Details for: LAP3

Gene ID: 51056

Symbol: LAP3

Ensembl ID: ENSG00000002549

Description: leucine aminopeptidase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 242.2447
    Cell Significance Index: -37.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 137.3976
    Cell Significance Index: -34.8500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 104.5036
    Cell Significance Index: -43.0500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 93.0322
    Cell Significance Index: -37.8000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 92.6878
    Cell Significance Index: -43.7600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 82.5063
    Cell Significance Index: -42.4400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 65.2139
    Cell Significance Index: -43.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.0108
    Cell Significance Index: -38.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.5211
    Cell Significance Index: -41.3300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.7965
    Cell Significance Index: -34.2800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.2780
    Cell Significance Index: -34.6400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.7018
    Cell Significance Index: -42.2300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.3341
    Cell Significance Index: -18.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.0082
    Cell Significance Index: 120.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.9576
    Cell Significance Index: 101.9700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.8412
    Cell Significance Index: 34.0300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.8060
    Cell Significance Index: 31.9200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.5096
    Cell Significance Index: 12.3100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.3151
    Cell Significance Index: 14.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9477
    Cell Significance Index: 44.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9348
    Cell Significance Index: 844.0200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.9167
    Cell Significance Index: 24.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7511
    Cell Significance Index: 88.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7061
    Cell Significance Index: 45.5600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.6964
    Cell Significance Index: 5.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6937
    Cell Significance Index: 9.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6934
    Cell Significance Index: 306.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6277
    Cell Significance Index: 80.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6200
    Cell Significance Index: 76.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6116
    Cell Significance Index: 60.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5767
    Cell Significance Index: 79.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5522
    Cell Significance Index: 301.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5356
    Cell Significance Index: 24.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4975
    Cell Significance Index: 98.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4812
    Cell Significance Index: 62.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4736
    Cell Significance Index: 10.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4622
    Cell Significance Index: 83.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3727
    Cell Significance Index: 19.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3656
    Cell Significance Index: 16.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3594
    Cell Significance Index: 25.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2902
    Cell Significance Index: 8.5200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1935
    Cell Significance Index: 4.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1767
    Cell Significance Index: 33.6300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.1722
    Cell Significance Index: 1.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1705
    Cell Significance Index: 34.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1567
    Cell Significance Index: 11.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1194
    Cell Significance Index: 42.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1067
    Cell Significance Index: 3.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0348
    Cell Significance Index: 0.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0048
    Cell Significance Index: 0.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0032
    Cell Significance Index: -2.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0118
    Cell Significance Index: -22.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0140
    Cell Significance Index: -10.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0141
    Cell Significance Index: -25.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0202
    Cell Significance Index: -31.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0203
    Cell Significance Index: -14.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0273
    Cell Significance Index: -37.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0360
    Cell Significance Index: -0.9600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0460
    Cell Significance Index: -29.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0581
    Cell Significance Index: -43.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0586
    Cell Significance Index: -1.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0748
    Cell Significance Index: -46.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0750
    Cell Significance Index: -42.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0775
    Cell Significance Index: -35.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1128
    Cell Significance Index: -32.4700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1258
    Cell Significance Index: -0.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1302
    Cell Significance Index: -22.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1855
    Cell Significance Index: -3.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2151
    Cell Significance Index: -31.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2214
    Cell Significance Index: -25.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2247
    Cell Significance Index: -47.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2387
    Cell Significance Index: -27.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2839
    Cell Significance Index: -7.4700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2885
    Cell Significance Index: -7.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3349
    Cell Significance Index: -16.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3481
    Cell Significance Index: -27.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3534
    Cell Significance Index: -9.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3583
    Cell Significance Index: -27.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3932
    Cell Significance Index: -6.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4008
    Cell Significance Index: -41.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4393
    Cell Significance Index: -24.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4588
    Cell Significance Index: -14.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4662
    Cell Significance Index: -16.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4677
    Cell Significance Index: -28.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4698
    Cell Significance Index: -31.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5080
    Cell Significance Index: -32.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5128
    Cell Significance Index: -13.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5203
    Cell Significance Index: -14.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5721
    Cell Significance Index: -30.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6051
    Cell Significance Index: -37.1000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.6265
    Cell Significance Index: -9.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6270
    Cell Significance Index: -25.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7076
    Cell Significance Index: -31.3000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.7431
    Cell Significance Index: -4.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7591
    Cell Significance Index: -15.8900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.7726
    Cell Significance Index: -7.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8263
    Cell Significance Index: -31.2900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.8442
    Cell Significance Index: -12.6500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8829
    Cell Significance Index: -32.4100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.9196
    Cell Significance Index: -15.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The LAP3 gene exhibits several key characteristics that distinguish it from other enzymes: 1. **Aminopeptidase activity**: LAP3 is a type II transmembrane aminopeptidase, which means it possesses a catalytic site that allows it to degrade peptides from the N-terminus. 2. **Metalloexopeptidase activity**: LAP3 also exhibits metalloexopeptidase activity, which involves the degradation of peptides in the presence of metal ions. 3. **Expression in diverse cell types**: LAP3 is expressed in various cell types, including hematopoietic cells, epithelial cells, and immune cells, highlighting its importance in maintaining tissue homeostasis and immune function. 4. **Role in protein degradation**: LAP3 plays a crucial role in protein degradation, which is essential for maintaining cellular homeostasis and regulating protein turnover. **Pathways and Functions** LAP3 is involved in several signaling pathways, including: 1. **Focal adhesion**: LAP3 is involved in the regulation of focal adhesion, which is essential for cell migration, adhesion, and signaling. 2. **Cytoplasmic signaling**: LAP3 is also involved in cytoplasmic signaling pathways, which regulate various cellular processes, including protein degradation and immune responses. 3. **Proteolysis**: LAP3 plays a crucial role in proteolysis, which is essential for maintaining cellular homeostasis and regulating protein turnover. 4. **Immune regulation**: LAP3 is involved in immune regulation, including the degradation of peptides and the regulation of immune responses. **Clinical Significance** The LAP3 gene has several clinical implications, including: 1. **Immune disorders**: LAP3 is involved in immune regulation, and alterations in its expression or function may contribute to immune disorders, such as autoimmune diseases. 2. **Cancer**: LAP3 is involved in cancer progression, and its expression may contribute to tumorigenesis. 3. **Neurological disorders**: LAP3 is involved in neurological disorders, such as Alzheimer's disease, and its expression may contribute to disease progression. 4. **Infectious diseases**: LAP3 is involved in the regulation of immune responses, and alterations in its expression or function may contribute to infectious diseases. In conclusion, the LAP3 gene plays a crucial role in cellular functions, signaling pathways, and immune regulation. Its clinical significance is underscored by its involvement in immune disorders, cancer, neurological disorders, and infectious diseases. Further research is necessary to fully elucidate the functions and clinical implications of the LAP3 gene.

Genular Protein ID: 3154623332

Symbol: AMPL_HUMAN

Name: N/A

UniProtKB Accession Codes:

P28838 B3KMQ3 Q6IAM6 Q6P0L6 Q9UQE3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEBI 28 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 3 EMBL 6 Ensembl 3 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 RefSeq 1 Rhea 6 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1908238

Title: Structural and immunological evidence for the identity of prolyl aminopeptidase with leucyl aminopeptidase.

PubMed ID: 1908238

DOI: 10.1016/0006-291x(91)91057-j

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 519
  • Mass: 56166
  • Checksum: D960F8F5B9024585
  • Sequence:
    • MFLLPLPAAG RVVVRRLAVR RFGSRSLSTA DMTKGLVLGI YSKEKEDDVP QFTSAGENFD 
KLLAGKLRET LNISGPPLKA GKTRTFYGLH QDFPSVVLVG LGKKAAGIDE QENWHEGKEN 
IRAAVAAGCR QIQDLELSSV EVDPCGDAQA AAEGAVLGLY EYDDLKQKKK MAVSAKLYGS 
GDQEAWQKGV LFASGQNLAR QLMETPANEM TPTRFAEIIE KNLKSASSKT EVHIRPKSWI 
EEQAMGSFLS VAKGSDEPPV FLEIHYKGSP NANEPPLVFV GKGITFDSGG ISIKASANMD 
LMRADMGGAA TICSAIVSAA KLNLPINIIG LAPLCENMPS GKANKPGDVV RAKNGKTIQV 
DNTDAEGRLI LADALCYAHT FNPKVILNAA TLTGAMDVAL GSGATGVFTN SSWLWNKLFE 
ASIETGDRVW RMPLFEHYTR QVVDCQLADV NNIGKYRSAG ACTAAAFLKE FVTHPKWAHL 
DIAGVMTNKD EVPYLRKGMT GRPTRTLIEF LLRFSQDNA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.