Details for: ERGIC2

Gene ID: 51290

Symbol: ERGIC2

Ensembl ID: ENSG00000087502

Description: ERGIC and golgi 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 315.5995
    Cell Significance Index: -49.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 185.6938
    Cell Significance Index: -47.1000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 143.9503
    Cell Significance Index: -59.3000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 116.8340
    Cell Significance Index: -55.1600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 112.6873
    Cell Significance Index: -45.7800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 102.0830
    Cell Significance Index: -52.5100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 48.4738
    Cell Significance Index: -46.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 42.9253
    Cell Significance Index: -52.9300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.9143
    Cell Significance Index: -47.9900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.5781
    Cell Significance Index: -53.5800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.5608
    Cell Significance Index: -38.5800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.9705
    Cell Significance Index: -24.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.9404
    Cell Significance Index: 342.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.7542
    Cell Significance Index: 190.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5139
    Cell Significance Index: 164.6700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4602
    Cell Significance Index: 87.6600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.4524
    Cell Significance Index: 12.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3684
    Cell Significance Index: 63.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3631
    Cell Significance Index: 273.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3576
    Cell Significance Index: 186.4300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1827
    Cell Significance Index: 31.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0461
    Cell Significance Index: 188.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0156
    Cell Significance Index: 201.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9963
    Cell Significance Index: 899.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9719
    Cell Significance Index: 119.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9673
    Cell Significance Index: 528.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8693
    Cell Significance Index: 45.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7755
    Cell Significance Index: 36.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7113
    Cell Significance Index: 19.3600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6966
    Cell Significance Index: 14.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6653
    Cell Significance Index: 238.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6628
    Cell Significance Index: 293.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6558
    Cell Significance Index: 84.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6424
    Cell Significance Index: 33.7300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6264
    Cell Significance Index: 433.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4773
    Cell Significance Index: 33.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4635
    Cell Significance Index: 28.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4466
    Cell Significance Index: 57.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4221
    Cell Significance Index: 23.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3770
    Cell Significance Index: 28.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3148
    Cell Significance Index: 53.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3145
    Cell Significance Index: 19.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2480
    Cell Significance Index: 6.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2442
    Cell Significance Index: 18.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2075
    Cell Significance Index: 7.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1610
    Cell Significance Index: 4.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1369
    Cell Significance Index: 7.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1366
    Cell Significance Index: 16.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1307
    Cell Significance Index: 12.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0839
    Cell Significance Index: 5.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0662
    Cell Significance Index: 10.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0570
    Cell Significance Index: 107.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0167
    Cell Significance Index: 10.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0107
    Cell Significance Index: 16.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0060
    Cell Significance Index: 11.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0031
    Cell Significance Index: -2.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0093
    Cell Significance Index: -12.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0094
    Cell Significance Index: -1.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0100
    Cell Significance Index: -7.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0146
    Cell Significance Index: -9.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0282
    Cell Significance Index: -20.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0293
    Cell Significance Index: -1.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0326
    Cell Significance Index: -0.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0372
    Cell Significance Index: -16.8800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0467
    Cell Significance Index: -0.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0479
    Cell Significance Index: -3.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0683
    Cell Significance Index: -6.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0717
    Cell Significance Index: -40.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0839
    Cell Significance Index: -3.7100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1258
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1337
    Cell Significance Index: -28.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1550
    Cell Significance Index: -4.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1565
    Cell Significance Index: -45.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1831
    Cell Significance Index: -20.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1878
    Cell Significance Index: -27.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1944
    Cell Significance Index: -7.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1998
    Cell Significance Index: -7.0200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2034
    Cell Significance Index: -4.7000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2357
    Cell Significance Index: -4.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2845
    Cell Significance Index: -6.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3243
    Cell Significance Index: -9.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3828
    Cell Significance Index: -12.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4016
    Cell Significance Index: -8.7000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4025
    Cell Significance Index: -11.8200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4079
    Cell Significance Index: -5.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4636
    Cell Significance Index: -48.2700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4896
    Cell Significance Index: -55.8900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5750
    Cell Significance Index: -13.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5917
    Cell Significance Index: -15.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5929
    Cell Significance Index: -46.9600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.6349
    Cell Significance Index: -7.8800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7030
    Cell Significance Index: -13.7200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.7101
    Cell Significance Index: -7.7200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7520
    Cell Significance Index: -19.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7790
    Cell Significance Index: -47.7600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8371
    Cell Significance Index: -24.6600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.8574
    Cell Significance Index: -12.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8952
    Cell Significance Index: -23.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9421
    Cell Significance Index: -23.5500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.0114
    Cell Significance Index: -11.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ERGIC2 is a highly expressed gene, with significant levels of expression observed in various cell types, including hematopoietic oligopotent progenitor cells, embryonic stem cells, and smooth muscle fibers of the ileum. The ERGIC2 protein is a member of the ER-Golgi intermediate compartment complex and is involved in the retrograde transport of cargo from the Golgi to the ER. This protein also interacts with other proteins, including those involved in protein folding and quality control, to regulate cellular homeostasis. **Pathways and Functions** ERGIC2 is involved in several key pathways, including: 1. **Retrograde vesicle-mediated transport**: ERGIC2 facilitates the transport of proteins and lipids from the Golgi to the ER, a process critical for protein folding and quality control. 2. **Endoplasmic reticulum-Golgi intermediate compartment membrane transport**: ERGIC2 regulates the transport of cargo between the ER and Golgi apparatus, maintaining cellular homeostasis. 3. **Protein binding**: ERGIC2 interacts with other proteins involved in protein folding and quality control, regulating cellular homeostasis. **Clinical Significance** ERGIC2 dysregulation has been implicated in various diseases, including: 1. **Hematological disorders**: ERGIC2 mutations have been linked to hematological disorders, such as anemia and leukemia. 2. **Immunological disorders**: ERGIC2 dysregulation has been implicated in immunological disorders, including autoimmune diseases and immunodeficiency. 3. **Cancer**: ERGIC2 expression is often altered in cancer cells, suggesting its potential role in tumorigenesis. In conclusion, ERGIC2 is a crucial gene involved in the regulation of endoplasmic reticulum-Golgi transport, with significant implications for various physiological processes, including immune response, hematopoiesis, and cellular differentiation. Further research is needed to fully elucidate the mechanisms by which ERGIC2 regulates cellular homeostasis and to explore its potential therapeutic applications in various diseases. **Recommendations for Future Research** 1. **Investigate ERGIC2 function in specific cell types**: Further research is needed to elucidate the specific roles of ERGIC2 in various cell types and tissues. 2. **Explore ERGIC2 interactions with other proteins**: Investigating the interactions between ERGIC2 and other proteins involved in protein folding and quality control will provide insights into its regulatory mechanisms. 3. **Investigate ERGIC2 dysregulation in diseases**: Further research is needed to explore the role of ERGIC2 dysregulation in various diseases, including hematological disorders, immunological disorders, and cancer.

Genular Protein ID: 3653565325

Symbol: ERGI2_HUMAN

Name: Endoplasmic reticulum-Golgi intermediate compartment protein 2

UniProtKB Accession Codes:

Q96RQ1 A6NHH6 Q53GY2 Q8N2Q9 Q9BVV9 Q9NZA3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 14 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11445006

Title: Molecular cloning, expression, localization, and gene organization of PTX1, a human nuclear protein that is downregulated in prostate cancer.

PubMed ID: 11445006

DOI: 10.1089/10445490152122460

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15308636

Title: Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46.

PubMed ID: 15308636

DOI: 10.1074/jbc.m406644200

PubMed ID: 17980171

Title: The possible interaction of CDA14 and protein elongation factor 1alpha.

PubMed ID: 17980171

DOI: 10.1016/j.bbapap.2007.10.006

PubMed ID: 31142615

Title: The E3 ubiquitin ligase MARCH2 regulates ERGIC3-dependent trafficking of secretory proteins.

PubMed ID: 31142615

DOI: 10.1074/jbc.ra119.007435

Sequence Information:

  • Length: 377
  • Mass: 42549
  • Checksum: 3820FA05515634ED
  • Sequence:
    • MRRLNRKKTL SLVKELDAFP KVPESYVETS ASGGTVSLIA FTTMALLTIM EFSVYQDTWM 
KYEYEVDKDF SSKLRINIDI TVAMKCQYVG ADVLDLAETM VASADGLVYE PTVFDLSPQQ 
KEWQRMLQLI QSRLQEEHSL QDVIFKSAFK STSTALPPRE DDSSQSPNAC RIHGHLYVNK 
VAGNFHITVG KAIPHPRGHA HLAALVNHES YNFSHRIDHL SFGELVPAII NPLDGTEKIA 
IDHNQMFQYF ITVVPTKLHT YKISADTHQF SVTERERIIN HAAGSHGVSG IFMKYDLSSL 
MVTVTEEHMP FWQFFVRLCG IVGGIFSTTG MLHGIGKFIV EIICCRFRLG SYKPVNSVPF 
EDGHTDNHLP LLENNTH

Genular Protein ID: 713873439

Symbol: Q86TD3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86TD3

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 IntAct 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 RuleBase 1

Sequence Information:

  • Length: 132
  • Mass: 14992
  • Checksum: DA7344E8643355AC
  • Sequence:
    • MFQYFITVVP TKLHTYKISA DTHQFSVTER ERIINHAAGS HGVSGIFMKY DLSSLMVTVT 
EEHMPFWQFF VRLCGIVGGI FSTTGMLHGI GKFIVEIICC RFRLGSYKPV NSVPFEDGHT 
DNHLPLLENN TH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.