell Significance Index: -15.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1446
    Cell Significance Index: -14.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1488
    Cell Significance Index: -2.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1710
    Cell Significance Index: -11.0300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1723
    Cell Significance Index: -4.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1901
    Cell Significance Index: -15.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2031
    Cell Significance Index: -15.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2055
    Cell Significance Index: -7.1400
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.2304
    Cell Significance Index: -1.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2394
    Cell Significance Index: -6.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2449
    Cell Significance Index: -16.4700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2541
    Cell Significance Index: -11.0500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2603
    Cell Significance Index: -6.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2682
    Cell Significance Index: -16.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2810
    Cell Significance Index: -13.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2899
    Cell Significance Index: -15.2200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2900
    Cell Significance Index: -6.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3221
    Cell Significance Index: -15.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3233
    Cell Significance Index: -4.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3330
    Cell Significance Index: -17.3000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.3374
    Cell Significance Index: -2.2000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3521
    Cell Significance Index: -4.0000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3750
    Cell Significance Index: -9.5800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3820
    Cell Significance Index: -7.6700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3894
    Cell Significance Index: -11.4700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4004
    Cell Significance Index: -8.3100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4048
    Cell Significance Index: -6.1000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4194
    Cell Significance Index: -5.9700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4216
    Cell Significance Index: -12.0300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4270
    Cell Significance Index: -13.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulator:** MN1 is a transcriptional regulator that controls the expression of genes involved in various cellular processes. 2. **Proto-Oncogene:** MN1 is a proto-oncogene, which means it has the potential to become an oncogene if mutated or overexpressed. 3. **Cell Type-Specific Expression:** MN1 is significantly expressed in multiple cell types, including enterocytes, colon goblet cells, and cardiac muscle myoblasts. 4. **Intramembranous Ossification:** MN1 is involved in the regulation of intramembranous ossification, a process critical for bone development. **Pathways and Functions:** 1. **Regulation of Cell Cycle:** MN1 regulates the cell cycle, specifically the G1/S phase transition, by controlling the expression of genes involved in cell cycle progression. 2. **DNA-templated Transcription:** MN1 regulates DNA-templated transcription by controlling the expression of genes involved in transcriptional regulation. 3. **Protein Binding:** MN1 binds to proteins, influencing their activity and localization within the cell. 4. **Vitamin D Receptor Signaling Pathway:** MN1 positively regulates the vitamin D receptor signaling pathway, which is critical for bone homeostasis and calcium metabolism. 5. **Negative Regulation of Osteoblast Proliferation:** MN1 negatively regulates osteoblast proliferation, which is essential for maintaining bone homeostasis. **Clinical Significance:** 1. **Bone Diseases:** MN1 dysregulation has been implicated in various bone diseases, including osteoporosis and bone cancer. 2. **Cancer:** MN1 overexpression has been observed in certain types of cancer, including breast and prostate cancer. 3. **Neurological Disorders:** MN1 has been implicated in neurological disorders, including autism and schizophrenia. 4. **Cardiac Disease:** MN1 has been linked to cardiac disease, including heart failure and cardiac arrhythmias. 5. **Regenerative Medicine:** MN1 has the potential to be used as a therapeutic target for regenerative medicine applications, including bone repair and tissue engineering. In conclusion, the MN1 proto-oncogene is a multifaceted regulator of cellular processes, with significant implications for our understanding of bone development, cancer, and neurological disorders. Further research is necessary to fully elucidate the functions of MN1 and its role in human disease.

Genular Protein ID: 1576260985

Symbol: MN1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q10571 A9Z1V9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 6 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7731706

Title: Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma.

PubMed ID: 7731706

PubMed ID: 7731705

Title: Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11.

PubMed ID: 7731705

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 9026990

Title: The characteristics of different types of mRNA expressed in the human brain.

PubMed ID: 9026990

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 31839203

Title: Gain-of-function MN1 truncation variants cause a recognizable syndrome with craniofacial and brain abnormalities.

PubMed ID: 31839203

DOI: 10.1016/j.ajhg.2019.11.011

PubMed ID: 31834374

Title: MN1 C-terminal truncation syndrome is a novel neurodevelopmental and craniofacial disorder with partial rhombencephalosynapsis.

PubMed ID: 31834374

DOI: 10.1093/brain/awz379

Sequence Information:

  • Length: 1320
  • Mass: 136001
  • Checksum: 41CFFE16E5688B1C
  • Sequence:
    • MFGLDQFEPQ VNSRNAGQGE RNFNETGLSM NTHFKAPAFH TGGPPGPVDP AMSALGEPPI 
LGMNMEPYGF HARGHSELHA GGLQAQPVHG FFGGQQPHHG HPGSHHPHQH HPHFGGNFGG 
PDPGASCLHG GRLLGYGGAA GGLGSQPPFA EGYEHMAESQ GPESFGPQRP GNLPDFHSSG 
ASSHAVPAPC LPLDQSPNRA ASFHGLPSSS GSDSHSLEPR RVTNQGAVDS LEYNYPGEAP 
SGHFDMFSPS DSEGQLPHYA AGRQVPGGAF PGASAMPRAA GMVGLSKMHA QPPQQQPQQQ 
QQPQQQQQQH GVFFERFSGA RKMPVGLEPS VGSRHPLMQP PQQAPPPPQQ QPPQQPPQQQ 
PPPPPGLLVR QNSCPPALPR PQQGEAGTPS GGLQDGGPML PSQHAQFEYP IHRLENRSMH 
PYSEPVFSMQ HPPPQQAPNQ RLQHFDAPPY MNVAKRPRFD FPGSAGVDRC ASWNGSMHNG 
ALDNHLSPSA YPGLPGEFTP PVPDSFPSGP PLQHPAPDHQ SLQQQQQQQQ QQQQQQQQQQ 
QQQQQQQQQQ RQNAALMIKQ MASRNQQQRL RQPNLAQLGH PGDVGQGGLV HGGPVGGLAQ 
PNFEREGGST GAGRLGTFEQ QAPHLAQESA WFSGPHPPPG DLLPRRMGGS GLPADCGPHD 
PSLAPPPPPG GSGVLFRGPL QEPMRMPGEG HVPALPSPGL QFGGSLGGLG QLQSPGAGVG 
LPSAASERRP PPPDFATSAL GGQPGFPFGA AGRQSTPHSG PGVNSPPSAG GGGGSSGGGG 
GGGAYPPQPD FQPSQRTSAS KLGALSLGSF NKPSSKDNLF GQSCLAALST ACQNMIASLG 
APNLNVTFNK KNPPEGKRKL SQNETDGAAV AGNPGSDYFP GGTAPGAPGP GGPSGTSSSG 
SKASGPPNPP AQGDGTSLSP NYTLESTSGN DGKPVSGGGG RGRGRRKRDS GHVSPGTFFD 
KYSAAPDSGG APGVSPGQQQ ASGAAVGGSS AGETRGAPTP HEKALTSPSW GKGAELLLGD 
QPDLIGSLDG GAKSDSSSPN VGEFASDEVS TSYANEDEVS SSSDNPQALV KASRSPLVTG 
SPKLPPRGVG AGEHGPKAPP PALGLGIMSN STSTPDSYGG GGGPGHPGTP GLEQVRTPTS 
SSGAPPPDEI HPLEILQAQI QLQRQQFSIS EDQPLGLKGG KKGECAVGAS GAQNGDSELG 
SCCSEAVKSA MSTIDLDSLM AEHSAAWYMP ADKALVDSAD DDKTLAPWEK AKPQNPNSKE 
AHDLPANKAS ASQPGSHLQC LSVHCTDDVG DAKARASVPT WRSLHSDISN RFGTFVAALT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.