Details for: RLIM

Gene ID: 51132

Symbol: RLIM

Ensembl ID: ENSG00000131263

Description: ring finger protein, LIM domain interacting

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 266.5463
    Cell Significance Index: -41.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 161.9400
    Cell Significance Index: -41.0800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 79.1617
    Cell Significance Index: -32.1600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 73.1747
    Cell Significance Index: -37.6400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 63.7311
    Cell Significance Index: -42.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.7133
    Cell Significance Index: -42.8000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.7368
    Cell Significance Index: -32.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.6910
    Cell Significance Index: -39.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.9502
    Cell Significance Index: -43.2100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.7130
    Cell Significance Index: -23.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6697
    Cell Significance Index: -10.2200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 4.0216
    Cell Significance Index: 66.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.4128
    Cell Significance Index: 238.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.9225
    Cell Significance Index: 224.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3024
    Cell Significance Index: 17.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1229
    Cell Significance Index: 1013.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8309
    Cell Significance Index: 166.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7483
    Cell Significance Index: 81.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7225
    Cell Significance Index: 117.5100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6183
    Cell Significance Index: 37.1200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.6113
    Cell Significance Index: 69.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5384
    Cell Significance Index: 14.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5135
    Cell Significance Index: 63.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4265
    Cell Significance Index: 152.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4235
    Cell Significance Index: 76.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3826
    Cell Significance Index: 21.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3693
    Cell Significance Index: 10.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3405
    Cell Significance Index: 185.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3239
    Cell Significance Index: 64.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2462
    Cell Significance Index: 170.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2396
    Cell Significance Index: 32.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2148
    Cell Significance Index: 94.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1487
    Cell Significance Index: 6.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1251
    Cell Significance Index: 5.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1241
    Cell Significance Index: 8.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1148
    Cell Significance Index: 14.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0984
    Cell Significance Index: 2.8200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0760
    Cell Significance Index: 1.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0576
    Cell Significance Index: 108.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0549
    Cell Significance Index: 1.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0230
    Cell Significance Index: 3.9300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0072
    Cell Significance Index: 0.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0060
    Cell Significance Index: 0.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0014
    Cell Significance Index: 0.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0049
    Cell Significance Index: -7.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0060
    Cell Significance Index: -0.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0111
    Cell Significance Index: -20.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0152
    Cell Significance Index: -9.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0185
    Cell Significance Index: -13.6900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0233
    Cell Significance Index: -17.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0265
    Cell Significance Index: -3.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0299
    Cell Significance Index: -40.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0309
    Cell Significance Index: -1.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0395
    Cell Significance Index: -17.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0396
    Cell Significance Index: -22.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0468
    Cell Significance Index: -35.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0769
    Cell Significance Index: -7.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0849
    Cell Significance Index: -1.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0877
    Cell Significance Index: -12.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0951
    Cell Significance Index: -10.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0973
    Cell Significance Index: -12.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1040
    Cell Significance Index: -29.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1102
    Cell Significance Index: -23.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1113
    Cell Significance Index: -8.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1143
    Cell Significance Index: -5.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1589
    Cell Significance Index: -4.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1604
    Cell Significance Index: -10.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1652
    Cell Significance Index: -12.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1875
    Cell Significance Index: -8.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1985
    Cell Significance Index: -13.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1986
    Cell Significance Index: -3.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2693
    Cell Significance Index: -5.7400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2822
    Cell Significance Index: -4.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3165
    Cell Significance Index: -8.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3190
    Cell Significance Index: -8.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3470
    Cell Significance Index: -18.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3665
    Cell Significance Index: -38.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3909
    Cell Significance Index: -17.2900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3963
    Cell Significance Index: -8.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3984
    Cell Significance Index: -31.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4714
    Cell Significance Index: -17.8500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4773
    Cell Significance Index: -12.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5145
    Cell Significance Index: -10.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5624
    Cell Significance Index: -34.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6031
    Cell Significance Index: -19.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6234
    Cell Significance Index: -17.7900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.6285
    Cell Significance Index: -5.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6381
    Cell Significance Index: -22.1800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6804
    Cell Significance Index: -7.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6897
    Cell Significance Index: -36.2100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7408
    Cell Significance Index: -21.8200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7547
    Cell Significance Index: -4.5600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8337
    Cell Significance Index: -8.6300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.8464
    Cell Significance Index: -16.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8611
    Cell Significance Index: -25.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8654
    Cell Significance Index: -43.7300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.9077
    Cell Significance Index: -21.7700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.9432
    Cell Significance Index: -38.6500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.9553
    Cell Significance Index: -13.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9566
    Cell Significance Index: -31.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RLIM is a member of the RING finger protein family, characterized by its ability to interact with LIM domains, a conserved protein motif involved in protein-protein interactions. The gene is primarily expressed in hematopoietic cells, including erythroblasts, mast cells, and T cells. Its expression is also detected in non-hematopoietic cells, such as goblet cells and bronchial epithelial cells, indicating a broader role in immune system regulation. **Pathways and Functions:** RLIM is involved in several key immune-related pathways, including: 1. **Adaptive Immune System:** RLIM regulates the development and function of T cells, including CD8+ and CD4+ T cells, by modulating the ubiquitination and degradation of key transcription factors and signaling molecules. 2. **Antigen Processing and Presentation:** RLIM interacts with major histocompatibility complex (MHC) class I molecules, influencing the processing and presentation of antigens to T cells. 3. **Cytosol:** RLIM regulates the ubiquitination and degradation of cytosolic proteins involved in immune signaling, including those involved in the NF-κB and MAPK pathways. 4. **Metal Ion Binding:** The gene's ability to bind metal ions suggests a role in protein-protein interactions and regulation of immune cell function. **Clinical Significance:** RLIM's dysregulation has been implicated in various immune-related disorders, including: 1. **Autoimmune Diseases:** Altered expression of RLIM has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where immune cell dysfunction contributes to disease pathogenesis. 2. **Cancer:** RLIM's role in regulating immune cell function and tumor cell evasion highlights its potential as a therapeutic target in cancer immunotherapy. 3. **Immunodeficiency Disorders:** Mutations in the RLIM gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID), where impaired immune cell function leads to recurrent infections and increased susceptibility to infections. In conclusion, RLIM plays a critical role in regulating the immune system, and its dysregulation has significant implications for immune-related disorders. Further research is needed to fully elucidate the mechanisms by which RLIM regulates immune cell function and to explore its potential as a therapeutic target in autoimmune and immune-related diseases.

Genular Protein ID: 3904245330

Symbol: RNF12_HUMAN

Name: E3 ubiquitin-protein ligase RLIM

UniProtKB Accession Codes:

Q9NVW2 B2RBQ1 D3DTE0 Q96D38 Q9Y598

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 8 Ensembl 2 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 11013082

Title: Functional characterization of the gene encoding RLIM, the corepressor of LIM homeodomain transcription factors.

PubMed ID: 11013082

DOI: 10.1006/geno.2000.6311

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19117995

Title: Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer.

PubMed ID: 19117995

DOI: 10.1158/0008-5472.can-08-1630

PubMed ID: 19945382

Title: RNF12 is an X-encoded dose-dependent activator of X chromosome inactivation.

PubMed ID: 19945382

DOI: 10.1016/j.cell.2009.10.034

PubMed ID: 19164295

Title: Ubiquitin ligase RLIM modulates telomere length homeostasis through a proteolysis of TRF1.

PubMed ID: 19164295

DOI: 10.1074/jbc.m806702200

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25735484

Title: Syndromic X-linked intellectual disability segregating with a missense variant in RLIM.

PubMed ID: 25735484

DOI: 10.1038/ejhg.2015.30

PubMed ID: 25787250

Title: Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.

PubMed ID: 25787250

DOI: 10.1073/pnas.1503696112

PubMed ID: 25644381

Title: X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes.

PubMed ID: 25644381

DOI: 10.1038/mp.2014.193

Sequence Information:

  • Length: 624
  • Mass: 68549
  • Checksum: 4D583FA6872B51D3
  • Sequence:
    • MENSDSNDKG SGDQSAAQRR SQMDRLDREE AFYQFVNNLS EEDYRLMRDN NLLGTPGEST 
EEELLRRLQQ IKEGPPPQNS DENRGGDSSD DVSNGDSIID WLNSVRQTGN TTRSGQRGNQ 
SWRAVSRTNP NSGDFRFSLE INVNRNNGSQ NSENENEPSA RRSSGENVEN NSQRQVENPR 
SESTSARPSR SERNSTEALT EVPPTRGQRR ARSRSPDHRR TRARAERSRS PLHPMSEIPR 
RSHHSISSQT FEHPLVNETE GSSRTRHHVT LRQQISGPEL LSRGLFAASG TRNASQGAGS 
SDTAASGEST GSGQRPPTIV LDLQVRRVRP GEYRQRDSIA SRTRSRSQTP NNTVTYESER 
GGFRRTFSRS ERAGVRTYVS TIRIPIRRIL NTGLSETTSV AIQTMLRQIM TGFGELSYFM 
YSDSDSEPTG SVSNRNMERA ESRSGRGGSG GGSSSGSSSS SSSSSSSSSS SSSSSSPSSS 
SGGESSETSS DLFEGSNEGS SSSGSSGARR EGRHRAPVTF DESGSLPFLS LAQFFLLNED 
DDDQPRGLTK EQIDNLAMRS FGENDALKTC SVCITEYTEG NKLRKLPCSH EYHVHCIDRW 
LSENSTCPIC RRAVLASGNR ESVV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.