Details for: VPS36

Gene ID: 51028

Symbol: VPS36

Ensembl ID: ENSG00000136100

Description: vacuolar protein sorting 36 homolog

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 319.5212
    Cell Significance Index: -49.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 170.0419
    Cell Significance Index: -43.1300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 111.4705
    Cell Significance Index: -45.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 103.3705
    Cell Significance Index: -42.0000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 103.3418
    Cell Significance Index: -48.7900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 93.2764
    Cell Significance Index: -47.9800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 72.9931
    Cell Significance Index: -48.9800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.2632
    Cell Significance Index: -42.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.6803
    Cell Significance Index: -51.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.8057
    Cell Significance Index: -45.0200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.1372
    Cell Significance Index: -51.8400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.5469
    Cell Significance Index: -27.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.2776
    Cell Significance Index: -37.7100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.9269
    Cell Significance Index: 22.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.6694
    Cell Significance Index: 36.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.5725
    Cell Significance Index: 299.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.0296
    Cell Significance Index: 127.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7729
    Cell Significance Index: 355.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4528
    Cell Significance Index: 40.6000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.4218
    Cell Significance Index: 27.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3745
    Cell Significance Index: 62.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3369
    Cell Significance Index: 38.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2733
    Cell Significance Index: 82.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2116
    Cell Significance Index: 148.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1498
    Cell Significance Index: 24.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0543
    Cell Significance Index: 190.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0321
    Cell Significance Index: 370.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0181
    Cell Significance Index: 165.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0081
    Cell Significance Index: 27.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9480
    Cell Significance Index: 58.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8975
    Cell Significance Index: 178.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8515
    Cell Significance Index: 60.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8433
    Cell Significance Index: 39.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8296
    Cell Significance Index: 749.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7943
    Cell Significance Index: 351.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7660
    Cell Significance Index: 105.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7211
    Cell Significance Index: 37.4600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6430
    Cell Significance Index: 7.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6328
    Cell Significance Index: 48.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5856
    Cell Significance Index: 319.8000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5760
    Cell Significance Index: 62.6600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4922
    Cell Significance Index: 25.6400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4128
    Cell Significance Index: 10.6100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3688
    Cell Significance Index: 8.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3460
    Cell Significance Index: 65.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3437
    Cell Significance Index: 16.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3366
    Cell Significance Index: 18.8900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2510
    Cell Significance Index: 6.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2454
    Cell Significance Index: 24.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2426
    Cell Significance Index: 8.5300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1762
    Cell Significance Index: 1.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1336
    Cell Significance Index: 8.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0987
    Cell Significance Index: 12.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0748
    Cell Significance Index: 115.1600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0641
    Cell Significance Index: 0.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0619
    Cell Significance Index: 1.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0603
    Cell Significance Index: 113.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0457
    Cell Significance Index: 84.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0404
    Cell Significance Index: 29.6500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0387
    Cell Significance Index: 0.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0312
    Cell Significance Index: 19.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0228
    Cell Significance Index: 1.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0185
    Cell Significance Index: 25.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0042
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0090
    Cell Significance Index: -1.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0104
    Cell Significance Index: -4.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0142
    Cell Significance Index: -0.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0160
    Cell Significance Index: -0.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0268
    Cell Significance Index: -20.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0400
    Cell Significance Index: -4.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0503
    Cell Significance Index: -37.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0527
    Cell Significance Index: -5.3800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0772
    Cell Significance Index: -0.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0824
    Cell Significance Index: -46.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0877
    Cell Significance Index: -54.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1254
    Cell Significance Index: -5.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1342
    Cell Significance Index: -10.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1475
    Cell Significance Index: -42.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1642
    Cell Significance Index: -23.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2313
    Cell Significance Index: -8.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2367
    Cell Significance Index: -7.5800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2372
    Cell Significance Index: -3.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2514
    Cell Significance Index: -52.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3016
    Cell Significance Index: -34.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3472
    Cell Significance Index: -8.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3733
    Cell Significance Index: -9.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3867
    Cell Significance Index: -30.6300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3895
    Cell Significance Index: -5.7500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4273
    Cell Significance Index: -3.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4320
    Cell Significance Index: -44.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4386
    Cell Significance Index: -15.2400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5400
    Cell Significance Index: -14.2000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5465
    Cell Significance Index: -10.1000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5526
    Cell Significance Index: -15.8400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5809
    Cell Significance Index: -8.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6030
    Cell Significance Index: -36.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6236
    Cell Significance Index: -15.9300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6349
    Cell Significance Index: -15.4900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6860
    Cell Significance Index: -15.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6944
    Cell Significance Index: -48.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** VPS36 is a gene that belongs to the vacuolar protein-sorting-associated protein family, which plays a crucial role in the regulation of protein transport within the cell. The gene is widely expressed in various cell types, including hematopoietic oligopotent progenitor cells, embryonic stem cells, and mucosal type mast cells. Its expression is also observed in the smooth muscle fibers of the ileum and peripheral blood mononuclear cells. **Pathways and Functions:** VPS36 is involved in multiple cellular pathways, including: 1. **Endosomal sorting complex required for transport (escrt)**: VPS36 is a key component of the escrt complex, which is responsible for the sorting of proteins to the multivesicular body (MVB) pathway. 2. **Membrane trafficking**: VPS36 is involved in the regulation of membrane trafficking, including the transport of proteins to the vacuole and the formation of the MVB. 3. **Autophagy**: VPS36 is also involved in the regulation of autophagy, a process by which cells recycle damaged or dysfunctional proteins and organelles. 4. **Viral infection pathways**: VPS36 has been shown to play a role in the regulation of viral infection pathways, including the formation of the MVB and the transport of viral proteins to the vacuole. **Functions:** The functions of VPS36 are multifaceted and involve the regulation of various cellular processes, including: 1. **Protein transport**: VPS36 is responsible for the transport of proteins to the vacuole and the MVB. 2. **Cellular stress response**: VPS36 is involved in the regulation of the cellular stress response, including the recycling of damaged or dysfunctional proteins and organelles. 3. **Immune response**: VPS36 has been shown to play a role in the regulation of the immune response, including the transport of antigens to the MVB and the presentation of antigens to T cells. **Clinical Significance:** The clinical significance of VPS36 is multifaceted and involves the regulation of various diseases, including: 1. **Autoimmune disorders**: VPS36 has been shown to play a role in the regulation of autoimmune disorders, including the transport of antigens to the MVB and the presentation of antigens to T cells. 2. **Cancer**: VPS36 has been implicated in the regulation of cancer, including the transport of proteins to the vacuole and the formation of the MVB. 3. **Infectious diseases**: VPS36 has been shown to play a role in the regulation of infectious diseases, including the formation of the MVB and the transport of viral proteins to the vacuole. In conclusion, VPS36 is a multifaceted gene that plays a crucial role in various cellular processes, including protein transport, cellular stress response, and immune response. Its clinical significance is multifaceted and involves the regulation of various diseases, including autoimmune disorders, cancer, and infectious diseases. Further research is needed to fully understand the functions and significance of VPS36, but it is clear that this gene is a key player in the regulation of cellular processes and disease.

Genular Protein ID: 3424227423

Symbol: VPS36_HUMAN

Name: Vacuolar protein-sorting-associated protein 36

UniProtKB Accession Codes:

Q86VN1 A8K125 Q3ZCV7 Q5H9S1 Q5VXB6 Q9H8Z5 Q9Y3E3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14505570

Title: The protein network of HIV budding.

PubMed ID: 14505570

DOI: 10.1016/s0092-8674(03)00714-1

PubMed ID: 14519844

Title: Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.

PubMed ID: 14519844

DOI: 10.1073/pnas.2133846100

PubMed ID: 17010938

Title: RILP interacts with VPS22 and VPS36 of ESCRT-II and regulates their membrane recruitment.

PubMed ID: 17010938

DOI: 10.1016/j.bbrc.2006.09.064

PubMed ID: 16973552

Title: Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release.

PubMed ID: 16973552

DOI: 10.1128/jvi.01049-06

PubMed ID: 17714434

Title: Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradation.

PubMed ID: 17714434

DOI: 10.1111/j.1600-0854.2007.00630.x

PubMed ID: 20682791

Title: A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.

PubMed ID: 20682791

DOI: 10.1074/jbc.m110.154120

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 17057716

Title: Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain.

PubMed ID: 17057716

DOI: 10.1038/nsmb1160

PubMed ID: 18539118

Title: Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex.

PubMed ID: 18539118

DOI: 10.1016/j.devcel.2008.04.004

Sequence Information:

  • Length: 386
  • Mass: 43817
  • Checksum: 21E1E66F71BA7764
  • Sequence:
    • MDRFVWTSGL LEINETLVIQ QRGVRIYDGE EKIKFDAGTL LLSTHRLIWR DQKNHECCMA 
ILLSQIVFIE EQAAGIGKSA KIVVHLHPAP PNKEPGPFQS SKNSYIKLSF KEHGQIEFYR 
RLSEEMTQRR WENMPVSQSL QTNRGPQPGR IRAVGIVGIE RKLEEKRKET DKNISEAFED 
LSKLMIKAKE MVELSKSIAN KIKDKQGDIT EDETIRFKSY LLSMGIANPV TRETYGSGTQ 
YHMQLAKQLA GILQVPLEER GGIMSLTEVY CLVNRARGME LLSPEDLVNA CKMLEALKLP 
LRLRVFDSGV MVIELQSHKE EEMVASALET VSEKGSLTSE EFAKLVGMSV LLAKERLLLA 
EKMGHLCRDD SVEGLRFYPN LFMTQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.