Details for: HAO2

Gene ID: 51179

Symbol: HAO2

Ensembl ID: ENSG00000116882

Description: hydroxyacid oxidase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 10.0928
    Cell Significance Index: 13.0600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 5.6192
    Cell Significance Index: 47.7600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.0037
    Cell Significance Index: 50.5200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.8528
    Cell Significance Index: 36.2300
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.5548
    Cell Significance Index: 14.4300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.8550
    Cell Significance Index: 12.6200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.7900
    Cell Significance Index: 13.3100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5661
    Cell Significance Index: 4.5200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.3241
    Cell Significance Index: 5.5400
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.2123
    Cell Significance Index: 0.5600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.0585
    Cell Significance Index: 0.1300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.0405
    Cell Significance Index: 0.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0154
    Cell Significance Index: 1.0900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0078
    Cell Significance Index: 0.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0062
    Cell Significance Index: 0.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0057
    Cell Significance Index: 0.1500
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.0018
    Cell Significance Index: 0.0200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0049
    Cell Significance Index: -9.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0061
    Cell Significance Index: -4.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0064
    Cell Significance Index: -0.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0087
    Cell Significance Index: -1.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0088
    Cell Significance Index: -5.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0090
    Cell Significance Index: -6.6700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0103
    Cell Significance Index: -0.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0111
    Cell Significance Index: -0.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0118
    Cell Significance Index: -6.6700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0122
    Cell Significance Index: -0.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0142
    Cell Significance Index: -26.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0167
    Cell Significance Index: -9.1300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0176
    Cell Significance Index: -0.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0177
    Cell Significance Index: -27.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0206
    Cell Significance Index: -27.9900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0225
    Cell Significance Index: -0.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0242
    Cell Significance Index: -8.6700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0281
    Cell Significance Index: -0.3700
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0306
    Cell Significance Index: -0.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0321
    Cell Significance Index: -4.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0321
    Cell Significance Index: -6.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0322
    Cell Significance Index: -14.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0325
    Cell Significance Index: -0.6800
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0327
    Cell Significance Index: -0.2800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0349
    Cell Significance Index: -0.5600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0353
    Cell Significance Index: -0.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0354
    Cell Significance Index: -6.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0369
    Cell Significance Index: -7.4000
  • Cell Name: collagen secreting cell (CL0000667)
    Fold Change: -0.0377
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0380
    Cell Significance Index: -6.4900
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0382
    Cell Significance Index: -0.2000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0414
    Cell Significance Index: -0.5000
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.0417
    Cell Significance Index: -0.2400
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0442
    Cell Significance Index: -0.4000
  • Cell Name: smooth muscle cell of the pulmonary artery (CL0002591)
    Fold Change: -0.0446
    Cell Significance Index: -0.3800
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0477
    Cell Significance Index: -0.4800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0481
    Cell Significance Index: -0.6100
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0490
    Cell Significance Index: -0.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0498
    Cell Significance Index: -14.3200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0517
    Cell Significance Index: -0.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0521
    Cell Significance Index: -6.4100
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0595
    Cell Significance Index: -0.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0607
    Cell Significance Index: -6.2100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0653
    Cell Significance Index: -0.7100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0666
    Cell Significance Index: -0.6400
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0711
    Cell Significance Index: -0.6900
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0731
    Cell Significance Index: -0.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0732
    Cell Significance Index: -8.5300
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.0735
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0789
    Cell Significance Index: -9.0400
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0844
    Cell Significance Index: -0.5200
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0874
    Cell Significance Index: -0.5800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1067
    Cell Significance Index: -1.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1088
    Cell Significance Index: -6.6900
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1159
    Cell Significance Index: -0.7100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1231
    Cell Significance Index: -2.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1373
    Cell Significance Index: -9.2400
  • Cell Name: contractile cell (CL0000183)
    Fold Change: -0.1964
    Cell Significance Index: -0.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2043
    Cell Significance Index: -26.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2089
    Cell Significance Index: -7.2600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2180
    Cell Significance Index: -6.4200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2278
    Cell Significance Index: -3.1600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2357
    Cell Significance Index: -2.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2408
    Cell Significance Index: -18.4800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2485
    Cell Significance Index: -3.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2730
    Cell Significance Index: -9.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2803
    Cell Significance Index: -7.5100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2852
    Cell Significance Index: -3.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2951
    Cell Significance Index: -7.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3005
    Cell Significance Index: -14.1300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.3043
    Cell Significance Index: -3.5300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3102
    Cell Significance Index: -7.4400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3174
    Cell Significance Index: -6.9500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.3230
    Cell Significance Index: -4.4300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3333
    Cell Significance Index: -9.5100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3340
    Cell Significance Index: -7.1400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.3389
    Cell Significance Index: -5.4500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3454
    Cell Significance Index: -8.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3544
    Cell Significance Index: -26.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3569
    Cell Significance Index: -20.0300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3746
    Cell Significance Index: -10.0200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3803
    Cell Significance Index: -4.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HAO2 is a peroxisomal enzyme that exhibits (S)-2-hydroxy-acid oxidase activity, enabling it to catalyze the conversion of hydroxyacids into carboxylic acids. The enzyme is characterized by its ability to bind Fmn (ferrochelatase), a cofactor essential for the electron transport chain. HAO2 is also notable for its involvement in fatty acid alpha-oxidation, fatty acid metabolism, and peroxisomal lipid metabolism, highlighting its central role in lipid catabolism. Furthermore, the enzyme's expression in various cell types, including hematopoietic stem cells and liver dendritic cells, underscores its importance in multiple physiological processes. **Pathways and Functions:** HAO2 is integral to several metabolic pathways, including: 1. **Fatty acid alpha-oxidation**: HAO2 facilitates the breakdown of fatty acids into acetyl-CoA, which can then be fed into the citric acid cycle for energy production. 2. **Fatty acid metabolism**: The enzyme plays a critical role in regulating lipid homeostasis by controlling the flux of fatty acids through various metabolic pathways. 3. **Peroxisomal lipid metabolism**: HAO2 is involved in the degradation of peroxisomal lipids, contributing to the maintenance of peroxisome function and lipid homeostasis. 4. **Metabolism of lipids**: The enzyme's activity is essential for the regulation of lipid metabolism, influencing energy production, cell growth, and differentiation. **Clinical Significance:** Dysregulation of HAO2 has been implicated in various diseases, including: 1. **Metabolic disorders**: Alterations in HAO2 expression have been linked to metabolic disorders, such as fatty liver disease and obesity. 2. **Neurodegenerative diseases**: Impaired HAO2 function has been associated with neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Cancer**: The enzyme's role in fatty acid metabolism suggests that HAO2 may be involved in cancer development and progression. In conclusion, HAO2 is a crucial enzyme involved in fatty acid metabolism, with significant implications for energy production, lipid homeostasis, and disease pathogenesis. Further research on this enzyme is necessary to fully elucidate its role in human physiology and disease.

Genular Protein ID: 1534429399

Symbol: HAOX2_HUMAN

Name: (S)-2-hydroxy-acid oxidase, peroxisomal

UniProtKB Accession Codes:

Q9NYQ3 Q2TU86 Q5QP00 Q9UJS6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 23 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 9 Ensembl 3 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 6 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10777549

Title: Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases.

PubMed ID: 10777549

DOI: 10.1074/jbc.275.17.12590

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 351
  • Mass: 38839
  • Checksum: 7330DE44E282947D
  • Sequence:
    • MSLVCLTDFQ AHAREQLSKS TRDFIEGGAD DSITRDDNIA AFKRIRLRPR YLRDVSEVDT 
RTTIQGEEIS APICIAPTGF HCLVWPDGEM STARAAQAAG ICYITSTFAS CSLEDIVIAA 
PEGLRWFQLY VHPDLQLNKQ LIQRVESLGF KALVITLDTP VCGNRRHDIR NQLRRNLTLT 
DLQSPKKGNA IPYFQMTPIS TSLCWNDLSW FQSITRLPII LKGILTKEDA ELAVKHNVQG 
IIVSNHGGRQ LDEVLASIDA LTEVVAAVKG KIEVYLDGGV RTGNDVLKAL ALGAKCIFLG 
RPILWGLACK GEHGVKEVLN ILTNEFHTSM ALTGCRSVAE INRNLVQFSR L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.