Details for: ZNF580

Gene ID: 51157

Symbol: ZNF580

Ensembl ID: ENSG00000213015

Description: zinc finger protein 580

Associated with

  • Cellular response to hydrogen peroxide
    (GO:0070301)
  • Chemotaxis
    (GO:0006935)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Inflammatory response
    (GO:0006954)
  • Metal ion binding
    (GO:0046872)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of endothelial cell migration
    (GO:0010595)
  • Positive regulation of endothelial cell proliferation
    (GO:0001938)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of leukocyte chemotaxis
    (GO:0002690)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 143.3024
    Cell Significance Index: -22.2900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 76.5248
    Cell Significance Index: -19.4100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 50.1565
    Cell Significance Index: -23.6800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 46.5118
    Cell Significance Index: -23.9300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 35.4981
    Cell Significance Index: -23.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.8815
    Cell Significance Index: -23.2800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 9.1860
    Cell Significance Index: 147.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.8317
    Cell Significance Index: -20.9800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.2148
    Cell Significance Index: -22.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.0009
    Cell Significance Index: -23.6800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 3.0060
    Cell Significance Index: 25.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.9559
    Cell Significance Index: 204.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.1429
    Cell Significance Index: 249.7300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.8530
    Cell Significance Index: 14.8000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.6788
    Cell Significance Index: 21.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6188
    Cell Significance Index: 97.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4819
    Cell Significance Index: 40.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4495
    Cell Significance Index: 199.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8661
    Cell Significance Index: 40.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8611
    Cell Significance Index: 25.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8427
    Cell Significance Index: 17.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8086
    Cell Significance Index: 28.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7972
    Cell Significance Index: 41.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7845
    Cell Significance Index: 92.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7829
    Cell Significance Index: 427.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7502
    Cell Significance Index: 48.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7247
    Cell Significance Index: 54.0100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6510
    Cell Significance Index: 15.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6499
    Cell Significance Index: 34.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6344
    Cell Significance Index: 572.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6273
    Cell Significance Index: 77.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5818
    Cell Significance Index: 36.6700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5675
    Cell Significance Index: 6.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5650
    Cell Significance Index: 101.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5371
    Cell Significance Index: 69.3900
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.5161
    Cell Significance Index: 2.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.4931
    Cell Significance Index: 141.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4883
    Cell Significance Index: 22.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4830
    Cell Significance Index: 78.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4633
    Cell Significance Index: 32.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4627
    Cell Significance Index: 204.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4040
    Cell Significance Index: 39.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4005
    Cell Significance Index: 18.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3754
    Cell Significance Index: 9.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3714
    Cell Significance Index: 74.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3615
    Cell Significance Index: 46.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3573
    Cell Significance Index: 7.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3474
    Cell Significance Index: 10.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2952
    Cell Significance Index: 56.1800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.1909
    Cell Significance Index: 1.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1878
    Cell Significance Index: 67.3600
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.1850
    Cell Significance Index: 1.5300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1743
    Cell Significance Index: 1.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1608
    Cell Significance Index: 4.3100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1188
    Cell Significance Index: 1.3500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1019
    Cell Significance Index: 2.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0966
    Cell Significance Index: 2.7700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.0889
    Cell Significance Index: 0.5500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0518
    Cell Significance Index: 0.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0514
    Cell Significance Index: 0.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0454
    Cell Significance Index: 2.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0417
    Cell Significance Index: 2.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0236
    Cell Significance Index: 17.8800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0178
    Cell Significance Index: 13.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0127
    Cell Significance Index: 0.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0090
    Cell Significance Index: 6.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0069
    Cell Significance Index: -13.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0114
    Cell Significance Index: -21.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0137
    Cell Significance Index: -21.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0183
    Cell Significance Index: -24.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0193
    Cell Significance Index: -1.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0194
    Cell Significance Index: -14.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0319
    Cell Significance Index: -17.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0334
    Cell Significance Index: -21.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0454
    Cell Significance Index: -7.7600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0470
    Cell Significance Index: -1.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0494
    Cell Significance Index: -22.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0765
    Cell Significance Index: -8.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0786
    Cell Significance Index: -6.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0815
    Cell Significance Index: -16.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1011
    Cell Significance Index: -1.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1124
    Cell Significance Index: -23.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1255
    Cell Significance Index: -4.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1496
    Cell Significance Index: -21.7400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2153
    Cell Significance Index: -3.9800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2170
    Cell Significance Index: -17.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2257
    Cell Significance Index: -23.5000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.2569
    Cell Significance Index: -1.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2894
    Cell Significance Index: -16.2400
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.2901
    Cell Significance Index: -1.3400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3180
    Cell Significance Index: -4.4600
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.3370
    Cell Significance Index: -1.9800
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.3554
    Cell Significance Index: -1.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3657
    Cell Significance Index: -24.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3862
    Cell Significance Index: -23.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4025
    Cell Significance Index: -11.8600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4333
    Cell Significance Index: -6.8800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4420
    Cell Significance Index: -10.6000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4590
    Cell Significance Index: -18.8100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4849
    Cell Significance Index: -5.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZN580 is a member of the zinc finger protein family, characterized by its unique DNA-binding domain that allows it to interact with specific DNA sequences. This protein exhibits a high degree of specificity in its binding, enabling it to regulate gene expression by interacting with RNA polymerase II-specific transcription factors. The expression of ZNF580 is observed in various cell types, including polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, smooth muscle fibers, and immune cells such as CD8+ alpha-beta T cells and regulatory T cells. **Pathways and Functions:** ZN580 is involved in multiple signaling pathways, including: 1. **Cellular response to hydrogen peroxide**: ZNF580 regulates the expression of genes involved in the response to oxidative stress, allowing cells to adapt to changes in their environment. 2. **Chemotaxis**: This protein plays a crucial role in the migration of cells, particularly in the context of immune responses, where it influences the movement of leukocytes towards sites of inflammation. 3. **Chromatin regulation**: ZNF580 interacts with chromatin to modulate gene expression, influencing the transcriptional activity of various genes. 4. **Inflammatory response**: By regulating the expression of pro-inflammatory genes, ZNF580 contributes to the orchestration of immune responses and the resolution of inflammation. 5. **Metal ion binding**: This protein exhibits metal ion-binding capabilities, which may be involved in its DNA-binding activity and transcriptional regulation. **Clinical Significance:** ZN580's involvement in various cellular processes has significant implications for our understanding of immune-related disorders. For instance: 1. **Autoimmune diseases**: Alterations in ZNF580 expression or function may contribute to the development of autoimmune diseases, such as rheumatoid arthritis or multiple sclerosis. 2. **Cancer**: ZNF580's role in regulating gene expression and cell proliferation may influence cancer progression, making it a potential target for cancer therapy. 3. **Inflammatory disorders**: The protein's involvement in inflammatory responses suggests that ZNF580 may be a valuable therapeutic target for conditions characterized by excessive inflammation, such as atherosclerosis or inflammatory bowel disease. In conclusion, ZNF580 is a multifaceted protein that plays a critical role in regulating various cellular processes, including inflammation, cell migration, and gene expression. Its involvement in immune-related disorders and cancer highlights the importance of further research into the functions of this protein, which may lead to the development of novel therapeutic strategies.

Genular Protein ID: 1588492730

Symbol: ZN580_HUMAN

Name: Zinc finger protein 580

UniProtKB Accession Codes:

Q9UK33 B2RC05 Q9NPP7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SMART 1 SMR 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20382120

Title: Sphingosine-1-phosphate induces human endothelial VEGF and MMP-2 production via transcription factor ZNF580: novel insights into angiogenesis.

PubMed ID: 20382120

DOI: 10.1016/j.bbrc.2010.04.019

PubMed ID: 21599657

Title: ZNF580, a novel C2H2 zinc-finger transcription factor, interacts with the TGF-beta signal molecule Smad2.

PubMed ID: 21599657

DOI: 10.1042/cbi20110050

PubMed ID: 21830064

Title: ROS-induced ZNF580 expression: a key role for H2O2/NF-kappaB signaling pathway in vascular endothelial inflammation.

PubMed ID: 21830064

DOI: 10.1007/s11010-011-1013-0

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 172
  • Mass: 18756
  • Checksum: 55A89DD94E0440A8
  • Sequence:
    • MLLLPPRPPH PRSSSPEAMD PPPPKAPPFP KAEGPSSTPS SAAGPRPPRL GRHLLIDANG 
VPYTYTVQLE EEPRGPPQRE APPGEPGPRK GYSCPECARV FASPLRLQSH RVSHSDLKPF 
TCGACGKAFK RSSHLSRHRA THRARAGPPH TCPLCPRRFQ DAAELAQHVR LH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.