Details for: DYNC1LI1

Gene ID: 51143

Symbol: DYNC1LI1

Ensembl ID: ENSG00000144635

Description: dynein cytoplasmic 1 light intermediate chain 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 262.4317
    Cell Significance Index: -40.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 174.9701
    Cell Significance Index: -44.3800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 107.0282
    Cell Significance Index: -44.0900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 103.2888
    Cell Significance Index: -48.7700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 97.7952
    Cell Significance Index: -39.7300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 87.8913
    Cell Significance Index: -45.2100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 72.8441
    Cell Significance Index: -48.8800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.7914
    Cell Significance Index: -39.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.8011
    Cell Significance Index: -47.8400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.1347
    Cell Significance Index: -43.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.4092
    Cell Significance Index: -48.9700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.5878
    Cell Significance Index: -32.5200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.0463
    Cell Significance Index: -17.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5480
    Cell Significance Index: 310.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.3436
    Cell Significance Index: 84.6800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.2185
    Cell Significance Index: 14.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1499
    Cell Significance Index: 69.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0395
    Cell Significance Index: 63.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7738
    Cell Significance Index: 277.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7267
    Cell Significance Index: 321.3000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7132
    Cell Significance Index: 9.7300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.7036
    Cell Significance Index: 5.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6943
    Cell Significance Index: 95.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6852
    Cell Significance Index: 38.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6189
    Cell Significance Index: 428.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5928
    Cell Significance Index: 323.7200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5625
    Cell Significance Index: 13.4900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5579
    Cell Significance Index: 38.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5408
    Cell Significance Index: 107.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4754
    Cell Significance Index: 58.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4616
    Cell Significance Index: 83.2200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4612
    Cell Significance Index: 5.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4232
    Cell Significance Index: 29.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4130
    Cell Significance Index: 26.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3896
    Cell Significance Index: 29.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3653
    Cell Significance Index: 17.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2821
    Cell Significance Index: 36.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2146
    Cell Significance Index: 4.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1815
    Cell Significance Index: 9.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1771
    Cell Significance Index: 33.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1583
    Cell Significance Index: 4.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1357
    Cell Significance Index: 23.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1190
    Cell Significance Index: 5.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1115
    Cell Significance Index: 13.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1036
    Cell Significance Index: 13.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0534
    Cell Significance Index: 3.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0399
    Cell Significance Index: 36.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0232
    Cell Significance Index: 43.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0180
    Cell Significance Index: 24.4200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0140
    Cell Significance Index: 0.2400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0140
    Cell Significance Index: 0.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0115
    Cell Significance Index: 1.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0086
    Cell Significance Index: 0.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0040
    Cell Significance Index: 2.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0023
    Cell Significance Index: -3.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0081
    Cell Significance Index: -14.9800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0103
    Cell Significance Index: -7.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0187
    Cell Significance Index: -11.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0227
    Cell Significance Index: -16.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0261
    Cell Significance Index: -11.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0318
    Cell Significance Index: -24.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0348
    Cell Significance Index: -0.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0354
    Cell Significance Index: -0.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0404
    Cell Significance Index: -2.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0517
    Cell Significance Index: -7.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0524
    Cell Significance Index: -29.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0867
    Cell Significance Index: -8.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0924
    Cell Significance Index: -2.6500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0982
    Cell Significance Index: -2.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1103
    Cell Significance Index: -5.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1180
    Cell Significance Index: -24.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1219
    Cell Significance Index: -6.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1431
    Cell Significance Index: -16.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1463
    Cell Significance Index: -42.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1514
    Cell Significance Index: -4.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1696
    Cell Significance Index: -5.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1711
    Cell Significance Index: -19.6000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1869
    Cell Significance Index: -21.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2220
    Cell Significance Index: -14.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2506
    Cell Significance Index: -11.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2974
    Cell Significance Index: -11.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3023
    Cell Significance Index: -8.7100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3764
    Cell Significance Index: -8.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3852
    Cell Significance Index: -7.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4379
    Cell Significance Index: -45.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4539
    Cell Significance Index: -35.9500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4782
    Cell Significance Index: -7.0600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5702
    Cell Significance Index: -4.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5747
    Cell Significance Index: -12.0300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6092
    Cell Significance Index: -11.8900
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.6165
    Cell Significance Index: -4.6600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6393
    Cell Significance Index: -14.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6585
    Cell Significance Index: -17.3200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6658
    Cell Significance Index: -14.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6790
    Cell Significance Index: -41.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6807
    Cell Significance Index: -17.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7147
    Cell Significance Index: -20.9900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.7473
    Cell Significance Index: -7.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8649
    Cell Significance Index: -18.4200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.8677
    Cell Significance Index: -10.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Dynein Complex Component**: DYNC1LI1 is a light intermediate chain of the cytoplasmic dynein complex, which is a heterotetrameric motor protein composed of heavy chains and light chains. 2. **Microtubule-Based Movement**: The cytoplasmic dynein complex, including DYNC1LI1, is responsible for microtubule-based movement, which is essential for maintaining cellular organization and responding to cellular stress. 3. **Cell Division and Cytokinesis**: DYNC1LI1 plays a crucial role in regulating cell cycle progression, particularly during mitosis, and is involved in the separation of sister chromatids. 4. **Autophagy and Degradation**: DYNC1LI1 is also implicated in autophagy, a process by which cells degrade and recycle damaged or dysfunctional components. **Pathways and Functions** 1. **Adaptive Immune Response**: DYNC1LI1 is expressed in immune cells and plays a role in regulating the adaptive immune response, particularly during the removal of pathogens and presentation of antigens to T-cells. 2. **Autophagy and Degradation**: DYNC1LI1 is involved in the regulation of autophagy, a process by which cells degrade and recycle damaged or dysfunctional components, such as proteins and organelles. 3. **Cell Cycle Regulation**: DYNC1LI1 regulates cell cycle progression, particularly during mitosis, and is involved in the separation of sister chromatids. 4. **Intracellular Transport**: DYNC1LI1 is involved in the regulation of intracellular transport, including the movement of vesicles and organelles along microtubules. **Clinical Significance** 1. **Immune System Disorders**: Abnormalities in DYNC1LI1 expression or function may contribute to immune system disorders, such as autoimmune diseases or immunodeficiency. 2. **Cancer**: DYNC1LI1 is overexpressed in certain types of cancer, including leukemia and lymphoma, and may contribute to tumorigenesis and cancer progression. 3. **Neurological Disorders**: DYNC1LI1 has been implicated in neurological disorders, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), and may contribute to the development of these conditions. 4. **Pediatric Disorders**: DYNC1LI1 has been associated with certain pediatric disorders, such as polycythemia vera and myeloproliferative neoplasms, and may contribute to the development of these conditions. In conclusion, DYNC1LI1 is a crucial gene that plays a significant role in various cellular processes, including adaptive immune response, autophagy, and cell cycle regulation. Abnormalities in DYNC1LI1 expression or function may contribute to immune system disorders, cancer, and neurological disorders, highlighting the importance of further research into the function and regulation of this gene.

Genular Protein ID: 3320736074

Symbol: DC1L1_HUMAN

Name: Cytoplasmic dynein 1 light intermediate chain 1

UniProtKB Accession Codes:

Q9Y6G9 A2RRG7 Q53HC8 Q53HK7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 1 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19229290

Title: Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint.

PubMed ID: 19229290

DOI: 10.1038/emboj.2009.38

PubMed ID: 20006841

Title: Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit.

PubMed ID: 20006841

DOI: 10.1016/j.chom.2009.11.006

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20026645

Title: Rab11-FIP3 links the Rab11 GTPase and cytoplasmic dynein to mediate transport to the endosomal-recycling compartment.

PubMed ID: 20026645

DOI: 10.1242/jcs.052670

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 523
  • Mass: 56579
  • Checksum: 29159F560E382095
  • Sequence:
    • MAAVGRVGSF GSSPPGLSST YTGGPLGNEI ASGNGGAAAG DDEDGQNLWS CILSEVSTRS 
RSKLPAGKNV LLLGEDGAGK TSLIRKIQGI EEYKKGRGLE YLYLNVHDED RDDQTRCNVW 
ILDGDLYHKG LLKFSLDAVS LKDTLVMLVV DMSKPWTALD SLQKWASVVR EHVDKLKIPP 
EEMKQMEQKL IRDFQEYVEP GEDFPASPQR RNTASQEDKD DSVVLPLGAD TLTHNLGIPV 
LVVCTKCDAI SVLEKEHDYR DEHFDFIQSH IRKFCLQYGA ALIYTSVKEN KNIDLVYKYI 
VQKLYGFPYK IPAVVVEKDA VFIPAGWDND KKIGILHENF QTLKAEDNFE DIITKPPVRK 
FVHEKEIMAE DDQVFLMKLQ SLLAKQPPTA AGRPVDASPR VPGGSPRTPN RSVSSNVASV 
SPIPAGSKKI DPNMKAGATS EGVLANFFNS LLSKKTGSPG GPGVSGGSPA GGAGGGSSGL 
PPSTKKSGQK PVLDVHAELD RITRKPVTVS PTTPTSPTEG EAS

Genular Protein ID: 1963334066

Symbol: E9PHI6_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PHI6

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 407
  • Mass: 43194
  • Checksum: FA324BBE59A730A8
  • Sequence:
    • MAAVGRVGSF GSSPPGLSST YTGGPLGNEI ASGNGGAAAG DDEDGQNLWS CILSEVSTRS 
RSKLPAGKNV LLLVIRDFQE YVEPGEDFPA SPQRRNTASQ EDKDDSVVLP LGADTLTHNL 
GIPVLVVCTK CDAISVLEKE HDYRDEHFDF IQSHIRKFCL QYGAALIYTS VKENKNIDLV 
YKYIVQKLYG FPYKIPAVVV EKDAVFIPAG WDNDKKIGIL HENFQTLKAE DNFEDIITKP 
PVRKFVHEKE IMAEDDQVFL MKLQSLLAKQ PPTAAGRPVD ASPRVPGGSP RTPNRSVSSN 
VASVSPIPAG SKKIDPNMKA GATSEGVLAN FFNSLLSKKT GSPGGPGVSG GSPAGGAGGG 
SSGLPPSTKK SGQKPVLDVH AELDRITRKP VTVSPTTPTS PTEGEAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.