Details for: PCMT1

Gene ID: 5110

Symbol: PCMT1

Ensembl ID: ENSG00000120265

Description: protein-L-isoaspartate (D-aspartate) O-methyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 239.1587
    Cell Significance Index: -37.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 203.5141
    Cell Significance Index: -51.6200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 144.9699
    Cell Significance Index: -59.7200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 129.6167
    Cell Significance Index: -61.2000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 128.7854
    Cell Significance Index: -52.3200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 113.9613
    Cell Significance Index: -58.6200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 91.4053
    Cell Significance Index: -61.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 46.2385
    Cell Significance Index: -57.0100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.8482
    Cell Significance Index: -54.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.9881
    Cell Significance Index: -63.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.7936
    Cell Significance Index: -39.6300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.1221
    Cell Significance Index: 163.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1852
    Cell Significance Index: 438.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.5285
    Cell Significance Index: 53.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2793
    Cell Significance Index: 34.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2077
    Cell Significance Index: 165.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1830
    Cell Significance Index: 646.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1778
    Cell Significance Index: 54.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.1733
    Cell Significance Index: 30.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1194
    Cell Significance Index: 52.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0807
    Cell Significance Index: 80.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0709
    Cell Significance Index: 131.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0651
    Cell Significance Index: 382.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0146
    Cell Significance Index: 201.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0091
    Cell Significance Index: 129.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9398
    Cell Significance Index: 169.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8942
    Cell Significance Index: 395.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8047
    Cell Significance Index: 49.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8029
    Cell Significance Index: 23.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6819
    Cell Significance Index: 80.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6639
    Cell Significance Index: 85.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5898
    Cell Significance Index: 95.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5851
    Cell Significance Index: 15.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4298
    Cell Significance Index: 32.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4148
    Cell Significance Index: 41.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4060
    Cell Significance Index: 17.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4008
    Cell Significance Index: 26.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3991
    Cell Significance Index: 25.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3859
    Cell Significance Index: 27.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3743
    Cell Significance Index: 8.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3580
    Cell Significance Index: 24.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3140
    Cell Significance Index: 11.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2977
    Cell Significance Index: 50.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2766
    Cell Significance Index: 14.3700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2171
    Cell Significance Index: 6.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1722
    Cell Significance Index: 4.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1644
    Cell Significance Index: 10.3600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1284
    Cell Significance Index: 2.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1050
    Cell Significance Index: 2.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0885
    Cell Significance Index: 1.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0880
    Cell Significance Index: 135.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0874
    Cell Significance Index: 118.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0734
    Cell Significance Index: 135.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0418
    Cell Significance Index: 78.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0225
    Cell Significance Index: 4.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0142
    Cell Significance Index: 9.0500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0096
    Cell Significance Index: 0.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0041
    Cell Significance Index: 3.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0069
    Cell Significance Index: -5.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0097
    Cell Significance Index: -7.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0150
    Cell Significance Index: -9.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0234
    Cell Significance Index: -1.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0518
    Cell Significance Index: -23.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0611
    Cell Significance Index: -6.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0692
    Cell Significance Index: -39.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1099
    Cell Significance Index: -3.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1215
    Cell Significance Index: -25.5900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1574
    Cell Significance Index: -2.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1678
    Cell Significance Index: -19.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1909
    Cell Significance Index: -54.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2025
    Cell Significance Index: -29.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2083
    Cell Significance Index: -4.3600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2170
    Cell Significance Index: -6.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2633
    Cell Significance Index: -30.1700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2869
    Cell Significance Index: -6.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3196
    Cell Significance Index: -11.2300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3254
    Cell Significance Index: -37.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3476
    Cell Significance Index: -8.8800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4459
    Cell Significance Index: -10.8800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4697
    Cell Significance Index: -4.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5372
    Cell Significance Index: -11.4400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5601
    Cell Significance Index: -12.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5749
    Cell Significance Index: -59.8600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.5882
    Cell Significance Index: -9.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5973
    Cell Significance Index: -19.1300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6417
    Cell Significance Index: -50.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6443
    Cell Significance Index: -8.7900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.6500
    Cell Significance Index: -5.1900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6604
    Cell Significance Index: -11.1300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7453
    Cell Significance Index: -17.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7619
    Cell Significance Index: -46.7100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.8204
    Cell Significance Index: -10.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8299
    Cell Significance Index: -22.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8415
    Cell Significance Index: -43.8300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.8517
    Cell Significance Index: -15.0500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.9666
    Cell Significance Index: -14.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9757
    Cell Significance Index: -24.3900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9839
    Cell Significance Index: -28.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.9996
    Cell Significance Index: -45.3100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.0245
    Cell Significance Index: -6.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PCMT1 is a cytosolic enzyme that catalyzes the O-methylation of L-isoaspartyl residues, a process essential for protein stability and function. The gene is highly expressed in various cell types, including erythroid progenitor cells, GABAergic amacrine cells, and peripheral nervous system neurons. Notably, PCMT1 is also expressed in placental villous trophoblasts and oocytes, highlighting its importance in embryonic development and reproductive health. **Pathways and Functions:** PCMT1 is involved in several key pathways, including: 1. **Protein repair:** PCMT1 plays a crucial role in the repair of damaged proteins by removing isoaspartyl residues, which can destabilize proteins and lead to cellular dysfunction. 2. **Protein metabolism:** The methylation of isoaspartyl residues by PCMT1 regulates protein degradation and turnover, influencing cellular homeostasis. 3. **Cell signaling:** PCMT1 is involved in the regulation of cell signaling pathways, including those involved in cell growth, differentiation, and survival. 4. **Extracellular vesicle formation:** PCMT1 has been implicated in the formation of extracellular vesicles, which play a critical role in intercellular communication and disease progression. **Clinical Significance:** Dysregulation of PCMT1 has been linked to various diseases, including: 1. **Neurodegenerative disorders:** PCMT1 mutations have been associated with neurodegenerative diseases, such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS). 2. **Cancer:** PCMT1 expression has been linked to cancer progression and metastasis, suggesting its potential as a therapeutic target. 3. **Reproductive disorders:** PCMT1 has been implicated in reproductive health, with dysregulation contributing to infertility and pregnancy complications. In conclusion, PCMT1 is a vital enzyme involved in protein modification, repair, and metabolism. Its dysregulation has far-reaching consequences, contributing to various diseases. Further research is necessary to fully elucidate the role of PCMT1 in human health and disease, with potential therapeutic implications for the treatment of neurodegenerative, cancerous, and reproductive disorders.

Genular Protein ID: 3211634273

Symbol: PIMT_HUMAN

Name: L-isoaspartyl protein carboxyl methyltransferase

UniProtKB Accession Codes:

P22061 A8K109 J3KP72 Q14661 Q16556 Q5VYC1 Q5VYC2 Q93061 Q96II9 Q99625 Q9BQV7 Q9BQV8 Q9NP03

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 15 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 4 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2684970

Title: Sequence of the D-aspartyl/L-isoaspartyl protein methyltransferase from human erythrocytes. Common sequence motifs for protein, DNA, RNA, and small molecule S-adenosylmethionine-dependent methyltransferases.

PubMed ID: 2684970

DOI: 10.1016/s0021-9258(19)47228-1

PubMed ID: 1339271

Title: Alternative splicing of the human isoaspartyl protein carboxyl methyltransferase RNA leads to the generation of a C-terminal -RDEL sequence in isozyme II.

PubMed ID: 1339271

DOI: 10.1016/s0006-291x(05)80987-8

PubMed ID: 7592526

Title: Characterization of three cDNAs encoding two isozymes of an isoaspartyl protein carboxyl methyltransferase from human erythroid leukemia cells.

PubMed ID: 7592526

DOI: 10.1093/oxfordjournals.jbchem.a124763

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8914929

Title: Structure of the human gene encoding the protein repair L-isoaspartyl (D-aspartyl) O-methyltransferase.

PubMed ID: 8914929

DOI: 10.1006/abbi.1996.0513

PubMed ID: 3167043

Title: Purification of homologous protein carboxyl methyltransferase isozymes from human and bovine erythrocytes.

PubMed ID: 3167043

DOI: 10.1021/bi00414a042

PubMed ID: 8074695

Title: Amino acid polymorphisms of the human L-isoaspartyl/D-aspartyl methyltransferase involved in protein repair.

PubMed ID: 8074695

DOI: 10.1006/bbrc.1994.2209

PubMed ID: 1998518

Title: Distinct C-terminal sequences of isozymes I and II of the human erythrocyte L-isoaspartyl/D-aspartyl protein methyltransferase.

PubMed ID: 1998518

DOI: 10.1016/s0006-291x(05)81242-2

PubMed ID: 6469980

Title: Synthetic peptide substrates for the erythrocyte protein carboxyl methyltransferase. Detection of a new site of methylation at isomerized L-aspartyl residues.

PubMed ID: 6469980

DOI: 10.1016/s0021-9258(18)90571-5

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 10496068

Title: Polymorphic forms of the protein L-isoaspartate (D-aspartate) O-methyltransferase involved in the repair of age-damaged proteins.

PubMed ID: 10496068

DOI: 10.1007/s100380050161

PubMed ID: 11792715

Title: Crystal structure of human L-isoaspartyl methyltransferase.

PubMed ID: 11792715

DOI: 10.1074/jbc.m200229200

PubMed ID: 11847284

Title: Crystal structure of human L-isoaspartyl-O-methyl-transferase with S-adenosyl homocysteine at 1.6-A resolution and modeling of an isoaspartyl-containing peptide at the active site.

PubMed ID: 11847284

DOI: 10.1110/ps.37802

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 227
  • Mass: 24636
  • Checksum: 4EB1122379C8040A
  • Sequence:
    • MAWKSGGASH SELIHNLRKN GIIKTDKVFE VMLATDRSHY AKCNPYMDSP QSIGFQATIS 
APHMHAYALE LLFDQLHEGA KALDVGSGSG ILTACFARMV GCTGKVIGID HIKELVDDSV 
NNVRKDDPTL LSSGRVQLVV GDGRMGYAEE APYDAIHVGA AAPVVPQALI DQLKPGGRLI 
LPVGPAGGNQ MLEQYDKLQD GSIKMKPLMG VIYVPLTDKE KQWSRWK

Genular Protein ID: 3161816856

Symbol: A0A3F2YNX8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A3F2YNX8

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 4 RuleBase 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 250
  • Mass: 26361
  • Checksum: 95F899BFEEEF0443
  • Sequence:
    • MPGARSGGSG GDGSNSGSYS GDASGAVTVW EVVSLLGKLL GTVVALKVVL YLLRVCLAMA 
WKSGGASHSE LIHNLRSFQA TISAPHMHAY ALELLFDQLH EGAKALDVGS GSGILTACFA 
RMVGCTGKVI GIDHIKELVD DSVNNVRKDD PTLLSSGRVQ LVVGDGRMGY AEEAPYDAIH 
VGAAAPVVPQ ALIDQLKPGG RLILPVGPAG GNQMLEQYDK LQDGSIKMKP LMGVIYVPLT 
DKEKQWSRWK

Genular Protein ID: 3593269537

Symbol: F6S8N6_HUMAN

Name: N/A

UniProtKB Accession Codes:

F6S8N6

Database IDs:

ARBA 9 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 4 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 250
  • Mass: 26627
  • Checksum: A9CF3295AA1A5F91
  • Sequence:
    • MPGARSGGSG GDGSNSGSYS GDASGAVTVW EVVSLLGKLL GTVVALKVVL YLLRVCLAMA 
WKSGGASHSE LIHNLRKNGI IKTDKVFEVM LATDRSHYAK CNPYMDSPQS IGFQATISAP 
HMVGCTGKVI GIDHIKELVD DSVNNVRKDD PTLLSSGRVQ LVVGDGRMGY AEEAPYDAIH 
VGAAAPVVPQ ALIDQLKPGG RLILPVGPAG GNQMLEQYDK LQDGSIKMKP LMGVIYVPLT 
DKEKQWSRWK

Genular Protein ID: 3293805285

Symbol: B7Z972_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z972

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 4 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 4 Gene3D 1 IntAct 1 InterPro 2 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 ProteomicsDB 1 RefSeq 1 Rhea 4 RuleBase 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 192
  • Mass: 20683
  • Checksum: 7FE654080BBF8CA0
  • Sequence:
    • MAWKSGGASH SELIHNLRSF QATISAPHMH AYALELLFDQ LHEGAKALDV GSGSGILTAC 
FARMVGCTGK VIGIDHIKEL VDDSVNNVRK DDPTLLSSGR VQLVVGDGRM GYAEEAPYDA 
IHVGAAAPVV PQALIDQLKP GGRLILPVGP AGGNQMLEQY DKLQDGSIKM KPLMGVIYVP 
LTDKEKQWSR WK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.