Details for: MT1A

Gene ID: 4489

Symbol: MT1A

Ensembl ID: ENSG00000205362

Description: metallothionein 1A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 39.4854
    Cell Significance Index: 19.8300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 8.8550
    Cell Significance Index: 156.4800
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 6.4183
    Cell Significance Index: 73.9200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.3306
    Cell Significance Index: 152.8100
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 3.9036
    Cell Significance Index: 18.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.8686
    Cell Significance Index: 99.4400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.8521
    Cell Significance Index: 26.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.7460
    Cell Significance Index: 73.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.8823
    Cell Significance Index: 113.0000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.5746
    Cell Significance Index: 3.5500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.2942
    Cell Significance Index: 21.8000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.9991
    Cell Significance Index: 10.4300
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.6862
    Cell Significance Index: 7.5800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.6844
    Cell Significance Index: 3.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5790
    Cell Significance Index: 74.2300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4635
    Cell Significance Index: 32.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3741
    Cell Significance Index: 60.8400
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.3353
    Cell Significance Index: 3.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3273
    Cell Significance Index: 295.5400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.2508
    Cell Significance Index: 1.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2288
    Cell Significance Index: 17.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1552
    Cell Significance Index: 18.0900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1452
    Cell Significance Index: 14.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1215
    Cell Significance Index: 3.5000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.1016
    Cell Significance Index: 0.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0847
    Cell Significance Index: 16.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0757
    Cell Significance Index: 3.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0340
    Cell Significance Index: 6.7400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0251
    Cell Significance Index: 0.3700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0246
    Cell Significance Index: 0.3700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0241
    Cell Significance Index: 0.4700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0238
    Cell Significance Index: 0.2000
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.0234
    Cell Significance Index: 0.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0151
    Cell Significance Index: 0.5300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0106
    Cell Significance Index: 0.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0080
    Cell Significance Index: 0.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0009
    Cell Significance Index: -0.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0020
    Cell Significance Index: -0.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0029
    Cell Significance Index: -0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0065
    Cell Significance Index: -12.2500
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.0069
    Cell Significance Index: -0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0104
    Cell Significance Index: -19.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0124
    Cell Significance Index: -19.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0135
    Cell Significance Index: -2.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0137
    Cell Significance Index: -7.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0144
    Cell Significance Index: -19.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0169
    Cell Significance Index: -12.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0179
    Cell Significance Index: -11.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0180
    Cell Significance Index: -13.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0227
    Cell Significance Index: -16.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0298
    Cell Significance Index: -13.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0299
    Cell Significance Index: -16.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0408
    Cell Significance Index: -5.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0424
    Cell Significance Index: -12.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0439
    Cell Significance Index: -15.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0490
    Cell Significance Index: -7.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0556
    Cell Significance Index: -1.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0564
    Cell Significance Index: -10.1700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0584
    Cell Significance Index: -0.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0608
    Cell Significance Index: -3.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0621
    Cell Significance Index: -7.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0641
    Cell Significance Index: -4.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0744
    Cell Significance Index: -7.6000
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.0774
    Cell Significance Index: -0.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0800
    Cell Significance Index: -16.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0812
    Cell Significance Index: -1.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0830
    Cell Significance Index: -17.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1110
    Cell Significance Index: -2.4100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1302
    Cell Significance Index: -6.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1380
    Cell Significance Index: -15.8100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1395
    Cell Significance Index: -5.7200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1408
    Cell Significance Index: -1.6000
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1514
    Cell Significance Index: -1.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1656
    Cell Significance Index: -17.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1702
    Cell Significance Index: -13.4800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1744
    Cell Significance Index: -2.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1953
    Cell Significance Index: -9.1800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2159
    Cell Significance Index: -3.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2266
    Cell Significance Index: -17.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2305
    Cell Significance Index: -14.1700
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.2392
    Cell Significance Index: -2.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2461
    Cell Significance Index: -15.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2509
    Cell Significance Index: -16.8700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.2710
    Cell Significance Index: -2.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2770
    Cell Significance Index: -14.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2776
    Cell Significance Index: -5.8100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2790
    Cell Significance Index: -2.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2876
    Cell Significance Index: -15.1000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.3018
    Cell Significance Index: -4.8700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3213
    Cell Significance Index: -11.8000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3327
    Cell Significance Index: -6.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3406
    Cell Significance Index: -15.8800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3417
    Cell Significance Index: -5.1200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3460
    Cell Significance Index: -5.8200
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.3569
    Cell Significance Index: -2.0600
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.3621
    Cell Significance Index: -5.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3723
    Cell Significance Index: -10.1400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4028
    Cell Significance Index: -6.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4056
    Cell Significance Index: -10.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4126
    Cell Significance Index: -10.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Metal ion binding:** MT1A is characterized by its ability to bind metals, including zinc, copper, and cadmium, which is essential for its function in metal ion homeostasis. 2. **Cellular localization:** MT1A is primarily localized in the cytosol and nucleus, suggesting its involvement in regulating metal ion homeostasis and cellular processes. 3. **Expression in various cell types:** MT1A is expressed in a wide range of cell types, including fibroblasts, muscle cells, and endothelial cells, indicating its importance in maintaining tissue integrity and function. 4. **Regulation of growth:** MT1A has been shown to regulate cell growth, suggesting its involvement in cellular proliferation and differentiation. **Pathways and Functions:** 1. **Intracellular zinc ion homeostasis:** MT1A plays a crucial role in regulating zinc ion homeostasis, which is essential for maintaining cellular function and preventing zinc toxicity. 2. **Detoxification of copper ion:** MT1A is involved in the detoxification of copper ions, which is essential for preventing copper toxicity and maintaining cellular homeostasis. 3. **Response to metal ions:** MT1A is activated in response to metal ions, such as cadmium and copper, which allows it to regulate metal ion homeostasis and prevent metal ion toxicity. 4. **Negative regulation of growth:** MT1A has been shown to regulate cell growth, suggesting its involvement in cellular proliferation and differentiation. **Clinical Significance:** The dysregulation of MT1A has been implicated in various diseases, including: 1. **Cancer:** Alterations in MT1A expression have been observed in various types of cancer, suggesting its involvement in cancer development and progression. 2. **Neurodegenerative diseases:** MT1A has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, suggesting its involvement in maintaining neuronal homeostasis. 3. **Metal toxicity:** MT1A has been shown to play a crucial role in detoxifying metal ions, such as cadmium and copper, which is essential for preventing metal toxicity and maintaining cellular homeostasis. In conclusion, MT1A is a multifaceted gene involved in metal ion homeostasis and cellular regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its role in maintaining cellular balance and preventing disease. Further research is needed to elucidate the mechanisms by which MT1A regulates metal ion homeostasis and its involvement in various diseases.

Genular Protein ID: 3269198757

Symbol: MT1A_HUMAN

Name: Metallothionein-1A

UniProtKB Accession Codes:

P04731 Q86YX5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 28 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 10 EMBL 5 Ensembl 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6327055

Title: Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids.

PubMed ID: 6327055

DOI: 10.1016/0092-8674(84)90322-2

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 61
  • Mass: 6120
  • Checksum: 8FBA7C54EE8B6A13
  • Sequence:
    • MDPNCSCATG GSCTCTGSCK CKECKCTSCK KSCCSCCPMS CAKCAQGCIC KGASEKCSCC 
A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.