Details for: FIS1

Gene ID: 51024

Symbol: FIS1

Ensembl ID: ENSG00000214253

Description: fission, mitochondrial 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 508.0837
    Cell Significance Index: -79.0300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 344.3319
    Cell Significance Index: -87.3400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 256.4647
    Cell Significance Index: -105.6500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 207.0013
    Cell Significance Index: -97.7300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 176.5603
    Cell Significance Index: -90.8200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 146.1651
    Cell Significance Index: -98.0800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 72.8007
    Cell Significance Index: -89.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 27.2120
    Cell Significance Index: -107.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 25.9215
    Cell Significance Index: -69.4400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.4040
    Cell Significance Index: -62.6700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.5645
    Cell Significance Index: -25.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.7172
    Cell Significance Index: 219.9400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.4964
    Cell Significance Index: 28.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.2808
    Cell Significance Index: 411.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.2781
    Cell Significance Index: 1244.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.2313
    Cell Significance Index: 274.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.0967
    Cell Significance Index: 287.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.7690
    Cell Significance Index: 226.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.6356
    Cell Significance Index: 76.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5668
    Cell Significance Index: 116.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.5160
    Cell Significance Index: 670.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4567
    Cell Significance Index: 39.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.4251
    Cell Significance Index: 100.7900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.3574
    Cell Significance Index: 12.5000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2711
    Cell Significance Index: 37.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2306
    Cell Significance Index: 158.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1508
    Cell Significance Index: 74.2500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0847
    Cell Significance Index: 25.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0265
    Cell Significance Index: 46.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8709
    Cell Significance Index: 786.4000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.8488
    Cell Significance Index: 15.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8289
    Cell Significance Index: 43.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6447
    Cell Significance Index: 185.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6225
    Cell Significance Index: 73.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6110
    Cell Significance Index: 12.7900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.4659
    Cell Significance Index: 3.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3152
    Cell Significance Index: 63.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2665
    Cell Significance Index: 52.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2035
    Cell Significance Index: 5.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1976
    Cell Significance Index: 149.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1750
    Cell Significance Index: 128.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0423
    Cell Significance Index: 1.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0097
    Cell Significance Index: 3.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0026
    Cell Significance Index: 0.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0158
    Cell Significance Index: -2.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0299
    Cell Significance Index: -0.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0362
    Cell Significance Index: -68.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0422
    Cell Significance Index: -4.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0711
    Cell Significance Index: -131.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0875
    Cell Significance Index: -134.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1028
    Cell Significance Index: -139.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1040
    Cell Significance Index: -77.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1071
    Cell Significance Index: -68.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1083
    Cell Significance Index: -17.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1601
    Cell Significance Index: -15.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1654
    Cell Significance Index: -93.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1852
    Cell Significance Index: -84.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1873
    Cell Significance Index: -116.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2522
    Cell Significance Index: -29.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3062
    Cell Significance Index: -24.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3851
    Cell Significance Index: -20.2200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4009
    Cell Significance Index: -7.4100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4086
    Cell Significance Index: -24.5300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4345
    Cell Significance Index: -6.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4469
    Cell Significance Index: -51.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4584
    Cell Significance Index: -12.8100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5014
    Cell Significance Index: -12.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5072
    Cell Significance Index: -14.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5531
    Cell Significance Index: -34.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5552
    Cell Significance Index: -116.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6015
    Cell Significance Index: -87.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7888
    Cell Significance Index: -27.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8909
    Cell Significance Index: -54.7600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.9430
    Cell Significance Index: -13.4000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.9557
    Cell Significance Index: -10.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0201
    Cell Significance Index: -106.2200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.1131
    Cell Significance Index: -9.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.1572
    Cell Significance Index: -88.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.1911
    Cell Significance Index: -38.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.2934
    Cell Significance Index: -86.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.3912
    Cell Significance Index: -37.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.4614
    Cell Significance Index: -31.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.5073
    Cell Significance Index: -84.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.5707
    Cell Significance Index: -21.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.5799
    Cell Significance Index: -96.8700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.7737
    Cell Significance Index: -22.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.8406
    Cell Significance Index: -39.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.8452
    Cell Significance Index: -47.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.8810
    Cell Significance Index: -47.0200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.8875
    Cell Significance Index: -55.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.9326
    Cell Significance Index: -97.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -2.0093
    Cell Significance Index: -53.8400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -2.0654
    Cell Significance Index: -84.6300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -2.3082
    Cell Significance Index: -14.2100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.3613
    Cell Significance Index: -86.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.3655
    Cell Significance Index: -104.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -2.7809
    Cell Significance Index: -97.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.8124
    Cell Significance Index: -106.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.8263
    Cell Significance Index: -81.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -2.8838
    Cell Significance Index: -94.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Mitochondrial localization**: FIS1 is specifically localized to the mitochondrial outer membrane, where it regulates mitochondrial fission. 2. **Role in mitochondrial dynamics**: FIS1 is involved in the regulation of mitochondrial fission, which is essential for maintaining mitochondrial function and overall cellular health. 3. **Regulation of ATP metabolic process**: FIS1 negatively regulates the ATP metabolic process, which is crucial for maintaining energy homeostasis within the cell. 4. **Regulation of fatty acid transport**: FIS1 also negatively regulates fatty acid transport, which is essential for maintaining lipid homeostasis within the cell. 5. **Interactions with other proteins**: FIS1 interacts with other proteins, including those involved in mitochondrial fission, to regulate its activity. **Pathways and Functions** 1. **Mitochondrial fission pathway**: FIS1 is involved in the regulation of mitochondrial fission, which is mediated by the Drp1 (Dynamin-related protein 1) pathway. 2. **Negative regulation of ATP metabolic process**: FIS1 negatively regulates the ATP metabolic process by inhibiting the activity of key enzymes involved in ATP production. 3. **Negative regulation of fatty acid transport**: FIS1 negatively regulates fatty acid transport by inhibiting the activity of key enzymes involved in fatty acid metabolism. 4. **Regulation of intrinsic apoptotic signaling pathway**: FIS1 positively regulates the intrinsic apoptotic signaling pathway, which is involved in programmed cell death. **Clinical Significance** 1. **Neurodegenerative disorders**: Dysregulation of FIS1 has been linked to various neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. **Metabolic disorders**: FIS1 dysregulation has also been linked to metabolic disorders, including type 2 diabetes and metabolic syndrome. 3. **Cancer**: FIS1 dysregulation has been observed in various types of cancer, including colorectal cancer and breast cancer. 4. **Cardiovascular disease**: FIS1 dysregulation has also been linked to cardiovascular disease, including atherosclerosis and heart failure. In conclusion, FIS1 is a critical regulator of mitochondrial dynamics and function, and its dysregulation has been linked to various diseases, including neurodegenerative disorders, metabolic disorders, and cancer. Further research is needed to fully understand the role of FIS1 in maintaining cellular health and to develop therapeutic strategies to target its dysregulation.

Genular Protein ID: 3500198028

Symbol: FIS1_HUMAN

Name: Mitochondrial fission 1 protein

UniProtKB Accession Codes:

Q9Y3D6 Q9BTP3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12783892

Title: hFis1, a novel component of the mammalian mitochondrial fission machinery.

PubMed ID: 12783892

DOI: 10.1074/jbc.m303758200

PubMed ID: 12861026

Title: The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1.

PubMed ID: 12861026

DOI: 10.1128/mcb.23.15.5409-5420.2003

PubMed ID: 14996942

Title: Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology.

PubMed ID: 14996942

DOI: 10.1242/jcs.01058

PubMed ID: 16118244

Title: Regulation of mitochondrial fission and apoptosis by the mitochondrial outer membrane protein hFis1.

PubMed ID: 16118244

DOI: 10.1242/jcs.02537

PubMed ID: 16107562

Title: A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells.

PubMed ID: 16107562

DOI: 10.1091/mbc.e05-02-0159

PubMed ID: 16874301

Title: A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics.

PubMed ID: 16874301

DOI: 10.1038/sj.emboj.7601249

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20826455

Title: PEX11 family members are membrane elongation factors that coordinate peroxisome proliferation and maintenance.

PubMed ID: 20826455

DOI: 10.1242/jcs.064907

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21701560

Title: Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission.

PubMed ID: 21701560

DOI: 10.1038/emboj.2011.198

PubMed ID: 23921378

Title: MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission.

PubMed ID: 23921378

DOI: 10.1074/jbc.m113.479873

PubMed ID: 23283981

Title: Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission.

PubMed ID: 23283981

DOI: 10.1091/mbc.e12-10-0721

PubMed ID: 23530241

Title: Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission.

PubMed ID: 23530241

DOI: 10.1073/pnas.1300855110

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 14705031

Title: Cytosolic domain of the human mitochondrial fission protein fis1 adopts a TPR fold.

PubMed ID: 14705031

DOI: 10.1002/prot.10524

PubMed ID: 14623186

Title: The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle.

PubMed ID: 14623186

DOI: 10.1016/j.jmb.2003.09.064

PubMed ID: 24196833

Title: Mutations in Fis1 disrupt orderly disposal of defective mitochondria.

PubMed ID: 24196833

DOI: 10.1091/mbc.e13-09-0525

Sequence Information:

  • Length: 152
  • Mass: 16938
  • Checksum: 6E76EC02B3731A9B
  • Sequence:
    • MEAVLNELVS VEDLLKFEKK FQSEKAAGSV SKSTQFEYAW CLVRSKYNDD IRKGIVLLEE 
LLPKGSKEEQ RDYVFYLAVG NYRLKEYEKA LKYVRGLLQT EPQNNQAKEL ERLIDKAMKK 
DGLVGMAIVG GMALGVAGLA GLIGLAVSKS KS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.