Details for: JPT1

Gene ID: 51155

Symbol: JPT1

Ensembl ID: ENSG00000189159

Description: Jupiter microtubule associated homolog 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 182.8145
    Cell Significance Index: -75.3100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 152.1003
    Cell Significance Index: -71.8100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 134.7434
    Cell Significance Index: -69.3100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 107.0456
    Cell Significance Index: -71.8300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.1775
    Cell Significance Index: -48.7000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.1422
    Cell Significance Index: -49.5800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 6.1888
    Cell Significance Index: 53.1800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.7588
    Cell Significance Index: -10.4200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.6469
    Cell Significance Index: 22.6600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.5858
    Cell Significance Index: 105.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.3175
    Cell Significance Index: 69.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.9748
    Cell Significance Index: 32.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.8279
    Cell Significance Index: 61.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.7483
    Cell Significance Index: 1500.9100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.6822
    Cell Significance Index: 24.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.5889
    Cell Significance Index: 305.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.2756
    Cell Significance Index: 118.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.1668
    Cell Significance Index: 133.1800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.8835
    Cell Significance Index: 65.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8271
    Cell Significance Index: 329.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.7551
    Cell Significance Index: 46.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7150
    Cell Significance Index: 210.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6755
    Cell Significance Index: 36.3000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.3694
    Cell Significance Index: 10.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.2871
    Cell Significance Index: 370.3300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2848
    Cell Significance Index: 17.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.2647
    Cell Significance Index: 94.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2258
    Cell Significance Index: 121.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2217
    Cell Significance Index: 55.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2002
    Cell Significance Index: 56.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1289
    Cell Significance Index: 145.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7008
    Cell Significance Index: 45.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6210
    Cell Significance Index: 274.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5861
    Cell Significance Index: 16.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5102
    Cell Significance Index: 9.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4851
    Cell Significance Index: 97.3200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4111
    Cell Significance Index: 6.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3975
    Cell Significance Index: 10.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3245
    Cell Significance Index: 64.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3075
    Cell Significance Index: 58.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2980
    Cell Significance Index: 40.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2700
    Cell Significance Index: 96.8400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2504
    Cell Significance Index: 17.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2009
    Cell Significance Index: 7.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1660
    Cell Significance Index: 21.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1296
    Cell Significance Index: 2.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0694
    Cell Significance Index: 1.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0307
    Cell Significance Index: 0.8200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0088
    Cell Significance Index: 0.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0081
    Cell Significance Index: 0.4500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0045
    Cell Significance Index: -0.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0140
    Cell Significance Index: -10.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0290
    Cell Significance Index: -54.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0315
    Cell Significance Index: -1.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0368
    Cell Significance Index: -3.7600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0379
    Cell Significance Index: -69.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0429
    Cell Significance Index: -66.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0560
    Cell Significance Index: -76.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0573
    Cell Significance Index: -42.0400
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -0.0756
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0895
    Cell Significance Index: -66.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0961
    Cell Significance Index: -61.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1172
    Cell Significance Index: -66.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1274
    Cell Significance Index: -79.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1468
    Cell Significance Index: -66.6300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1510
    Cell Significance Index: -6.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1707
    Cell Significance Index: -7.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2244
    Cell Significance Index: -11.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2447
    Cell Significance Index: -41.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2495
    Cell Significance Index: -4.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3710
    Cell Significance Index: -42.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3788
    Cell Significance Index: -79.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3969
    Cell Significance Index: -10.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4053
    Cell Significance Index: -47.2400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.4119
    Cell Significance Index: -2.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4209
    Cell Significance Index: -61.1900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.5984
    Cell Significance Index: -5.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6890
    Cell Significance Index: -71.7400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.7246
    Cell Significance Index: -4.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.7709
    Cell Significance Index: -22.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7741
    Cell Significance Index: -61.3100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.8541
    Cell Significance Index: -11.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8886
    Cell Significance Index: -68.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9256
    Cell Significance Index: -58.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1379
    Cell Significance Index: -28.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1530
    Cell Significance Index: -70.6900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2311
    Cell Significance Index: -36.2600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.3115
    Cell Significance Index: -30.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.4114
    Cell Significance Index: -62.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.4986
    Cell Significance Index: -38.5200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.5231
    Cell Significance Index: -10.3200
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -1.5258
    Cell Significance Index: -7.9900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.5330
    Cell Significance Index: -12.2400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.5535
    Cell Significance Index: -16.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.6420
    Cell Significance Index: -47.0700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.6628
    Cell Significance Index: -61.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.6677
    Cell Significance Index: -63.1500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.6860
    Cell Significance Index: -55.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.8483
    Cell Significance Index: -64.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.8600
    Cell Significance Index: -59.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** JPT1 is a microtubule-associated protein that exhibits androgen-regulated expression, indicating its involvement in hormonal signaling pathways. The protein's ability to bind to microtubules and other cellular components suggests its role in maintaining cytoskeletal integrity and cellular organization. Furthermore, JPT1's expression in various cell types, including immune cells, highlights its potential involvement in immune regulation and function. **Pathways and Functions:** JPT1's involvement in microtubule organization and protein binding suggests its role in various cellular processes, including: 1. **Microtubule organization:** JPT1's ability to bind to microtubules may regulate their dynamics, stability, and organization, which are critical for cellular processes such as cell division, transport, and signaling. 2. **Protein binding:** JPT1's capacity to bind to other proteins may modulate their activity, localization, and interactions, which can influence cellular signaling and immune responses. 3. **Cytoskeletal organization:** JPT1's involvement in microtubule organization and protein binding may contribute to the regulation of cytoskeletal dynamics, which is essential for cell shape, movement, and signaling. **Clinical Significance:** JPT1's expression in immune cells and other cell types suggests its potential involvement in various diseases and conditions, including: 1. **Immune disorders:** Dysregulation of JPT1's expression or function may contribute to immune-related disorders, such as autoimmune diseases or immunodeficiencies. 2. **Cancer:** Alterations in JPT1's expression or function may contribute to cancer progression, metastasis, or immune evasion. 3. **Neurological disorders:** JPT1's involvement in microtubule organization and protein binding may contribute to the pathogenesis of neurological disorders, such as neurodegenerative diseases or cognitive disorders. In conclusion, JPT1 is a multifunctional protein that plays a critical role in various cellular processes, including microtubule organization, protein binding, and cytoskeletal organization. Its expression in immune cells and other cell types highlights its potential involvement in immune regulation and function, as well as its clinical significance in various diseases and conditions. Further research is necessary to fully elucidate the mechanisms by which JPT1 regulates cellular processes and its role in human disease.

Genular Protein ID: 3324858762

Symbol: JUPI1_HUMAN

Name: Androgen-regulated protein 2

UniProtKB Accession Codes:

Q9UK76 B2R6K3 Q53FG7 Q7Z2D2 Q7Z2F0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 6 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 6 STRING 1 SignaLink 1 TopDownProteomics 3 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15094197

Title: Cloning, expression and subcellular localization of HN1 and HN1L genes, as well as characterization of their orthologs, defining an evolutionarily conserved gene family.

PubMed ID: 15094197

DOI: 10.1016/j.gene.2004.02.025

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16602700

Title: Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins.

PubMed ID: 16602700

DOI: 10.1021/pr050415p

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21323578

Title: Ubiquitously expressed hematological and neurological expressed 1 downregulates Akt-mediated GSK3beta signaling, and its knockdown results in deregulated G2/M transition in prostate cells.

PubMed ID: 21323578

DOI: 10.1089/dna.2010.1128

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22155408

Title: Androgen regulated HN1 leads proteosomal degradation of androgen receptor (AR) and negatively influences AR mediated transactivation in prostate cells.

PubMed ID: 22155408

DOI: 10.1016/j.mce.2011.11.027

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25450365

Title: MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1.

PubMed ID: 25450365

DOI: 10.1016/j.bbrc.2014.10.049

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25169422

Title: HN1 negatively influences the beta-catenin/E-cadherin interaction, and contributes to migration in prostate cells.

PubMed ID: 25169422

DOI: 10.1002/jcb.24956

Sequence Information:

  • Length: 154
  • Mass: 16015
  • Checksum: 1B443E4C7A28F093
  • Sequence:
    • MTTTTTFKGV DPNSRNSSRV LRPPGGGSNF SLGFDEPTEQ PVRKNKMASN IFGTPEENQA 
SWAKSAGAKS SGGREDLESS GLQRRNSSEA SSGDFLDLKG EGDIHENVDT DLPGSLGQSE 
EKPVPAAPVP SPVAPAPVPS RRNPPGGKSS LVLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.