Details for: SNU13

Gene ID: 4809

Symbol: SNU13

Ensembl ID: ENSG00000100138

Description: small nuclear ribonucleoprotein 13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 243.2834
    Cell Significance Index: -100.2200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 207.6271
    Cell Significance Index: -84.3500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 200.0328
    Cell Significance Index: -94.4400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 181.9065
    Cell Significance Index: -93.5700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 141.3962
    Cell Significance Index: -94.8800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 90.1080
    Cell Significance Index: -86.0300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.5432
    Cell Significance Index: -60.3900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 21.8984
    Cell Significance Index: -67.2600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.4914
    Cell Significance Index: -25.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.7759
    Cell Significance Index: 198.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.0082
    Cell Significance Index: 1642.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.7970
    Cell Significance Index: 384.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.7750
    Cell Significance Index: 206.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.7460
    Cell Significance Index: 128.0300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.6793
    Cell Significance Index: 315.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.6597
    Cell Significance Index: 72.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.5850
    Cell Significance Index: 74.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.5547
    Cell Significance Index: 75.0300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.5330
    Cell Significance Index: 53.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.4452
    Cell Significance Index: 315.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.4400
    Cell Significance Index: 64.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.4038
    Cell Significance Index: 295.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.3886
    Cell Significance Index: 112.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.3803
    Cell Significance Index: 429.0900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.2550
    Cell Significance Index: 24.5200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.1821
    Cell Significance Index: 24.7900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.9583
    Cell Significance Index: 34.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.9152
    Cell Significance Index: 135.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.8990
    Cell Significance Index: 839.6000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.7622
    Cell Significance Index: 14.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.7267
    Cell Significance Index: 111.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.7085
    Cell Significance Index: 59.3700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.6041
    Cell Significance Index: 37.0600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.5295
    Cell Significance Index: 14.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.5257
    Cell Significance Index: 195.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0455
    Cell Significance Index: 54.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0018
    Cell Significance Index: 52.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9165
    Cell Significance Index: 181.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8805
    Cell Significance Index: 176.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6204
    Cell Significance Index: 61.3700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3696
    Cell Significance Index: 333.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3448
    Cell Significance Index: 123.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2618
    Cell Significance Index: 49.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2380
    Cell Significance Index: 180.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2105
    Cell Significance Index: 9.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1654
    Cell Significance Index: 4.7700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1553
    Cell Significance Index: 9.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0985
    Cell Significance Index: 72.2300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0945
    Cell Significance Index: 1.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0434
    Cell Significance Index: 1.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0099
    Cell Significance Index: -0.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0105
    Cell Significance Index: -7.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0109
    Cell Significance Index: -20.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0120
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0205
    Cell Significance Index: -3.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0503
    Cell Significance Index: -92.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0520
    Cell Significance Index: -5.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0609
    Cell Significance Index: -93.8000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0692
    Cell Significance Index: -94.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0970
    Cell Significance Index: -71.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1003
    Cell Significance Index: -63.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1333
    Cell Significance Index: -4.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1460
    Cell Significance Index: -82.3100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1660
    Cell Significance Index: -1.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1683
    Cell Significance Index: -76.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1689
    Cell Significance Index: -105.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1754
    Cell Significance Index: -20.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2426
    Cell Significance Index: -6.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2732
    Cell Significance Index: -78.6100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3783
    Cell Significance Index: -15.5000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4499
    Cell Significance Index: -8.3200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4783
    Cell Significance Index: -12.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4827
    Cell Significance Index: -101.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4858
    Cell Significance Index: -70.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4950
    Cell Significance Index: -57.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.5042
    Cell Significance Index: -82.0100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5052
    Cell Significance Index: -7.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5366
    Cell Significance Index: -42.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5414
    Cell Significance Index: -33.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6014
    Cell Significance Index: -40.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7002
    Cell Significance Index: -18.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7274
    Cell Significance Index: -55.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8898
    Cell Significance Index: -92.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.0284
    Cell Significance Index: -57.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.0559
    Cell Significance Index: -73.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.0782
    Cell Significance Index: -23.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.1034
    Cell Significance Index: -35.3400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.1636
    Cell Significance Index: -7.0300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.1637
    Cell Significance Index: -8.9700
  • Cell Name: germ cell (CL0000586)
    Fold Change: -1.1867
    Cell Significance Index: -8.9600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.1896
    Cell Significance Index: -16.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2151
    Cell Significance Index: -35.7900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.2374
    Cell Significance Index: -12.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.4495
    Cell Significance Index: -88.8700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.4740
    Cell Significance Index: -25.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.6492
    Cell Significance Index: -72.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.6867
    Cell Significance Index: -28.9100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.7063
    Cell Significance Index: -20.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.7660
    Cell Significance Index: -37.6100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.7760
    Cell Significance Index: -10.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The SNU13 gene is a member of the small nuclear ribonucleoprotein (snRNP) family, which assembles to form the spliceosome, a complex molecular machine responsible for RNA splicing and processing. The SNU13 gene encodes for the NH2L1_HUMAN protein, also known as NHP2-like protein 1, which is a component of the U4/U6.U5 tri-snRNP complex. This complex is essential for the catalytic site of the spliceosome, facilitating the precise removal of introns and the joining of exons during RNA splicing. **Pathways and Functions:** The SNU13 gene is involved in various RNA processing pathways, including: 1. **RNA Splicing:** The SNU13 gene is a key component of the U4/U6.U5 tri-snRNP complex, which assembles to form the catalytic site of the spliceosome. This complex is responsible for the precise removal of introns and the joining of exons during RNA splicing. 2. **Ribosomal Small Subunit Biogenesis:** The SNU13 gene is also involved in the biogenesis of the ribosomal small subunit, which is essential for protein synthesis. 3. **Metabolism of RNA:** The SNU13 gene is involved in the metabolism of RNA, including the processing of capped intron-containing pre-mRNA. 4. **Immune Regulation:** The SNU13 gene has been shown to be significantly expressed in various immune cells, including myeloid dendritic cells, CD8-positive T cells, and monocytes. These cells play a crucial role in the initiation and regulation of immune responses. **Clinical Significance:** The SNU13 gene has been implicated in various human diseases, including: 1. **Immune Disorders:** Dysregulation of the SNU13 gene has been linked to immune disorders, such as autoimmune diseases and immunodeficiencies. 2. **Cancer:** The SNU13 gene has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma. 3. **Neurological Disorders:** The SNU13 gene has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the SNU13 gene plays a vital role in RNA processing and immune regulation, with implications for various human diseases. Further research is necessary to fully understand the mechanisms by which the SNU13 gene regulates RNA processing and immune responses, and to explore its potential as a therapeutic target for the treatment of diseases.

Genular Protein ID: 3511426137

Symbol: NH2L1_HUMAN

Name: NHP2-like protein 1

UniProtKB Accession Codes:

P55769

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 7 EMDB 27 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 32 PDBsum 32 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8978773

Title: Cloning and mapping of a human novel cDNA (NHP2L1) that encodes a protein highly homologous to yeast nuclear protein NHP2.

PubMed ID: 8978773

DOI: 10.1159/000134186

PubMed ID: 10545122

Title: Functional interaction of a novel 15.5kD [U4/U6.U5] tri-snRNP protein with the 5' stem-loop of U4 snRNA.

PubMed ID: 10545122

DOI: 10.1093/emboj/18.21.6119

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10593953

Title: HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation.

PubMed ID: 10593953

DOI: 10.1074/jbc.274.51.36544

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 16723661

Title: The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP.

PubMed ID: 16723661

DOI: 10.1261/rna.55406

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11163207

Title: Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment.

PubMed ID: 11163207

DOI: 10.1016/s1097-2765(00)00131-3

PubMed ID: 18044964

Title: Functional implications for a prototypical K-turn binding protein from structural and dynamical studies of 15.5K.

PubMed ID: 18044964

DOI: 10.1021/bi701254q

PubMed ID: 17412961

Title: Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP.

PubMed ID: 17412961

DOI: 10.1126/science.1137924

PubMed ID: 21784869

Title: Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31.

PubMed ID: 21784869

DOI: 10.1261/rna.2690611

PubMed ID: 26912367

Title: Molecular architecture of the human U4/U6.U5 tri-snRNP.

PubMed ID: 26912367

DOI: 10.1126/science.aad2085

PubMed ID: 28781166

Title: Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.

PubMed ID: 28781166

DOI: 10.1016/j.cell.2017.07.011

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

  • Length: 128
  • Mass: 14174
  • Checksum: 78849EBB497089ED
  • Sequence:
    • MTEADVNPKA YPLADAHLTK KLLDLVQQSC NYKQLRKGAN EATKTLNRGI SEFIVMAADA 
EPLEIILHLP LLCEDKNVPY VFVRSKQALG RACGVSRPVI ACSVTIKEGS QLKQQIQSIQ 
QSIERLLV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.