Details for: MTX1

Gene ID: 4580

Symbol: MTX1

Ensembl ID: ENSG00000173171

Description: metaxin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 106.4642
    Cell Significance Index: -16.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 70.0984
    Cell Significance Index: -17.7800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 52.2110
    Cell Significance Index: -24.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 51.6668
    Cell Significance Index: -20.9900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 45.3260
    Cell Significance Index: -23.3200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 36.8393
    Cell Significance Index: -24.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.1945
    Cell Significance Index: -21.1900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.6243
    Cell Significance Index: -21.7300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.3945
    Cell Significance Index: -17.1300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7881
    Cell Significance Index: -22.8400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.4730
    Cell Significance Index: -16.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.7538
    Cell Significance Index: 320.9200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.2917
    Cell Significance Index: 10.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2914
    Cell Significance Index: 127.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1676
    Cell Significance Index: 1054.2600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.1115
    Cell Significance Index: 15.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.0004
    Cell Significance Index: 26.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9902
    Cell Significance Index: 68.4800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9499
    Cell Significance Index: 44.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9294
    Cell Significance Index: 27.3000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8454
    Cell Significance Index: 6.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7234
    Cell Significance Index: 9.8700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7116
    Cell Significance Index: 16.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7104
    Cell Significance Index: 13.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6363
    Cell Significance Index: 17.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6031
    Cell Significance Index: 44.9500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5977
    Cell Significance Index: 6.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5907
    Cell Significance Index: 69.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5899
    Cell Significance Index: 322.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5572
    Cell Significance Index: 26.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5554
    Cell Significance Index: 19.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5484
    Cell Significance Index: 14.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5410
    Cell Significance Index: 239.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5198
    Cell Significance Index: 10.8800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4952
    Cell Significance Index: 4.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4711
    Cell Significance Index: 30.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4641
    Cell Significance Index: 63.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4577
    Cell Significance Index: 82.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4363
    Cell Significance Index: 30.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4096
    Cell Significance Index: 50.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3395
    Cell Significance Index: 43.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3222
    Cell Significance Index: 41.3100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2957
    Cell Significance Index: 3.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2826
    Cell Significance Index: 56.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2816
    Cell Significance Index: 14.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2676
    Cell Significance Index: 12.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2511
    Cell Significance Index: 5.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2442
    Cell Significance Index: 15.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2221
    Cell Significance Index: 5.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1860
    Cell Significance Index: 5.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1201
    Cell Significance Index: 22.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0527
    Cell Significance Index: 10.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0506
    Cell Significance Index: 1.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0311
    Cell Significance Index: 0.8700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0161
    Cell Significance Index: 11.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0133
    Cell Significance Index: 10.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0130
    Cell Significance Index: 9.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0077
    Cell Significance Index: -14.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0086
    Cell Significance Index: -1.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0103
    Cell Significance Index: -1.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0121
    Cell Significance Index: -22.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0137
    Cell Significance Index: -0.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0142
    Cell Significance Index: -0.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0142
    Cell Significance Index: -2.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0149
    Cell Significance Index: -22.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0161
    Cell Significance Index: -5.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0179
    Cell Significance Index: -24.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0241
    Cell Significance Index: -17.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0302
    Cell Significance Index: -19.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0360
    Cell Significance Index: -20.3300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0423
    Cell Significance Index: -1.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0446
    Cell Significance Index: -5.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0476
    Cell Significance Index: -29.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0494
    Cell Significance Index: -22.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0688
    Cell Significance Index: -19.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1172
    Cell Significance Index: -24.6800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1183
    Cell Significance Index: -2.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1229
    Cell Significance Index: -17.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1618
    Cell Significance Index: -8.5000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1884
    Cell Significance Index: -14.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2030
    Cell Significance Index: -15.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2069
    Cell Significance Index: -5.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2184
    Cell Significance Index: -22.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2566
    Cell Significance Index: -14.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2771
    Cell Significance Index: -17.0300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.2784
    Cell Significance Index: -1.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3175
    Cell Significance Index: -21.3500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3410
    Cell Significance Index: -17.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3421
    Cell Significance Index: -20.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3920
    Cell Significance Index: -9.8000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4078
    Cell Significance Index: -16.7100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4081
    Cell Significance Index: -4.2300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4207
    Cell Significance Index: -7.4400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4388
    Cell Significance Index: -12.9300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.4448
    Cell Significance Index: -2.9000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4849
    Cell Significance Index: -6.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4849
    Cell Significance Index: -21.4500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.4940
    Cell Significance Index: -3.0400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5143
    Cell Significance Index: -18.8800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.5290
    Cell Significance Index: -7.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MTX1 is a small protein, with an estimated molecular weight of approximately 14 kDa. It is highly expressed in various cell types, including retinal ganglion cells, extravillous trophoblasts, pulmonary interstitial fibroblasts, and pancreatic acinar cells. MTX1 is primarily localized to the mitochondrial outer membrane (MOM), where it interacts with other components to regulate mitochondrial function and biogenesis. One of the key characteristics of MTX1 is its ability to interact with the Miro complex, a mitochondrial outer membrane protein complex that is involved in mitochondrial dynamics and biogenesis. MTX1's interaction with Miro is crucial for the proper organization of the MOM and the regulation of mitochondrial cristae formation. **Pathways and Functions** MTX1's involvement in mitochondrial biogenesis and organization is mediated through its interactions with various signaling pathways. These pathways include: 1. **Rho GTPase cycle**: MTX1 interacts with Rho GTPases, which are involved in the regulation of mitochondrial dynamics and biogenesis. 2. **Rac2 GTPase cycle**: MTX1 also interacts with Rac2 GTPases, which are involved in the regulation of mitochondrial cristae formation and biogenesis. 3. **Miro GTPase cycle**: As mentioned earlier, MTX1 interacts with the Miro complex, which is involved in mitochondrial outer membrane organization and biogenesis. 4. **Sam complex**: MTX1 interacts with the Sam complex, a mitochondrial protein complex that is involved in the regulation of mitochondrial protein import and biogenesis. MTX1's functions include: 1. **Mitochondrial outer membrane organization**: MTX1 regulates the organization of the MOM, which is crucial for the proper functioning of mitochondria. 2. **Cristae formation**: MTX1's interaction with Miro and Rac2 GTPases is crucial for the formation of cristae, which are the infoldings of the MOM that increase the surface area of the mitochondrion. 3. **Protein import**: MTX1 regulates the import of proteins into the mitochondrion, which is essential for mitochondrial function and biogenesis. **Clinical Significance** MTX1's dysregulation has been implicated in various diseases, including: 1. **Mitochondrial disorders**: Mutations in MTX1 have been associated with mitochondrial disorders, such as mitochondrial myopathies and neurodegenerative diseases. 2. **Cancer**: MTX1's dysregulation has been implicated in cancer, including breast cancer and lung cancer. 3. **Metabolic disorders**: MTX1's dysregulation has been associated with metabolic disorders, including diabetes and obesity. In conclusion, MTX1 is a critical protein that plays a central role in the organization and biogenesis of mitochondria. Its dysregulation has been implicated in various diseases, highlighting the importance of MTX1 in maintaining mitochondrial function and overall cellular health.

Genular Protein ID: 1191172913

Symbol: MTX1_HUMAN

Name: Metaxin-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8660965

Title: Structure and organization of the human metaxin gene (MTX) and pseudogene.

PubMed ID: 8660965

DOI: 10.1006/geno.1996.0181

PubMed ID: 9331372

Title: Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease.

PubMed ID: 9331372

DOI: 10.1101/gr.7.10.1020

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10381257

Title: Metaxin 1 interacts with metaxin 2, a novel related protein associated with the mammalian mitochondrial outer membrane.

PubMed ID: 10381257

DOI: 10.1002/(sici)1097-4644(19990701)74:1<11::aid-jcb2>3.3.co;2-m

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22114354

Title: MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization.

PubMed ID: 22114354

DOI: 10.1091/mbc.e11-09-0774

PubMed ID: 25997101

Title: QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology.

PubMed ID: 25997101

DOI: 10.7554/elife.06265

PubMed ID: 25621951

Title: USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria.

PubMed ID: 25621951

DOI: 10.1038/ncb3097

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 31644573

Title: Armadillo repeat-containing protein 1 is a dual localization protein associated with mitochondrial intermembrane space bridging complex.

PubMed ID: 31644573

DOI: 10.1371/journal.pone.0218303

Sequence Information:

  • Length: 466
  • Mass: 51463
  • Checksum: 2F98ABCA860F50E2
  • Sequence:
  • MLLGGPPRSP RSGTSPKGPW SSTGHVQFGK SPQTWPRRTR PRSPEPAAPS GVRGSTWTRR 
    RDSPRRAGPT ALSRYVGHLW MGRRPPSPEA RGPVPRSSAA SRARRSLASP GISPGPLTAT 
    IGGAVAGGGP RQGRAEAHKE VFPGQRVGKM AAPMELFCWS GGWGLPSVDL DSLAVLTYAR 
    FTGAPLKVHK ISNPWQSPSG TLPALRTSHG EVISVPHKII THLRKEKYNA DYDLSARQGA 
    DTLAFMSLLE EKLLPVLVHT FWIDTKNYVE VTRKWYAEAM PFPLNFFLPG RMQRQYMERL 
    QLLTGEHRPE DEEELEKELY REARECLTLL SQRLGSQKFF FGDAPASLDA FVFSYLALLL 
    QAKLPSGKLQ VHLRGLHNLC AYCTHILSLY FPWDGAEVPP QRQTPAGPET EEEPYRRRNQ 
    ILSVLAGLAA MVGYALLSGI VSIQRATPAR APGTRTLGMA EEDEEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.