Details for: MRPL27

Gene ID: 51264

Symbol: MRPL27

Ensembl ID: ENSG00000108826

Description: mitochondrial ribosomal protein L27

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 198.6239
    Cell Significance Index: -30.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 146.6626
    Cell Significance Index: -37.2000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 108.4361
    Cell Significance Index: -44.6700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 92.2853
    Cell Significance Index: -43.5700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 81.2232
    Cell Significance Index: -41.7800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 65.0947
    Cell Significance Index: -43.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.8333
    Cell Significance Index: -41.7200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.3000
    Cell Significance Index: -32.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.2619
    Cell Significance Index: -44.4400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.9834
    Cell Significance Index: -33.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 5.5380
    Cell Significance Index: 645.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.9188
    Cell Significance Index: 175.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.2302
    Cell Significance Index: 115.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.8756
    Cell Significance Index: 305.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8570
    Cell Significance Index: 50.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.6242
    Cell Significance Index: 75.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5516
    Cell Significance Index: 70.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4965
    Cell Significance Index: 269.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4376
    Cell Significance Index: 176.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4187
    Cell Significance Index: 774.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3929
    Cell Significance Index: 98.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3164
    Cell Significance Index: 17.9600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.3076
    Cell Significance Index: 10.4400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0783
    Cell Significance Index: 9.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0525
    Cell Significance Index: 144.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0233
    Cell Significance Index: 120.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0157
    Cell Significance Index: 449.0600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9445
    Cell Significance Index: 19.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8911
    Cell Significance Index: 66.4200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8269
    Cell Significance Index: 19.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8050
    Cell Significance Index: 17.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7264
    Cell Significance Index: 71.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6937
    Cell Significance Index: 18.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5797
    Cell Significance Index: 74.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5738
    Cell Significance Index: 19.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5731
    Cell Significance Index: 113.7300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5352
    Cell Significance Index: 8.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5280
    Cell Significance Index: 100.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5243
    Cell Significance Index: 14.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5223
    Cell Significance Index: 66.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5188
    Cell Significance Index: 27.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4637
    Cell Significance Index: 21.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.4366
    Cell Significance Index: 125.6100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4355
    Cell Significance Index: 12.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3933
    Cell Significance Index: 355.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3198
    Cell Significance Index: 20.6400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2839
    Cell Significance Index: 3.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2082
    Cell Significance Index: 13.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1982
    Cell Significance Index: 39.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1961
    Cell Significance Index: 6.2800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1913
    Cell Significance Index: 2.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0791
    Cell Significance Index: 59.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0735
    Cell Significance Index: 53.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0522
    Cell Significance Index: 18.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0376
    Cell Significance Index: 1.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0349
    Cell Significance Index: 2.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0085
    Cell Significance Index: -1.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0087
    Cell Significance Index: -16.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0238
    Cell Significance Index: -2.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0240
    Cell Significance Index: -44.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0288
    Cell Significance Index: -44.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0320
    Cell Significance Index: -43.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0357
    Cell Significance Index: -1.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0444
    Cell Significance Index: -28.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0448
    Cell Significance Index: -33.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0637
    Cell Significance Index: -28.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0654
    Cell Significance Index: -36.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0773
    Cell Significance Index: -48.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1199
    Cell Significance Index: -7.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1770
    Cell Significance Index: -20.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2082
    Cell Significance Index: -16.4900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2134
    Cell Significance Index: -1.7400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2141
    Cell Significance Index: -5.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2228
    Cell Significance Index: -32.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2286
    Cell Significance Index: -15.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2305
    Cell Significance Index: -48.5500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2429
    Cell Significance Index: -4.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2763
    Cell Significance Index: -7.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3245
    Cell Significance Index: -5.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3605
    Cell Significance Index: -20.2300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.3897
    Cell Significance Index: -4.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3951
    Cell Significance Index: -4.7100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3999
    Cell Significance Index: -4.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4191
    Cell Significance Index: -43.6400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4849
    Cell Significance Index: -6.2100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.4958
    Cell Significance Index: -4.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5086
    Cell Significance Index: -34.2000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5585
    Cell Significance Index: -16.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5919
    Cell Significance Index: -36.2900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6566
    Cell Significance Index: -17.6000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6924
    Cell Significance Index: -12.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7059
    Cell Significance Index: -36.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7193
    Cell Significance Index: -15.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7265
    Cell Significance Index: -18.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8369
    Cell Significance Index: -37.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.8490
    Cell Significance Index: -24.4600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8545
    Cell Significance Index: -12.6200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.8888
    Cell Significance Index: -5.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.9412
    Cell Significance Index: -16.1300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9458
    Cell Significance Index: -34.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization:** MRPL27 is a mitochondrial ribosomal protein, specifically localized to the mitochondrial large ribosomal subunit. 2. **Translation regulation:** MRPL27 plays a critical role in regulating mitochondrial translation elongation and termination. 3. **Protein binding:** MRPL27 interacts with various mitochondrial proteins, including other ribosomal subunits, and regulates their assembly and function. 4. **RNA binding:** MRPL27 binds to mitochondrial mRNAs, influencing their translation and ensuring the proper expression of mitochondrial genes. 5. **Cellular expression:** MRPL27 is expressed in various cell types, including hematopoietic stem cells, embryonic stem cells, and smooth muscle fibers. **Pathways and Functions:** 1. **Mitochondrial translation:** MRPL27 is essential for the translation of mitochondrial mRNAs into functional proteins, regulating cellular metabolism and energy production. 2. **Mitochondrial inner membrane:** MRPL27 interacts with other mitochondrial proteins, contributing to the structure and function of the mitochondrial inner membrane. 3. **Protein binding and regulation:** MRPL27 regulates the assembly and function of mitochondrial ribosomes, ensuring the proper expression of mitochondrial genes. 4. **Immune regulation:** MRPL27 has been implicated in modulating immune responses, particularly in the context of autoimmune conditions. **Clinical Significance:** 1. **Mitochondrial disorders:** Dysregulation of MRPL27 has been linked to various mitochondrial disorders, including neurodegenerative diseases, metabolic disorders, and cardiomyopathies. 2. **Cancer:** MRPL27 expression has been altered in several types of cancer, suggesting its potential role in tumorigenesis and cancer progression. 3. **Autoimmune conditions:** MRPL27 has been implicated in modulating immune responses, particularly in autoimmune conditions such as rheumatoid arthritis and multiple sclerosis. 4. **Therapeutic targeting:** Understanding the role of MRPL27 in disease pathogenesis may lead to the development of novel therapeutic strategies targeting mitochondrial function and immune regulation. In conclusion, MRPL27 is a critical component of the mitochondrial large ribosomal subunit, playing a pivotal role in regulating mitochondrial translation and function. Dysregulation of MRPL27 has been implicated in various diseases, including mitochondrial disorders, cancer, and autoimmune conditions. Further research is necessary to fully elucidate the role of MRPL27 in human health and disease, with potential therapeutic implications for the treatment of these conditions.

Genular Protein ID: 4128763357

Symbol: RM27_HUMAN

Name: 39S ribosomal protein L27, mitochondrial

UniProtKB Accession Codes:

Q9P0M9 B2RE14

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 23 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 61 PDBsum 61 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11279069

Title: Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria.

PubMed ID: 11279069

DOI: 10.1074/jbc.m100432200

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25278503

Title: Structure of the large ribosomal subunit from human mitochondria.

PubMed ID: 25278503

DOI: 10.1126/science.1258026

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

PubMed ID: 28892042

Title: Structures of the human mitochondrial ribosome in native states of assembly.

PubMed ID: 28892042

DOI: 10.1038/nsmb.3464

PubMed ID: 35177605

Title: A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.

PubMed ID: 35177605

DOI: 10.1038/s41467-022-28503-5

Sequence Information:

  • Length: 148
  • Mass: 16073
  • Checksum: 90945F471E80EFB6
  • Sequence:
    • MASVVLALRT RTAVTSLLSP TPATALAVRY ASKKSGGSSK NLGGKSSGRR QGIKKMEGHY 
VHAGNIIATQ RHFRWHPGAH VGVGKNKCLY ALEEGIVRYT KEVYVPHPRN TEAVDLITRL 
PKGAVLYKTF VHVVPAKPEG TFKLVAML

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.