Details for: COMMD2

Gene ID: 51122

Symbol: COMMD2

Ensembl ID: ENSG00000114744

Description: COMM domain containing 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 220.2575
    Cell Significance Index: -34.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 124.4661
    Cell Significance Index: -31.5700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 85.1079
    Cell Significance Index: -35.0600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 80.4664
    Cell Significance Index: -37.9900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 77.4633
    Cell Significance Index: -31.4700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 70.6086
    Cell Significance Index: -36.3200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 56.7194
    Cell Significance Index: -38.0600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.0089
    Cell Significance Index: -31.5200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.2525
    Cell Significance Index: -37.3000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.0177
    Cell Significance Index: -29.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.6248
    Cell Significance Index: -37.9800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.6934
    Cell Significance Index: -23.6300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.3505
    Cell Significance Index: -11.7100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4998
    Cell Significance Index: 90.0400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1179
    Cell Significance Index: 23.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7770
    Cell Significance Index: 106.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7522
    Cell Significance Index: 47.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6820
    Cell Significance Index: 47.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6719
    Cell Significance Index: 366.9200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6549
    Cell Significance Index: 7.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6277
    Cell Significance Index: 125.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6080
    Cell Significance Index: 28.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5629
    Cell Significance Index: 248.8900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5423
    Cell Significance Index: 69.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5137
    Cell Significance Index: 60.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4893
    Cell Significance Index: 36.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4820
    Cell Significance Index: 13.1200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4580
    Cell Significance Index: 5.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4577
    Cell Significance Index: 87.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4497
    Cell Significance Index: 89.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3636
    Cell Significance Index: 44.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3618
    Cell Significance Index: 65.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3549
    Cell Significance Index: 25.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3420
    Cell Significance Index: 44.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3068
    Cell Significance Index: 10.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3014
    Cell Significance Index: 14.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2631
    Cell Significance Index: 16.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2389
    Cell Significance Index: 85.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2251
    Cell Significance Index: 14.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2138
    Cell Significance Index: 12.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1780
    Cell Significance Index: 4.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1721
    Cell Significance Index: 4.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1711
    Cell Significance Index: 4.9300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.1692
    Cell Significance Index: 2.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1646
    Cell Significance Index: 16.2800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1459
    Cell Significance Index: 1.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1352
    Cell Significance Index: 3.6100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1004
    Cell Significance Index: 90.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0916
    Cell Significance Index: 15.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0798
    Cell Significance Index: 55.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0135
    Cell Significance Index: 0.6100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0108
    Cell Significance Index: 0.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0077
    Cell Significance Index: 14.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0075
    Cell Significance Index: 14.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0053
    Cell Significance Index: -3.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0066
    Cell Significance Index: -4.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0068
    Cell Significance Index: -4.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0076
    Cell Significance Index: -11.6900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0083
    Cell Significance Index: -5.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0083
    Cell Significance Index: -0.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0097
    Cell Significance Index: -0.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0151
    Cell Significance Index: -0.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0158
    Cell Significance Index: -11.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0221
    Cell Significance Index: -30.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0371
    Cell Significance Index: -16.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0380
    Cell Significance Index: -5.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0389
    Cell Significance Index: -21.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0406
    Cell Significance Index: -4.1500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0565
    Cell Significance Index: -1.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0764
    Cell Significance Index: -3.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0790
    Cell Significance Index: -16.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0850
    Cell Significance Index: -9.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0924
    Cell Significance Index: -26.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1338
    Cell Significance Index: -15.5900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1487
    Cell Significance Index: -16.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1546
    Cell Significance Index: -4.3200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1622
    Cell Significance Index: -0.9800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1707
    Cell Significance Index: -4.3600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2042
    Cell Significance Index: -1.7200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2597
    Cell Significance Index: -5.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2604
    Cell Significance Index: -7.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2910
    Cell Significance Index: -6.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3361
    Cell Significance Index: -5.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3499
    Cell Significance Index: -36.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3854
    Cell Significance Index: -30.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4002
    Cell Significance Index: -26.9100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4088
    Cell Significance Index: -5.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4158
    Cell Significance Index: -21.6600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4163
    Cell Significance Index: -4.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4665
    Cell Significance Index: -28.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4865
    Cell Significance Index: -12.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5064
    Cell Significance Index: -13.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5103
    Cell Significance Index: -16.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5174
    Cell Significance Index: -22.8900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5225
    Cell Significance Index: -12.5300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5590
    Cell Significance Index: -6.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5620
    Cell Significance Index: -18.4000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6043
    Cell Significance Index: -17.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6185
    Cell Significance Index: -23.4200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6287
    Cell Significance Index: -11.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Domain Structure:** The COMMD2 protein possesses a unique COMM domain, which enables it to interact with various partners and regulate cellular processes. 2. **Cellular Expression:** COMMD2 is expressed in a wide range of cell types, including hematopoietic cells, smooth muscle fibers, and epithelial cells. 3. **Protein Interaction:** COMMD2 interacts with multiple proteins, including those involved in protein modification, signaling, and cellular differentiation. **Pathways and Functions:** 1. **Neddylation Pathway:** COMMD2 is involved in the regulation of the neddylation pathway, which is crucial for protein degradation and cellular homeostasis. 2. **Protein Binding:** COMMD2 interacts with proteins involved in protein modification, signaling, and cellular differentiation, influencing the fate of immune cells and tissue homeostasis. 3. **Cellular Differentiation:** COMMD2 plays a role in regulating cellular differentiation, particularly in hematopoietic cells, influencing the development of immune cells and tissue homeostasis. 4. **Inflammation Regulation:** COMMD2 modulates inflammation by regulating the activity of immune cells and the production of inflammatory cytokines. **Clinical Significance:** 1. **Immune System Disorders:** Dysregulation of COMMD2 has been implicated in various immune system disorders, including autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** COMMD2 is overexpressed in certain types of cancer, including leukemia and lymphoma, suggesting its potential role in tumorigenesis. 3. **Neurological Disorders:** COMMD2 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, highlighting its potential role in neurodegenerative diseases. 4. **Infectious Diseases:** COMMD2 plays a role in regulating the immune response to infections, and its dysregulation may contribute to the development of infectious diseases. In conclusion, COMMD2 is a multifunctional gene that plays a critical role in regulating immune responses, cellular differentiation, and protein modification. Its dysregulation has been implicated in various immune system disorders, cancer, neurological disorders, and infectious diseases, highlighting the importance of further research into its functions and clinical significance.

Genular Protein ID: 2311305855

Symbol: COMD2_HUMAN

Name: COMM domain-containing protein 2

UniProtKB Accession Codes:

Q86X83 Q561V4 Q9H3L5 Q9Y5V1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 4 Ensembl 1 ExpressionAtlas 1 GO 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15799966

Title: COMMD proteins, a novel family of structural and functional homologs of MURR1.

PubMed ID: 15799966

DOI: 10.1074/jbc.m501928200

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21778237

Title: COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.

PubMed ID: 21778237

DOI: 10.1074/jbc.m111.278408

PubMed ID: 23637203

Title: Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel.

PubMed ID: 23637203

DOI: 10.1152/ajprenal.00158.2013

PubMed ID: 23563313

Title: CCDC22 deficiency in humans blunts activation of proinflammatory NF-kappaB signaling.

PubMed ID: 23563313

DOI: 10.1172/jci66466

PubMed ID: 25355947

Title: COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.

PubMed ID: 25355947

DOI: 10.1091/mbc.e14-06-1073

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28892079

Title: Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.

PubMed ID: 28892079

DOI: 10.1038/ncb3610

Sequence Information:

  • Length: 199
  • Mass: 22745
  • Checksum: ECB4B7C26FCEA0F2
  • Sequence:
    • MLLELSEEHK EHLAFLPQVD SAVVAEFGRI AVEFLRRGAN PKIYEGAARK LNVSSDTVQH 
GVEGLTYLLT ESSKLMISEL DFQDSVFVLG FSEELNKLLL QLYLDNRKEI RTILSELAPS 
LPSYHNLEWR LDVQLASRSL RQQIKPAVTI KLHLNQNGDH NTKVLQTDPA TLLHLVQQLE 
QALEEMKTNH CRRVVRNIK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.