Details for: CHMP1A

Gene ID: 5119

Symbol: CHMP1A

Ensembl ID: ENSG00000131165

Description: charged multivesicular body protein 1A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 171.3328
    Cell Significance Index: -26.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 112.0865
    Cell Significance Index: -28.4300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 64.8666
    Cell Significance Index: -30.6300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 64.7898
    Cell Significance Index: -26.6900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 58.4581
    Cell Significance Index: -30.0700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 45.8778
    Cell Significance Index: -30.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.8590
    Cell Significance Index: -30.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.8956
    Cell Significance Index: -23.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.0815
    Cell Significance Index: -31.8900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.9706
    Cell Significance Index: -21.4100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.8662
    Cell Significance Index: -10.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.7559
    Cell Significance Index: 321.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.7473
    Cell Significance Index: 23.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4382
    Cell Significance Index: 156.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3296
    Cell Significance Index: 79.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8653
    Cell Significance Index: 44.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7010
    Cell Significance Index: 24.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6831
    Cell Significance Index: 14.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6565
    Cell Significance Index: 188.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6311
    Cell Significance Index: 13.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5908
    Cell Significance Index: 38.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5903
    Cell Significance Index: 533.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5748
    Cell Significance Index: 103.6300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5626
    Cell Significance Index: 8.4300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.5606
    Cell Significance Index: 3.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5354
    Cell Significance Index: 15.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5193
    Cell Significance Index: 283.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4884
    Cell Significance Index: 60.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4777
    Cell Significance Index: 211.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4532
    Cell Significance Index: 21.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4513
    Cell Significance Index: 90.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4441
    Cell Significance Index: 20.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4320
    Cell Significance Index: 59.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4243
    Cell Significance Index: 11.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3751
    Cell Significance Index: 44.2300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3616
    Cell Significance Index: 10.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3537
    Cell Significance Index: 70.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3523
    Cell Significance Index: 15.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3336
    Cell Significance Index: 24.8600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3307
    Cell Significance Index: 8.8300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3081
    Cell Significance Index: 21.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2677
    Cell Significance Index: 34.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2553
    Cell Significance Index: 32.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2164
    Cell Significance Index: 11.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2000
    Cell Significance Index: 19.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1743
    Cell Significance Index: 28.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1705
    Cell Significance Index: 32.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1546
    Cell Significance Index: 55.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1535
    Cell Significance Index: 4.2900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1287
    Cell Significance Index: 1.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1121
    Cell Significance Index: 7.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0970
    Cell Significance Index: 2.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0905
    Cell Significance Index: 3.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0442
    Cell Significance Index: 1.1900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0411
    Cell Significance Index: 0.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0366
    Cell Significance Index: 0.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0264
    Cell Significance Index: 18.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0064
    Cell Significance Index: 12.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0061
    Cell Significance Index: 0.1800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0083
    Cell Significance Index: -15.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0086
    Cell Significance Index: -6.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0136
    Cell Significance Index: -20.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0180
    Cell Significance Index: -13.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0197
    Cell Significance Index: -12.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0203
    Cell Significance Index: -27.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0307
    Cell Significance Index: -5.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0324
    Cell Significance Index: -3.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0347
    Cell Significance Index: -25.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0385
    Cell Significance Index: -0.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0463
    Cell Significance Index: -26.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0470
    Cell Significance Index: -21.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0589
    Cell Significance Index: -36.7900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0876
    Cell Significance Index: -1.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1038
    Cell Significance Index: -6.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1174
    Cell Significance Index: -13.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1275
    Cell Significance Index: -18.5400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1373
    Cell Significance Index: -1.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1628
    Cell Significance Index: -10.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1694
    Cell Significance Index: -35.6800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1963
    Cell Significance Index: -2.2300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2244
    Cell Significance Index: -2.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2423
    Cell Significance Index: -18.5900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2564
    Cell Significance Index: -6.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2933
    Cell Significance Index: -30.5400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3018
    Cell Significance Index: -23.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3072
    Cell Significance Index: -7.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3201
    Cell Significance Index: -17.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3637
    Cell Significance Index: -11.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4114
    Cell Significance Index: -25.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4234
    Cell Significance Index: -12.4700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4291
    Cell Significance Index: -7.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4366
    Cell Significance Index: -11.6800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4708
    Cell Significance Index: -13.4400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4719
    Cell Significance Index: -4.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5172
    Cell Significance Index: -22.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5616
    Cell Significance Index: -12.9800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5905
    Cell Significance Index: -10.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6095
    Cell Significance Index: -23.0800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.6557
    Cell Significance Index: -9.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CHMP1A is a multifunctional protein that interacts with various cellular components, including the ESCRT-III complex, autophagosomes, and lysosomes. It is characterized by its ability to bind to ubiquitin-free proteins, which are then sorted into MVBs for degradation. CHMP1A also plays a role in regulating the activity of the ESCRT-III complex, which is essential for the formation of MVBs. Additionally, CHMP1A is involved in the regulation of protein degradation, cell growth, and survival. **Pathways and Functions:** CHMP1A is involved in several cellular pathways, including: 1. **Autophagy:** CHMP1A plays a crucial role in the regulation of autophagy, which is a process by which cells degrade and recycle damaged or dysfunctional cellular components. 2. **Endosomal sorting:** CHMP1A is involved in the sorting of proteins into MVBs, which is essential for the regulation of protein degradation and cell growth. 3. **Protein degradation:** CHMP1A is involved in the degradation of ubiquitin-free proteins, which are then sorted into MVBs for degradation. 4. **Cell growth and survival:** CHMP1A plays a role in regulating cell growth and survival by controlling the levels of proteins that are essential for these processes. **Clinical Significance:** Dysregulation of CHMP1A has been implicated in various diseases, including: 1. **Cancer:** CHMP1A is often overexpressed in cancer cells, which can lead to the degradation of tumor suppressor proteins and the promotion of cancer progression. 2. **Neurodegenerative diseases:** CHMP1A has been implicated in the regulation of autophagy in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Infectious diseases:** CHMP1A is involved in the regulation of viral budding and infection, and its dysregulation can lead to the development of viral diseases. **Significantly Expressed Cells:** CHMP1A is expressed in various cell types, including: 1. **Epithelial cells:** CHMP1A is expressed in epithelial cells of the esophagus, stomach, and colon. 2. **Neurons:** CHMP1A is expressed in peripheral nervous system neurons. 3. **Placental cells:** CHMP1A is expressed in placental villous trophoblast cells. In conclusion, CHMP1A is a multifunctional protein that plays a crucial role in various cellular processes, including autophagy, endosomal sorting, and protein degradation. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, and infectious diseases. Further research is needed to fully understand the functions and clinical significance of CHMP1A.

Genular Protein ID: 2310705199

Symbol: CHM1A_HUMAN

Name: Charged multivesicular body protein 1a

UniProtKB Accession Codes:

Q9HD42 A2RU09 Q14468 Q15779 Q96G31

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 49 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8863740

Title: Molecular cloning, expression and chromosomal localization of a human gene encoding a 33 kDa putative metallopeptidase (PRSM1).

PubMed ID: 8863740

DOI: 10.1016/0378-1119(96)00510-0

PubMed ID: 11559747

Title: CHMP1 is a novel nuclear matrix protein affecting chromatin structure and cell-cycle progression.

PubMed ID: 11559747

DOI: 10.1242/jcs.114.13.2383

PubMed ID: 7584044

Title: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7584044

DOI: 10.1093/dnares/1.5.223

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11559748

Title: CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins.

PubMed ID: 11559748

DOI: 10.1242/jcs.114.13.2395

PubMed ID: 14505570

Title: The protein network of HIV budding.

PubMed ID: 14505570

DOI: 10.1016/s0092-8674(03)00714-1

PubMed ID: 14519844

Title: Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.

PubMed ID: 14519844

DOI: 10.1073/pnas.2133846100

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19129480

Title: Essential role of hIST1 in cytokinesis.

PubMed ID: 19129480

DOI: 10.1091/mbc.e08-05-0474

PubMed ID: 19129479

Title: Biochemical analyses of human IST1 and its function in cytokinesis.

PubMed ID: 19129479

DOI: 10.1091/mbc.e08-05-0475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23023333

Title: CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development.

PubMed ID: 23023333

DOI: 10.1038/ng.2425

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17928862

Title: ESCRT-III recognition by VPS4 ATPases.

PubMed ID: 17928862

DOI: 10.1038/nature06172

PubMed ID: 23045692

Title: ESCRT-III binding protein MITD1 is involved in cytokinesis and has an unanticipated PLD fold that binds membranes.

PubMed ID: 23045692

DOI: 10.1073/pnas.1206839109

Sequence Information:

  • Length: 196
  • Mass: 21703
  • Checksum: 85D0ED7D10828D60
  • Sequence:
    • MDDTLFQLKF TAKQLEKLAK KAEKDSKAEQ AKVKKALLQK NVECARVYAE NAIRKKNEGV 
NWLRMASRVD AVASKVQTAV TMKGVTKNMA QVTKALDKAL STMDLQKVSS VMDRFEQQVQ 
NLDVHTSVME DSMSSATTLT TPQEQVDSLI MQIAEENGLE VLDQLSQLPE GASAVGESSV 
RSQEDQLSRR LAALRN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.