NTRK1 | ENSG00000198400 | NCBI 4914

Details for: NTRK1

Gene ID: 4914

Symbol: NTRK1

Ensembl ID: ENSG00000198400

Description: neurotrophic receptor tyrosine kinase 1

Associated with

Activation of trka receptors
(R-HSA-187015)
Arms-mediated activation
(R-HSA-170984)
Frs2-mediated activation
(R-HSA-170968)
Ngf-independant trka activation
(R-HSA-187024)
Pi3k/akt activation
(R-HSA-198203)
Plc-gamma1 signalling
(R-HSA-167021)
Prolonged erk activation events
(R-HSA-169893)
Retrograde neurotrophin signalling
(R-HSA-177504)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signalling to erks
(R-HSA-187687)
Signalling to p38 via rit and rin
(R-HSA-187706)
Signalling to ras
(R-HSA-167044)
Signalling to stat3
(R-HSA-198745)
Signal transduction
(R-HSA-162582)
Trka activation by ngf
(R-HSA-187042)
Atp binding
(GO:0005524)
Axon
(GO:0030424)
Axon guidance
(GO:0007411)
Axonogenesis involved in innervation
(GO:0060385)
B cell differentiation
(GO:0030183)
Behavioral response to formalin induced pain
(GO:0061368)
Cell surface
(GO:0009986)
Cell surface receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Cellular response to amyloid-beta
(GO:1904646)
Cellular response to nerve growth factor stimulus
(GO:1990090)
Cellular response to nicotine
(GO:0071316)
Circadian rhythm
(GO:0007623)
Dendrite
(GO:0030425)
Detection of mechanical stimulus involved in sensory perception of pain
(GO:0050966)
Detection of temperature stimulus involved in sensory perception of pain
(GO:0050965)
Early endosome
(GO:0005769)
Early endosome membrane
(GO:0031901)
Endosome membrane
(GO:0010008)
Ephrin receptor signaling pathway
(GO:0048013)
Gpi-linked ephrin receptor activity
(GO:0005004)
Identical protein binding
(GO:0042802)
Kinase binding
(GO:0019900)
Late endosome
(GO:0005770)
Late endosome membrane
(GO:0031902)
Learning or memory
(GO:0007611)
Mechanoreceptor differentiation
(GO:0042490)
Mitochondrion
(GO:0005739)
Multicellular organism development
(GO:0007275)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of neuron apoptotic process
(GO:0043524)
Nerve growth factor binding
(GO:0048406)
Nerve growth factor receptor activity
(GO:0010465)
Nerve growth factor signaling pathway
(GO:0038180)
Neuronal cell body
(GO:0043025)
Neuron apoptotic process
(GO:0051402)
Neuron development
(GO:0048666)
Neuron projection development
(GO:0031175)
Neurotrophin binding
(GO:0043121)
Neurotrophin p75 receptor binding
(GO:0005166)
Neurotrophin receptor activity
(GO:0005030)
Neurotrophin trk receptor signaling pathway
(GO:0048011)
Olfactory nerve development
(GO:0021553)
Peptidyl-tyrosine autophosphorylation
(GO:0038083)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of programmed cell death
(GO:0043068)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of ras protein signal transduction
(GO:0046579)
Positive regulation of synapse assembly
(GO:0051965)
Positive regulation of synaptic transmission, glutamatergic
(GO:0051968)
Programmed cell death involved in cell development
(GO:0010623)
Protein-containing complex
(GO:0032991)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Receptor complex
(GO:0043235)
Response to axon injury
(GO:0048678)
Response to electrical stimulus
(GO:0051602)
Response to hydrostatic pressure
(GO:0051599)
Response to nutrient levels
(GO:0031667)
Response to xenobiotic stimulus
(GO:0009410)
Sertoli cell development
(GO:0060009)
Spermatogenesis
(GO:0007283)
Sympathetic nervous system development
(GO:0048485)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 35.8095
Cell Significance Index: -5.5700
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 23.4581
Cell Significance Index: -5.9500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 8.7383
Cell Significance Index: -3.5500
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 4.8177
Cell Significance Index: -5.9400
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 3.6478
Cell Significance Index: 88.3600
Cell Name: chromaffin cell (CL0000166)
Fold Change: 2.2510
Cell Significance Index: 24.8000
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.5317
Cell Significance Index: 6.4500
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.4280
Cell Significance Index: 3.7700
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.2789
Cell Significance Index: 2.1500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.1866
Cell Significance Index: 27.1200
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.1723
Cell Significance Index: 1.4900
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 0.1612
Cell Significance Index: 1.7900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1379
Cell Significance Index: 7.2400
Cell Name: helper T cell (CL0000912)
Fold Change: 0.0493
Cell Significance Index: 0.7000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0458
Cell Significance Index: 2.9600
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0440
Cell Significance Index: 30.4200
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.0379
Cell Significance Index: 0.3100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0333
Cell Significance Index: 1.8700
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.0292
Cell Significance Index: 0.4200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0259
Cell Significance Index: 5.1900
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0045
Cell Significance Index: 2.8600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0033
Cell Significance Index: 6.2900
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.0005
Cell Significance Index: 0.0100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0004
Cell Significance Index: -0.0600
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0037
Cell Significance Index: -6.8800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0042
Cell Significance Index: -6.5200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0055
Cell Significance Index: -7.5200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0076
Cell Significance Index: -5.7800
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0085
Cell Significance Index: -3.0400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0090
Cell Significance Index: -6.6900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0092
Cell Significance Index: -2.6400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0094
Cell Significance Index: -4.2500
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0095
Cell Significance Index: -5.1800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0115
Cell Significance Index: -6.4900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0118
Cell Significance Index: -2.1200
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0119
Cell Significance Index: -0.1700
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0145
Cell Significance Index: -0.7300
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0219
Cell Significance Index: -4.3400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0249
Cell Significance Index: -3.0600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0249
Cell Significance Index: -1.1000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0251
Cell Significance Index: -4.2800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0279
Cell Significance Index: -1.4500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0312
Cell Significance Index: -6.5700
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0375
Cell Significance Index: -4.8500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0416
Cell Significance Index: -1.9400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0432
Cell Significance Index: -5.1000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0434
Cell Significance Index: -4.4300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0436
Cell Significance Index: -1.6500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0447
Cell Significance Index: -5.1200
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0467
Cell Significance Index: -2.0300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0487
Cell Significance Index: -5.6700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0530
Cell Significance Index: -5.5200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0655
Cell Significance Index: -4.8800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0659
Cell Significance Index: -4.4300
Cell Name: diffuse bipolar 4 cell (CL4033031)
Fold Change: -0.0674
Cell Significance Index: -0.8200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0690
Cell Significance Index: -5.3000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0692
Cell Significance Index: -1.7800
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0722
Cell Significance Index: -1.5800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0732
Cell Significance Index: -3.4400
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0752
Cell Significance Index: -3.9200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0760
Cell Significance Index: -1.5900
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0780
Cell Significance Index: -2.7100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0815
Cell Significance Index: -5.0100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0849
Cell Significance Index: -2.3100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0864
Cell Significance Index: -5.3000
Cell Name: flat midget bipolar cell (CL4033033)
Fold Change: -0.0869
Cell Significance Index: -1.0800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0964
Cell Significance Index: -4.3700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0984
Cell Significance Index: -2.7500
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.1026
Cell Significance Index: -1.2800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1099
Cell Significance Index: -3.1500
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.1136
Cell Significance Index: -1.2400
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1148
Cell Significance Index: -4.0200
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.1187
Cell Significance Index: -1.7300
Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: -0.1190
Cell Significance Index: -1.6300
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1192
Cell Significance Index: -4.8900
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.1212
Cell Significance Index: -1.5300
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.1223
Cell Significance Index: -2.0600
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1231
Cell Significance Index: -3.9200
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: -0.1244
Cell Significance Index: -1.5800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1245
Cell Significance Index: -3.3300
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.1291
Cell Significance Index: -1.9100
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1307
Cell Significance Index: -4.2800
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.1315
Cell Significance Index: -1.4300
Cell Name: stromal cell of endometrium (CL0002255)
Fold Change: -0.1371
Cell Significance Index: -1.9500
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.1382
Cell Significance Index: -1.9800
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1403
Cell Significance Index: -4.1200
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.1496
Cell Significance Index: -3.7300
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: -0.1503
Cell Significance Index: -1.6600
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: -0.1511
Cell Significance Index: -1.2500
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1529
Cell Significance Index: -4.5100
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1560
Cell Significance Index: -4.1800
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: -0.1592
Cell Significance Index: -1.5400
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1605
Cell Significance Index: -4.0900
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1605
Cell Significance Index: -2.7500
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.1648
Cell Significance Index: -4.1100
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.1661
Cell Significance Index: -2.3300
Cell Name: osteoblast (CL0000062)
Fold Change: -0.1670
Cell Significance Index: -1.6200
Cell Name: sensory neuron (CL0000101)
Fold Change: -0.1671
Cell Significance Index: -0.9500
Cell Name: retinal astrocyte (CL4033015)
Fold Change: -0.1716
Cell Significance Index: -1.6800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1721
Cell Significance Index: -2.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** NTRK1 is a transmembrane receptor tyrosine kinase that contains an extracellular domain with a characteristic ligand-binding site for NGF and other neurotrophins. The receptor has two tyrosine kinase domains, which are responsible for autophosphorylation and the activation of downstream signaling pathways. NTRK1 is highly expressed in the nervous system, particularly in neurons, glial cells, and other cells involved in neural development and function. The gene is also expressed in other tissues, including the kidney, intestine, and heart. **Pathways and Functions** NTRK1 is involved in a wide range of cellular processes, including: 1. **Neurotrophin signaling**: NTRK1 binds to NGF and other neurotrophins, leading to the activation of downstream signaling pathways that regulate cell survival, differentiation, and migration. 2. **Axon guidance**: NTRK1 plays a crucial role in the formation of axons and the guidance of axonal growth. 3. **Neuronal cell body**: NTRK1 regulates the development and maintenance of the neuronal cell body, including the formation of dendrites and synapses. 4. **Cell proliferation and differentiation**: NTRK1 regulates cell proliferation and differentiation in the nervous system, particularly during development. 5. **Survival and death**: NTRK1 regulates cell survival and death in the nervous system, particularly in response to axonal injury or other forms of cellular stress. **Clinical Significance** Dysregulation of NTRK1 has been implicated in various neurological disorders, including: 1. **Neurodegenerative diseases**: NTRK1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer**: NTRK1 is overexpressed in certain types of cancer, including breast cancer, lung cancer, and melanoma. 3. **Neuropathic pain**: NTRK1 has been implicated in the development of neuropathic pain, particularly in response to axonal injury or other forms of cellular stress. 4. **Developmental disorders**: NTRK1 has been implicated in the development of developmental disorders, such as autism spectrum disorder and intellectual disability. In conclusion, NTRK1 is a critical gene that plays a central role in the development, growth, and maintenance of the nervous system. Its dysregulation has been implicated in various neurological disorders, including neurodegenerative diseases, cancer, neuropathic pain, and developmental disorders. Further research is needed to fully understand the mechanisms by which NTRK1 regulates cellular processes and to develop effective therapeutic strategies for the treatment of these disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

High affinity nerve growth factor receptor
X5DR71_HUMAN

Genular Protein ID: 1869237471

Symbol: NTRK1_HUMAN

Name: High affinity nerve growth factor receptor

UniProtKB Accession Codes:

P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7

Database IDs:

Citations:

PubMed ID: 2927393

Title: Molecular and biochemical characterization of the human trk proto-oncogene.

PubMed ID: 2927393

DOI: 10.1128/mcb.9.1.24-33.1989

PubMed ID: 7823156

Title: Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins.

PubMed ID: 7823156

DOI: 10.1523/jneurosci.15-01-00477.1995

PubMed ID: 9290260

Title: Structure and organization of the human TRKA gene encoding a high affinity receptor for nerve growth factor.

PubMed ID: 9290260

DOI: 10.1007/bf02766957

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15870692

Title: Methylation adjacent to negatively regulating AP-1 site reactivates TrkA gene expression during cancer progression.

PubMed ID: 15870692

DOI: 10.1038/sj.onc.1208697

PubMed ID: 2869410

Title: A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences.

PubMed ID: 2869410

DOI: 10.1038/319743a0

PubMed ID: 2966065

Title: Activation of the receptor kinase domain of the trk oncogene by recombination with two different cellular sequences.

PubMed ID: 2966065

DOI: 10.1002/j.1460-2075.1988.tb02794.x

PubMed ID: 7565764

Title: The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain.

PubMed ID: 7565764

DOI: 10.1128/mcb.15.11.6118

PubMed ID: 1532241

Title: TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas.

PubMed ID: 1532241

PubMed ID: 1850821

Title: High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor.

PubMed ID: 1850821

DOI: 10.1038/350678a0

PubMed ID: 1849459

Title: The trk proto-oncogene encodes a receptor for nerve growth factor.

PubMed ID: 1849459

DOI: 10.1016/0092-8674(91)90419-y

PubMed ID: 1281417

Title: Nerve growth factor mediates signal transduction through trk homodimer receptors.

PubMed ID: 1281417

DOI: 10.1016/0896-6273(92)90066-m

PubMed ID: 8325889

Title: Tissue-specific alternative splicing generates two isoforms of the trkA receptor.

PubMed ID: 8325889

DOI: 10.1016/s0021-9258(18)82449-8

PubMed ID: 7510697

Title: A Trk nerve growth factor (NGF) receptor point mutation affecting interaction with phospholipase C-gamma 1 abolishes NGF-promoted peripherin induction but not neurite outgrowth.

PubMed ID: 7510697

DOI: 10.1016/s0021-9258(17)37053-9

PubMed ID: 8155326

Title: Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses.

PubMed ID: 8155326

DOI: 10.1016/0896-6273(94)90223-2

PubMed ID: 11244088

Title: The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor.

PubMed ID: 11244088

DOI: 10.1074/jbc.c000869200

PubMed ID: 15488758

Title: TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.

PubMed ID: 15488758

DOI: 10.1016/j.ccr.2004.09.011

PubMed ID: 21102451

Title: Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.

PubMed ID: 21102451

DOI: 10.1038/nn.2689

PubMed ID: 22649032

Title: Structural and functional insights into lipid-bound nerve growth factors.

PubMed ID: 22649032

DOI: 10.1096/fj.12-207316

PubMed ID: 26446845

Title: GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival.

PubMed ID: 26446845

DOI: 10.1091/mbc.e15-02-0087

PubMed ID: 27445338

Title: Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).

PubMed ID: 27445338

DOI: 10.1074/jbc.m116.722637

PubMed ID: 28177573

Title: Novel NTRK1 mutations associated with congenital insensitivity to pain with anhidrosis verified by functional studies.

PubMed ID: 28177573

DOI: 10.1111/jns.12205

PubMed ID: 8524391

Title: Structure and ligand recognition of the phosphotyrosine binding domain of Shc.

PubMed ID: 8524391

DOI: 10.1038/378584a0

PubMed ID: 10388563

Title: Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.

PubMed ID: 10388563

DOI: 10.1006/jmbi.1999.2816

PubMed ID: 10490030

Title: Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor.

PubMed ID: 10490030

DOI: 10.1038/43705

PubMed ID: 17196528

Title: Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors.

PubMed ID: 17196528

DOI: 10.1016/j.neuron.2006.09.034

PubMed ID: 8696348

Title: Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis.

PubMed ID: 8696348

DOI: 10.1038/ng0896-485

PubMed ID: 10090906

Title: A novel NTRK1 mutation associated with congenital insensitivity to pain with anhidrosis.

PubMed ID: 10090906

DOI: 10.1086/302319

PubMed ID: 10330344

Title: Congenital insensitivity to pain with anhidrosis: novel mutations in the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor.

PubMed ID: 10330344

DOI: 10.1086/302422

PubMed ID: 10443680

Title: Mutation analysis reveals novel sequence variants in NTRK1 in sporadic human medullary thyroid carcinoma.

PubMed ID: 10443680

DOI: 10.1210/jcem.84.8.5901

PubMed ID: 10233776

Title: A novel point mutation affecting the tyrosine kinase domain of the TRKA gene in a family with congenital insensitivity to pain with anhidrosis.

PubMed ID: 10233776

DOI: 10.1046/j.1523-1747.1999.00569.x

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 10861667

Title: Congenital insensitivity to pain with anhidrosis (CIPA) in Israeli-Bedouins: genetic heterogeneity, novel mutations in the TRKA/NGF receptor gene, clinical findings, and results of nerve conduction studies.

PubMed ID: 10861667

DOI: 10.1002/1096-8628(20000619)92:5<353::aid-ajmg12>3.0.co;2-c

PubMed ID: 10982191

Title: Mutation and polymorphism analysis of the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor in congenital insensitivity to pain with anhidrosis (CIPA) families.

PubMed ID: 10982191

DOI: 10.1007/s004390051018

PubMed ID: 10567924

Title: The Gly571Arg mutation, associated with the autonomic and sensory disorder congenital insensitivity to pain with anhidrosis, causes the inactivation of the NTRK1/nerve growth factor receptor.

PubMed ID: 10567924

DOI: 10.1002/(sici)1097-4652(200001)182:1<127::aid-jcp14>3.0.co;2-0

PubMed ID: 11310631

Title: A novel TRK A (NTRK1) mutation associated with hereditary sensory and autonomic neuropathy type V.

PubMed ID: 11310631

DOI: 10.1002/ana.103

PubMed ID: 11159935

Title: Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor.

PubMed ID: 11159935

DOI: 10.1093/hmg/10.3.179

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 18077166

Title: Novel missense, insertion and deletion mutations in the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1) associated with congenital insensitivity to pain with anhidrosis.

PubMed ID: 18077166

DOI: 10.1016/j.nmd.2007.10.005

PubMed ID: 22302274

Title: Frequency of mutations in the genes associated with hereditary sensory and autonomic neuropathy in a UK cohort.

PubMed ID: 22302274

DOI: 10.1007/s00415-011-6397-y

PubMed ID: 28328124

Title: Exome sequencing identifies novel NTRK1 mutations in patients with HSAN-IV phenotype.

PubMed ID: 28328124

DOI: 10.1002/ajmg.a.38120

PubMed ID: 27676246

Title: A comprehensive functional analysis of NTRK1 missense mutations causing hereditary sensory and autonomic neuropathy type IV (HSAN IV).

PubMed ID: 27676246

DOI: 10.1002/humu.23123

Sequence Information:

Length: 796
Mass: 87497
Checksum: 6C15C721E336B601
Sequence:

MLRGGRRGQL GWHSWAAGPG SLLAWLILAS AGAAPCPDAC CPHGSSGLRC TRDGALDSLH 
HLPGAENLTE LYIENQQHLQ HLELRDLRGL GELRNLTIVK SGLRFVAPDA FHFTPRLSRL 
NLSFNALESL SWKTVQGLSL QELVLSGNPL HCSCALRWLQ RWEEEGLGGV PEQKLQCHGQ 
GPLAHMPNAS CGVPTLKVQV PNASVDVGDD VLLRCQVEGR GLEQAGWILT ELEQSATVMK 
SGGLPSLGLT LANVTSDLNR KNVTCWAEND VGRAEVSVQV NVSFPASVQL HTAVEMHHWC 
IPFSVDGQPA PSLRWLFNGS VLNETSFIFT EFLEPAANET VRHGCLRLNQ PTHVNNGNYT 
LLAANPFGQA SASIMAAFMD NPFEFNPEDP IPVSFSPVDT NSTSGDPVEK KDETPFGVSV 
AVGLAVFACL FLSTLLLVLN KCGRRNKFGI NRPAVLAPED GLAMSLHFMT LGGSSLSPTE 
GKGSGLQGHI IENPQYFSDA CVHHIKRRDI VLKWELGEGA FGKVFLAECH NLLPEQDKML 
VAVKALKEAS ESARQDFQRE AELLTMLQHQ HIVRFFGVCT EGRPLLMVFE YMRHGDLNRF 
LRSHGPDAKL LAGGEDVAPG PLGLGQLLAV ASQVAAGMVY LAGLHFVHRD LATRNCLVGQ 
GLVVKIGDFG MSRDIYSTDY YRVGGRTMLP IRWMPPESIL YRKFTTESDV WSFGVVLWEI 
FTYGKQPWYQ LSNTEAIDCI TQGRELERPR ACPPEVYAIM RGCWQREPQQ RHSIKDVHAR 
LQALAQAPPV YLDVLG

Genular Protein ID: 302292927

Symbol: X5DR71_HUMAN

Name: N/A

UniProtKB Accession Codes:

X5DR71

Database IDs:

Citations:

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

Sequence Information:

Length: 790
Mass: 86880
Checksum: 25F05BADA8A2A50C
Sequence:

MLRGGRRGQL GWHSWAAGPG SLLAWLILAS AGAAPCPDAC CPHGSSGLRC TRDGALDSLH 
HLPGAENLTE LYIENQQHLQ HLELRDLRGL GELRNLTIVK SGLRFVAPDA FHFTPRLSRL 
NLSFNALESL SWKTVQGLSL QELVLSGNPL HCSCALRWLQ RWEEEGLGGV PEQKLQCHGQ 
GPLAHMPNAS CGVPTLKVQV PNASVDVGDD VLLRCQVEGR GLEQAGWILT ELEQSATVMK 
SGGLPSLGLT LANVTSDLNR KNVTCWAEND VGRAEVSVQV NVSFPASVQL HTAVEMHHWC 
IPFSVDGQPA PSLRWLFNGS VLNETSFIFT EFLEPAANET VRHGCLRLNQ PTHVNNGNYT 
LLAANPFGQA SASIMAAFMD NPFEFNPEDP IPDTNSTSGD PVEKKDETPF GVSVAVGLAV 
FACLFLSTLL LVLNKCGRRN KFGINRPAVL APEDGLAMSL HFMTLGGSSL SPTEGKGSGL 
QGHIIENPQY FSDACVHHIK RRDIVLKWEL GEGAFGKVFL AECHNLLPEQ DKMLVAVKAL 
KEASESARQD FQREAELLTM LQHQHIVRFF GVCTEGRPLL MVFEYMRHGD LNRFLRSHGP 
DAKLLAGGED VAPGPLGLGQ LLAVASQVAA GMVYLAGLHF VHRDLATRNC LVGQGLVVKI 
GDFGMSRDIY STDYYRVGGR TMLPIRWMPP ESILYRKFTT ESDVWSFGVV LWEIFTYGKQ 
PWYQLSNTEA IDCITQGREL ERPRACPPEV YAIMRGCWQR EPQQRHSIKD VHARLQALAQ 
APPVYLDVLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: NTRK1

Associated with

Cells (max top 100)

Other Information

Molecular and biochemical characterization of the human trk proto-oncogene. PubMed ID: 2927393

Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins. PubMed ID: 7823156

Structure and organization of the human TRKA gene encoding a high affinity receptor for nerve growth factor. PubMed ID: 9290260

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Methylation adjacent to negatively regulating AP-1 site reactivates TrkA gene expression during cancer progression. PubMed ID: 15870692

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. PubMed ID: 2869410

Activation of the receptor kinase domain of the trk oncogene by recombination with two different cellular sequences. PubMed ID: 2966065

The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain. PubMed ID: 7565764

TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas. PubMed ID: 1532241

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor. PubMed ID: 1850821

The trk proto-oncogene encodes a receptor for nerve growth factor. PubMed ID: 1849459

Nerve growth factor mediates signal transduction through trk homodimer receptors. PubMed ID: 1281417

Tissue-specific alternative splicing generates two isoforms of the trkA receptor. PubMed ID: 8325889

A Trk nerve growth factor (NGF) receptor point mutation affecting interaction with phospholipase C-gamma 1 abolishes NGF-promoted peripherin induction but not neurite outgrowth. PubMed ID: 7510697

Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses. PubMed ID: 8155326

The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor. PubMed ID: 11244088

TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma. PubMed ID: 15488758

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. PubMed ID: 21102451

Structural and functional insights into lipid-bound nerve growth factors. PubMed ID: 22649032

GGA3 mediates TrkA endocytic recycling to promote sustained Akt phosphorylation and cell survival. PubMed ID: 26446845

Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3). PubMed ID: 27445338

Novel NTRK1 mutations associated with congenital insensitivity to pain with anhidrosis verified by functional studies. PubMed ID: 28177573

Structure and ligand recognition of the phosphotyrosine binding domain of Shc. PubMed ID: 8524391

Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC. PubMed ID: 10388563

Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor. PubMed ID: 10490030

Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. PubMed ID: 17196528

Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis. PubMed ID: 8696348

A novel NTRK1 mutation associated with congenital insensitivity to pain with anhidrosis. PubMed ID: 10090906

Congenital insensitivity to pain with anhidrosis: novel mutations in the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor. PubMed ID: 10330344

Mutation analysis reveals novel sequence variants in NTRK1 in sporadic human medullary thyroid carcinoma. PubMed ID: 10443680

A novel point mutation affecting the tyrosine kinase domain of the TRKA gene in a family with congenital insensitivity to pain with anhidrosis. PubMed ID: 10233776

Characterization of single-nucleotide polymorphisms in coding regions of human genes. PubMed ID: 10391209

Congenital insensitivity to pain with anhidrosis (CIPA) in Israeli-Bedouins: genetic heterogeneity, novel mutations in the TRKA/NGF receptor gene, clinical findings, and results of nerve conduction studies. PubMed ID: 10861667

Mutation and polymorphism analysis of the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor in congenital insensitivity to pain with anhidrosis (CIPA) families. PubMed ID: 10982191

The Gly571Arg mutation, associated with the autonomic and sensory disorder congenital insensitivity to pain with anhidrosis, causes the inactivation of the NTRK1/nerve growth factor receptor. PubMed ID: 10567924

A novel TRK A (NTRK1) mutation associated with hereditary sensory and autonomic neuropathy type V. PubMed ID: 11310631

Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor. PubMed ID: 11159935

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

Novel missense, insertion and deletion mutations in the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1) associated with congenital insensitivity to pain with anhidrosis. PubMed ID: 18077166

Frequency of mutations in the genes associated with hereditary sensory and autonomic neuropathy in a UK cohort. PubMed ID: 22302274

Exome sequencing identifies novel NTRK1 mutations in patients with HSAN-IV phenotype. PubMed ID: 28328124

A comprehensive functional analysis of NTRK1 missense mutations causing hereditary sensory and autonomic neuropathy type IV (HSAN IV). PubMed ID: 27676246

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. PubMed ID: 24722188