Details for: NTHL1

Gene ID: 4913

Symbol: NTHL1

Ensembl ID: ENSG00000065057

Description: nth like DNA glycosylase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 117.5221
    Cell Significance Index: -18.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 54.9985
    Cell Significance Index: -13.9500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 46.2437
    Cell Significance Index: -19.0500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.4362
    Cell Significance Index: -17.2400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 40.4132
    Cell Significance Index: -19.0800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.2353
    Cell Significance Index: -17.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.3615
    Cell Significance Index: -18.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.9354
    Cell Significance Index: -15.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.9214
    Cell Significance Index: -19.4200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.7897
    Cell Significance Index: -11.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.1390
    Cell Significance Index: -6.8700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.6686
    Cell Significance Index: 18.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.6425
    Cell Significance Index: 191.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4960
    Cell Significance Index: 89.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4664
    Cell Significance Index: 159.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2542
    Cell Significance Index: 203.9800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.1286
    Cell Significance Index: 9.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9419
    Cell Significance Index: 60.7700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9082
    Cell Significance Index: 19.0100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8029
    Cell Significance Index: 18.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7581
    Cell Significance Index: 52.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6839
    Cell Significance Index: 31.0000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5824
    Cell Significance Index: 4.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4949
    Cell Significance Index: 48.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4929
    Cell Significance Index: 269.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4770
    Cell Significance Index: 65.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4725
    Cell Significance Index: 22.0300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4374
    Cell Significance Index: 15.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4218
    Cell Significance Index: 21.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4166
    Cell Significance Index: 53.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3986
    Cell Significance Index: 20.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3820
    Cell Significance Index: 11.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3452
    Cell Significance Index: 311.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3433
    Cell Significance Index: 68.1400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.3315
    Cell Significance Index: 3.4200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2667
    Cell Significance Index: 3.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1865
    Cell Significance Index: 35.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1798
    Cell Significance Index: 79.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1696
    Cell Significance Index: 30.5700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1484
    Cell Significance Index: 1.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1481
    Cell Significance Index: 18.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1463
    Cell Significance Index: 10.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1389
    Cell Significance Index: 17.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1316
    Cell Significance Index: 6.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1269
    Cell Significance Index: 25.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1244
    Cell Significance Index: 14.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1108
    Cell Significance Index: 3.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0955
    Cell Significance Index: 2.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0916
    Cell Significance Index: 1.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0732
    Cell Significance Index: 1.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0631
    Cell Significance Index: 3.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0563
    Cell Significance Index: 20.2000
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.0484
    Cell Significance Index: 0.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0335
    Cell Significance Index: 0.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0120
    Cell Significance Index: 9.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0091
    Cell Significance Index: 0.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0048
    Cell Significance Index: -0.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0060
    Cell Significance Index: -0.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0077
    Cell Significance Index: -5.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0089
    Cell Significance Index: -16.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0114
    Cell Significance Index: -21.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0116
    Cell Significance Index: -17.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0160
    Cell Significance Index: -11.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0171
    Cell Significance Index: -23.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0266
    Cell Significance Index: -19.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0271
    Cell Significance Index: -17.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0278
    Cell Significance Index: -0.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0325
    Cell Significance Index: -18.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0350
    Cell Significance Index: -15.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0400
    Cell Significance Index: -4.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0414
    Cell Significance Index: -4.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0415
    Cell Significance Index: -25.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0539
    Cell Significance Index: -15.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0599
    Cell Significance Index: -10.2300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0814
    Cell Significance Index: -1.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0827
    Cell Significance Index: -6.1600
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: -0.0986
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1100
    Cell Significance Index: -23.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1166
    Cell Significance Index: -16.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1192
    Cell Significance Index: -3.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1514
    Cell Significance Index: -4.2300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1532
    Cell Significance Index: -3.3200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1655
    Cell Significance Index: -2.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1742
    Cell Significance Index: -10.7100
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1789
    Cell Significance Index: -1.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1869
    Cell Significance Index: -2.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1872
    Cell Significance Index: -11.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1887
    Cell Significance Index: -19.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1973
    Cell Significance Index: -15.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2056
    Cell Significance Index: -5.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2138
    Cell Significance Index: -16.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2521
    Cell Significance Index: -16.9500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2827
    Cell Significance Index: -4.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2850
    Cell Significance Index: -15.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3176
    Cell Significance Index: -14.0500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3179
    Cell Significance Index: -2.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3210
    Cell Significance Index: -8.5700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3286
    Cell Significance Index: -9.6800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3587
    Cell Significance Index: -5.6900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3618
    Cell Significance Index: -6.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NTHL1 is a member of the DNA glycosylase family, which consists of enzymes that recognize and remove damaged or modified bases from DNA. The gene encodes a protein that recognizes and processes oxidized pyrimidine nucleobase lesions, specifically 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 2,6-diamino-4-hydroxy-6-hydroxymethyl-5-oxopurine (2,6-DHP). NTHL1 is a 4 iron, 4 sulfur cluster binding protein, which is essential for its enzymatic activity. The protein is also involved in the recognition and association of DNA glycosylase with sites containing affected pyrimidines, resolving abasic sites (ap sites) and facilitating the repair of damaged DNA. **Pathways and Functions** NTHL1 plays a critical role in the base excision repair (BER) pathway, which is a multi-step process that involves the recognition, removal, and repair of damaged bases from DNA. The gene's product is involved in the following pathways: 1. **Base Excision Repair (BER)**: NTHL1 recognizes and processes oxidized pyrimidine nucleobase lesions, leading to the excision of damaged bases from DNA. 2. **Ap Site Formation**: NTHL1 helps to resolve abasic sites (ap sites) by recognizing and processing damaged pyrimidines. 3. **DNA Repair**: NTHL1 is involved in the repair of damaged DNA by removing oxidized pyrimidine nucleobase lesions and restoring the integrity of the genome. **Clinical Significance** Dysregulation or mutations in the NTHL1 gene have been implicated in various diseases, including: 1. **Genetic disorders**: Mutations in NTHL1 have been associated with genetic disorders such as Fanconi anemia, a rare genetic disorder characterized by congenital abnormalities and a high risk of cancer. 2. **Cancer**: Overexpression of NTHL1 has been linked to cancer development, as the enzyme's ability to repair damaged DNA can lead to the accumulation of mutations that drive tumorigenesis. 3. **Neurodegenerative diseases**: NTHL1 has been implicated in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, where oxidative stress and DNA damage contribute to disease progression. In conclusion, NTHL1 is a critical component of the base excision repair pathway, playing a vital role in maintaining genome stability and preventing DNA damage. Dysregulation or mutations in the gene can lead to various diseases, highlighting the importance of NTHL1 in maintaining genome integrity and preventing disease.

Genular Protein ID: 2186798097

Symbol: NTH_HUMAN

Name: N/A

UniProtKB Accession Codes:

P78549 Q1MVR1 Q99566 Q99794 Q9BPX2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 9 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 Rhea 4 SABIO-RK 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9045706

Title: Cloning and expression of the cDNA encoding the human homologue of the DNA repair enzyme, Escherichia coli endonuclease III.

PubMed ID: 9045706

DOI: 10.1074/jbc.272.10.6733

PubMed ID: 8990169

Title: Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III.

PubMed ID: 8990169

DOI: 10.1073/pnas.94.1.109

PubMed ID: 9831664

Title: Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease III with those of the adjacent parts of TSC2 and SLC9A3R2 genes.

PubMed ID: 9831664

DOI: 10.1016/s0378-1119(98)00485-5

PubMed ID: 9705289

Title: Purification and characterization of human NTH1, a homolog of Escherichia coli endonuclease III. Direct identification of Lys-212 as the active nucleophilic residue.

PubMed ID: 9705289

DOI: 10.1074/jbc.273.34.21585

PubMed ID: 10882850

Title: Cell-cycle regulation, intracellular sorting and induced overexpression of the human NTH1 DNA glycosylase involved in removal of formamidopyrimidine residues from DNA.

PubMed ID: 10882850

DOI: 10.1016/s0921-8777(00)00015-x

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12144783

Title: Truncation of amino-terminal tail stimulates activity of human endonuclease III (hNTH1).

PubMed ID: 12144783

DOI: 10.1016/s0022-2836(02)00623-x

PubMed ID: 9611236

Title: Mitochondrial targeting of human DNA glycosylases for repair of oxidative DNA damage.

PubMed ID: 9611236

DOI: 10.1093/nar/26.12.2917

PubMed ID: 9890904

Title: Excision of products of oxidative DNA base damage by human NTH1 protein.

PubMed ID: 9890904

DOI: 10.1021/bi9819071

PubMed ID: 9927729

Title: Nucleotide excision repair 3' endonuclease XPG stimulates the activity of base excision repair enzyme thymine glycol DNA glycosylase.

PubMed ID: 9927729

DOI: 10.1093/nar/27.4.979

PubMed ID: 11380260

Title: Human endonuclease III acts preferentially on DNA damage opposite guanine residues in DNA.

PubMed ID: 11380260

DOI: 10.1021/bi0028901

PubMed ID: 11695910

Title: Mutation at active site lysine 212 to arginine uncouples the glycosylase activity from the lyase activity of human endonuclease III.

PubMed ID: 11695910

DOI: 10.1021/bi011053b

PubMed ID: 11287425

Title: Stimulation of human endonuclease III by Y box-binding protein 1 (DNA-binding protein B). Interaction between a base excision repair enzyme and a transcription factor.

PubMed ID: 11287425

DOI: 10.1074/jbc.m101594200

PubMed ID: 11328882

Title: Escherichia coli Nth and human hNTH1 DNA glycosylases are involved in removal of 8-oxoguanine from 8-oxoguanine/guanine mispairs in DNA.

PubMed ID: 11328882

DOI: 10.1093/nar/29.9.1975

PubMed ID: 12531031

Title: Differential intracellular localization of the human and mouse endonuclease III homologs and analysis of the sorting signals.

PubMed ID: 12531031

DOI: 10.1016/s1568-7864(02)00145-3

PubMed ID: 12140329

Title: Identification of 5-formyluracil DNA glycosylase activity of human hNTH1 protein.

PubMed ID: 12140329

DOI: 10.1093/nar/gkf460

PubMed ID: 12519758

Title: Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activity.

PubMed ID: 12519758

DOI: 10.1074/jbc.m212168200

PubMed ID: 14734554

Title: Differential specificity of human and Escherichia coli endonuclease III and VIII homologues for oxidative base lesions.

PubMed ID: 14734554

DOI: 10.1074/jbc.m400393200

PubMed ID: 15533839

Title: DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells.

PubMed ID: 15533839

DOI: 10.1016/j.dnarep.2004.08.002

PubMed ID: 17923696

Title: Initiation of base excision repair of oxidative lesions in nucleosomes by the human, bifunctional DNA glycosylase NTH1.

PubMed ID: 17923696

DOI: 10.1128/mcb.00791-07

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20005182

Title: Non-specific DNA binding interferes with the efficient excision of oxidative lesions from chromatin by the human DNA glycosylase, NEIL1.

PubMed ID: 20005182

DOI: 10.1016/j.dnarep.2009.11.005

PubMed ID: 20110254

Title: Fluorescent probes for the analysis of DNA strand scission in base excision repair.

PubMed ID: 20110254

DOI: 10.1093/nar/gkq022

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21930793

Title: Nucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repair.

PubMed ID: 21930793

DOI: 10.1128/mcb.05715-11

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25938944

Title: A germline homozygous mutation in the base-excision repair gene NTHL1 causes adenomatous polyposis and colorectal cancer.

PubMed ID: 25938944

DOI: 10.1038/ng.3287

PubMed ID: 29610152

Title: NTH1 Is a New Target for Ubiquitylation-Dependent Regulation by TRIM26 Required for the Cellular Response to Oxidative Stress.

PubMed ID: 29610152

DOI: 10.1128/mcb.00616-17

Sequence Information:

  • Length: 304
  • Mass: 33570
  • Checksum: DA97D508BE3D83F0
  • Sequence:
    • MTALSARMLT RSRSLGPGAG PRGCREEPGP LRRREAAAEA RKSHSPVKRP RKAQRLRVAY 
EGSDSEKGEG AEPLKVPVWE PQDWQQQLVN IRAMRNKKDA PVDHLGTEHC YDSSAPPKVR 
RYQVLLSLML SSQTKDQVTA GAMQRLRARG LTVDSILQTD DATLGKLIYP VGFWRSKVKY 
IKQTSAILQQ HYGGDIPASV AELVALPGVG PKMAHLAMAV AWGTVSGIAV DTHVHRIANR 
LRWTKKATKS PEETRAALEE WLPRELWHEI NGLLVGFGQQ TCLPVHPRCH ACLNQALCPA 
AQGL

Genular Protein ID: 1177656687

Symbol: E5KTI5_HUMAN

Name: N/A

UniProtKB Accession Codes:

E5KTI5

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 9 DNASU 1 DisGeNET 1 EC 1 EMBL 43 ExpressionAtlas 1 GO 9 Gene3D 1 HAMAP 1 HAMAP-Rule 1 HOGENOM 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 Pfam 2 RefSeq 1 Rhea 4 SAM 1 SMART 3 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 20843780

Title: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing.

PubMed ID: 20843780

DOI: 10.1093/nar/gkq750

Sequence Information:

  • Length: 312
  • Mass: 34390
  • Checksum: 379816A1E0B45050
  • Sequence:
    • MCSPQESGMT ALSARMLTRS RSLGPGAGPR GCREEPGPLR RREAAAEARK SHSPVKRPRK 
AQRLRVAYEG SDSEKGEGAE PLKVPVWEPQ DWQQQLVNIR AMRNKKDAPV DHLGTEHCYD 
SSAPPKVRRY QVLLSLMLSS QTKDQVTAGA MQRLRARGLT VDSILQTDDA TLGKLIYPVG 
FWRSKVKYIK QTSAILQQHY GGDIPASVAE LVALPGVGPK MAHLAMAVAW GTVSGIAVDT 
HVHRIANRLR WTKKATKSPE ETRAALEEWL PRELWHEING LLVGFGQQTC LPVHPRCHAC 
LNQALCPAAQ GL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.