Details for: NFATC4

Gene ID: 4776

Symbol: NFATC4

Ensembl ID: ENSG00000100968

Description: nuclear factor of activated T cells 4

Associated with

  • Brain-derived neurotrophic factor receptor signaling pathway
    (GO:0031547)
  • Branching involved in blood vessel morphogenesis
    (GO:0001569)
  • Calcineurin-nfat signaling cascade
    (GO:0033173)
  • Cellular respiration
    (GO:0045333)
  • Cellular response to lithium ion
    (GO:0071285)
  • Cellular response to uv
    (GO:0034644)
  • Chromatin
    (GO:0000785)
  • Cytosol
    (GO:0005829)
  • Dendrite morphogenesis
    (GO:0048813)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Heart development
    (GO:0007507)
  • Inflammatory response
    (GO:0006954)
  • Intrinsic apoptotic signaling pathway in response to dna damage
    (GO:0008630)
  • Long-term memory
    (GO:0007616)
  • Long-term synaptic potentiation
    (GO:0060291)
  • Negative regulation of dendrite morphogenesis
    (GO:0050774)
  • Negative regulation of mirna transcription
    (GO:1902894)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of synapse maturation
    (GO:2000297)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of wnt signaling pathway
    (GO:0030178)
  • Neuron apoptotic process
    (GO:0051402)
  • Nuclear speck
    (GO:0016607)
  • Nucleus
    (GO:0005634)
  • Peroxisome proliferator activated receptor binding
    (GO:0042975)
  • Positive regulation of apoptotic signaling pathway
    (GO:2001235)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Protein binding
    (GO:0005515)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Synapse maturation
    (GO:0060074)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription regulator complex
    (GO:0005667)
  • Vascular associated smooth muscle cell development
    (GO:0097084)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 97.0136
    Cell Significance Index: -15.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 59.8872
    Cell Significance Index: -15.1900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 36.1939
    Cell Significance Index: -14.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 28.7637
    Cell Significance Index: -13.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8342
    Cell Significance Index: -15.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6872
    Cell Significance Index: 19.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5764
    Cell Significance Index: 520.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5094
    Cell Significance Index: 69.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5024
    Cell Significance Index: 10.5200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.5013
    Cell Significance Index: 8.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4365
    Cell Significance Index: 50.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3857
    Cell Significance Index: 10.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3780
    Cell Significance Index: 61.4800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3348
    Cell Significance Index: 16.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3143
    Cell Significance Index: 34.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2726
    Cell Significance Index: 5.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2705
    Cell Significance Index: 14.0500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.2177
    Cell Significance Index: 1.0100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1795
    Cell Significance Index: 1.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1745
    Cell Significance Index: 12.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1697
    Cell Significance Index: 16.7900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1691
    Cell Significance Index: 2.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1617
    Cell Significance Index: 9.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1559
    Cell Significance Index: 19.9900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0778
    Cell Significance Index: 0.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0609
    Cell Significance Index: 1.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0484
    Cell Significance Index: 1.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0479
    Cell Significance Index: 2.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0472
    Cell Significance Index: 2.6500
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.0373
    Cell Significance Index: 0.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0338
    Cell Significance Index: 0.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0268
    Cell Significance Index: 4.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0256
    Cell Significance Index: 48.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0197
    Cell Significance Index: 12.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0155
    Cell Significance Index: 8.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0142
    Cell Significance Index: 0.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0131
    Cell Significance Index: 0.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0093
    Cell Significance Index: 4.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0075
    Cell Significance Index: 1.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0069
    Cell Significance Index: 12.6500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0056
    Cell Significance Index: 0.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0050
    Cell Significance Index: 7.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0042
    Cell Significance Index: 0.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0032
    Cell Significance Index: 0.4700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0050
    Cell Significance Index: -0.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0106
    Cell Significance Index: -3.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0108
    Cell Significance Index: -14.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0153
    Cell Significance Index: -11.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0166
    Cell Significance Index: -12.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0171
    Cell Significance Index: -12.9600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0213
    Cell Significance Index: -0.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0221
    Cell Significance Index: -12.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0246
    Cell Significance Index: -1.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0251
    Cell Significance Index: -11.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0253
    Cell Significance Index: -0.8800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0257
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0264
    Cell Significance Index: -16.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0316
    Cell Significance Index: -11.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0443
    Cell Significance Index: -5.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0517
    Cell Significance Index: -1.1000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0590
    Cell Significance Index: -1.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0651
    Cell Significance Index: -11.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0654
    Cell Significance Index: -13.1100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0684
    Cell Significance Index: -0.9600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0714
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0725
    Cell Significance Index: -15.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0739
    Cell Significance Index: -8.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0774
    Cell Significance Index: -2.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0793
    Cell Significance Index: -8.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0884
    Cell Significance Index: -4.1200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0921
    Cell Significance Index: -2.2300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0939
    Cell Significance Index: -2.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0966
    Cell Significance Index: -12.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0991
    Cell Significance Index: -11.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1012
    Cell Significance Index: -2.1000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1024
    Cell Significance Index: -0.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1094
    Cell Significance Index: -11.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1396
    Cell Significance Index: -3.9000
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.1430
    Cell Significance Index: -1.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1436
    Cell Significance Index: -10.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1616
    Cell Significance Index: -12.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1717
    Cell Significance Index: -11.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1742
    Cell Significance Index: -13.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1918
    Cell Significance Index: -9.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1953
    Cell Significance Index: -12.3100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2042
    Cell Significance Index: -2.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2098
    Cell Significance Index: -10.9300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2204
    Cell Significance Index: -1.3800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2285
    Cell Significance Index: -4.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2511
    Cell Significance Index: -6.8400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2525
    Cell Significance Index: -3.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2706
    Cell Significance Index: -14.2100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.2774
    Cell Significance Index: -4.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3113
    Cell Significance Index: -9.1700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3454
    Cell Significance Index: -14.1500
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.3590
    Cell Significance Index: -4.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3633
    Cell Significance Index: -16.0700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3735
    Cell Significance Index: -13.7100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.3926
    Cell Significance Index: -2.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3945
    Cell Significance Index: -10.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NFATC4 is a transcription factor that regulates gene expression by binding to specific DNA sequences. It is a member of the NFAT family, which is characterized by its ability to bind to the calcium-calmodulin-dependent phosphatase calcineurin. NFATC4 has been shown to interact with other transcription factors, such as NFAT1 and NFAT2, to regulate the expression of target genes. The protein is primarily localized to the nucleus, where it regulates transcription by binding to specific DNA sequences. **Pathways and Functions** NFATC4 is involved in several signaling pathways, including: 1. **Calcineurin-NFAT signaling cascade**: This pathway is involved in the regulation of cytokine production, dendrite morphogenesis, and neuronal development. 2. **Brain-derived neurotrophic factor receptor signaling pathway**: This pathway is involved in the regulation of neuronal survival and differentiation. 3. **Branching involved in blood vessel morphogenesis**: This pathway is involved in the regulation of vascular development. 4. **Inflammatory response**: NFATC4 has been shown to regulate the expression of pro-inflammatory cytokines, such as TNF-α. 5. **Neuron development**: NFATC4 regulates the expression of genes involved in neuronal development, such as those involved in dendrite morphogenesis and synapse maturation. **Clinical Significance** NFATC4 has been implicated in several diseases, including: 1. **Autoimmune diseases**: NFATC4 has been shown to regulate the expression of pro-inflammatory cytokines, which are involved in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Neurological disorders**: NFATC4 has been implicated in the regulation of neuronal development and function, and has been shown to be involved in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: NFATC4 has been shown to regulate the expression of genes involved in cell proliferation and survival, and has been implicated in the pathogenesis of certain types of cancer, such as breast cancer and lung cancer. In conclusion, NFATC4 is a transcription factor that plays a crucial role in the regulation of immune responses, neuronal development, and vascular development. Its dysregulation has been implicated in several diseases, including autoimmune diseases, neurological disorders, and cancer. Further research is needed to fully understand the role of NFATC4 in human disease and to develop therapeutic strategies to target this transcription factor.

Genular Protein ID: 1697919086

Symbol: NFAC4_HUMAN

Name: Nuclear factor of activated T-cells, cytoplasmic 4

UniProtKB Accession Codes:

Q14934 B4DDG5 B4DY55 B5B2U7 B5B2U8 B5B2U9 B5B2V0 B5B2V1 B5B2V2 B5B2V3 B5B2V4 B5B2V5 B5B2V7 B5B2V8 B5B2V9 B5B2W0 B5B2W1 B5B2W2 B5B2W3 B5B2W4 B5B2W5 B5B2W6 B5B2W7 B5B2W8 B5B2W9 B5B2X0 Q7Z598 Q96H68

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 8 CDD 2 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 29 Ensembl 48 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 24 Pumba 1 RNAct 1 RefSeq 9 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7749981

Title: Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins.

PubMed ID: 7749981

DOI: 10.1016/1074-7613(95)90027-6

PubMed ID: 18675896

Title: Alternative splicing and expression of human and mouse NFAT genes.

PubMed ID: 18675896

DOI: 10.1016/j.ygeno.2008.06.011

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10089876

Title: Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT.

PubMed ID: 10089876

DOI: 10.1016/s0092-8674(00)80571-1

PubMed ID: 11514544

Title: Requirement of two NFATc4 transactivation domains for CBP potentiation.

PubMed ID: 11514544

DOI: 10.1074/jbc.m102961200

PubMed ID: 11997522

Title: Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases.

PubMed ID: 11997522

DOI: 10.1128/mcb.22.11.3892-3904.2002

PubMed ID: 12370307

Title: Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth.

PubMed ID: 12370307

DOI: 10.1128/mcb.22.21.7603-7613.2002

PubMed ID: 17875713

Title: Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation.

PubMed ID: 17875713

DOI: 10.1158/0008-5472.can-06-4788

PubMed ID: 17213202

Title: RSK2 mediates muscle cell differentiation through regulation of NFAT3.

PubMed ID: 17213202

DOI: 10.1074/jbc.m611322200

PubMed ID: 18668201

Title: Repression of NFAT3 transcriptional activity by estrogen receptors.

PubMed ID: 18668201

DOI: 10.1007/s00018-008-8273-1

PubMed ID: 19026640

Title: Regulation of the stability and transcriptional activity of NFATc4 by ubiquitination.

PubMed ID: 19026640

DOI: 10.1016/j.febslet.2008.11.009

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18347059

Title: Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4.

PubMed ID: 18347059

DOI: 10.1128/mcb.01847-07

PubMed ID: 18691762

Title: The interleukin-1 receptor associated kinase 1 contributes to the regulation of NFAT.

PubMed ID: 18691762

DOI: 10.1016/j.molimm.2008.06.023

PubMed ID: 18218901

Title: NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins.

PubMed ID: 18218901

DOI: 10.1126/science.1151227

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 25663301

Title: Transcriptional regulation of BACE1 by NFAT3 leads to enhanced amyloidogenic processing.

PubMed ID: 25663301

DOI: 10.1007/s11064-015-1533-1

Sequence Information:

  • Length: 902
  • Mass: 95449
  • Checksum: AE94C5D1325D24D7
  • Sequence:
    • MGAASCEDEE LEFKLVFGEE KEAPPLGAGG LGEELDSEDA PPCCRLALGE PPPYGAAPIG 
IPRPPPPRPG MHSPPPRPAP SPGTWESQPA RSVRLGGPGG GAGGAGGGRV LECPSIRITS 
ISPTPEPPAA LEDNPDAWGD GSPRDYPPPE GFGGYREAGG QGGGAFFSPS PGSSSLSSWS 
FFSDASDEAA LYAACDEVES ELNEAASRFG LGSPLPSPRA SPRPWTPEDP WSLYGPSPGG 
RGPEDSWLLL SAPGPTPASP RPASPCGKRR YSSSGTPSSA SPALSRRGSL GEEGSEPPPP 
PPLPLARDPG SPGPFDYVGA PPAESIPQKT RRTSSEQAVA LPRSEEPASC NGKLPLGAEE 
SVAPPGGSRK EVAGMDYLAV PSPLAWSKAR IGGHSPIFRT SALPPLDWPL PSQYEQLELR 
IEVQPRAHHR AHYETEGSRG AVKAAPGGHP VVKLLGYSEK PLTLQMFIGT ADERNLRPHA 
FYQVHRITGK MVATASYEAV VSGTKVLEMT LLPENNMAAN IDCAGILKLR NSDIELRKGE 
TDIGRKNTRV RLVFRVHVPQ GGGKVVSVQA ASVPIECSQR SAQELPQVEA YSPSACSVRG 
GEELVLTGSN FLPDSKVVFI ERGPDGKLQW EEEATVNRLQ SNEVTLTLTV PEYSNKRVSR 
PVQVYFYVSN GRRKRSPTQS FRFLPVICKE EPLPDSSLRG FPSASATPFG TDMDFSPPRP 
PYPSYPHEDP ACETPYLSEG FGYGMPPLYP QTGPPPSYRP GLRMFPETRG TTGCAQPPAV 
SFLPRPFPSD PYGGRGSSFS LGLPFSPPAP FRPPPLPASP PLEGPFPSQS DVHPLPAEGY 
NKVGPGYGPG EGAPEQEKSR GGYSSGFRDS VPIQGITLEE VSEIIGRDLS GFPAPPGEEP 
PA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.