Details for: NUCB1

Gene ID: 4924

Symbol: NUCB1

Ensembl ID: ENSG00000104805

Description: nucleobindin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 344.3372
    Cell Significance Index: -53.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 200.4389
    Cell Significance Index: -50.8400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 135.4315
    Cell Significance Index: -55.0200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 130.5275
    Cell Significance Index: -61.6300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 118.8895
    Cell Significance Index: -61.1600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 92.1356
    Cell Significance Index: -61.8300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 58.3089
    Cell Significance Index: -55.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 46.7413
    Cell Significance Index: -57.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.1831
    Cell Significance Index: -48.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.3369
    Cell Significance Index: -60.5200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.6515
    Cell Significance Index: -41.9300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.0025
    Cell Significance Index: -24.0800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 4.4817
    Cell Significance Index: 37.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.6603
    Cell Significance Index: 138.5700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.4695
    Cell Significance Index: 43.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.1894
    Cell Significance Index: 64.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6868
    Cell Significance Index: 231.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.6770
    Cell Significance Index: 78.1900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.2183
    Cell Significance Index: 13.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1676
    Cell Significance Index: 149.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9934
    Cell Significance Index: 542.5000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9778
    Cell Significance Index: 882.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9216
    Cell Significance Index: 19.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8976
    Cell Significance Index: 110.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8330
    Cell Significance Index: 150.1600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7661
    Cell Significance Index: 14.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7472
    Cell Significance Index: 55.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7062
    Cell Significance Index: 15.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6753
    Cell Significance Index: 134.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6162
    Cell Significance Index: 79.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6067
    Cell Significance Index: 121.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5371
    Cell Significance Index: 14.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5229
    Cell Significance Index: 23.7000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5072
    Cell Significance Index: 4.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4909
    Cell Significance Index: 217.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4693
    Cell Significance Index: 24.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4597
    Cell Significance Index: 23.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4583
    Cell Significance Index: 13.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4406
    Cell Significance Index: 71.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3936
    Cell Significance Index: 18.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3764
    Cell Significance Index: 64.2700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3744
    Cell Significance Index: 24.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3272
    Cell Significance Index: 22.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3230
    Cell Significance Index: 8.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3083
    Cell Significance Index: 58.6700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2900
    Cell Significance Index: 20.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2697
    Cell Significance Index: 96.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2202
    Cell Significance Index: 5.7900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2182
    Cell Significance Index: 2.7900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1606
    Cell Significance Index: 111.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1207
    Cell Significance Index: 14.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0980
    Cell Significance Index: 1.6400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0934
    Cell Significance Index: 0.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0556
    Cell Significance Index: 42.0900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0231
    Cell Significance Index: 2.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0062
    Cell Significance Index: 11.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0021
    Cell Significance Index: 0.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0003
    Cell Significance Index: -0.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0079
    Cell Significance Index: -5.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0105
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0199
    Cell Significance Index: -14.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0227
    Cell Significance Index: -41.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0285
    Cell Significance Index: -2.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0327
    Cell Significance Index: -50.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0405
    Cell Significance Index: -25.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0478
    Cell Significance Index: -65.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0665
    Cell Significance Index: -42.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0740
    Cell Significance Index: -41.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0856
    Cell Significance Index: -38.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1452
    Cell Significance Index: -30.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1604
    Cell Significance Index: -18.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1676
    Cell Significance Index: -5.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1701
    Cell Significance Index: -48.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2793
    Cell Significance Index: -40.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3055
    Cell Significance Index: -35.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3398
    Cell Significance Index: -7.8500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4484
    Cell Significance Index: -51.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4599
    Cell Significance Index: -14.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4870
    Cell Significance Index: -13.6100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5077
    Cell Significance Index: -12.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5504
    Cell Significance Index: -33.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5518
    Cell Significance Index: -57.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6133
    Cell Significance Index: -41.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6971
    Cell Significance Index: -55.2100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6987
    Cell Significance Index: -24.2800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.7085
    Cell Significance Index: -10.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7224
    Cell Significance Index: -40.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7492
    Cell Significance Index: -47.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8524
    Cell Significance Index: -22.8000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.8783
    Cell Significance Index: -13.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8793
    Cell Significance Index: -21.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9181
    Cell Significance Index: -56.2900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.9307
    Cell Significance Index: -9.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9443
    Cell Significance Index: -18.4300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.0109
    Cell Significance Index: -51.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.1172
    Cell Significance Index: -49.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.1330
    Cell Significance Index: -24.1300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.1978
    Cell Significance Index: -17.6800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.2811
    Cell Significance Index: -52.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3013
    Cell Significance Index: -38.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression in diverse cell types**: NUCB1 is expressed in a wide range of cell types, including endocardial cells, myeloid leukocytes, decidual cells, lung endothelial cells, blood cells, and various types of epithelial cells. 2. **Calcium ion binding**: NUCB1 binds calcium ions, which is crucial for various cellular processes, including signaling and protein function. 3. **DNA binding**: NUCB1 binds to DNA, suggesting its involvement in gene regulation and transcriptional control. 4. **Signal transduction**: NUCB1 is involved in small GTPase-mediated signal transduction, which is essential for cellular communication and response to external stimuli. **Pathways and Functions:** NUCB1 is involved in several signaling pathways, including: 1. **Calcium ion signaling**: NUCB1 binds calcium ions, which triggers various cellular responses, including protein phosphorylation and activation. 2. **DNA binding and transcriptional regulation**: NUCB1 binds to DNA, influencing gene expression and transcriptional control. 3. **G-protein alpha-subunit binding**: NUCB1 interacts with G-proteins, which are crucial for signal transduction and cellular communication. 4. **Protein binding and regulation**: NUCB1 interacts with various proteins, including insulin-like growth factor binding proteins (IGFBPs), regulating their function and activity. **Clinical Significance:** The NUCB1 gene's involvement in immune regulation and cellular function has significant implications for various diseases, including: 1. **Immune disorders**: NUCB1's role in immune cell function suggests its involvement in autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: NUCB1's interaction with G-proteins and protein binding activities may influence cancer cell growth, migration, and metastasis. 3. **Cardiovascular disease**: NUCB1's expression in endothelial cells and its involvement in calcium ion signaling may contribute to cardiovascular disease, including atherosclerosis and hypertension. 4. **Neurological disorders**: NUCB1's interaction with G-proteins and protein binding activities may influence neurological function and be involved in diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, the NUCB1 gene is a multifaceted gene with far-reaching implications in immune regulation and cellular function. Further research is needed to fully understand its role in various diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 3294992711

Symbol: NUCB1_HUMAN

Name: Nucleobindin-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1520323

Title: Molecular cloning of nucleobindin, a novel DNA-binding protein that contains both a signal peptide and a leucine zipper structure.

PubMed ID: 1520323

DOI: 10.1016/s0006-291x(05)81503-7

PubMed ID: 8661046

Title: Organization of the human gene for nucleobindin (NUC) and its chromosomal assignment to 19q13.2-q13.4.

PubMed ID: 8661046

DOI: 10.1006/geno.1996.0263

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7589456

Title: Interaction of the protein nucleobindin with G alpha i2, as revealed by the yeast two-hybrid system.

PubMed ID: 7589456

DOI: 10.1016/0014-5793(95)01031-9

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 30194280

Title: A biochemical and genetic discovery pipeline identifies PLCdelta4b as a nonreceptor activator of heterotrimeric G-proteins.

PubMed ID: 30194280

DOI: 10.1074/jbc.ra118.003580

PubMed ID: 15287731

Title: Structural studies on the Ca2+-binding domain of human nucleobindin (Calnuc).

PubMed ID: 15287731

DOI: 10.1021/bi049310a

Sequence Information:

  • Length: 461
  • Mass: 53879
  • Checksum: 913C4B87C2A644C5
  • Sequence:
  • MPPSGPRGTL LLLPLLLLLL LRAVLAVPLE RGAPNKEETP ATESPDTGLY YHRYLQEVID 
    VLETDGHFRE KLQAANAEDI KSGKLSRELD FVSHHVRTKL DELKRQEVSR LRMLLKAKMD 
    AEQDPNVQVD HLNLLKQFEH LDPQNQHTFE ARDLELLIQT ATRDLAQYDA AHHEEFKRYE 
    MLKEHERRRY LESLGEEQRK EAERKLEEQQ RRHREHPKVN VPGSQAQLKE VWEELDGLDP 
    NRFNPKTFFI LHDINSDGVL DEQELEALFT KELEKVYDPK NEEDDMREME EERLRMREHV 
    MKNVDTNQDR LVTLEEFLAS TQRKEFGDTG EGWETVEMHP AYTEEELRRF EEELAAREAE 
    LNAKAQRLSQ ETEALGRSQG RLEAQKRELQ QAVLHMEQRK QQQQQQQGHK APAAHPEGQL 
    KFHPDTDDVP VPAPAGDQKE VDTSEKKLLE RLPEVEVPQH L

Genular Protein ID: 1745732760

Symbol: A8K7Q1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 461
  • Mass: 53883
  • Checksum: DBDC44392B5562E2
  • Sequence:
  • MPPSGPRGTL LLLPLLLLLL LRAVLAVPLE RGAPNKEETP ATESPDTGLY YHRYLQEVID 
    VLETDGHFRE KLQAANAEDI KSGKLSRELD FVSHHVRTKL DELKRQEVSR LRMLLKAKMD 
    AEQDPNVQVD HLNLLKQFEH LDPQNQHTFE ARDLELLIQT ATRDLAQYDA AHHEEFKRYE 
    MLKEHERRRY LESLGEEQRK EAERKLEEQQ RRHREHPKVN VPGSQAQLKE VWEELDGLDP 
    NRFNPKTFFI LHDINSDGVL DEQELEALFT KELEKVHDPK NEEDDMREME EERLRMWEHV 
    MKNVDTNQDR LVTLEEFLAS TQRKEFGDTG EGWETVEMHP AYTEEELRRF EEELAAREAE 
    LNAKAQRLSQ ETEALGRSQG RLEAQKRELQ QAVLHMEQRK QQQQQQQGHK APAAHPEGQL 
    KFHPDTDDVP VPAPAGDQKE VDTSEKKLLE RLPEVEVPQH L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.