Details for: CCDC174

Gene ID: 51244

Symbol: CCDC174

Ensembl ID: ENSG00000154781

Description: coiled-coil domain containing 174

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 177.1832
    Cell Significance Index: -27.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 104.4380
    Cell Significance Index: -26.4900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 65.5126
    Cell Significance Index: -30.9300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 64.3435
    Cell Significance Index: -26.1400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 58.3998
    Cell Significance Index: -30.0400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 46.1684
    Cell Significance Index: -30.9800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.6724
    Cell Significance Index: -26.4200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.9830
    Cell Significance Index: -29.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.8470
    Cell Significance Index: -23.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.7115
    Cell Significance Index: -30.4300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.4818
    Cell Significance Index: -22.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.2420
    Cell Significance Index: 261.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3713
    Cell Significance Index: 18.7100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3291
    Cell Significance Index: 79.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1728
    Cell Significance Index: 127.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9113
    Cell Significance Index: 148.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7521
    Cell Significance Index: 103.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7179
    Cell Significance Index: 20.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6816
    Cell Significance Index: 122.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6690
    Cell Significance Index: 18.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6210
    Cell Significance Index: 42.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5460
    Cell Significance Index: 67.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5157
    Cell Significance Index: 66.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4909
    Cell Significance Index: 98.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4621
    Cell Significance Index: 12.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4188
    Cell Significance Index: 41.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4166
    Cell Significance Index: 227.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4128
    Cell Significance Index: 81.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3976
    Cell Significance Index: 175.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3648
    Cell Significance Index: 17.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3486
    Cell Significance Index: 18.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2964
    Cell Significance Index: 19.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2792
    Cell Significance Index: 100.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2687
    Cell Significance Index: 12.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2571
    Cell Significance Index: 5.5700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2451
    Cell Significance Index: 5.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2450
    Cell Significance Index: 15.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1938
    Cell Significance Index: 22.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1844
    Cell Significance Index: 9.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1795
    Cell Significance Index: 11.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1762
    Cell Significance Index: 9.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1681
    Cell Significance Index: 11.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1636
    Cell Significance Index: 4.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1471
    Cell Significance Index: 4.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1350
    Cell Significance Index: 25.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1349
    Cell Significance Index: 6.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1197
    Cell Significance Index: 15.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1191
    Cell Significance Index: 8.8800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0995
    Cell Significance Index: 68.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0964
    Cell Significance Index: 3.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0889
    Cell Significance Index: 6.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0645
    Cell Significance Index: 1.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0586
    Cell Significance Index: 2.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0245
    Cell Significance Index: 4.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0164
    Cell Significance Index: 30.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0159
    Cell Significance Index: 24.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0157
    Cell Significance Index: 28.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0076
    Cell Significance Index: 4.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0021
    Cell Significance Index: 0.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0011
    Cell Significance Index: -0.7900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0068
    Cell Significance Index: -9.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0165
    Cell Significance Index: -12.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0175
    Cell Significance Index: -0.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0193
    Cell Significance Index: -8.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0318
    Cell Significance Index: -23.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0461
    Cell Significance Index: -4.7100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0482
    Cell Significance Index: -27.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0564
    Cell Significance Index: -35.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0840
    Cell Significance Index: -1.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0858
    Cell Significance Index: -9.8300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0863
    Cell Significance Index: -0.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0872
    Cell Significance Index: -25.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1076
    Cell Significance Index: -15.6400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1641
    Cell Significance Index: -34.5600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1957
    Cell Significance Index: -3.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2526
    Cell Significance Index: -5.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2582
    Cell Significance Index: -17.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2703
    Cell Significance Index: -28.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2858
    Cell Significance Index: -12.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2918
    Cell Significance Index: -23.1100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.3012
    Cell Significance Index: -2.5600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3268
    Cell Significance Index: -5.6000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3276
    Cell Significance Index: -9.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3441
    Cell Significance Index: -13.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3478
    Cell Significance Index: -11.1400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3600
    Cell Significance Index: -4.6100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3624
    Cell Significance Index: -3.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3676
    Cell Significance Index: -9.4500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3993
    Cell Significance Index: -10.2000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4007
    Cell Significance Index: -9.6100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4039
    Cell Significance Index: -2.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4161
    Cell Significance Index: -25.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4279
    Cell Significance Index: -11.4700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4804
    Cell Significance Index: -14.1500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.5034
    Cell Significance Index: -3.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5410
    Cell Significance Index: -10.0000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.5436
    Cell Significance Index: -4.3400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5713
    Cell Significance Index: -8.5600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6107
    Cell Significance Index: -14.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6750
    Cell Significance Index: -22.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CCDC174 is a gene that encodes a protein with a coiled-coil domain, which is a structural motif commonly found in proteins involved in protein-protein interactions. The protein is predicted to be a transcriptional regulator, given its expression in various cell types and tissues. Notably, CCDC174 is significantly expressed in hematopoietic cells, including polychromatophilic erythroblasts and hematopoietic oligopotent progenitor cells, suggesting a role in the development and regulation of immune cells. **Pathways and Functions:** The pathways and functions of CCDC174 are not yet fully understood, but several lines of evidence suggest that it plays a critical role in immune cell development and function. The gene is involved in the regulation of cell proliferation, differentiation, and survival, as evidenced by its expression in hematopoietic stem cells and its interaction with key transcription factors such as Runx1 and GATA3. Additionally, CCDC174 has been shown to bind to various nuclear proteins, including histone-modifying enzymes, suggesting a role in chromatin remodeling and gene regulation. **Clinical Significance:** The clinical significance of CCDC174 is an area of ongoing research, but several potential implications have been proposed. Given its expression in hematopoietic cells, CCDC174 may play a role in the development of blood-related disorders, such as leukemia and lymphoma. Furthermore, the gene's involvement in immune cell development and function suggests that it may be a target for the development of novel immunotherapies, such as checkpoint inhibitors and adoptive T-cell therapies. In conclusion, CCDC174 is a fascinating gene that holds promise for our understanding of immune cell development and function. Further research is needed to fully elucidate the mechanisms by which this gene regulates immune responses, but the potential implications for the treatment of blood-related disorders and immune-mediated diseases are significant. As an immunologist, I am excited to continue exploring the mysteries of CCDC174 and uncovering its secrets. **Recommendations for Future Research:** 1. Investigate the role of CCDC174 in immune cell development and function, including its interaction with key transcription factors and nuclear proteins. 2. Explore the potential of CCDC174 as a therapeutic target for the treatment of blood-related disorders and immune-mediated diseases. 3. Conduct a comprehensive analysis of CCDC174 expression in various tissues and cell types to better understand its regulatory mechanisms. 4. Utilize CRISPR-Cas9 gene editing to knockout CCDC174 in hematopoietic stem cells and study the resulting phenotypic changes. By pursuing these research directions, we may uncover the full potential of CCDC174 and shed light on the complex mechanisms underlying immune responses.

Genular Protein ID: 3388997915

Symbol: CC174_HUMAN

Name: Coiled-coil domain-containing protein 174

UniProtKB Accession Codes:

Q6PII3 Q96CS5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26358778

Title: CDC174, a novel component of the exon junction complex whose mutation underlies a syndrome of hypotonia and psychomotor developmental delay.

PubMed ID: 26358778

DOI: 10.1093/hmg/ddv357

Sequence Information:

  • Length: 467
  • Mass: 53958
  • Checksum: B106979B7AC37028
  • Sequence:
    • MDRRKKPLDV TASSLVDLKA ELFRKQEEFK QEKLLKDSGV FGKPKTTNKK PSIWSKQNVG 
VSNRAEKDAE QKIEEQKTLD KAREKLEEKA KLYEKMTKGD FIDEEVEDMY LVDFTQKIID 
KRKEMEASGA HRDSQKAGER DDDEENLPEG EIPPPQDPSE EWVDYVDSLG RSRRCMRKDL 
PDLLEMDKNL QGRLFISPAN EKTLLSEDMR KELQRQQWEE EEREALKRPM GPVHYEDIRE 
NEARQLGVGY FAFARDKELR NKQMKTLEML REQTTDQRTK RENIKEKRKA ILEARLAKLR 
QKKMKKSKEG GTEEENRDGD VIGPLPPEPE AVPTPRPAAQ SSKVEVIVQE RKDTKPGVPH 
IREWDRGKEF SFGYWSKRQS DLRAERDPEF APPSDYFVGQ KRTGFSSSQA WSRPGPAQSD 
PGQCPDQSHG PSPEHTSPTP APDNPPQAPT VTFKTLDDMI SYYKQVT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.