Details for: NINJ1

Gene ID: 4814

Symbol: NINJ1

Ensembl ID: ENSG00000131669

Description: ninjurin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 187.0196
    Cell Significance Index: -29.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 100.2983
    Cell Significance Index: -25.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 71.3587
    Cell Significance Index: -28.9900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 65.6821
    Cell Significance Index: -31.0100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 61.2965
    Cell Significance Index: -31.5300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 30.5161
    Cell Significance Index: -29.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.5694
    Cell Significance Index: -29.0600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.0150
    Cell Significance Index: -24.1500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.7244
    Cell Significance Index: -23.7300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.4277
    Cell Significance Index: -29.3100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.9097
    Cell Significance Index: 30.2200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.3498
    Cell Significance Index: -9.5200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.8441
    Cell Significance Index: 71.0500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.7920
    Cell Significance Index: 108.7000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 3.6925
    Cell Significance Index: 30.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.7061
    Cell Significance Index: 36.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.7024
    Cell Significance Index: 120.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.6940
    Cell Significance Index: 126.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6041
    Cell Significance Index: 260.9000
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 1.2893
    Cell Significance Index: 22.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2652
    Cell Significance Index: 1142.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1615
    Cell Significance Index: 31.6200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1434
    Cell Significance Index: 33.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9649
    Cell Significance Index: 44.9900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9521
    Cell Significance Index: 103.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8973
    Cell Significance Index: 53.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8849
    Cell Significance Index: 113.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8578
    Cell Significance Index: 379.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7217
    Cell Significance Index: 394.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7157
    Cell Significance Index: 98.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6095
    Cell Significance Index: 31.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5971
    Cell Significance Index: 77.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5930
    Cell Significance Index: 27.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5805
    Cell Significance Index: 71.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4659
    Cell Significance Index: 32.2200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4564
    Cell Significance Index: 8.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4268
    Cell Significance Index: 22.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4192
    Cell Significance Index: 75.5600
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.4081
    Cell Significance Index: 3.3800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3447
    Cell Significance Index: 2.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3368
    Cell Significance Index: 66.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3076
    Cell Significance Index: 30.4300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2288
    Cell Significance Index: 6.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1753
    Cell Significance Index: 4.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1618
    Cell Significance Index: 30.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1608
    Cell Significance Index: 18.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0820
    Cell Significance Index: 14.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0684
    Cell Significance Index: 1.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0589
    Cell Significance Index: 21.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0434
    Cell Significance Index: 0.9400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0423
    Cell Significance Index: 31.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0380
    Cell Significance Index: 28.7600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0246
    Cell Significance Index: 1.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0228
    Cell Significance Index: 4.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0214
    Cell Significance Index: 40.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0166
    Cell Significance Index: 1.7000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0038
    Cell Significance Index: -0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0056
    Cell Significance Index: -3.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0061
    Cell Significance Index: -4.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0103
    Cell Significance Index: -18.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0108
    Cell Significance Index: -0.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0120
    Cell Significance Index: -18.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0154
    Cell Significance Index: -20.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0246
    Cell Significance Index: -15.3400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0259
    Cell Significance Index: -0.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0380
    Cell Significance Index: -21.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0413
    Cell Significance Index: -18.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0515
    Cell Significance Index: -1.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0642
    Cell Significance Index: -7.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0674
    Cell Significance Index: -4.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0725
    Cell Significance Index: -20.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0742
    Cell Significance Index: -15.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0850
    Cell Significance Index: -2.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1271
    Cell Significance Index: -18.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1358
    Cell Significance Index: -15.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2028
    Cell Significance Index: -9.1900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2042
    Cell Significance Index: -23.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2523
    Cell Significance Index: -19.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2616
    Cell Significance Index: -7.3100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2641
    Cell Significance Index: -3.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2693
    Cell Significance Index: -28.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2725
    Cell Significance Index: -20.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2738
    Cell Significance Index: -9.6200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2871
    Cell Significance Index: -14.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3541
    Cell Significance Index: -14.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3628
    Cell Significance Index: -9.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3687
    Cell Significance Index: -11.8100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3757
    Cell Significance Index: -2.2700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3779
    Cell Significance Index: -3.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4004
    Cell Significance Index: -24.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4067
    Cell Significance Index: -25.0000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4209
    Cell Significance Index: -5.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4578
    Cell Significance Index: -30.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4708
    Cell Significance Index: -29.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4792
    Cell Significance Index: -10.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4803
    Cell Significance Index: -26.9500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5555
    Cell Significance Index: -14.1900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5765
    Cell Significance Index: -13.3200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.5794
    Cell Significance Index: -2.6800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.6746
    Cell Significance Index: -14.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NINJ1 is a member of the immunoglobulin superfamily, characterized by its ability to bind to various ligands, including proteoglycans, collagens, and other extracellular matrix components. This interaction enables NINJ1 to modulate cell adhesion, migration, and proliferation. Additionally, NINJ1 has been shown to interact with various signaling molecules, including integrins, receptors, and cytokines, which further underscores its role in regulating immune responses and tissue homeostasis. **Pathways and Functions:** NINJ1 is involved in multiple signaling pathways that regulate immune responses, including: 1. **Angiogenesis**: NINJ1 promotes angiogenesis by binding to vascular endothelial growth factor (VEGF) and stimulating the proliferation and migration of endothelial cells. 2. **Cell Adhesion**: NINJ1 interacts with integrins and other adhesion molecules to regulate cell-cell and cell-extracellular matrix interactions, which is crucial for tissue regeneration and immune cell migration. 3. **Inflammatory Response**: NINJ1 is involved in the regulation of inflammatory responses by interacting with pro-inflammatory cytokines and chemokines, such as TNF-α and IL-1β. 4. **Programmed Cell Death**: NINJ1 has been implicated in pyroptosis, a form of programmed cell death that is mediated by the activation of caspase-1. **Clinical Significance:** NINJ1 has been implicated in various pathological conditions, including: 1. **Cancer**: NINJ1 overexpression has been observed in various types of cancer, including breast, prostate, and lung cancer, where it promotes tumor progression and metastasis. 2. **Inflammatory Diseases**: NINJ1 has been implicated in the regulation of inflammatory responses, which is critical in the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Infectious Diseases**: NINJ1 has been shown to regulate the response to lipopolysaccharide (LPS) and other bacterial components, which is essential for the clearance of infections. In conclusion, Ninjurin 1 is a multifunctional gene that plays a critical role in regulating immune responses, tissue regeneration, and cancer progression. Further research is needed to elucidate the mechanisms by which NINJ1 regulates these processes and to explore its potential as a therapeutic target for various diseases. **Recommendations:** 1. **Immunotherapy**: Targeting NINJ1 with antibodies or small molecules may be a promising approach for the treatment of cancer and inflammatory diseases. 2. **Regenerative Medicine**: Understanding the role of NINJ1 in tissue regeneration may lead to the development of novel therapies for wound healing and tissue repair. 3. **Infectious Disease Research**: Further investigation of NINJ1's role in the response to infections may reveal new strategies for the prevention and treatment of infectious diseases. By exploring the complexities of Ninjurin 1, we may uncover new avenues for the treatment of various diseases and improve our understanding of the intricate mechanisms that regulate immune responses and tissue homeostasis.

Genular Protein ID: 4070870751

Symbol: NINJ1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q92982 Q6GU89 Q8WUV5 Q9BT07

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 3 Ensembl 1 GO 23 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8780658

Title: Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth.

PubMed ID: 8780658

DOI: 10.1016/s0896-6273(00)80166-x

PubMed ID: 9465296

Title: The human homologue of the ninjurin gene maps to the candidate region of hereditary sensory neuropathy type I (HSNI).

PubMed ID: 9465296

DOI: 10.1006/geno.1997.5084

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9261151

Title: Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule.

PubMed ID: 9261151

DOI: 10.1074/jbc.272.34.21373

PubMed ID: 22162058

Title: Role of Ninjurin-1 in the migration of myeloid cells to central nervous system inflammatory lesions.

PubMed ID: 22162058

DOI: 10.1002/ana.22519

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 26677008

Title: Ninjurin1 regulates lipopolysaccharide-induced inflammation through direct binding.

PubMed ID: 26677008

DOI: 10.3892/ijo.2015.3296

PubMed ID: 32883094

Title: Anti-inflammatory actions of soluble ninjurin-1 ameliorate atherosclerosis.

PubMed ID: 32883094

DOI: 10.1161/circulationaha.120.046907

PubMed ID: 32147432

Title: Ninjurin-1 upregulated by TNFalpha receptor 1 stimulates monocyte adhesion to human TNFalpha-activated endothelial cells; benefic effects of amlodipine.

PubMed ID: 32147432

DOI: 10.1016/j.lfs.2020.117518

PubMed ID: 33028854

Title: Ninjurin 1 dodecamer peptide containing the N-terminal adhesion motif (N-NAM) exerts proangiogenic effects in HUVECs and in the postischemic brain.

PubMed ID: 33028854

DOI: 10.1038/s41598-020-73340-5

PubMed ID: 33472215

Title: NINJ1 mediates plasma membrane rupture during lytic cell death.

PubMed ID: 33472215

DOI: 10.1038/s41586-021-03218-7

PubMed ID: 36468682

Title: Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death.

PubMed ID: 36468682

DOI: 10.7554/elife.78609

PubMed ID: 37196676

Title: Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury.

PubMed ID: 37196676

DOI: 10.1038/s41586-023-06191-5

PubMed ID: 38396301

Title: NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis.

PubMed ID: 38396301

DOI: 10.1038/s44318-024-00055-y

PubMed ID: 37198476

Title: Structural basis of NINJ1-mediated plasma membrane rupture in cell death.

PubMed ID: 37198476

DOI: 10.1038/s41586-023-05991-z

PubMed ID: 38614101

Title: NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks.

PubMed ID: 38614101

DOI: 10.1016/j.cell.2024.03.008

Sequence Information:

  • Length: 152
  • Mass: 16345
  • Checksum: FEACA99450187855
  • Sequence:
    • MDSGTEEYEL NGGLPPGTPG SPDASPARWG WRHGPINVNH YASKKSAAES MLDIALLMAN 
ASQLKAVVEQ GPSFAFYVPL VVLISISLVL QIGVGVLLIF LVKYDLNNPA KHAKLDFLNN 
LATGLVFIIV VVNIFITAFG VQKPLMDMAP QQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.