Details for: PODXL2

Gene ID: 50512

Symbol: PODXL2

Ensembl ID: ENSG00000114631

Description: podocalyxin like 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 191.0055
    Cell Significance Index: -29.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 115.9502
    Cell Significance Index: -29.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.1696
    Cell Significance Index: -29.8000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.7691
    Cell Significance Index: -26.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.7307
    Cell Significance Index: 195.8800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.4082
    Cell Significance Index: 52.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6076
    Cell Significance Index: 159.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.5414
    Cell Significance Index: 97.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5275
    Cell Significance Index: 248.4300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.5222
    Cell Significance Index: 18.8800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.4602
    Cell Significance Index: 11.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.3946
    Cell Significance Index: 85.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2832
    Cell Significance Index: 460.2500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.2559
    Cell Significance Index: 30.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2363
    Cell Significance Index: 57.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0334
    Cell Significance Index: 62.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8631
    Cell Significance Index: 173.1400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.7478
    Cell Significance Index: 21.3400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.7440
    Cell Significance Index: 5.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6867
    Cell Significance Index: 474.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6316
    Cell Significance Index: 13.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5529
    Cell Significance Index: 15.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5243
    Cell Significance Index: 473.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4686
    Cell Significance Index: 89.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4674
    Cell Significance Index: 32.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4667
    Cell Significance Index: 10.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4030
    Cell Significance Index: 27.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3930
    Cell Significance Index: 50.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2895
    Cell Significance Index: 13.1200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.2761
    Cell Significance Index: 3.5800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2668
    Cell Significance Index: 2.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2031
    Cell Significance Index: 3.4800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.1958
    Cell Significance Index: 2.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1786
    Cell Significance Index: 9.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1776
    Cell Significance Index: 6.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1516
    Cell Significance Index: 82.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1465
    Cell Significance Index: 5.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1464
    Cell Significance Index: 4.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1343
    Cell Significance Index: 59.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0810
    Cell Significance Index: 1.6800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0714
    Cell Significance Index: 1.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0353
    Cell Significance Index: 6.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0276
    Cell Significance Index: 2.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0137
    Cell Significance Index: 1.6000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0049
    Cell Significance Index: -0.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0116
    Cell Significance Index: -21.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0129
    Cell Significance Index: -1.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0166
    Cell Significance Index: -12.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0196
    Cell Significance Index: -36.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0230
    Cell Significance Index: -35.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0249
    Cell Significance Index: -33.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0265
    Cell Significance Index: -19.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0338
    Cell Significance Index: -0.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0348
    Cell Significance Index: -22.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0371
    Cell Significance Index: -28.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0437
    Cell Significance Index: -24.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0536
    Cell Significance Index: -33.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0556
    Cell Significance Index: -3.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0594
    Cell Significance Index: -26.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0628
    Cell Significance Index: -12.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0703
    Cell Significance Index: -8.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0750
    Cell Significance Index: -21.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0792
    Cell Significance Index: -13.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0796
    Cell Significance Index: -10.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0920
    Cell Significance Index: -2.5700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1365
    Cell Significance Index: -2.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1521
    Cell Significance Index: -32.0400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1668
    Cell Significance Index: -1.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1709
    Cell Significance Index: -8.0300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1716
    Cell Significance Index: -20.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1740
    Cell Significance Index: -25.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1830
    Cell Significance Index: -18.6900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1831
    Cell Significance Index: -3.6200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1854
    Cell Significance Index: -1.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1864
    Cell Significance Index: -3.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1951
    Cell Significance Index: -4.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2103
    Cell Significance Index: -5.5300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2273
    Cell Significance Index: -2.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2463
    Cell Significance Index: -12.8300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2524
    Cell Significance Index: -3.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2575
    Cell Significance Index: -29.5000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2619
    Cell Significance Index: -2.2000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2654
    Cell Significance Index: -3.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2943
    Cell Significance Index: -30.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2967
    Cell Significance Index: -19.1400
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.3033
    Cell Significance Index: -2.2900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3105
    Cell Significance Index: -24.5900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3182
    Cell Significance Index: -10.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3391
    Cell Significance Index: -20.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3413
    Cell Significance Index: -8.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3619
    Cell Significance Index: -11.8500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3666
    Cell Significance Index: -7.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3963
    Cell Significance Index: -30.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4305
    Cell Significance Index: -19.0400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.4809
    Cell Significance Index: -3.0200
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.5120
    Cell Significance Index: -4.5100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.5152
    Cell Significance Index: -6.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5327
    Cell Significance Index: -15.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5395
    Cell Significance Index: -20.4300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.5428
    Cell Significance Index: -6.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PODXL2 is a transmembrane protein that belongs to the podocalyxin family, characterized by its unique structure and function. It is predominantly expressed in hematopoietic cells, including polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, and CD8-alpha-beta-positive, alpha-beta intraepithelial T cells. PODXL2 has been shown to play a crucial role in the regulation of cell adhesion, migration, and signaling, which are essential processes in the immune response. **Pathways and Functions:** PODXL2 is involved in several signaling pathways, including: 1. **Leukocyte tethering or rolling:** PODXL2 has been shown to interact with selectins, which are crucial for the initial tethering and rolling of leukocytes on the endothelial surface. This interaction is essential for the recruitment of immune cells to sites of inflammation. 2. **Glycosaminoglycan binding:** PODXL2 has been found to bind to glycosaminoglycans, which are important components of the extracellular matrix. This interaction regulates cell adhesion, migration, and signaling. 3. **Protein binding:** PODXL2 has been shown to interact with various proteins, including integrins, which are essential for cell adhesion and migration. **Clinical Significance:** PODXL2 has been implicated in various diseases, including: 1. **Autoimmune disorders:** Alterations in PODXL2 expression have been observed in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. These alterations may contribute to the dysregulation of immune cell function and the development of disease. 2. **Cancer:** PODXL2 has been found to be overexpressed in certain types of cancer, including leukemia and lymphoma. This overexpression may contribute to the progression of disease and the development of resistance to therapy. 3. **Neurological disorders:** PODXL2 has been implicated in neurological disorders, such as Parkinson's disease and Alzheimer's disease. Alterations in PODXL2 expression have been observed in these diseases, which may contribute to the development of disease. In conclusion, PODXL2 is a protein that plays a critical role in the regulation of immune cell function and the development of various diseases. Further research is necessary to fully understand the mechanisms by which PODXL2 regulates immune cell function and its role in disease.

Genular Protein ID: 2819223556

Symbol: PDXL2_HUMAN

Name: Podocalyxin-like protein 2

UniProtKB Accession Codes:

Q9NZ53 Q6UVY4 Q8WUV6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10722749

Title: Identification of endoglycan, a member of the CD34/podocalyxin family of sialomucins.

PubMed ID: 10722749

DOI: 10.1074/jbc.275.12.9001

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12889478

Title: Endoglycan, a member of the CD34 family, functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x.

PubMed ID: 12889478

DOI: 10.1074/jbc.m304204200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18606703

Title: Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins.

PubMed ID: 18606703

DOI: 10.4049/jimmunol.181.2.1480

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

Sequence Information:

  • Length: 605
  • Mass: 65076
  • Checksum: 2F9B8DC51F7FC22A
  • Sequence:
    • MGRLLRAARL PPLLSPLLLL LVGGAFLGAC VAGSDEPGPE GLTSTSLLDL LLPTGLEPLD 
SEEPSETMGL GAGLGAPGSG FPSEENEESR ILQPPQYFWE EEEELNDSSL DLGPTADYVF 
PDLTEKAGSI EDTSQAQELP NLPSPLPKMN LVEPPWHMPP REEEEEEEEE EEREKEEVEK 
QEEEEEEELL PVNGSQEEAK PQVRDFSLTS SSQTPGATKS RHEDSGDQAS SGVEVESSMG 
PSLLLPSVTP TTVTPGDQDS TSQEAEATVL PAAGLGVEFE APQEASEEAT AGAAGLSGQH 
EEVPALPSFP QTTAPSGAEH PDEDPLGSRT SASSPLAPGD MELTPSSATL GQEDLNQQLL 
EGQAAEAQSR IPWDSTQVIC KDWSNLAGKN YIILNMTENI DCEVFRQHRG PQLLALVEEV 
LPRHGSGHHG AWHISLSKPS EKEQHLLMTL VGEQGVVPTQ DVLSMLGDIR RSLEEIGIQN 
YSTTSSCQAR ASQVRSDYGT LFVVLVVIGA ICIIIIALGL LYNCWQRRLP KLKHVSHGEE 
LRFVENGCHD NPTLDVASDS QSEMQEKHPS LNGGGALNGP GSWGALMGGK RDPEDSDVFE 
EDTHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.