Details for: SHISA5

Gene ID: 51246

Symbol: SHISA5

Ensembl ID: ENSG00000164054

Description: shisa family member 5

Associated with

  • Metabolism of proteins
    (R-HSA-392499)
  • Post-translational protein modification
    (R-HSA-597592)
  • Post-translational protein phosphorylation
    (R-HSA-8957275)
  • Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
    (R-HSA-381426)
  • Endoplasmic reticulum
    (GO:0005783)
  • Endoplasmic reticulum lumen
    (GO:0005788)
  • Endoplasmic reticulum membrane
    (GO:0005789)
  • Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
    (GO:0042771)
  • Nuclear membrane
    (GO:0031965)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Protein binding
    (GO:0005515)
  • Ww domain binding
    (GO:0050699)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 263.0103
    Cell Significance Index: -40.9100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 150.2897
    Cell Significance Index: -38.1200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 111.9560
    Cell Significance Index: -46.1200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 103.6043
    Cell Significance Index: -42.0900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 97.2417
    Cell Significance Index: -45.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 90.1464
    Cell Significance Index: -46.3700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 68.5074
    Cell Significance Index: -45.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.0621
    Cell Significance Index: -43.2300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.2188
    Cell Significance Index: -44.2700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.5422
    Cell Significance Index: -32.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.3552
    Cell Significance Index: -27.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.9555
    Cell Significance Index: -19.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.5155
    Cell Significance Index: 409.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.0985
    Cell Significance Index: 61.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.7040
    Cell Significance Index: 47.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.5888
    Cell Significance Index: 286.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4776
    Cell Significance Index: 181.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4062
    Cell Significance Index: 73.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.2163
    Cell Significance Index: 22.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0829
    Cell Significance Index: 148.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0198
    Cell Significance Index: 27.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7987
    Cell Significance Index: 21.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6180
    Cell Significance Index: 177.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5843
    Cell Significance Index: 37.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5619
    Cell Significance Index: 66.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5611
    Cell Significance Index: 71.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5205
    Cell Significance Index: 284.2400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4505
    Cell Significance Index: 9.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4263
    Cell Significance Index: 85.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3979
    Cell Significance Index: 28.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3444
    Cell Significance Index: 68.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3126
    Cell Significance Index: 30.9300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2949
    Cell Significance Index: 3.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2915
    Cell Significance Index: 128.8900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2894
    Cell Significance Index: 2.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2540
    Cell Significance Index: 229.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2254
    Cell Significance Index: 6.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1656
    Cell Significance Index: 114.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1566
    Cell Significance Index: 56.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1446
    Cell Significance Index: 24.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1422
    Cell Significance Index: 3.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0773
    Cell Significance Index: 9.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0760
    Cell Significance Index: 14.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0322
    Cell Significance Index: 2.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0312
    Cell Significance Index: 0.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0254
    Cell Significance Index: 47.8500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0137
    Cell Significance Index: 0.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0003
    Cell Significance Index: -0.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0006
    Cell Significance Index: -0.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0039
    Cell Significance Index: -2.9800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0045
    Cell Significance Index: -0.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0070
    Cell Significance Index: -10.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0094
    Cell Significance Index: -7.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0094
    Cell Significance Index: -12.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0126
    Cell Significance Index: -7.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0130
    Cell Significance Index: -24.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0236
    Cell Significance Index: -1.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0310
    Cell Significance Index: -1.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0329
    Cell Significance Index: -3.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0482
    Cell Significance Index: -35.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0504
    Cell Significance Index: -22.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0507
    Cell Significance Index: -28.6000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0861
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0990
    Cell Significance Index: -20.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1267
    Cell Significance Index: -18.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1468
    Cell Significance Index: -17.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1477
    Cell Significance Index: -4.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1959
    Cell Significance Index: -22.4400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2058
    Cell Significance Index: -5.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2121
    Cell Significance Index: -9.8900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2124
    Cell Significance Index: -24.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2660
    Cell Significance Index: -5.6700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2719
    Cell Significance Index: -3.7100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2798
    Cell Significance Index: -4.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2872
    Cell Significance Index: -7.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3977
    Cell Significance Index: -41.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4062
    Cell Significance Index: -24.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4067
    Cell Significance Index: -27.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4224
    Cell Significance Index: -22.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4259
    Cell Significance Index: -9.8400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4509
    Cell Significance Index: -5.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4612
    Cell Significance Index: -35.3900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4832
    Cell Significance Index: -8.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4921
    Cell Significance Index: -30.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4929
    Cell Significance Index: -13.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5025
    Cell Significance Index: -17.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5462
    Cell Significance Index: -43.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5648
    Cell Significance Index: -16.1900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6071
    Cell Significance Index: -15.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6080
    Cell Significance Index: -34.1200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.6362
    Cell Significance Index: -9.1500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6434
    Cell Significance Index: -6.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6848
    Cell Significance Index: -43.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7098
    Cell Significance Index: -36.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8524
    Cell Significance Index: -37.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9329
    Cell Significance Index: -32.6800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9482
    Cell Significance Index: -27.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9995
    Cell Significance Index: -37.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0287
    Cell Significance Index: -33.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0414
    Cell Significance Index: -30.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SHISA5 is a member of the Shisa family of proteins, which are characterized by their WW domain-binding ability. This domain is involved in protein-protein interactions, which play a crucial role in the regulation of various cellular processes. SHISA5 is primarily localized to the endoplasmic reticulum (ER) and has been shown to interact with proteins involved in protein modification, such as phosphorylation and ubiquitination. Its expression is observed in multiple cell types, including hematopoietic progenitor cells, embryonic stem cells, and immune cells. **Pathways and Functions:** SHISA5 is involved in several cellular pathways, including: 1. **Intrinsic apoptotic signaling pathway in response to DNA damage**: SHISA5 has been shown to interact with p53 class mediators, which are involved in the regulation of apoptosis in response to DNA damage. 2. **Positive regulation of canonical NF-κB signaling**: SHISA5 has been implicated in the regulation of NF-κB signaling, which is a key pathway involved in immune responses and inflammation. 3. **Regulation of IGF transport and uptake**: SHISA5 has been shown to interact with insulin-like growth factor binding proteins (IGFBPs), which are involved in the regulation of IGF transport and uptake. 4. **Protein binding and post-translational protein modification**: SHISA5 has been shown to interact with various proteins involved in protein modification, such as phosphorylation and ubiquitination. **Clinical Significance:** The dysregulation of SHISA5 has been implicated in various diseases, including cancer and immune disorders. For example: 1. **Cancer**: SHISA5 has been shown to be overexpressed in certain types of cancer, including breast and lung cancer. Its dysregulation may contribute to tumorigenesis and cancer progression. 2. **Immune disorders**: SHISA5 has been implicated in the regulation of immune responses, particularly in the context of intrinsic apoptotic signaling pathways. Its dysregulation may contribute to immune disorders, such as autoimmune diseases and immunodeficiency disorders. 3. **Regenerative medicine**: SHISA5 has been shown to be expressed in embryonic stem cells and has been implicated in the regulation of cellular homeostasis. Its dysregulation may contribute to the failure of embryonic stem cell differentiation and the development of regenerative medicine therapies. In conclusion, SHISA5 is a gene that plays a critical role in immune regulation and cellular homeostasis. Its dysregulation has been implicated in various diseases, including cancer and immune disorders. Further research into the role of SHISA5 in immune regulation and cellular homeostasis is necessary to fully understand its clinical significance and potential therapeutic applications.

Genular Protein ID: 1212826581

Symbol: SHSA5_HUMAN

Name: Protein shisa-5

UniProtKB Accession Codes:

Q8N114 B3KW99 F8W9N8 Q69YY9 Q7Z433 Q8NHL9 Q96MW8 Q9BV58

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 13 Ensembl 6 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 2 RefSeq 10 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12135983

Title: Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane.

PubMed ID: 12135983

DOI: 10.1083/jcb.200203006

PubMed ID: 12761501

Title: Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.

PubMed ID: 12761501

DOI: 10.1038/sj.onc.1206406

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17889823

Title: The calcium binding protein ALG-2 binds and stabilizes Scotin, a p53-inducible gene product localized at the endoplasmic reticulum membrane.

PubMed ID: 17889823

DOI: 10.1016/j.abb.2007.07.028

Sequence Information:

  • Length: 240
  • Mass: 25582
  • Checksum: 7C4A8E7A2AD8E272
  • Sequence:
    • MTAPVPAPRI LLPLLLLLLL TPPPGARGEV CMASRGLSLF PESCPDFCCG TCDDQYCCSD 
VLKKFVWSEE RCAVPEASVP ASVEPVEQLG SALRFRPGYN DPMSGFGATL AVGLTIFVLS 
VVTIIICFTC SCCCLYKTCR RPRPVVTTTT STTVVHAPYP QPPSVPPSYP GPSYQGYHTM 
PPQPGMPAAP YPMQYPPPYP AQPMGPPAYH ETLAGGAAAP YPASQPPYNP AYMDAPKAAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.