Details for: RNF181

Gene ID: 51255

Symbol: RNF181

Ensembl ID: ENSG00000168894

Description: ring finger protein 181

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 291.8122
    Cell Significance Index: -45.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 162.1962
    Cell Significance Index: -41.1400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 139.3138
    Cell Significance Index: -57.3900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 113.0850
    Cell Significance Index: -53.3900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 102.1219
    Cell Significance Index: -52.5300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 79.9079
    Cell Significance Index: -53.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.2424
    Cell Significance Index: -50.8500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.5477
    Cell Significance Index: -53.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.4627
    Cell Significance Index: -41.3500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.8259
    Cell Significance Index: -31.6800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.4628
    Cell Significance Index: 35.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 3.5160
    Cell Significance Index: 571.8400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.5285
    Cell Significance Index: 74.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.4995
    Cell Significance Index: 116.5400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.3263
    Cell Significance Index: 21.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.0701
    Cell Significance Index: 154.2800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.6134
    Cell Significance Index: 29.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.5057
    Cell Significance Index: 70.7700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.3758
    Cell Significance Index: 15.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3524
    Cell Significance Index: 738.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3427
    Cell Significance Index: 184.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3404
    Cell Significance Index: 69.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.2388
    Cell Significance Index: 32.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2164
    Cell Significance Index: 143.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1646
    Cell Significance Index: 143.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1400
    Cell Significance Index: 205.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1268
    Cell Significance Index: 30.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0955
    Cell Significance Index: 141.5300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.9798
    Cell Significance Index: 6.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.9059
    Cell Significance Index: 20.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8867
    Cell Significance Index: 57.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8738
    Cell Significance Index: 18.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8596
    Cell Significance Index: 110.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8425
    Cell Significance Index: 24.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8282
    Cell Significance Index: 366.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7367
    Cell Significance Index: 72.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7017
    Cell Significance Index: 49.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4969
    Cell Significance Index: 84.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3450
    Cell Significance Index: 65.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3365
    Cell Significance Index: 7.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3153
    Cell Significance Index: 14.2900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2422
    Cell Significance Index: 4.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2206
    Cell Significance Index: 6.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1790
    Cell Significance Index: 4.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1498
    Cell Significance Index: 113.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1212
    Cell Significance Index: 4.2100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0761
    Cell Significance Index: 1.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0684
    Cell Significance Index: 3.5900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0562
    Cell Significance Index: 0.9400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0432
    Cell Significance Index: 38.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0363
    Cell Significance Index: 7.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0153
    Cell Significance Index: 11.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0003
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0074
    Cell Significance Index: -5.4700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0212
    Cell Significance Index: -40.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0354
    Cell Significance Index: -22.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0365
    Cell Significance Index: -67.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0429
    Cell Significance Index: -66.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0492
    Cell Significance Index: -66.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0500
    Cell Significance Index: -3.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0564
    Cell Significance Index: -31.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0692
    Cell Significance Index: -43.9300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0723
    Cell Significance Index: -8.2600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0756
    Cell Significance Index: -0.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1011
    Cell Significance Index: -36.2700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1043
    Cell Significance Index: -0.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1124
    Cell Significance Index: -51.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1130
    Cell Significance Index: -22.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1190
    Cell Significance Index: -13.6300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1300
    Cell Significance Index: -1.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1317
    Cell Significance Index: -15.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1352
    Cell Significance Index: -28.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1404
    Cell Significance Index: -40.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2226
    Cell Significance Index: -6.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2392
    Cell Significance Index: -6.1100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2594
    Cell Significance Index: -2.8200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2904
    Cell Significance Index: -4.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3323
    Cell Significance Index: -8.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3351
    Cell Significance Index: -48.7100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.3454
    Cell Significance Index: -1.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4121
    Cell Significance Index: -32.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5153
    Cell Significance Index: -53.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5308
    Cell Significance Index: -17.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6871
    Cell Significance Index: -42.2300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7035
    Cell Significance Index: -18.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7139
    Cell Significance Index: -43.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7266
    Cell Significance Index: -55.7600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7282
    Cell Significance Index: -29.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7337
    Cell Significance Index: -10.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7860
    Cell Significance Index: -52.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7964
    Cell Significance Index: -16.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8290
    Cell Significance Index: -46.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9024
    Cell Significance Index: -26.5800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.9960
    Cell Significance Index: -13.9600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.0309
    Cell Significance Index: -14.4600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.0345
    Cell Significance Index: -8.6900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.0882
    Cell Significance Index: -18.7600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.1184
    Cell Significance Index: -56.5200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1883
    Cell Significance Index: -43.6200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.2349
    Cell Significance Index: -10.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Ubiquitin Ligase Activity**: RNF181 possesses E3 ubiquitin ligase activity, which enables it to ubiquitinate target proteins, marking them for degradation or modification. 2. **Protein Binding**: RNF181 interacts with various proteins, including other ubiquitin ligases, metal ions, and protein substrates, facilitating its regulatory functions. 3. **Cellular Localization**: RNF181 is expressed in multiple cell types, including hematopoietic cells, embryonic stem cells, and immune cells, indicating its involvement in various cellular processes. **Pathways and Functions** RNF181 is involved in several cellular pathways, including: 1. **Metabolism of Proteins**: RNF181 regulates protein degradation and modification, influencing protein turnover and cellular homeostasis. 2. **Cytoplasmic Processes**: RNF181 interacts with metal ions, which are essential for its enzymatic activity, and regulates protein ubiquitination and autoubiquitination. 3. **Immune Cell Regulation**: RNF181 is expressed in immune cells, including T cells and natural killer cells, where it regulates immune responses and cellular signaling. **Clinical Significance** RNF181 has been implicated in various diseases, including: 1. **Cancer**: Overexpression of RNF181 has been observed in several types of cancer, including breast, lung, and colon cancer, suggesting its role in tumorigenesis and cancer progression. 2. **Autoimmune Diseases**: RNF181 has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it regulates immune responses and tissue damage. 3. **Immunodeficiency**: RNF181 has been shown to regulate T cell development and function, suggesting its role in immunodeficiency disorders. In conclusion, RNF181 is a multifunctional protein that plays a critical role in regulating protein ubiquitination, autoubiquitination, and metal ion binding. Its involvement in various cellular pathways, including metabolism of proteins and immune cell regulation, highlights its significance in maintaining cellular homeostasis and immune function. Further research is necessary to elucidate the clinical significance of RNF181 and its potential as a therapeutic target for various diseases.

Genular Protein ID: 2467448036

Symbol: RN181_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9P0P0 Q53H81

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18331836

Title: RN181, a novel ubiquitin E3 ligase that interacts with the KVGFFKR motif of platelet integrin alpha(IIb)beta3.

PubMed ID: 18331836

DOI: 10.1016/j.bbrc.2008.02.142

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24811749

Title: Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.

PubMed ID: 24811749

DOI: 10.1002/embj.201386906

Sequence Information:

  • Length: 153
  • Mass: 17909
  • Checksum: AF0CEC8D438FF0AB
  • Sequence:
    • MASYFDEHDC EPSDPEQETR TNMLLELARS LFNRMDFEDL GLVVDWDHHL PPPAAKTVVE 
NLPRTVIRGS QAELKCPVCL LEFEEEETAI EMPCHHLFHS SCILPWLSKT NSCPLCRYEL 
PTDDDTYEEH RRDKARKQQQ QHRLENLHGA MYT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.