Details for: NINJ1
Gene ID: 4814
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: NINJ1
Ensembl ID: ENSG00000131669
Description: ninjurin 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 44.14rCSI 34.01%PRS 68.71
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CSI 43.58rCSI 40.21%PRS 69.2
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CSI 36.64rCSI 69.17%PRS 77.56
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CSI 19.72rCSI 24.8%PRS 78.75
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CSI 18.13rCSI 23.76%PRS 80.41
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CSI 15.31rCSI 24.54%PRS 85.47
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CSI 14.32rCSI 15.35%PRS 67.55
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CSI 13.85rCSI 25.2%PRS 81.21
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CSI 12.98rCSI 11.92%PRS 76.4
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CSI 12.65rCSI 9.5%PRS 73.2
-
CSI 12.05rCSI 12.6%PRS 65.25
-
CSI 11.66rCSI 8.14%PRS 70.28
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CSI 11.49rCSI 25.29%PRS 71.43
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CSI 11.38rCSI 8.95%PRS 73.87
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CSI 11.09rCSI 13.72%PRS 64.23
-
CSI 10.24rCSI 47.3%PRS 84.19
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CSI 10.18rCSI 7.62%PRS 81.9
-
CSI 10.05rCSI 10.41%PRS 73.19
-
CSI 9.87rCSI 15.92%PRS 69.66
-
CSI 9.87rCSI 7.31%PRS 60.15
-
CSI 8.03rCSI 12.27%PRS 76.44
-
CSI 7.9rCSI 8.24%PRS 67.32
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CSI 7.73rCSI 6.79%PRS 72.74
-
CSI 7.66rCSI 9.44%PRS 78.05
-
CSI 7.6rCSI 7.96%PRS 64.04
-
CSI 7.52rCSI 12.18%PRS 63.35
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CSI 7.37rCSI 14.69%PRS 83.36
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CSI 7.36rCSI 19.03%PRS 62.3
-
CSI 7.35rCSI 14.3%PRS 70.42
-
CSI 7.31rCSI 44.25%PRS 84.01
-
CSI 7rCSI 13.87%PRS 78.98
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CSI 6.74rCSI 8.62%PRS 85.03
-
CSI 6.71rCSI 8.11%PRS 76.26
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CSI 6.62rCSI 6.51%PRS 82.71
-
CSI 6.54rCSI 5.48%PRS 71.09
-
CSI 6.18rCSI 8.56%PRS 67.18
-
CSI 6.14rCSI 14.73%PRS 75.77
-
CSI 6.1rCSI 8.79%PRS 75.77
-
CSI 6.09rCSI 9.3%PRS 81.88
-
CSI 6.09rCSI 4.37%PRS 81.3
-
CSI 5.99rCSI 9.2%PRS 76.66
-
CSI 5.94rCSI 5.12%PRS 71.51
-
CSI 5.9rCSI 15.39%PRS 67.39
-
CSI 5.87rCSI 5.21%PRS 65.09
-
CSI 5.52rCSI 12.63%PRS 67.75
-
CSI 5.48rCSI 4.57%PRS 74.87
-
CSI 5.47rCSI 7.02%PRS 71.82
-
CSI 5.32rCSI 4.03%PRS 80.8
-
CSI 5.22rCSI 5.87%PRS 83.35
-
CSI 5.17rCSI 13.14%PRS 61.21
-
CSI 5.1rCSI 12.63%PRS 66.09
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CSI 5.04rCSI 9.1%PRS 78.84
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CSI 5rCSI 3.48%PRS 82.48
-
CSI 4.99rCSI 8.93%PRS 66.86
-
CSI 4.76rCSI 4.43%PRS 68.07
-
CSI 4.72rCSI 5.75%PRS 74.82
-
CSI 4.69rCSI 26.25%PRS 72.42
-
CSI 4.59rCSI 6.11%PRS 73.61
-
CSI 4.52rCSI 3.62%PRS 85.83
-
CSI 4.47rCSI 9.98%PRS 75.06
-
CSI 4.44rCSI 7.61%PRS 75.51
-
CSI 4.4rCSI 7%PRS 60.05
-
CSI 4.03rCSI 5.02%PRS 78.02
-
CSI 4rCSI 5.86%PRS 78.59
-
CSI 3.92rCSI 3.44%PRS 76.24
-
CSI 3.82rCSI 2.66%PRS 78.88
-
CSI 3.8rCSI 4.87%PRS 64.1
-
CSI 3.79rCSI 8.5%PRS 83.13
-
CSI 3.73rCSI 3.59%PRS 67.11
-
CSI 3.56rCSI 6.08%PRS 83.88
-
CSI 3.56rCSI 3.78%PRS 75.9
-
CSI 3.39rCSI 8.58%PRS 74.78
-
CSI 3.27rCSI 2.48%PRS 80.5
-
CSI 3.19rCSI 3.07%PRS 58.67
-
CSI 3.18rCSI 2.63%PRS 69.76
-
CSI 3.17rCSI 11.13%PRS 78.65
-
CSI 3.17rCSI 4.54%PRS 70.07
-
CSI 3.12rCSI 4.26%PRS 68.38
-
CSI 3.09rCSI 4.78%PRS 65.86
-
CSI 3.05rCSI 2.88%PRS 66.41
-
CSI 2.89rCSI 8.28%PRS 86.36
-
CSI 2.86rCSI 4.47%PRS 88.54
-
CSI 2.82rCSI 11.26%PRS 80.74
-
CSI 2.81rCSI 5.32%PRS 92.14
-
CSI 2.79rCSI 2.17%PRS 70.31
-
CSI 2.76rCSI 2.24%PRS 67.78
-
CSI 2.7rCSI 5.14%PRS 81.02
-
CSI 2.67rCSI 4.76%PRS 79.76
-
CSI 2.65rCSI 5.49%PRS 64.41
-
CSI 2.61rCSI 3.63%PRS 66.08
-
CSI 2.6rCSI 3.31%PRS 73.55
-
CSI 2.51rCSI 4.57%PRS 81.29
-
CSI 2.49rCSI 3.4%PRS 73.17
-
CSI 2.48rCSI 3.63%PRS 62.5
-
CSI 2.45rCSI 1.93%PRS 54.45
-
CSI 2.44rCSI 1.65%PRS 80.93
-
CSI 2.41rCSI 3.84%PRS 59.57
-
CSI 2.37rCSI 4.9%PRS 67.54
-
CSI 2.35rCSI 3.4%PRS 82.56
-
CSI 2.35rCSI 2.06%PRS 55.28
-
CSI 0.1rCSI 2.8%PRS 83.9%
-
CSI 0.3rCSI 6.2%PRS 82.5%
-
CSI 0.3rCSI 4.8%PRS 85.1%
-
CSI 0.5rCSI 2.7%PRS 75.0%
-
CSI 0.5rCSI 1.7%PRS 74.6%
-
CSI 0.5rCSI 3.4%PRS 78.9%
-
CSI 0.5rCSI 5.3%PRS 84.1%
-
CSI 0.5rCSI 2.2%PRS 67.5%
-
CSI 0.5rCSI 2.2%PRS 78.5%
-
CSI 0.6rCSI 4.1%PRS 90.7%
-
CSI 0.7rCSI 3.6%PRS 77.9%
-
CSI 0.8rCSI 3.5%PRS 90.5%
-
CSI 0.8rCSI 3.5%PRS 77.8%
-
CSI 0.9rCSI 2.2%PRS 88.0%
-
CSI 0.9rCSI 3.7%PRS 78.1%
-
CSI 0.9rCSI 2.5%PRS 77.3%
-
CSI 1.0rCSI 4.8%PRS 80.0%
-
CSI 1.0rCSI 0.9%PRS 64.6%
-
CSI 1.1rCSI 6.2%PRS 75.3%
-
CSI 1.2rCSI 0.9%PRS 69.2%
-
CSI 1.2rCSI 6.9%PRS 86.9%
-
CSI 1.2rCSI 2.7%PRS 53.2%
-
CSI 1.3rCSI 1.6%PRS 77.7%
-
CSI 1.3rCSI 7.9%PRS 90.4%
-
CSI 1.3rCSI 6.6%PRS 66.6%
-
CSI 1.4rCSI 3.9%PRS 68.3%
-
CSI 1.4rCSI 2.4%PRS 39.7%
-
CSI 1.4rCSI 2.4%PRS 72.7%
-
CSI 1.4rCSI 1.4%PRS 86.1%
-
CSI 1.5rCSI 8.1%PRS 77.9%
-
CSI 1.5rCSI 4.4%PRS 77.7%
-
CSI 1.6rCSI 1.9%PRS 83.7%
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CSI 1.7rCSI 2.0%PRS 58.1%
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CSI 1.8rCSI 1.6%PRS 72.2%
-
CSI 1.8rCSI 2.2%PRS 65.5%
-
CSI 1.8rCSI 2.8%PRS 72.3%
-
CSI 1.9rCSI 3.6%PRS 85.1%
-
CSI 1.9rCSI 2.7%PRS 76.9%
-
CSI 1.9rCSI 2.3%PRS 69.4%
-
CSI 1.9rCSI 2.8%PRS 69.3%
-
CSI 1.9rCSI 8.0%PRS 68.8%
-
CSI 1.9rCSI 7.8%PRS 70.8%
-
CSI 2.0rCSI 4.5%PRS 70.1%
-
CSI 2.0rCSI 1.3%PRS 70.3%
-
CSI 2.0rCSI 7.1%PRS 85.8%
-
CSI 2.0rCSI 1.7%PRS 67.0%
-
CSI 2.1rCSI 2.4%PRS 74.2%
-
CSI 2.1rCSI 11.4%PRS 91.1%
-
CSI 2.2rCSI 7.1%PRS 66.8%
-
CSI 2.2rCSI 5.3%PRS 60.4%
-
CSI 2.2rCSI 3.2%PRS 72.2%
-
CSI 2.2rCSI 3.5%PRS 77.8%
-
CSI 2.2rCSI 3.1%PRS 89.5%
-
CSI 2.3rCSI 2.3%PRS 60.8%
-
CSI 2.3rCSI 1.8%PRS 87.3%
-
CSI 2.3rCSI 3.9%PRS 87.7%
-
CSI 2.3rCSI 5.4%PRS 83.6%
-
CSI 2.4rCSI 2.1%PRS 55.3%
-
CSI 2.4rCSI 3.4%PRS 82.6%
-
CSI 2.4rCSI 4.9%PRS 67.5%
-
CSI 2.4rCSI 3.8%PRS 59.6%
-
CSI 2.4rCSI 1.7%PRS 80.9%
-
CSI 2.5rCSI 1.9%PRS 54.5%
-
CSI 2.5rCSI 3.6%PRS 62.5%
-
CSI 2.5rCSI 3.4%PRS 73.2%
-
CSI 2.5rCSI 4.6%PRS 81.3%
-
CSI 2.6rCSI 3.3%PRS 73.6%
-
CSI 2.6rCSI 3.6%PRS 66.1%
-
CSI 2.7rCSI 5.5%PRS 64.4%
-
CSI 2.7rCSI 4.8%PRS 79.8%
-
CSI 2.7rCSI 5.1%PRS 81.0%
-
CSI 2.8rCSI 2.2%PRS 67.8%
-
CSI 2.8rCSI 2.2%PRS 70.3%
-
CSI 2.8rCSI 5.3%PRS 92.1%
-
CSI 2.8rCSI 11.3%PRS 80.7%
-
CSI 2.9rCSI 4.5%PRS 88.5%
-
CSI 2.9rCSI 8.3%PRS 86.4%
-
CSI 3.1rCSI 2.9%PRS 66.4%
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CSI 3.1rCSI 4.8%PRS 65.9%
-
CSI 3.1rCSI 4.3%PRS 68.4%
-
CSI 3.2rCSI 4.5%PRS 70.1%
-
CSI 3.2rCSI 11.1%PRS 78.7%
-
CSI 3.2rCSI 2.6%PRS 69.8%
-
CSI 3.2rCSI 3.1%PRS 58.7%
-
CSI 3.3rCSI 2.5%PRS 80.5%
-
CSI 3.4rCSI 8.6%PRS 74.8%
-
CSI 3.6rCSI 3.8%PRS 75.9%
-
CSI 3.6rCSI 6.1%PRS 83.9%
-
CSI 3.7rCSI 3.6%PRS 67.1%
-
CSI 3.8rCSI 8.5%PRS 83.1%
-
CSI 3.8rCSI 4.9%PRS 64.1%
-
CSI 3.8rCSI 2.7%PRS 78.9%
-
CSI 3.9rCSI 3.4%PRS 76.2%
-
CSI 4.0rCSI 5.9%PRS 78.6%
-
CSI 4.0rCSI 5.0%PRS 78.0%
-
CSI 4.4rCSI 7.0%PRS 60.1%
-
CSI 4.4rCSI 7.6%PRS 75.5%
-
CSI 4.5rCSI 10.0%PRS 75.1%
-
CSI 4.5rCSI 3.6%PRS 85.8%
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CSI 4.6rCSI 6.1%PRS 73.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 4070870751
Symbol: NINJ1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8780658
Title: Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth.
PubMed ID: 8780658
PubMed ID: 9465296
Title: The human homologue of the ninjurin gene maps to the candidate region of hereditary sensory neuropathy type I (HSNI).
PubMed ID: 9465296
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9261151
Title: Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule.
PubMed ID: 9261151
PubMed ID: 22162058
Title: Role of Ninjurin-1 in the migration of myeloid cells to central nervous system inflammatory lesions.
PubMed ID: 22162058
DOI: 10.1002/ana.22519
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 26677008
Title: Ninjurin1 regulates lipopolysaccharide-induced inflammation through direct binding.
PubMed ID: 26677008
PubMed ID: 32883094
Title: Anti-inflammatory actions of soluble ninjurin-1 ameliorate atherosclerosis.
PubMed ID: 32883094
PubMed ID: 32147432
Title: Ninjurin-1 upregulated by TNFalpha receptor 1 stimulates monocyte adhesion to human TNFalpha-activated endothelial cells; benefic effects of amlodipine.
PubMed ID: 32147432
PubMed ID: 33028854
Title: Ninjurin 1 dodecamer peptide containing the N-terminal adhesion motif (N-NAM) exerts proangiogenic effects in HUVECs and in the postischemic brain.
PubMed ID: 33028854
PubMed ID: 33472215
Title: NINJ1 mediates plasma membrane rupture during lytic cell death.
PubMed ID: 33472215
PubMed ID: 36468682
Title: Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death.
PubMed ID: 36468682
DOI: 10.7554/elife.78609
PubMed ID: 37196676
Title: Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury.
PubMed ID: 37196676
PubMed ID: 38396301
Title: NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis.
PubMed ID: 38396301
PubMed ID: 37198476
Title: Structural basis of NINJ1-mediated plasma membrane rupture in cell death.
PubMed ID: 37198476
PubMed ID: 38614101
Title: NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks.
PubMed ID: 38614101
Sequence Information:
- Length: 152
- Mass: 16345
- Checksum: FEACA99450187855
- Sequence:
MDSGTEEYEL NGGLPPGTPG SPDASPARWG WRHGPINVNH YASKKSAAES MLDIALLMAN ASQLKAVVEQ GPSFAFYVPL VVLISISLVL QIGVGVLLIF LVKYDLNNPA KHAKLDFLNN LATGLVFIIV VVNIFITAFG VQKPLMDMAP QQ